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*  NGF reprograms metastatic melanoma to a bipotent glial-melanocyte neural crest-like precursor | Biology Open
1996). Analysis of expression of the melanoma-associated antigens MART-1 and gp100 in metastatic melanoma cell lines and in in ... 2009). Establishment of a Screening System for Chemicals that Upregulate a Melanoma Antigen, Melan-A/MART-1. Tohoku J. Exp. Med ... 1998). Comparative analysis of the in vivo expression of tyrosinase, MART-1/Melan-A, and gp100 in metastatic melanoma lesions: ... 2012). Melanoma revives an embryonic migration program to promote plasticity and invasion. Pigment Cell Melanoma Res. 25, 573- ...
http://bio.biologists.org/content/7/1/bio030817
*  Targeted Immunotherapy Using Reconstituted Chaperone Complexes of Heat Shock Protein 110 and Melanoma-associated Antigen gp100 ...
Melanoma-associated antigen gp100 is highly expressed in about 80% of HLA-A2-positive malignant melanomas (23 , 24) . It can be ... human melanoma-associated antigen gp100) during heat shock. We demonstrate that hsp110 can form chaperone complexes with gp100 ... a study in which we use a tumor protein antigen as substrate, specifically melanoma-associated antigen gp100, was undertaken to ... hsp110 and gp100 mixture without heat shock; hsp110 plus previously heat-denatured gp100; CFA plus gp100; or the hsp110-gp100 ...
http://cancerres.aacrjournals.org/content/63/10/2553
*  Melanocyte Protein PMEL (ME20M or Melanocyte Protein Pmel 17 or Melanocytes Lineage Specific Antigen GP100 or Melanoma...
ME20M or Melanocyte Protein Pmel 17 or Melanocytes Lineage Specific Antigen GP100 or Melanoma Associated ME20 Antigen or P1 or ... ME20M or Melanocyte Protein Pmel 17 or Melanocytes Lineage Specific Antigen GP100 or Melanoma Associated ME20 Antigen or P1 or ... ME20M or Melanocyte Protein Pmel 17 or Melanocytes Lineage Specific Antigen GP100 or Melanoma Associated ME20 Antigen or P1 or ... ME20M or Melanocyte Protein Pmel 17 or Melanocytes Lineage Specific Antigen GP100 or Melanoma Associated ME20 Antigen or P1 or ...
https://www.marketresearch.com/Global-Markets-Direct-v3480/Melanocyte-Protein-PMEL-ME20M-Pmel-11679178/
*  Fusion of the dendritic cell-targeting chemokine MIP3α to melanoma antigen Gp100 in a therapeutic DNA vaccine significantly...
The current study shows that fusion of MIP3α to melanoma antigen gp100 enhances the immunogenicity and efficacy of a DNA ... here melanoma antigen gp100. Previous published work has indicated that MIP-3α targets nascent peptides to immature dendritic ... Antigen-only, irrelevant-antigen, and chemokine-fusion vaccines elicit significantly higher and similar CD4+ and CD8+ tumor- ... This platform has shown enhanced efficacy in prophylactic melanoma and therapeutic lymphoma model systems. The B16F10 melanoma ...
https://jitc.biomedcentral.com/articles/10.1186/s40425-016-0189-y
*  Table of Contents | Cancer Research
Immunization against Epitopes in the Human Melanoma Antigen gp100 following Patient Immunization with Synthetic Peptides ... Immunization against Epitopes in the Human Melanoma Antigen gp100 following Patient Immunization with Synthetic Peptides ... The SSX-2 Gene, Which Is Involved in the t(X;18) Translocation of Synovial Sarcomas, Codes for the Human Tumor Antigen HOM-MEL- ... The SSX-2 Gene, Which Is Involved in the t(X;18) Translocation of Synovial Sarcomas, Codes for the Human Tumor Antigen HOM-MEL- ...
http://cancerres.aacrjournals.org/content/56/20/
*  Vaccines | Free Full-Text | Chemokines as Cancer Vaccine Adjuvants | HTML
... in the many biological roles of chemokines in tumor immunology allow their exploitation in enhancing recruitment of antigen ... immunized mice with DCs co-transfected with XCL1 and melanoma antigen gp100 (XCL1/gp100-DC) using an adenoviral vector. Their ... He, S.; Wang, L.; Wu, Y.; Li, D.; Zhang, Y. CCL3 and CCL20-recruited dendritic cells modified by melanoma antigen gene-1 induce ... CCL5pDNA + gp100 pDNA vaccine, with CCL5 + hgp100 viral vector boost. Melanoma. Murine. [45]. ...
