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*  SIRT family in Endocrinology | Frontiers Research Topic
... is a member of the class III group of histone deacetylases, collectively called sirtuins. The mammalian sirtuin family consists ... is a member of the class III group of histone deacetylases, collectively called sirtuins. The mammalian sirtuin family consists ... is a member of the class III group of histone deacetylases, collectively called sirtuins. The mammalian sirtuin family consists ... Silent information regulator 1 (SIRT), also known as NAD-dependent deacetylase sirtuin, ...
https://www.frontiersin.org/research-topics/7143/sirt-family-in-endocrinology
*  Design and Synthesis of Novel Histone Deacetylase Inhibitor Derived from Nuclear Localizasion Signal Peptide
... a NLS-derived peptide to a HDAC surface recognition group and a hydroxamate zinc binding group to the surface recognition group ... a) Miller TA, Witter DJ, Belvedere S. Histone Deacetylase Inhibitors. J. Med. Chem. 2003;46:5097-5116. [PubMed] (b) Haggarty SJ ... Histone deacetylase (HDAC) inhibition has been clinically validated as a therapeutic strategy for cancer treatment with the FDA ... Isoform-selective histone deacetylase inhibitors. Chem Soc Rev. 2008;37:1402-1413. [PubMed] ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC2783919/
*  New study: NAD dependent protein deacetylase sirtuin 1 - pipeline review, H1 2017 - WhaTech
NAD Dependent Protein Deacetylase Sirtuin 1 (SIR2 Like Protein 1 or Sirtuin Type 1 or Regulatory Protein SIR2 Homolog 1 or ... It modulates chromatin function through deacetylation of histones and can promote alterations in the methylation of histones ... Group of intellectuals at Reports and Data partner to measure out actionable insights as well as primary and secondary data, ... NAD Dependent Protein Deacetylase Sirtuin 1 (SIR2 Like Protein 1 or Sirtuin Type 1 or Regulatory Protein SIR2 Homolog 1 or ...
https://www.whatech.com/market-research/medical/356831-new-study-nad-dependent-protein-deacetylase-sirtuin-1-pipeline-review-h1-2017
*  Highly Sensitive SensoLyte HDACs and HATs Assay Kits for Epigenetics Research - PR.com
Histone Deacetylase), SIRT (Sirtuin) 1 & 2 or HAT (Histone Acetyltransferases). ... Histone deacetylases have been grouped into three classes. Class I (HDAC 1, 2, 3, 8) and Class II (HDAC4, 5, 6, 7, and 9) are ... Histone deacetylases (HDACs), which catalyze the removal of acetyl groups from a ε-N-acetyl lysine amino acid on a histone, act ... AnaSpec has developed a series of highly sensitive assay kits for the detection of the activities of HDAC (Histone Deacetylase ...
https://www.pr.com/press-release/459774
*  MGH Center for Systems Biology :: Chemical Biology :: Publications
Targeting class I histone deacetylase 2 in MYC amplified group 3 medulloblastoma. ... Inhibition of histone deacetylase 6 improves long-term survival in a lethal septic model. ... Exploring the 3-piperidin-4-yl-1H-indole scaffold as a novel antimalarial chemotype. ... 2015;1(3):142-147 - PMID: 26955657 - PMCID: PMC4778250 - DOI: 10.1021/acscentsci.5b00121 ...
https://csb.mgh.harvard.edu/chemical_biology/publications?year=2015
*  Browse by Research Team - MDC Repository
Targeting class I histone deacetylase 2 in MYC amplified group 3 medulloblastoma.. Ecker, J. and Oehme, I. and Mazitschek, R. ... Targeting histone deacetylases in neuroblastoma.. Witt, O. and Deubzer, H.E. and Lodrini, M. and Milde, T. and Oehme, I. ... Histone deacetylase 10 promotes autophagy-mediated cell survival.. Oehme, I. and Linke, J.P. and Böck, B.C. and Milde, T. and ... Histone deacetylase 8 in neuroblastoma tumorigenesis.. Oehme, I. and Deubzer, H.E. and Wegener, D. and Pickert, D. and Linke, J ...
https://edoc.mdc-berlin.de/view/divisions/deubzer.html
*  Suppression of Excessive Histone Deacetylases Activity in Diabetic Hearts Attenuates Myocardial Ischemia/Reperfusion Injury via...
