Molecular remodeling of tip links underlies mechanosensory regeneration in auditory hair cells. - PubMed - NCBI
Molecular remodeling of tip links underlies mechanosensory regeneration in auditory hair cells.. Indzhykulian AA1, Stepanyan R ... In terminally differentiated mammalian auditory hair cells, tip links are subjected to sound-induced forces throughout an ... Molecular Remodeling of Tip Links Underlies Mechanosensory Regeneration in Auditory Hair Cells ... Molecular Remodeling of Tip Links Underlies Mechanosensory Regeneration in Auditory Hair Cells ...https://www.ncbi.nlm.nih.gov/pubmed/23776407
Regulated vesicular trafficking of specific PCDH15 and VLGR1 variants in auditory hair cells.
Cell Differentiation. Cell Polarity / physiology*. Disease Models, Animal. Gene Knockdown Techniques. Hair Cells, Auditory / ... of ribbon synapses suggesting these proteins may play different roles in terminal differentiation of auditory hair cells. The ... Immature mouse cochleae and UB/OC-1 cells were used in this work to address whether specific variants of PCDH15 and VLGR1 are ... being selectively transported to opposite poles of the hair cells. Confocal colocalization studies between apical and basal ...http://www.biomedsearch.com/nih/Regulated-Vesicular-Trafficking-Specific-PCDH15/23035094.html
CIB2, defective in isolated deafness, is key for auditory hair cell mechanotransduction and survival. - PubMed - NCBI
AIn the mouse differentiating hair cells, the migration of the kinocilium from the cell centre to the cell periphery between ... B) In the auditory sensory epithelium, sensory inner (IHCs) and outer (OHCs) hair cells are organized in a single row and three ... CIB2, defective in isolated deafness, is key for auditory hair cell mechanotransduction and survival.. Michel V1,2,3, Booth KT4 ... In the mature hair bundle, the kinocilium is lost from P10 onwards, and the top connectors in the outer hair cells replace the ...https://www.ncbi.nlm.nih.gov/pubmed/29084757
Somatostatin and gentamicin-induced auditory hair cell loss - Zurich Open Repository and Archive
Caelers, A; Monge, A; Brand, Y; Bodmer, D (2009). Somatostatin and gentamicin-induced auditory hair cell loss. Laryngoscope, ... OBJECTIVE/HYPOTHESIS: Hair cells of the mammalian auditory system do not regenerate, and therefore their loss leads to ... OBJECTIVE/HYPOTHESIS: Hair cells of the mammalian auditory system do not regenerate, and therefore their loss leads to ... Protection of auditory hair cells from gentamicin was tested using two different concentrations (1 microM and 5 microM, ...http://www.zora.uzh.ch/id/eprint/18734/
Mechanotransduction current is essential for stability of the transducing stereocilia in mammalian auditory hair cells | eLife
The remarkable lifelong stability of mechanotransducing stereocilia of the inner ear hair cells depends on the activity of the ... Our sense of hearing depends on cells known as hair cells that line the inner ear. Each hair cell has tiny projections called ... Eps8 regulates hair bundle length and functional maturation of mammalian auditory hair cells * V Zampini ... the auditory hair cells in the middle of the cochlea at P4-P5 may demonstrate phenomena that are present in older hair cells. ...https://elifesciences.org/articles/24661
Localization and expression of clarin-1, the Clrn1 gene product, in auditory hair cells and photoreceptors. - Semantic Scholar
... and in synaptic terminals present at the base of the auditory hair cells from E18 to P6. In the retina, clarin-1 localizes to ... We examined clarin-1 expression in the immortomouse-derived hair cell line UB/OC-1. Only isoform 2 is expressed in UB/OC-1 at ... The subcellular localization of clarin-1 in hair cells and photoreceptors suggests it functions at both the basal and apical ... suggesting this isoform is biologically relevant to hair cell function. The protein co-localizes with microtubules and post- ...https://www.semanticscholar.org/paper/Localization-and-expression-of-clarin-1%2C-the-Clrn1-Zallocchi-Meehan/11184b916c37974ccd41434008c59906986cf47d
