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*  LIG4 (-/-) HCT116 cell lines
Cell Number. 1x10⁶ Cell Culture. Revival. Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre ... What are X-MAN Cell Lines?. Horizon's X-MAN® (Mutant And Normal) cell lines are genetically engineered cell pairs containing ... Cell Line. HCT116 Functional Area. DNA Repair Primary Reference. Fattah, F., et al. (2010). Ku regulates the non-homologous end ... You're reviewing: Human LIG4 (-/-) HCT116 Cell Line * *Let us know your thoughts. ...
https://www.horizondiscovery.com/human-lig4-hct116-cell-line-hd-r02-063
*  Anticancer Effects of the Marine Sponge Lipastrotethya sp. Extract on Wild-Type and p53 Knockout HCT116 Cells
Extract on Wild-Type and p53 Knockout HCT116 Cells. Kiheon Choi,1,2 Hyun Kyung Lim,2 Sung Ryong Oh,2 Woo-Hyun Chung,1,2 and ... induces cell apoptosis and autophagy in human renal carcinoma cells," BioMed Research International, vol. 2015, Article ID ... "Induction of apoptosis by genipin inhibits cell proliferation in AGS human gastric cancer cells via Egr1/p21 signaling pathway ... M. R. Alison and C. E. Sarraf, "Apoptosis: a gene-directed programme of cell death," Journal of the Royal College of Physicians ...
https://www.hindawi.com/journals/ecam/2017/7174858/ref/
*  The Protective Roles of ROS-Mediated Mitophagy on 125I Seeds Radiation Induced Cell Death in HCT116 Cells
... Lelin Hu,1,2 Hao ... D. R. Green and B. Levine, "To be or not to be? How selective autophagy and cell death govern cell fate," Cell, vol. 157, no. 1 ... N. M. Mazure and J. Pouysségur, "Hypoxia-induced autophagy: cell death or cell survival?" Current Opinion in Cell Biology, vol ... J. Zhang and P. A. Ney, "Role of BNIP3 and NIX in cell death, autophagy, and mitophagy," Cell Death and Differentiation, vol. ...
https://www.hindawi.com/journals/omcl/2016/9460462/ref/
*  Molecules | Free Full-Text | Artesunate Activates the Intrinsic Apoptosis of HCT116 Cells through the Suppression of Fatty...
Subsequent assays showed that ART inhibits HCT116 cell proliferation through suppressing the fatty acid biosynthetic pathway ... quantitative proteomics approach was applied to identify differentially expressed proteins of HCT116 colorectal cancer cell ... our understanding of the underlying molecular mechanisms of ART for its therapeutic cytotoxic effect towards cancer cells. ... HCT116 cells were also treated with 2.2 μM ART for different time-span (from 0 to 48 h), and ART inhibited HCT116 cell ...
http://www.mdpi.com/1420-3049/22/8/1272/htm
*  HCT116 cells were treated with different doses of API ( | Open-i
HCT116 cells were treated with different doses of API (0.5, 1, 5, and 10 μM) for 48 h, harvested and stained with propidium ... pone.0175659.g001: HCT116 cells were treated with different doses of API (0.5, 1, 5, and 10 μM) for 48 h, harvested and stained ... pone.0175659.g001: HCT116 cells were treated with different doses of API (0.5, 1, 5, and 10 μM) for 48 h, harvested and stained ... with propidium iodide and subjected to flow cytometry.Histogram obtained indicated the accumulation cells in sub-G1 phase. ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC5383341_pone.0175659.g001&req=4
*  Knockdown of VASH1 in human colon cancer HCT116 cells p | Open-i
Knockdown of VASH1 in HCT116 cells dramatically pro ... Knockdown of VASH1 in human colon cancer HCT116 cells promoted ... knockdown of VASH1 in HCT116 cells dramatically promoted tumor growth, compared with the control shRNA-transfected HCT116 cells ... knockdown of VASH1 in HCT116 cells dramatically promoted tumor growth, compared with the control shRNA-transfected HCT116 cells ... Knockdown of VASH1 in HCT116 cells significantly increased Ki-67+ cell populations compared with control shRNA group in the ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC4480723_oncotarget-06-7880-g007&req=4
*  Debio 0507 primarily forms diaminocyclohexane-Pt-d(GpG) and -d(ApG) DNA adducts in HCT116 cells - Semantic Scholar
HCT116 cells were treated with IC50 doses of Debio 0507 or oxaliplatin for 3 days. Total cellular Pt-DNA adducts were ... and oxaliplatin-treated HCT116 human colon carcinoma cells by a combination of inductively coupled plasma mass spectrometry ( ... The Pt level/deoxynucleotide was 7.4/104 for DNA from Debio 0507-treated cells and 5.5/104 for oxaliplatin-treated cells ... Debio 0507 primarily forms diaminocyclohexane-Pt-d(GpG) and -d(ApG) DNA adducts in HCT116 cells. *. Christopher L King, ...
