Extragenic Suppressors of Loss-of-Function Mutations in the Aspergillus FlbA Regulator of G-Protein Signaling Domain Protein |...
1996 GAIP and RGS4 are GTPase activating proteins (GAPs) for the Gi subfamily of G protein α subunits. Cell 86: 445-452. ... 1996 RGS family members: GTPase-activating proteins for heterotrimeric G-protein α subunits. Nature 383: 172-175. ... probably working as a GTPase activating protein (GAP), thus allowing development to proceed. Inactivation of flbA or ... which apparently functions in part by activating the regulator of G-protein signaling (RGS) domain protein FlbA (Lee and Adams ...
A Conserved GEF for Rho-Family GTPases Acts in an EGF Signaling Pathway to Promote Sleep-like Quiescence in Caenorhabditis...
... a Rho-family GTPase guanine nucleotide-activating protein encoded by the crossveinless-c gene was recently implicated in sleep ... Next, we generated different vav-1 domain deletion constructs to determine which, if any, protein-protein interaction domains ... 2003 DroVav, the Drosophila melanogaster homologue of the mammalian Vav proteins, serves as a signal transducer protein in the ... 2004 Insulinoma-associated protein IA-2, a vesicle transmembrane protein, genetically interacts with UNC-31/CAPS and affects ...
Integration of Self and Non-self Recognition Modulates Asexual Cell-to-Cell Communication in Neurospora crassa | Genetics
... and the gyp-5 gene encodes a GTPase-activating protein orthologous to Gyp5p in Saccharomyces cerevisiae, which physically ... Protein prediction. To identify functional domains in the HAM-11 protein, we used the following protein-prediction software: ... 2004 Role of a mitogen-activated protein kinase pathway during conidial germination and hyphal fusion in Neurospora crassa. ... 2008 The nuclear Dbf2-related kinase COT1 and the mitogen-activated protein kinases MAK1 and MAK2 genetically interact to ...
Biogenesis of RNA Polymerases II and III Requires the Conserved GPN Small GTPases in Saccharomyces cerevisiae | Genetics
... reveals a homodimeric molecule with a canonical GTPase domain and the purified protein exhibits GTPase activity in vitro (Gras ... 2007 Structural insights into a new homodimeric self-activated GTPase family. EMBO Rep. 8: 569-575. ... 2010 The protein interaction network of the human transcription machinery reveals a role for the conserved GTPase RPAP4/GPN1 ... 2000 A novel cytoplasmic GTPase XAB1 interacts with DNA repair protein XPA. Nucleic Acids Res. 28: 4212-4218. ...
Isolation and Characterization of HRT1 Using a Genetic Screen for Mutants Unable to Degrade Gic2p in Saccharomyces cerevisiae |...
1997 The Cdc42 GTPase-associated proteins Gic1 and Gic2 are required for polarized cell growth in Saccharomyces cerevisiae. ... The mammalian E6-AP and Rsp5 proteins accept activated ubiquitin from the E2 enzyme through a transient thioester formed on a ... 1999 The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity. Genes Dev. 13: ... What is the role of ring-finger proteins in E3 ligases? A large number of ring-finger-containing proteins promote E2-dependent ...
Presenilin-Based Genetic Screens in Drosophila melanogaster Identify Novel Notch Pathway Modifiers | Genetics
Asha, H., N. D. de Ruiter, M. G. Wang and I. K. Hariharan, 1999 The Rap1 GTPase functions as a regulator of morphogenesis in ... Wilkin, M. B., M. N. Becker, D. Mulvey, I. Phan, A. Chao et al., 2000 Drosophila dumpy is a gigantic extracellular protein ... Wang, W., and G. Struhl, 2004 Drosophila Epsin mediates a select endocytic pathway that DSL ligands must enter to activate ... which functions as a chaperone-type protein that utilizes ATP hydrolysis to drive conformational changes in target proteins ( ...
The Ketel Gene Encodes a Drosophila Homologue of Importin-β | Genetics
In the cytoplasm Ran-GTP dissociates from importin-β and is converted to Ran-GDP by RanGTP-ase activating protein (RanGAP) and ... 2000 Chromatin-independent nuclear envelope assembly induced by Ran GTPase Xenopus egg extracts. Science 288: 1429-1432. ... The Ketel protein supports nuclear protein import: To decide whether the Ketel protein does indeed function as importin-β we ... The protein is cytoplasmic with pronounced accumulation in the NEs (Figure 7, A and C). Nurse cells dump their Ketel protein ...
Unusual and Typical Features of a Novel Restorer-of-Fertility Gene of Sugar Beet (Beta vulgaris L.) | Genetics
... the bvORF20 protein might interact directly with preSATP6. This protein-protein complex might alter the higher order structure ... a GTPase involved in mitochondrial fusion (Ehses et al. 2009; Head et al. 2009). However, bvORF20 appears to lack protease ... region of mRNAs whose translation it activates. Plant Cell 17: 2791-2804. ... The quadruplicated genes encoded a protein resembling OMA1, a protein known from yeast and mammals to be involved in ...