A synaptic F-actin network controls otoferlin-dependent exocytosis in auditory inner hair cells • Research - Institut Pasteur
We propose a new mechanistic model for vesicle exocytosis in auditory hair cells where the rate of vesicle recruitment to the ... A synaptic F-actin network controls otoferlin-dependent exocytosis in auditory inner hair cells. ... channels at the synaptic ribbons of auditory inner hair cells. This F-actin network is also found to provide mechanosensitivity ... Example: +cell +stem * Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.. Example: +cell - ...https://research.pasteur.fr/en/publication/a-synaptic-f-actin-network-controls-otoferlin-dependent-exocytosis-in-auditory-inner-hair-cells/
Synaptic specialization of auditory hair cells - Anthony Ricci
The peripheral auditory system communicates with the central nervous system through synapses between the sensory cells and the ... Synaptic specialization of auditory hair cells Ricci, Anthony J. Stanford University, Stanford, CA, United States ... Synaptic Specializations in Auditory Hair Cells. Ricci, Anthony J. / Stanford University. NIH 2015. R01 DC. Synaptic ... Schnee, M E; Castellano-MuÃ±oz, M; Ricci, A J (2013) Response properties from turtle auditory hair cell afferent fibers suggest ...http://grantome.com/grant/NIH/R01-DC009913-05
ETD | Transforming cochlear supporting cells into auditory hair cells for inner ear sensory organ regeneration | ID: 37720d11k ...
within the supporting cells. I show that ablating the endogenous hair cells modestly. increases the number of hair cells ... various conditions for hair cell regeneration and that the competency of supporting cells. conversion into hair cells may be ... inner ear is composed of sensory hair cells and interdigitating non-sensory supporting. cells. The hair cells are the primary ... Transforming cochlear supporting cells into auditory hair cells for inner ear sensory organ regeneration () 2018-08-28. Press ...https://etd.library.emory.edu/concern/etds/37720d11k?locale=en
Hair cell regeneration in the avian auditory epithelium. - Semantic Scholar
In birds and other non-mammals, regenerated hair cells arise from adjacent non-sensory (supporting) cells. Hair cell ... forming daughter cells that differentiate into either hair cells or supporting cells and thereby restore cytoarchitecture and ... However, mammals exhibit limited hair cell regeneration, particularly in the auditory epithelium. ... we have yet to determine why the mammalian auditory epithelium lacks the ability to regenerate hair cells spontaneously and ...https://www.semanticscholar.org/paper/Hair-cell-regeneration-in-the-avian-auditory-epith-Stone-Cotanche/57efefdc04b7462eae5d625fdfd928d1483a3482
Auditory Hair Cells and Sensory Transduction - Oxford Research Encyclopedia of Neuroscience
The proximal stimulus for all hair cells is deflection of the mechanosensitive hair bundle. Hair cells convert mechanical ... All these organs have a common receptor cell type, which is called the haircell, for the bundle of enlarged microvilli ... and then deliver these physical stimuli to the hair bundles. ... information contained within the temporal pattern of hair ... The proximal stimulus for all hair cells is deflection of the mechanosensitive hair bundle. Hair cells convert mechanical ...http://neuroscience.oxfordre.com/view/10.1093/acrefore/9780190264086.001.0001/acrefore-9780190264086-e-85?rskey=tVdbVi&result=3
Modes and Regulation of Endocytic Membrane Retrieval in Mouse Auditory Hair Cells
... of mouse auditory inner hair cells (IHCs), but its modes and molecular regulation are poorly understood. Electron microscopy ... Home → Publications → Modes and Regulation of Endocytic Membrane Retrieval in Mouse Auditory Hair Cells ... Modes and Regulation of Endocytic Membrane Retrieval in Mouse Auditory Hair Cells. The Journal of Neuroscience 34(3):707--716. ... Modes and Regulation of Endocytic Membrane Retrieval in Mouse Auditory Hair Cells ...http://www.bfnt-goettingen.de/Publications/articlereference.2014-10-23.7718285512
Microarray analysis of gene expression during auditory hair cell regeneration in zebrafish (Danio rerio) | BMC Bioinformatics |...
