Transfer of GPI-Linked Proteins to Transfused Patients With Paroxysmal Nocturnal Hemoglobinuria - Tabular View - ClinicalTrials...
GPI-linked proteins) in the transfused blood transfer to the patient's blood cells. GPI-linked proteins, which are normally ... If it is found that GPI-linked proteins transfer to the patient's cells, the study will also examine how long the proteins ... The purpose of this study is to examine protein transfer of GPI-linked proteins from transfused cells to deficient cells ... Transfer of GPI-Linked Proteins to Transfused Patients With Paroxysmal Nocturnal Hemoglobinuria. The safety and scientific ...https://clinicaltrials.gov/ct2/show/record/NCT00039923
Human dolichol‐phosphate‐mannose synthase consists of three subunits, DPM1, DPM2 and DPM3 | The EMBO Journal
GPI‐anchored proteins would not be synthesized and protein N‐glycosylation would be impaired. O‐ and C‐mannosylation of ... Kornfeld R and Kornfeld S (1985) Assembly of asparagine‐linked oligosaccharides. Annu Rev Biochem, 54, 631-664. ... For this, we used Lec15.B5 cells in which a cDNA of human CD59, a reporter GPI‐anchored protein, was stably transfected. CD59 ... These symptoms may be due to a lack of N‐glycan and/or a lack of GPI‐anchored proteins. ...http://emboj.embopress.org/content/19/11/2475
Paroxysmal Nocturnal Hemoglobinuria | Williams Hematology, 9e | AccessHemOnc | McGraw-Hill Medical
GPI) moiety that anchors some proteins to the cell surface. Consequently, all GPI-anchored proteins (GPI-APs) that are normally ... This div only appears when the trigger link is hovered over. Otherwise it is hidden from view. ... GPI, glycosylphosphatidylinositol; GPI-APs, glycosylphosphatidylinositol-anchored proteins; GVHD, graft-versus-host disease; ... that are the clinical hallmarks of PNH are a consequence of deficiency of the GPI-anchored complement regulatory proteins, CD55 ...http://hemonc.mhmedical.com/content.aspx?bookid=1581§ionid=101237594
Lipid rafts, caveolae and GPI-linked proteins.
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/108519 ...https://repository.ubn.ru.nl/handle/2066/108519
MEDLINE - Resultado de la b squeda |p gina 1|
GPI-Linked Proteins); 0 (NF-kappa B); 0 (VP40 protein, virus); 0 (Viral Envelope Proteins); 0 (Viral Matrix Proteins); 0 ( ... Prote nas Ligadas a GPI/gen tica. Prote nas Ligadas a GPI/metabolismo. C lulas HEK293. Humanos. FN-kappa B/gen tica. Dominios ... The effects of these proteins converge on an intracellular signaling pathway that depends on a protein modification termed ... activated NF-κB in concert with the Ebola virus proteins at least as effectively as wild-type BST2. Signaling by the GPI anchor ...http://bases.bireme.br/cgi-bin/wxislind.exe/iah/online/?IsisScript=iah/iah.xis&base=MEDLINE&lang=e&nextAction=lnk&exprSearch=ebola$
Hemopoesis Flashcards by adam wing | Brainscape
Pathgenesis: PIGA forms GPI which anchors proteins to cell surfaces. normally 3 GPI linked proteins inhibit complement ... Proteins affected- ankyrin Band 4.2(anchors spectrin on inside) Spectrin(main framework) Band 3(transmembrane protein that ... renal insufficiency secondary to hypercalcemia, bence jones proteins and amyloid deposition.. Diagnositic criteria- M-protein ... X-linked. may be due to natural selection. Clinical featuers. -acute hemolysis- 2-3 days afeter exposure to oxidant stress like ...https://www.brainscape.com/flashcards/hemopoesis-2813973/packs/4277871
GFR alpha-1/GDNF R alpha-1 Research Products: Novus Biologicals
PI-linked cell-surface accessory protein. *GDNF receptor alpha-1. *GPI-linked anchor protein ... Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRalpha, which ... GFRalpha-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Thus, GDNF, GFRalpha and ...https://www.novusbio.com/common-name/gfr-alpha-1-gdnf-r-alpha-1