HDACs family is composed of three distinct groups, nonsirtuin HDACs (class I, II) and longevity protein sirtuin deacetylases ( ... group. versus HG-Control group. versus HGHR group. versus HGHR+TSA group. ... and histone 4 (f). All the results are presented as mean ± SEM, /group. versus DIR group. versus DIR+TSA group. ... Histone deacetylases (HDACs) and the histone acetyl transferases (HATs) regulated global acetylation levels in mammals. They ...
https://www.hindawi.com/journals/jdr/2017/8208065/
*  The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent...
Eighteen distinct human histone deacetylases have been identified and are grouped in three classes based on their homology to ... In vitro deacetylase assay. Deacetylase assays were performed in 100 μl of SIRT deacetylase buffer (4 mM MgCl2, 0.2 mM ... consistent with a class III deacetylase. We identify this deacetylase as the nuclear-encoded human Sir2 homologue hSIRT3, and ... Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors. Nature. 401:188-193. ...
http://jcb.rupress.org/content/158/4/647
*  HDAC8 - Wikipedia
It has histone deacetylase activity and represses transcription when tethered to a promoter. Histone deacetylase 8 is involved ... "Characterization of a highly complex region in Xq13 and mapping of three isodicentric breakpoints associated with preleukemia ... "Expression of histone deacetylase 8, a class I histone deacetylase, is restricted to cells showing smooth muscle ... Histone deacetylase 8 is an enzyme that in humans is encoded by the HDAC8 gene. Histones play a critical role in ...
https://en.wikipedia.org/wiki/HDAC8
*  Stages II-III Multiple Myeloma « Tower Hematology Oncology Medical Group
Farydak® (panobinostat) is a drug that belongs to a class of drugs called histone deacetylase (HDAC) inhibitors. They work by ... Stages II-III Multiple Myeloma. Overview. Stage II or III multiple myeloma is characterized by an intermediate or high amount ... More than three-quarters (76%) of patients treated with the three-drug combination experienced complete or partial remissions ... Patients typically survive two to three years after treatment with Alkeran® and prednisone. While patients may respond more ...
http://www.toweroncology.com/types-of-cancer/multiple-myeloma/stages-ii-iii-multiple-myeloma/
*  Items where Year is 2012 - MDC Repository
Group by: Item Type , Creators Name. Jump to: Article , Book Section , Conference or Workshop Item , Review , Letter , ... Histone hypoacetylation is required to maintain late replication timing of constitutive heterochromatin.. Casas-Delucchi, C.S. ... Comparison of three multichannel transmit/receive radiofrequency coil configurations for anatomic and functional cardiac MRI at ... eggNOG v3.0: orthologous groups covering 1133 organisms at 41 different taxonomic ranges.. Powell, S. and Szklarczyk, D. and ...
https://edoc.mdc-berlin.de/view/year/2012.html
*  Epigenetic treatment of pancreatic cancer: is there a therapeutic perspective on the horizon? | Gut
According to their structural and functional qualities, HDAC proteins are grouped into three classes. Class III deacetylases ( ... deacetylation by different groups of histone deacetylases (HDACs) is responsible for repression of gene transcription (figure 1 ... histone deacetylase; H3, histone 3; KDM6, lysine demethylase 6; K27, lysine 27; me3, 3 methyl groups; PRC1/2, polycomb ... Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nat Rev Cancer 2006;6:38-51. doi ...
http://gut.bmj.com/content/early/2016/11/03/gutjnl-2016-312539.long
*  Histone Deacetylase Inhibition Blunts Ischemia/Reperfusion Injury by Inducing Cardiomyocyte AutophagyCLINICAL PERSPECTIVE |...