Immediately following noise exposure, zebrafish saccules exhibited significant hair cell loss in the caudal region. Hair cell ... Microarray analysis of gene expression during auditory hair cell regeneration in zebrafish (Danio rerio). ... the time course and gene expression of auditory hair cell regeneration has not been established for zebrafish (Danio rerio). ... This study establishes a time course of cell proliferation associated with hair cell regeneration in the zebrafish inner ear ...https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-9-S7-P15
Hair Cell Tuning and BK Splicing (1) | Auditory System | Ion Channel
Hair Cell Tuning and BK Splicing (1) - Download as PDF File (.pdf), Text File (.txt) or read online. Compares the distribution ... Hair Cell Tuning and BK Splicing (1). Uploaded by. Christopher Hurtado. Compares the distribution of BK channels on the ... Structure and Function of the Auditory. and Vestibular System - 1. ... Structure and Function of the Auditory. and Vestibular System - 1. ...https://ru.scribd.com/document/258393407/Hair-Cell-Tuning-and-BK-Splicing-1
North Atlantic Ocean Culprit of Dismal UK Summers | PlanetSave
New Compound Regenerates Auditory Hair Cells - Partially.... Antarctic Creatures Not Adapting to Warming Waters. ...https://planetsave.com/2012/10/09/north-atlantic-ocean-culprit-of-dismal-uk-summers/
talks.cam : Foster Talks
Symphony of a thousand hair cells: orchestrating auditory development. Prof. Corne Kros, Dept. of Biology and Environmental ... Molecular regulation of skeletal muscle stem cells in distinct cell states. Shahragim Tajbakhsh - Institut Pasteur, Stem Cells ... Stem cell renewal and lineage selection in mammalian epidermis.. Dr Fiona Watt, Wellcome Trust Centre for Stem Cell Research, ... Cell morphogenesis across scales: from molecular processes to cell-scale behaviour. Professor Ewa Paluch, University College ...https://talks.cam.ac.uk/show/archive/6283
Defining the cellular environment in the organ of Corti following extensive hair cell loss: a basis for future sensory cell...
... the sensory epithelium repairs to close the lesions but no new hair cells arise and hearing impairment ensues. For any cell ... Following the loss of hair cells from the mammalian cochlea, ... Year: 2007Hair cell regeneration in the avian auditory ... outer hair cell, IHC = inner hair cell; Dc = Deiters' cell, ip = inner pillar cell, op = outer pillar cell, Hc = Hensen's cell ... These new hair cells arise from the supporting cells, which are generally unaffected by those agents which kill hair cells. Two ...http://www.biomedsearch.com/nih/Defining-Cellular-Environment-in-Organ/22299045.html
GMS | 83. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e. V. | Pou4f3...
Pou4f3 mutant mice show stereocilia fusion and gaint stereocilia in auditory hair cells Meeting Abstract ... At the same stage, we also observed gaint stereocilia and stereocilia fusion in auditory hair cells by sanning electron ... that hearing loss in Family H was caused by appearance of gaint stereocilia and sterocilia fusion in auditory hair cells which ... The mutant mice displayed an elevation of auditory brianstem response (ABR) thresholds responsing to click and tones of ...http://www.egms.de/static/de/meetings/hnod2012/12hnod562.shtml
GMS | 83rd Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery | Pou4f3 mutant mice show...
