COX-2 inhibitors delay pancreatic cancer prec | EurekAlert!
By stalling the growth of PanINs, researchers hope to slow the development of or prevent pancreatic cancer. ... COX-2 inhibitors delay pancreatic cancer precursors in mice Peer-Reviewed Publication American Association for Cancer Research ... Eibl and others plan to study the long-term effects of nimesulide and additional COX-2 inhibitors on the onset and progression ... COX-2 inhibitors delay pancreatic cancer precursors in mice. American Association for Cancer Research ...
Toward a more efficient therapy for a specifi | EurekAlert!
Placental growth factor. Researchers from the team headed by Peter Carmeliet have studied the role of placental growth factor ( ... All of these findings indicate that the therapeutic potential of PIGF inhibitors in CML needs to be investigated further. ... have investigated the role of placental growth factor (PlGF) in mice with CML. Blocking this growth factor increases the life ... This uncontrolled growth may damage various tissues and adversely affect the production of normal blood cells in the bone ...
AI may help brain cancer patients avoid biops | EurekAlert!
"We would use AI to detect an IDH-mutated glioma, then use IDH inhibitors to slow down or reverse the tumor growth. The field of ... If effective, these inhibitors could combine with AI-imaging techniques to overhaul how some brain cancers are assessed and ... which produces an enzyme that in mutated form may trigger tumor growth in the brain. ...
Tamoxifen may boost PI3K signaling to increas | EurekAlert!
Life sciences/Biochemistry/Biomolecules/Enzyme inhibitors/Kinase inhibitors/PI3K inhibitors * /Life sciences/Biochemistry/ ... which drives breast tumor growth. Tamoxifen blocks estrogen receptor activity in the breast, but it can activate the estrogen ... "For women taking tamoxifen for breast cancer, there may be a possibility of using a PI3K inhibitor for those who are at an ... Concurrent treatment with PI3K pathway inhibitors may benefit at-risk patients Reports and Proceedings American Association for ...
New protein detonates 'invincible' bacteria f | EurekAlert!
"We hope our approach will be used to further identify new growth inhibitors and their targets across bacterial species and in ... In this way, the team identified a new small protein, growth inhibitor gene product (Gp) 0.6, which specifically targets and ... the researchers located mutations in bacterial genes that resisted the toxicity of growth inhibitors produced by bacterial ... The inhibitor was found to cripple the activity of a protein vital to bacterial cells -- a protein that maintains the bacterial ...
Mutation database helps personalized treatmen | EurekAlert!
"We have known for some time that some EGFR mutations correlate with response to tyrosine kinase inhibitors for lung cancer ... in a molecule called epithelial growth factor receptor (EGFR). Somatic mutations in this cell-surface molecule are known to ... In addition, independent patient data (IPD) for patients who have been treated with tyrosine kinase inhibitors and some who ... Ultimately, the database offers a chance to improve treatment for people receiving tyrosine kinase inhibitors. "We believe that ...
New HIF-2 kidney cancer therapy more effectiv | EurekAlert!
Kidney cancer cells hijack the same system to fuel their growth. HIF-2 inhibitors work by suppressing the effects of HIF-2 ... "Unlike existing VEGF inhibitors, the HIF-2 inhibitor blocks VEGF only in the cancer and therefore does not cause cardiac ... HIF-2 inhibitors, which grew out of research begun more than 20 years ago at UT Southwestern Medical Center, work by ... In the Nature study, researchers compared the two drugs head to head and found that the HIF-2 inhibitor was more active than ...
Chemotherapy fails for some blood cancer pati | EurekAlert!
Life sciences/Cell biology/Cellular physiology/Cell growth * /Health and medicine/Clinical medicine/Medical treatments/Cancer ... Upon further investigations, the team tested the STAT3 inhibitors - a substance and member of the STAT family that interferes ... Located on the X chromosome, the gene DDX3X processes cell information and transmits signals for cell growth. While past ... with biologic activity including growth and proliferation - and discovered that these inhibitors killed lymphoma cells with ...
CLOVES Syndrome: Remarkable improvement in th | EurekAlert!
This gene regulates cell proliferation and growth. When overly activated, it causes the excessive growth of those parts of the ... Guillaume Canaud then approached the Novartis laboratory working in the field of oncology on a specific inhibitor of the PIK3CA ... a specific inhibitor called BYL719, in a cohort of 19 patients treated at the Necker-Enfants Malades Hospital - AP-HP and ... and that her growth was not affected during the 12 months of treatment. ...
New approach to fighting Alzheimer's shows po | EurekAlert!
In particular, many U.S. patients take cholinesterase inhibitors, which increase levels of acetylcholine, a neurotransmitter ... researchers found that a cocktail of three naturally occurring nutrients believed to promote growth of those connections, known ... of nutrients that was developed at MIT has shown the potential to improve memory in Alzheimers patients by stimulating growth ...
AACR recognizes research team that developed treatment for late-stage prostate cancer | EurekAlert! Science News
... will award the ninth annual AACR Team Science Award to the Designing Androgen Receptor Inhibitors Team from Memorial Sloan ... the team used preclinical models to identify novel AR inhibitors that blocked the growth of tumors. These studies led to the ... The Designing AR Inhibitors Team is a multi-institutional team that is composed of Charles Sawyers, MD, PhD, team leader, ... After determining that AR overexpression was responsible for fueling the growth and survival of castration-resistant prostate ...
Researchers developed a small molecule that m | EurekAlert!
In the second stage, we confirmed that the small molecule controls tumor growth as effectively as the antibodies - it inhibits ... Therapeutic targeting of PD-1/PD-L1 blockade by novel small-molecule inhibitors recruits cytotoxic T cells into solid tumor ...
Endocrine Society honors endocrinology field's leaders with 2019 Laureate Awards | EurekAlert! Science News
... include the growth hormone receptor knock-out and demonstrated the important role of the growth hormone/insulin-like growth ... which resulted in the identification of a new inhibitor factor linked to premature sexual development. She previously won the ... Hobbs is a Howard Hughes Medical Institute Investigator and is Director of the McDermott Center for Human Growth and ... An internationally-renowned expert in the field of growth hormone research, Kopchick is a Goll-Ohio Eminent Scholar and ...