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*  Advances in LC-MS Glycopeptide Characterization
... By Amanda Maxwell 03.18.2015 Wu and colleagues (2014) have published an ... pGlyco: An Intact Glycopeptide Identification Pipeline. Despite the promise of liquid chromatography-mass spec... by Melissa J ... Accelerating ScienceAccelerating Proteomics / Post-Translational Modifications / Advances in LC-MS Glycopeptide ... Novel Glycopeptides Identified Through Retrospective Analysis. The study of extracellular O-linked glycosylation is restric... ...
https://www.thermofisher.com/blog/proteomics/advances-in-lc-ms-glycopeptide-characterization/
*  Glycopeptide Workflow | Thermo Fisher Scientific - DE
White Paper: Orbitrap Fusion MS for Glycan and Glycopeptide Analysis. *Poster Note: Comparison and Optimization of First and ... Application Note: HILIC - An Alternative Separation Technique for Glycopeptides. *Brochure: Glycan Analysis for Biotherapeutics ... types and MSn capabilities that enable the user to push the boundaries of what is possible in glycan and glycopeptides analyses ... Second Generation Quadrupole Dual Cell Linear Ion Trap Orbitrap MS for Glycopeptide Analysis ...
https://www.thermofisher.com/de/de/home/industrial/pharma-biopharma/biopharmaceutical-analytical-testing/glycan-analysis/glycopeptide-workflow.html
*  Selective Enrichment of Sialylated Glycopeptides | Thermo Fisher Scientific - US
Our results for neat glycopeptides corroborate the observation that the glycopeptides present in the Venn diagram for TiO2 were ... Examples of identified sialylated N-linked glycopeptides unique to TiO2-based enrichment strategy are shown in Figure 3. The ... LC-MS of enriched glycopeptides (Panel A); Thermo Scientific Orbitrap HCD spectrum (Panel B) and ion trap ETD spectrum (Panel C ... Efficient enrichment of sialylated N-linked glycopeptides using TiO2 has been reported.2,3 Graphite columns have affinity for ...
https://www.thermofisher.com/us/en/home/life-science/protein-biology/protein-biology-learning-center/protein-biology-resource-library/protein-biology-application-notes/selective-enrichment-sialylated-glycopeptides.html
*  Tag: O-glycopeptide | Highlight HEALTH
Scientists have found that cancer patients produce antibodies that target abnormal glycoproteins (proteins with sugar molecules attached) made by their tumors. The result of this work suggests that antitumor antibodies in the blood may provide a fruitful source of sensitive biomarkers for cancer detection. The study, supported in part by the National Cancer Institute (NCI), part of the National Institutes of Health, appears in the Feb. 15, 2010 issue of the journal Cancer Research.. ...
http://www.highlighthealth.com/tag/o-glycopeptide/
*  Amphipathic glycopeptides - The Arizona Board of Regents on Behalf of the University of Arizona
Amphipathic glycopeptides, the amino acid sequence of which comprises an N-terminal opioid message sequence, a C-terminal ... 2. The glycopeptide of claim 1, wherein the N-terminal opioid message sequence is Y-t-G-F- or Y-a-G-F-. 3. The glycopeptide of ... 5. The glycopeptide of claim 1, wherein the N-terminal opioid message sequence is Y-t-G-F-L-G-G-. 6. The glycopeptide of claim ... 8. The glycopeptide of claim 1, which adopts a helical conformation in the presence of a lipid bilayer. 9. The glycopeptide of ...
http://www.freepatentsonline.com/7803764.html
*  Rapid glycopeptide optimization via neoglycosylation - Patent # 8236926 - PatentGenius
Two viable approaches for optimizing known glycopeptide scaffolds have emerged--the chemical modification of existing scaffolds ... The present invention provides a strategy for glycopeptide optimization that involves chemoselective "neoglycosylation" ... 4 The lack of alternative therapeutics for VRE has increased interest in developing new glycopeptide derivatives to circumvent ... chemistry and uses this methodology to rapidly optimize teicoplanin-vancomycin hybrid glycopeptide antibiotics by exploringboth ...
http://www.patentgenius.com/patent/8236926.html
*  Glycopeptide Antibiotics - Prices and Information - GoodRx
Compare prices and find information about Glycopeptide Antibiotics prescription drugs. Glycopeptide antibiotics are used to ... Prices for Popular Glycopeptide Antibiotics. Popularity Brand Name (Generic Name) GoodRx Fair Price Price Trend. ... VANCOMYCIN is a glycopeptide antibiotic. It is used to treat certain kinds of bacterial infections in the bowel. It will not ... Glycopeptide antibiotics are used to treat bacterial infections, lower respiratory infections, skin infections, diarrhea, and ...
https://www.goodrx.com/glycopeptide-antibiotics
*  Identification of Sialic Acid Linkages on Intact Glycopeptides via Differential Chemical Modification Using IntactGIG-HILIC |...