At the same stage, we also observed gaint stereocilia and stereocilia fusion in auditory hair cells by sanning electron ... Pou4f3 mutant mice show stereocilia fusion and gaint stereocilia in auditory hair cells Meeting Abstract ... that hearing loss in Family H was caused by appearance of gaint stereocilia and sterocilia fusion in auditory hair cells which ... The mutant mice displayed an elevation of auditory brianstem response (ABR) thresholds responsing to click and tones of ...http://www.egms.de/static/en/meetings/hnod2012/12hnod562.shtml
2017 Archive | University of Maryland School of Medicine
Ronna P. Hertzano Discussed Her Research on Auditory Hair Cells. As a keynote speaker at the recent Association for Research in ... The issue is urgent, as there is currently no way to reverse hearing loss, largely because auditory hair cells, which sense ... Right now, there is no way to reverse this condition, largely because auditory hair cells, which sense sound and relay that ... Focusing on the use of genomics data in her research, she outlined new ways to understand the development of hair cells that ...http://www.medschool.umaryland.edu/news/2017/University-of-Maryland-School-of-Medicine-Researcher-Discusses-the-Genetics-of-Hearing-Loss-at-National-Otorhinolaryngology-Conference.html
Notch Signaling Limits Supporting Cell Plasticity in the Hair Cell-Damaged Early Postnatal Murine Cochlea
... which re-enter the cell cycle in response to hair cell damage , , auditory supporting cells in the murine hair cell- ... 6) for outer hair cells. Such Vm values show that the recorded hair cell-like cells as well as control hair cells were healthy ... In contrast, 90% of hair cell-like cells in Notch inhibited hair cell-ablated cultures expressed the outer hair cell specific ... for hair cell-like cells, compared to 1302±413 pA (n. =. 6) for inner hair cells and 853±196 pA (n. =. 8) for outer hair cells. ...http://pubmedcentralcanada.ca/pmcc/articles/PMC3758270/?lang=en-ca
NO-Sensitive Guanylate Cyclase Isoforms NO-GC1 and NO-GC2 Contribute to Noise-Induced Inner Hair Cell Synaptopathy | Molecular...
Yet inner hair cell (IHC) ribbons and auditory nerve responses showed significantly less deterioration in NO-GC1 KO and NO-GC2 ... 2007) Persistence of Ca(v)1.3 Ca2+ channels in mature outer hair cells supports outer hair cell afferent signaling. J Neurosci ... Deletion of NO-GC1 or NO-GC2 Preserves Inner Hair Cell and Auditory Nerve Fiber Function after Noise Exposure.. NO induces cGMP ... 2016) Loss of auditory sensitivity from inner hair cell synaptopathy can be centrally compensated in the young but not old ...http://molpharm.aspetjournals.org/content/92/4/375
York University: Christopher Bergevin's Homepage
Dynamics of auditory hair cells (Cell Dynamics Workshop 2014, slides) * Interrelations between otoacoustic emission delays and ... Comparison of otoacoustic emissions within gecko sub-families: Morphological implications for auditory function in lizards ( ... The following appear in What Fire is in Mine Ears: Progress in Auditory Biomechanics (American Institute of Physics) (2011; ... Comparative Auditory Biomechanics Probed by Otoacoustic Emissions (ASA 2013, talk - abstract) * Sound transmission in a simple ...http://www.yorku.ca/cberge/
Supra-Threshold Hearing and Fluctuation Profiles: Implications for Sensorineural and Hidden Hearing Loss | SpringerLink
An important topic in contemporary auditory science is supra-threshold hearing. Difficulty hearing at conversational speech ... Mechanoelectrical transduction in auditory hair cells. In: Eatock RA, Fay RR (eds) Vertebrate hair cells. Springer, New York, ... Russell IJ, Richardson GP, Cody AR (1986) Mechanosensitivity of mammalian auditory hair cells in vitro. Nature 321:517-519 ... A phenomenological model of the synapse between the inner hair cell and auditory nerve: long-term adaptation with power-law ...https://link.springer.com/article/10.1007%2Fs10162-018-0669-5
Farris HE, LeBlanc CL, Goswami J, Ricci AJ (2004) Probing the pore of the auditory hair cell mechanotransducer channel in ... Determining the location of TRPN1 in hair cells will help resolve this uncertainty, as will recordings from single hair cells. ... Similarities between cutaneous Merkel cells and mechanosensitive hair cells have fueled the speculation that Merkel cells are ... Fettiplace R, Ricci AJ (2003) Adaptation in auditory hair cells. Curr Opin Neurobiol 13: 446-451. ...http://www.jneurosci.org/content/24/42/9220