Search of: 'Paroxysmal nocturnal hemoglobinuria' - List Results - ClinicalTrials.gov
Transfer of GPI-Linked Proteins to Transfused Patients With Paroxysmal Nocturnal Hemoglobinuria. *Paroxysmal Hemoglobinuria ... The effect of ALN-CC5 on serum levels of C5 protein. 62. All. 18 Years to 45 Years (Adult). NCT02352493. ALN-CC5-001. January ...https://clinicaltrials.gov/ct2/results?cond=%22Paroxysmal+nocturnal+hemoglobinuria%22&show_rss=Y
RET proto-oncogene - Wikipedia
"A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor". Nature. 387 (6634): 717-21. doi:10.1038/ ... protein kinase activity. • kinase activity. • protein binding. • protein tyrosine kinase activity. • ATP binding. • Ras guanyl- ... membrane protein proteolysis. • phosphorylation. • transmembrane receptor protein tyrosine kinase signaling pathway. • positive ... Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7). *Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) ...https://en.wikipedia.org/wiki/RET_proto-oncogene
Vandlen R[au] - PubMed - NCBI
Citations may include links to full-text content from PubMed Central and publisher web sites. ... A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor. ... Translation levels control multi-spanning membrane protein expression.. Kim HS, Ernst JA, Brown C, Bostrom J, Fuh G, Lee CV, ... The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane ...https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Vandlen+R%5Bau%5D&dispmax=50
TLR4, Ethanol, and Lipid Rafts: A New Mechanism of Ethanol Action with Implications for other Receptor-Mediated Effects | The...
... similar to other GPI-linked proteins, resides in lipid rafts (42). Upon stimulation with specific ligand the recruitment of ... It has been suggested previously that EtOH may act on membrane proteins by disrupting protein-lipid interactions (22). If this ... some are enriched in caveolin and others concentrate clathrin and GPI-anchored proteins or dynamin (16, 17). It is generally ... a membrane-associated receptor that has a GPI-linked transmembrane but no intracellular domain, transduces signals by ...http://www.jimmunol.org/content/178/3/1243
HIV-1 replication in iDCs upregulates tetherin in a Nef | Open-i
GPI-Linked Proteins/antagonists & inhibitors/immunology/metabolism. *Gene Knockdown Techniques. *Interferon-alpha/immunology ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC3108291_1742-4690-8-26-8&req=4
benign endometrioid tumor of ovary 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
GPI-Linked Proteins. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Middle Aged. Neoplasm Metastasis. ... Chemical-registry-number] 0 / GPI-Linked Proteins; 0 / Membrane Glycoproteins; 0 / RNA, Messenger; 0 / mesothelin ... Tumor Suppressor Proteins / analysis. Tumor Suppressor Proteins / genetics. Uterine Cervical Neoplasms / chemistry. Uterine ... Chemical-registry-number] 0 / Antigens, CD30; 0 / KRT7 protein, human; 0 / Keratin-7; 0 / Organic Cation Transport Proteins; 0 ...http://www.bmlsearch.com/?kwr=benign+endometrioid+tumor+of+ovary+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0
benign mesothelioma of the pleura 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
MeSH-minor] GPI-Linked Proteins. Humans. Pleural Effusion, Malignant / metabolism. Survival Analysis ... GPI-Linked Proteins. Humans. Male. Middle Aged. Pleura / chemistry. Prognosis. Survival Analysis ... Chemical-registry-number] 0 / GPI-Linked Proteins; 0 / Membrane Glycoproteins; 0 / mesothelin; 106441-73-0 / Osteopontin ... Chemical-registry-number] 0 / GPI-Linked Proteins; 0 / Membrane Glycoproteins; 0 / mesothelin ...http://www.bmlsearch.com/?kwr=benign+mesothelioma+of+the+pleura+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0
Targeted Therapy against Human Lung Cancer in Nude Mice by High-Affinity Recombinant Antimesothelin Single-Chain Fv Immunotoxin...