https://www.semanticscholar.org/paper/Debio-0507-primarily-forms-diaminocyclohexane-Pt-d-King-Ramachandran/d7f86ac880f505ff8b02bc6acef78740b7736188
*  The mechanism of action of ginseng-induced inhibition of human colon cancer cell HCT116 proliferation is influenced by p21...
Western blot analyses of proteins involved in cell signaling, cell cycle, and apoptosis were performed on cell lysates from ... these data indicate that GE inhibits colon cancer HCT116 cell proliferation, at least in part, by inhibition of the cell cycle ... the IC50 in p21-null cells (0.42 mg/ml) was nearly two fold lower than that in wild-type cells (0.8 mg/ml). Cells were then ... The mechanism of action of ginseng-induced inhibition of human colon cancer cell HCT116 proliferation is influenced by p21 ...
http://cancerres.aacrjournals.org/content/66/8_Supplement/490.1
*  Cordycepin inhibits lipopolysaccharide-induced cell migration and invasion in human colorectal carcinoma HCT116 cells through...
P-227 - Cordycepin inhibits lipopolysaccharide-induced cell migration and invasion in human colorectal carcinoma HCT116 cells ... Cordycepin inhibits lipopolysaccharide-induced cell migration and invasion in human colorectal carcinoma HCT116 cells through ... prevented LPS-induced MMP-9 expression and cell invasion in HCT116 cells. However, an AMPK inhibitor, compound C, and knockdown ... These findings provide evidence that cordycepin suppresses the migration and invasion of HCT116 cells through modulating EP4 ...
https://oncologypro.esmo.org/Topics/Gastrointestinal-Cancers/Colon-and-Rectal-Cancer/Cordycepin-inhibits-lipopolysaccharide-induced-cell-migration-and-invasion-in-human-colorectal-carcinoma-HCT116-cells-through-down-regulation-of-prostaglandin-E2-receptor-EP4
*  A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells.
VER-155008 induced caspase-3/7 dependent apoptosis in BT474 cells and non-caspase dependent cell death in HCT116 cells. VER- ... The in vitro activity of VER-155008 was evaluated in HCT116, HT29, BT474 and MDA-MB-468 carcinoma cell lines. Cell ... Cell Line, Tumor. Cell Proliferation / drug effects. Colonic Neoplasms / drug therapy, pathology. Drug Delivery Systems. Drug ... 155008 potentiated the apoptotic potential of a small molecule Hsp90 inhibitor in HCT116 but not HT29 or MDA-MB-468 cells. In ...
http://www.biomedsearch.com/nih/novel-small-molecule-inhibitor-potentiates/20012863.html
*  Glutathione S-Transferase π1 Promotes Tumorigenicity in HCT116 Human Colon Cancer Cells | Cancer Research
1D). The resulting cells (hereafter called GSTP1−/− cells) are similar to their parental HCT116 (GSTP1+/+) cells, with the ... Targeted disruption of GSTP1 in HCT116 cells. Somatic cell knockout technology was used to generate clones of HCT116 human ... P , 0.01, Student's paired t test comparing GSTP1−/− to GSTP1+/+ cells in the same conditions. C, cell cycle analyses. Cells ... For cell proliferation studies, cells were harvested after 4 and 8 days and stained with trypan blue, and viable cells were ...