http://www.mdpi.com/2076-393X/1/4/444/htm
*  therapeutic vaccines for colorectal cancer | Springer for Research & Development
Immunizing patients with metastatic melanoma using recombinant adenoviruses encoding MART-1 or gp100 melanoma antigens. J Natl ... Immunization against epitopes in the human melanoma antigen gp100 following patient immunization with synthetic peptides. ... Augmentation of T-cell response with a melanoma cell vaccine expressing specific HLA-A antigens. Ann N Y Acad Sci 1993; 690: ... Polyvalent melanoma vaccine improves survival of patients with metastatic melanoma. Ann N Y Acad Sci 1993; 690: 120-34PubMed ...
https://rd.springer.com/article/10.2165/00024669-200403050-00004
*  Less Yin, More Yang: Confronting the Barriers to Cancer Immunotherapy | Clinical Cancer Research
Analysis of expression of the melanoma-associated antigens MART-1 and gp100 in metastatic melanoma cell lines and in in situ ... Recognition of multiple epitopes in the human melanoma antigen gp100 by tumor-infiltrating T lymphocytes associated with in ... Recombinant fowlpox viruses encoding the anchor-modified gp100 melanoma antigen can generate antitumor immune responses in ... Two of these antigens, MART-1 and gp100, seem to be expressed in the majority of fresh and cultured melanomas (12). Because ...
http://clincancerres.aacrjournals.org/content/13/18/5250.full
*  Plus it
B and C, modulation of cross-presentation of the melanoma gp100 antigen in vivo. Cells from the human melanoma cell line FEMX ... Using melanoma cells, we also found that fractions enriched for autophagosomes mediated the cross-presentation of gp100 antigen ... Knockdown of Beclin-1 in antigen donor cells decreased cross-presentation of tumor antigens by DC. A, B16 F10 melanoma cells ... Using both HEK 293T cells that expressed the model antigen OVA and melanoma cells as antigen donors, we show that ...
http://cancerres.aacrjournals.org/content/68/17/6889
*  Frontiers | Peptide and Peptide-Dependent Motions in MHC Proteins: Immunological Implications and Biophysical Underpinnings |...
Improved induction of melanoma-reactive CTL with peptides from the melanoma antigen gp100 modified at HLA-A*0201-binding ... A peptide that must move to optimize fit with a TCR, such as the Tax11-19 antigen presented by HLA-A2 in Figure 1A, will result ... Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody. ... Nakagawa M, Chiba-Kamoshida K, Udaka K, Nakanishi H. NMR study on the interaction between MHC class I protein and its antigen ...
https://www.frontiersin.org/articles/10.3389/fimmu.2017.00935/full
*  Distribution of TRP1 in the Golgi and associated vesicl | Open-i
We have positioned these organelles relative to endosomes and lysosomes in pigmented melanoma cells and melanocytes. Melanosome ... We have positioned these organelles relative to endosomes and lysosomes in pigmented melanoma cells and melanocytes. Melanosome ... and other pigmented melanoma cells and melanocytes (not shown) demonstrated that TRP1 and Pmel17 localized to vesicular ... and other pigmented melanoma cells and melanocytes (not shown) demonstrated that TRP1 and Pmel17 localized to vesicular ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2195785_JCB0010069.f3&req=4
*  CiNii 論文 - Cytokines Required for Induction of Histocompatibility Leukocyte Antigen-class I...
Recognition of multiple epitopes in the human melanoma antigen gp100 by tumor-infiltrating T lymphocytes associated with in ... Cloning of a new gene encoding an antigen recognized by melanoma-specific HLA-A24 restricted tumor-infiltrating lymphocytes ... A mutated β-catenin gene encodes a melanoma-specific antigen recognized by tumor infiltrating lymphocytes ROBBINS P. F. ... Role of antigen, CD8, and cytotoxic T lymphocyte (CTL) avidity in high dose antigen induction of apoptosis of effector CTL ...
http://ci.nii.ac.jp/naid/10008092645
*  Kinetics of TCR Use in Response to Repeated Epitope-Specific Immunization | The Journal of Immunology
Improved induction of melanoma reactive CTL with peptides from the melanoma antigen gp100 modified at HLA-A*0201 binding ... Recognition of multiple epitopes in the human melanoma antigen gp100 by tumor-infiltrating T lymphocytes associated with in ... 11). Patients with metastatic melanoma who received vaccination with the gp100 epitope gp100:209-217(210M) (abbreviated here as ... in melanoma patients exposed to the modified gp100 epitope gp100:209-217 (g209-2M) we observed in most patients that the Tc-pf ...
http://www.jimmunol.org/content/166/9/5817?ijkey=2968399c3e079c1915da8369c9afc68744af9c89&keytype2=tf_ipsecsha
*  No questions in Integrins - lookformedical.com
... and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or ... gp100 Melanoma Antigen (0) * Heterotrimeric GTP-Binding Proteins (0) * LDL-Receptor Related Protein-Associated Protein (0) ...
https://lookformedical.com/answers/en/questions/chemicals-and-drugs/amino-acids-peptides-and-proteins/proteins/membrane-proteins/receptors-cell-surface/receptors-immunologic/integrins
*  Therapeutic Effectiveness of Recombinant Cancer Vaccines Is Associated with a Prevalent T-Cell Receptor α Usage by Melanoma...