Histone Deacetylase Inhibition Blunts Ischemia/Reperfusion Injury by Inducing Cardiomyocyte AutophagyCLINICAL PERSPECTIVE. Min ... Histone Deacetylase Inhibition Blunts Ischemia/Reperfusion Injury by Inducing Cardiomyocyte AutophagyCLINICAL PERSPECTIVE ... Histone Deacetylase Inhibition Blunts Ischemia/Reperfusion Injury by Inducing Cardiomyocyte AutophagyCLINICAL PERSPECTIVE ... Histone Deacetylase Inhibition Blunts Ischemia/Reperfusion Injury by Inducing Cardiomyocyte AutophagyCLINICAL PERSPECTIVE ...
http://circ.ahajournals.org/content/129/10/1139.short?rss=1
*  Histone deacetylase - Wikipedia
... except class III) contain zinc and are known as Zn-dependent histone deacetylases. HDAC proteins are grouped into four classes ... Histone acetyltransferase (HAT) Histone deacetylase inhibitor Histone methyltransferase (HMT) Histone-modifying enzymes RNA ... Histone deacetylases remove those acetyl groups, increasing the positive charge of histone tails and encouraging high-affinity ... Histone deacetylases (EC 3.5.1.98, HDAC) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine ...
https://en.wikipedia.org/wiki/Histone_deacetylase
*  December | 2013 | alk-inhibitors
Group two received MEC only, group three received histone deacetylase inhibitor,and group four received DNA methyl transferase ... A total of 40 male SD rats U0126 had been divided into 4 groups. Group 1 served as manage and provided two ml saline, three ... the outcomes had been near to sham group. In DNMT inhibitor group, nevertheless, histology of lungs was worse than MEC group ... In group three, the HDAC inhibitor considerably lowered interstitial and alveolar edema, hemorrhage and inflammatory cell ...
https://alk-inhibitors.com/2013/12
*  Support for phosphoinositol 3 kinase and mTOR inhibitors as treatment for lupus using in-silico drug-repurposing analysis |...
Our exploratory analysis provides evidence that phosphoinositol 3 kinase and mammalian target of rapamycin (mTOR) inhibitors ... histone deacetylase (HDAC) inhibitors, and PKC activators, as well as three groups with negative scores, where we found ... Manipulation of B-cell responses with histone deacetylase inhibitors. Nat Commun. 2015;6:6838.View ArticlePubMedGoogle Scholar ... FOXP3+ regulatory T cell development and function require histone/protein deacetylase 3. J Clin Invest. 2015;125:1111-23.View ...
https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-017-1263-7
*  Sirtuins: Sir2-related NAD-dependent protein deacetylases | Genome Biology | Full Text
... are protein deacetylases dependent on nicotine adenine dinucleotide (NAD) and are found in organisms ranging from bacteria to ... which act on both histone and non-histone substrates despite their names. HDACs are grouped into three classes on the basis of ... Although Sirt3 shows robust histone deacetylase activity on a histone H4 peptide in vitro, the absence of histones in ... exerts both histone-deacetylase and robust ADP-ribosyltransferase activity on histones H2A and H2B [46]. García-Salcedo et al ...
https://genomebiology.biomedcentral.com/articles/10.1186/gb-2004-5-5-224
*  Angela K on Flipboard
Viability of D283 medulloblastoma cells treated with a histone deacetylase inhibitor combined with bombesin receptor ... When it comes to marijuana, there are really three kinds of people: those who say they've always thought it should be legal, ... and survival remains particularly poor in patients with Group 3 tumors. … ... b,Predictive factors for survival and correlation to toxicity in advanced Stage III non-small cell lung cancer patients with ...