Mesothelin is a GPI-linked glycoprotein present on the cell surface of normal mesothelial cells. GPI-linked proteins regulate a ... One candidate differentiation antigen, mesothelin, is a GPI 3-linked glycoprotein synthesized as a Mr 69,000 precursor; it is ... GPI-anchored cell-surface molecules complexed to protein tyrosine kinases. Science (Wash. DC), 254: 1016 -1019,1991 .. ... An antimesothelin disulfide-linked Fv (SS1 Fv) was fused to a truncated mutant of Pseudomonas exotoxin A to produce the ...http://mct.aacrjournals.org/content/1/8/595?ijkey=143a5aa49b5dc9a4703d98640d6d0d2ed8271b67&keytype2=tf_ipsecsha
Symmetry-breaking charge transfer in the excited state of directly linked push-pull porphyrin arrays.
... process in the excited state of a directly linked push-pull porphyrin dyad (AD) and triad (ADA) v... ... after they receive a blood transfusion to determine if certain proteins (GPI-linked proteins)... ... Transfer of GPI-Linked Proteins to Transfused Patients With Paroxysmal Nocturnal Hemoglobinuria ... Symmetry-breaking charge transfer in the excited state of directly linked push-pull porphyrin arrays.. 08:00 EDT 17th May 2017 ...https://www.bioportfolio.com/resources/pmarticle/1751561/Symmetry-breaking-charge-transfer-in-the-excited-state-of-directly-linked-push.html
A Drosophila Model of Multiple Endocrine Neoplasia Type 2 | Genetics
Klein, R. D., D. Sherman, W. H. Ho, D. Stone, G. L. Bennett et al., 1997 A GPI-linked protein that interacts with Ret to form a ... Melillo, R. M., M. Santoro, S. H. Ong, M. Billaud, A. Fusco et al., 2001 Docking protein FRS2 links the protein tyrosine kinase ... Buj-Bello, A., J. Adu, L. G. Pinon, A. Horton, J. Thompson et al., 1997 Neurturin responsiveness requires a GPI-linked receptor ... One gene, CG17204, shows weak similarity to GFRα proteins and contains a putative C-terminal GPI-anchor site, also suggestive ...http://www.genetics.org/content/171/3/1057
Raymond A[au] - PubMed - NCBI
Citations may include links to full-text content from PubMed Central and publisher web sites. ... The GPI-Linked Protein LY6A Drives AAV-PHP.B Transport across the Blood-Brain Barrier. ... Deimination of Human Hornerin Enhances its Processing by Calpain-1 and its Cross-Linking by Transglutaminases. ...https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Raymond+A%5Bau%5D&dispmax=50
Vascular Endothelial-Junctional Adhesion Molecule (VE-JAM)/JAM 2 Interacts with T, NK, and Dendritic Cells Through JAM 3 | The...