Mendiratta KS, Thai G, Elashi NK, et al Therapeutic tumor immunity induced by polyimmunization with melanoma antigens gp100 and ... 1C) ⇓ . No reactivity against either gp100 or p15E was detected in mice that rejected the melanoma after immunization with rAd- ... Although studies with melanoma patients failed to reveal a correlation between AV 2.1 usage and avidity of antigen recognition ... This suggests that tumor growth in the host did not generate per se an immune reactivity to different melanoma antigens ...
http://cancerres.aacrjournals.org/content/64/21/8068
*  Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor...
Improved induction of melanoma-reactive CTL with peptides from the melanoma antigen gp100 modified at HLA-A*0201-binding ... gp100), gp100280-288, presented by HLA-A*0201 (the most commonly-expressed human pHLA class I). This antigen has been a widely ... Immunization against epitopes in the human melanoma antigen gp100 following patient immunization with synthetic peptides. ... Table 2: Affinity Analysis (KD) of PMEL17 TCR and gp100 TCR to gp100280-288 peptide variants. Reprinted with permission from ...
https://www.jove.com/video/54991/using-x-ray-crystallography-biophysics-functional-assays-to-determine
*  Survivin as a Cancer Vaccine Target | OMICS International
1996) Improved induction of melanoma-reactive CTL with peptides from the melanoma antigen gp100 modified at HLA-A*0201-binding ... Tyrosinase and gp100 are proteins that can serve as antigens that are recognized by CTL in melanoma patients [59-61]. Peptide ... 1994) A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas. J ... 2007) Sustained antigen-specific antitumor recall response mediated by gene-modified CD4+ T helper-1 and CD8+ T cells. Cancer ...
https://www.omicsonline.org/open-access/survivin-as-a-cancer-vaccine-target-2157-7560.1000230.php?aid=26593
*  Translating Tumor Antigens into Cancer Vaccines | Clinical and Vaccine Immunology
Melanocyte lineage-specific antigen gp100 is recognized by melanoma-derived tumor-infiltrating lymphocytes. J. Exp. Med. 179: ... Recognition of multiple epitopes in the human melanoma antigen gp100 by tumor-infiltrating T lymphocytes associated with in ... Cross-priming of naive CD8 T cells against melanoma antigens using dendritic cells loaded with killed allogeneic melanoma cells ... overexpressed antigens.. Among shared tumor-specific antigens, cancer-testis (CT) antigens are expressed in histologically ...
https://cvi.asm.org/content/18/1/23
*  Cancers | Free Full-Text | The Future of Glioblastoma Therapy: Synergism of Standard of Care and Immunotherapy | HTML
gp100 (human melanoma-associated antigen). Highly immunogenic antigen in melanoma found to be expressed in GL26 and GL261 ... AIM-2 (Antigen isolated from Immunoselected Melanoma-2). Tumor antigen expressed in melanoma, as well as neuroectodermal, ... The melanoma-associated antigen (MAGE) family of peptides belongs to the cancer/testis tumor antigen group, which are normally ... MAGE-1 (melanoma-associated antigen). Immune-stimulating testis tumor antigen group with four-fold higher expression in GBM ...
https://www.mdpi.com/2072-6694/6/4/1953/htm
*  Vaccine Therapy With or Without Interleukin-2 in Treating Patients With Metastatic Melanoma - Full Text View - ClinicalTrials...
Melanoma (Skin) Biological: MART-1 antigen Biological: aldesleukin Biological: gp100 antigen Phase 1 Phase 2 ... cells presenting the MART-1 and gp100 melanoma antigens with or without interleukin-2 in patients with metastatic melanoma. ... Melanoma of Immunization With Dendritic Cells Presenting Epitopes Derived From The Melanoma Associated Antigens MART-1 and gp 100 ... OUTLINE: This is a dose-escalation study of dendritic cells pulsed with MART-1 and gp100 antigens. ...
https://clinicaltrials.gov/ct2/show/NCT00019214
*  Table of Contents - March 01, 1994, 179 (3) | JEM
Melanocyte lineage-specific antigen gp100 is recognized by melanoma-derived tumor-infiltrating lymphocytes. A B Bakker, M W ... TL antigen as a transplantation antigen recognized by TL-restricted cytotoxic T cells. A Morita, T Takahashi, E Stockert, E ... Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes. B Gaugler, B Van den ... Regulation of the expression of the hematopoietic stem cell antigen CD34: role of c-myb. P Melotti, D H Ku, B Calabretta ...
http://jem.rupress.org/content/179/3