http://cancerres.aacrjournals.org/content/65/20/9485
*  'MCC' protein interacts with E-cadherin and beta-catenin strengthening cell-cell adhesion of HCT116 colon cancer cells
These data provide a significant advance in the current understanding of cell-cell adhesion in colon cancer cells. ... These data provide a significant advance in the current understanding of cell-cell adhesion in colon cancer cells. ... Knockdown of MCC in HCT116 colon cancer cells caused a reduction in E-cadherin protein level, which is a hallmark of epithelial ... Knockdown of MCC in HCT116 colon cancer cells caused a reduction in E-cadherin protein level, which is a hallmark of epithelial ...
https://www.garvan.org.au/research/collaborative-programs/circa/publications/14498
*  Amlexanox and UPF1 Modulate Wnt Signaling and Apoptosis in HCT-116 Colorectal Cancer Cells
Amlexanox affects butyrate-modulated Wnt signaling and apoptosis of CRC cells. (A) Wnt signaling. HCT-116 cells transfected ... CBP and p300 are Wnt signaling coactivators that influence response to butyrate in CRC cells [13-15,18]. HCT-116 cells exhibit ... We determined the effects of enhanced NMD in HCT-116 cells, achieved through increased expression of UPF1. Cells stably ... Exp Cell Res. 2007;313:1652-66 12. Chiaro C, Lazarova DL, Bordonaro M. Tcf3 and cell cycle factors contribute to butyrate ...
http://jcancer.org/v10p0287.htm
*  The inhibitory effect of Manuka honey on human colon cancer HCT-116 and LoVo cell growth. Part 1: the suppression of cell...
Both cells were exposed to different concentrations of MH (0-20 mg mL−1 for HCT-116 cells and 0-50 mg mL−1 for LoVo cells) for ... MH induced cell cycle arrest in the S phase in HCT-116 cells, and simultaneously, in LoVo cells, it occurred in the G2/M phase ... The inhibitory effect of Manuka honey on human colon cancer HCT-116 and LoVo cell growth. Part 1: the suppression of cell ... The inhibitory effect of Manuka honey on human colon cancer HCT-116 and LoVo cell growth. Part 1: the suppression of cell ...
https://pubs.rsc.org/en/content/articlelanding/2018/fo/c8fo00164b
*  Molecules | Free Full-Text | Antiproliferative and Apoptotic Activity of Chamaecyparis obtusa Leaf Extract against the HCT116...
... exhibited anti-proliferative activity against HCT116 cells, while displaying no cytotoxicity against Chang liver cells. ... kinases played a key role in the apoptotic effect of the methanol extract of CO leaves in HCT116 human colon cancer cells. ... HCT116) were investigated. The methanol extract of CO leaves, at a concentration of 1.25 µg/mL, ... the anti-proliferative activities of the methanol and water extracts of CO leaves against a human colorectal cancer cell line ( ...
http://www.mdpi.com/1420-3049/20/10/18066
*  The effects of cadmium on heme oxygenase-1 in HCT116 human colon epithelial cells with or without iron deficiency, UNCG NC...
The effects of cadmium on heme oxygenase-1 in HCT116 human colon epithelial cells with or without iron deficiency. UNCG Author/ ... In my thesis project, the effects of cadmium on HO-1 in HCT116 human colon epithelial cells with or without iron deficiency ... The effects of cadmium on heme oxygenase-1 in HCT116 human colon epithelial cells with or without iron deficiency. PDF ( ... the results imply that cadmium could be more toxic to iron-deficient cells than to iron-sufficient cells, suggesting that ...
http://libres.uncg.edu/ir/uncg/listing.aspx?id=2342
*  MicroRNA Profiling of Oxaliplatin-Resistant HCT116 Colorectal Cancer Cells
Parental HCT116 cells also appeared more sensitive to SN-38 at 2 and 5 nM, compared to the resistant HCT116 cells (p , 0.05) ( ... 2A). Resistant HCT116 cells also exhibited an increased capacity to invade compared to the parental HCT116 cells (p , 0.001) ( ... Oxaliplatin-resistant HCT116 cells showed an increased ability to form spheres compared to parental HCT116 cells (p , 0.001) ( ... 1). Parental HCT116 cells were significantly more sensitive to oxaliplatin at 2 and 5 µM compared to the resistant HCT116 cells ...