https://flipboard.com/@1angel2
*  Mitochondrial Dysregulation in the Pathogenesis of Diabetes: Potential for Mitochondrial Biogenesis-Mediated Interventions
Sirtuins are a group of class III histone/protein deacetylases that are primarily known for their involvement in promoting ... More recently, another histone/protein deacetylase has gained increasing attention as a key regulator of metabolic activity in ... The insulin-resistant group did not only have higher intramyocellular lipid (IMCL) levels than the control group, but this was ... three of which are mainly localized to mitochondria (SIRT3, SIRT4, SIRT5) [51, 52]. SIRT1 is a NAD-dependent deacetylase that ...
https://www.hindawi.com/journals/jdr/2012/642038/
*  Plus it
Ac, acetyl groups; HDAC3, histone deacetylase 3; NCoR, nuclear receptor corepressor; SMRT, silencing mediator of retinoic acid ... and enzymes mediating their addition or removal include histone acetyltransferases (HAT) and histone deacetylases (HDAC), ... of histones and organize the chromatin structure. PTMs of histones influence transcription initiation and elongation by ... Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma. Nature 2011;476:298-303. ...
http://cancerdiscovery.aacrjournals.org/content/7/1/14
*  Targeting HDAC3 in CREBBP-Mutant Lymphomas Counterstrikes Unopposed Enhancer Deacetylation of B-cell Signaling and Immune...
Ac, acetyl groups; HDAC3, histone deacetylase 3; NCoR, nuclear receptor corepressor; SMRT, silencing mediator of retinoic acid ...
http://cancerdiscovery.aacrjournals.org/content/7/1/14.figures-only
*  Changes in the nuclear matrix of chicken erythrocytes that accompany maturation | Biochemical Journal
Common and different proteins belonging to one of the three groups were identified in nuclear matrices of immature and mature ... Investigation of the partitioning of histone deacetylase activity, an enzyme associated with the internal matrix, among the ... However, the activity of histone deacetylase and level of internal matrix proteins from mature-erythrocyte nuclear matrices ...
http://www.biochemj.org/content/320/1/257
*  Bruno C Medeiros, MD | Stanford Medicine Profiles
Combining these three factors segregates patients in three well-defined risk groups. These data suggest that ALC can be used in ... Histone deacetylase inhibitors such as vorinostat enhance gemtuzumab ozogamicin efficacy in vitro. We, therefore, investigated ... 131 days, P = 0.0026). Response rates were: group 1, one of 10 (10.0%); group 2A, 6 of 13 (46.2%); and group 2B, none of 8 (0 ... Epigenetic therapeutics such as the histone deacetylase inhibitor, vorinostat, and the DNA methyltransferase I inhibitor, ...
https://med.stanford.edu/profiles/bruno-medeiros?tab=research-and-scholarship
*  August 2015 - Ozgene
The group has three main research interests: First, Prof Mariadason's team investigates how epigenetic regulatory proteins such ... as histone deacetylases (HDACs) and bromodomain-containing proteins regulate colon cancer cell growth and survival. Second, ... The group uses genetically modified mouse models, one of which was generated by Ozgene in 37 weeks. Further improvements in ...
https://www.ozgene.com/publication/newsletter/24-newsletters/197-ozgene-news-august-2015
*  Gonçalo Castelo-Branco Group | Department of Medical Biochemistry and Biophysics | Karolinska Institutet
Our research group is interested in the molecular mechanisms defining the epigenetic state of stem/progenitor cells. We are ... We have so far uncover the role of specific histone deacetylases in the differentiation of neural stem cells into the ... The three of us and Dr. Claudia Kutter will be organising the second edition of the workshop in July 2018, for updates please ... Neural stem cell differentiation is dictated by distinct actions of nuclear receptor corepressors and histone deacetylases.. ...
http://ki.se/en/mbb/goncalo-castelo-branco-group