A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor. [Published erratum appears in 1998 Nature ... This led us to hypothesize and prove, through both protein/protein and protein/cell assays, that JAM 3 was the receptor for VE- ... Protein conjugation. VE-JAM/JAM 2.Fc, human IgG1, or JAM 3.Fc were biotinylated with 200 μg of EZ-Link sulfo-NHS-LC-biotin ( ... 4⇑C, lane 2). This band was not seen in conditions immunoprecipitated with an Fc-cross-linked human IgG/protein A matrix (Fig. ...http://www.jimmunol.org/content/168/4/1618
Howard Hughes Medical Institution - Research Output - Johns Hopkins University
GPI-Linked Proteins Saccharomyces cerevisiae Proteins Axon Dynamics during Neocortical Laminar Innervation. Hand, R. A., Khalid ... The DEAD-Box Protein Dhh1p Couples mRNA Decay and Translation by Monitoring Codon Optimality. Radhakrishnan, A., Chen, Y. H., ... Cas adaptor proteins organize the retinal ganglion cell layer downstream of integrin signaling. Riccomagno, M. M., Sun, L. O., ... Avoiding the ends: Internal epitope tagging of proteins using transposon Tn7. Zordan, R. E., Beliveau, B. J., Trow, J. A., ...https://jhu.pure.elsevier.com/en/organisations/howard-hughes-medical-institution-3/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Farticle
The in silico human surfaceome | PNAS
... and GPI-linked proteins are available (2⇓⇓⇓⇓⇓⇓-9). (ii) Prediction of the correct orientation of the protein within the ... In addition, 130 annotated GPI-linked human proteins (UniProt keyword: GPI-anchor) that do not have TM domains were included, ... ɑ-helical TM proteins, two β-barrel proteins, 12 proteins with intramembrane loops, and 2,389 proteins with a signal peptide ... structure/adhesion proteins; 18, ligand proteins; and 19, proteins of unknown function. (E) Overlap of proteins of the human ...https://www.pnas.org/content/115/46/E10988
Glycosylphosphatidyliositol anchor definition | Drugs.com
GPI-linked proteins are required for normal lymphocyte function and to maintain normal peripheral lymphoid homeostasis. ... Definition: a tether for some surface proteins to the cell membrane; these proteins are deficient in blood cells of patients ... with paroxysmal nocturnal hemoglobinuria as a result in a mutation in the X-linked phosphatidylinositolglycan complementation ...https://www.drugs.com/dict/glycosylphosphatidyliositol-anchor.html
Paroxysmal Nocturnal Hemoglobinuria | Springer for Research & Development
GPI)-linked surface proteins (Rosse 1990a). To date, 11 such proteins have been found to be missing or deficient on the ... 1989) (see Table 1). Other GPI-linked proteins that have not been identified are probably also missing. ... Rosse WF (1990a) Phosphatidylinositol-linked proteins and paroxysmal nocturnal hemoglobinuria. Blood 75: 1595-1601PubMedGoogle ... Identification of three novel Pl-linked proteins on granulocytes. In: Knapp W, Dorken B, Gilks WR, Rieber EP, Schmidt RE, Stein ...https://rd.springer.com/chapter/10.1007/978-3-642-77014-2_10
Mediators of innate immune recognition of bacteria concentrate in lipid rafts and facilitate lipopolysaccharide-induced cell...
... is a GPI-linked protein. A characteristic feature of GPI-anchored proteins is that they are found in microdomains ( Schroeder ... Gpi)-Anchored proteins - gpi-anchored proteins in liposomes and cells show similar behavior. Proc. Natl. Acad. Sci. USA 91, ... GPI)-linked protein, it transduces the signal by associating with other signalling molecules. Toll-like receptor (TLR)-4 has ... Brown, D. A. and Rose, J. K. ( 1992). Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during ...http://jcs.biologists.org/content/115/12/2603
Anti-Human CD59 antibody for Immunoprecipitation (IP)
... is a cell membrane protein which contains one UPAR/Ly6 domain. CD59 is a small, highly glycosylated, GPI-linked protein, with a ... Incorporation of leucocyte GPI-anchored proteins and protein tyrosine kinases into lipid-rich membrane domains of COS-7 cells. ... CD59 is involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. Defects in CD59 are the ... Rudd, Morgan, Wormald, Harvey, van den Berg, Davis, Ferguson, Dwek: "The glycosylation of the complement regulatory protein, ...http://www.antibodies-online.com/complement-system-pathway-11/cd59-antibody-2603/human-ip-12864/