http://www.oncm.org/v02p0111.htm
*  5-Fluorouracil Induce the Expression of TLR4 on HCT116 Colorectal Cancer Cell Line Expressing Different Variants of TLR4
The lowest IC50-value was measured in cells expressing the WT TLR4 and non-transfected cells were more resistance to the drug ... Cas3 and PARP activity and these effects were stronger in cells expressing WT TLR4 than the other cells. In conclusion, 5-FU- ... HCT116 was transfected with Flag-CMV1-TLR4 wild-type (WT) and D299G, T399I expression plasmids. The cytotoxic effect of 5-FU on ... study examined the impact of two common polymorphisms of the TLR4 genes on the response of the HCT116 colorectal cancer cells ...
http://ijpr.sbmu.ac.ir/article_1308.html
*  Calnexin, an ER-induced protein, is a prognostic marker and potential therapeutic target in colorectal cancer | Journal of...
Calnexin gene-silencing significantly reduced cell survival and increased cancer cell susceptibility to 5FU chemotherapy. ... The calnexin gene was silenced using siRNA in HCT116 cells. There were no increased levels of ER stress proteins in tumour ... 6d, **p , 0.01 versus HCT116 cells transfected with control siRNA and treated with vehicle; ###p , 0.001 versus HCT116 cells ... Calnexin gene silencing in HCT116 cells. HCT116 colon cancer cells were transfected with calnexin siRNA and control scramble ...
https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-016-0948-z
*  Guava | GreenMedInfo | Substance | Natural Medicine | Alternative
Meroterpenoids from guava fruit could induce apoptosis of HCT116 cells.Jun 20, 2017. ... A lycopene-rich extract from red guava was able to induce cytostatic and cytotoxic effects on breast cancer cells.Feb 28, 2018 ...
http://www.greenmedinfo.com/substance/guava
*  Anticancer potential of an ethanol extract of Asiasari radix against HCT-116 human colon cancer cells in vitro. - Semantic...
Taken together, these results suggest that EEAR inhibits the growth of the HCT-116 cells through induction of G2/M cell cycle ... EEAR significantly induced G2/M cell cycle arrest and apoptosis in HCT-116 cells. EEAR-induced apoptosis was observed in ... EEAR-induced apoptosis in HCT-116 cells was dependent on p53 expression, as determined by siRNA-mediated p53 knockdown. ... on HCT-116 human colon cancer cells and to investigate its underlying mechanisms of action. ...
https://www.semanticscholar.org/paper/Anticancer-potential-of-an-ethanol-extract-of-radix-Oh-Kim/d34c50c1db22f38772b8cf40c055d4635a118f32
*  October 2013 - Volume 19 - Issue 11 : Inflammatory Bowel Diseases
miR-106b Fine Tunes ATG16L1 Expression and Autophagic Activity in Intestinal Epithelial HCT116 Cells. Zhai, Zili; Wu, Feng; ... Myeloid-derived Suppressor Cells in the Inflammatory Bowel Diseases. Ostanin, Dmitry V.; Bhattacharya, Dhruva ... Therapeutic Evaluation of Ex Vivo-Generated Versus Natural Regulatory T-cells in a Mouse Model of Chronic Gut Inflammation. ... T300A Variant of Autophagy ATG16L1 Gene is Associated with Decreased Antigen Sampling and Processing by Dendritic Cells in ...
http://journals.lww.com/ibdjournal/Fulltext/2013/10000/href
*  Augmentation of Apoptosis and Tumor Regression by Flavopiridol in the Presence of CPT-11 in Hct116 Colon Cancer Monolayers and...
... deficient Hct116 cells to SN-38. A, dot plots of p21-deficient and parental Hct116 cells stained with MPM-2 antibody. The cells ... SN-38 Induces Cell Cycle Arrest at G2 in Hct116 Cells.. We examined cell cycle changes after SN-38 treatment in p21-intact and ... Hct116 cells (8 × 105) were plated, in duplicate, in 60-mm plates and incubated for 24 h to allow cells to adhere. Cells were ... Cell Culture and Drug Treatments for Cell Lines.. The p21-intact and -deficient Hct116 human colon cancer cell lines were ...
http://clincancerres.aacrjournals.org/content/7/12/4209