Mass spectrometric analysis of intact glycopeptides can reveal detailed information about glycosite, glycan structural features ... On the other hand, haptoglobin has both linked sialic acids on its glycopeptide, S1(2,6)S1(2,3)H5N4; similarly, glycopeptide ... e) The derivatized glycopeptides are enriched by HILIC SPE chromatography, and flow-through contains non-glycopeptides. (f) ... Other methods center on glycopeptide capture. Because each glycopeptide carries at least one glycan with vicinal hydroxyls, the ...
https://link.springer.com/article/10.1007%2Fs13361-018-1931-0
*  Affinity Enrichment and Characterization of Mucin Core-1 Type Glycopeptides from Bovine Serum | Molecular & Cellular Proteomics
To confirm that glycopeptide enrichment indeed occurred, the resulting glycopeptide-containing fractions were subjected to a ... Partial Deglycosylation of O-Glycopeptides. Sialic acid and β-galactose units of glycopeptides were removed by incubation with ... similar to glycopeptides identified from these experiments. Half of the glycopeptides listed in Tables I and II feature non- ... listed in Table II with the best representative glycopeptide sequences; all identified glycopeptides are listed in supplemental ...
https://www.mcponline.org/content/8/11/2515?ijkey=f6e05b7edf0026881d9a23b332dac368e32338b1&keytype2=tf_ipsecsha
*  PPT - Isolation of N- linked glycopeptides from plasma PowerPoint Presentation - ID:47282
D), Yield of N-linked glycopeptides via peptide-level SPEG by different amount of PNGase F-- 1.5 l PNGase F (1,250 U, New ... After the optimization of each step of the SPEG procedure as discussed above, one new flow of N-linked glycopeptide capture can ... PowerPoint Slideshow about 'Isolation of N- linked glycopeptides from plasma' - andrew. An Image/Link below is provided (as is ... Recently, we have developed a method for Solid-Phase Extraction of N-linked Glycopeptides (SPEG), and we have shown that ...
https://www.slideserve.com/andrew/isolation-of-n-linked-glycopeptides-from-plasma
*  Glycan and Glycopeptide Analysis | Mass Spectra Interpretation | Post Translational Modification
Perform Glycan and Glycopeptide Qualitative Analysis, Glycan Structure Prediction & Multi stage Mass Spectrometry (MSn) data ... An Innovative Glycan and Glycopeptide MSn Data Analysis Tool. SimGlycan predicts the structure of glycans and glycopeptides ... Glycan & Glycopeptide MS/MS Data Analysis for Studying Glycosylation. Protein Glycosylation, which is a key post-translational ... Glycopeptides are known to exhibit multiple biological functions. In order to identify distinct functional properties for ...
http://www.premierbiosoft.com/glycan/overview.html
*  beta-Lactam and glycopeptide antibiotics: first and last line of defense?
... Author(s). Jovetic, S.; Yang Zhu, Yang; Marcone, G.L ... many of which are ever-evolving and resistant to nearly all available antibiotics beta-Lactams and glycopeptides are used to ...
http://library.wur.nl/WebQuery/wurpubs/407402
*  Glycan and Glycopeptide Analysis | Mass Spectra Interpretation | Post Translational Modification
Perform Glycan and Glycopeptide Qualitative Analysis, Glycan Structure Prediction & Multi stage Mass Spectrometry (MSn) data ... Furthermore, comprehensive support for resolving glycopeptides using LC-MS/MS glycopeptide data facilitates glycosylation ... High throughput glycan & glycopeptide identification tool using mass spectrometry data. SimGlycan predicts structure of glycans ...
http://premierbiosoft.com/glycan/index.html
*  How to Dig Deeper? Improved Enrichment Methods for Mucin Core-1 Type Glycopeptides | Molecular & Cellular Proteomics
Partial Deglycosylation of O-Glycopeptides (14). Sialic acid and β-galactose units of glycopeptides were removed by incubation ... and sialylated glycopeptides are retained longer. As a result, sialylated glycopeptides can be selectively isolated from ... HCD data of glycopeptides representing this sequence stretch revealed the presence of HexNAc2, i.e. not only mucin core-1, but ... Identification of glycopeptides first was carried out by database searching of HCD and ETD MS/MS data (acquired on the isolated ...
https://www.mcponline.org/node/2573.full.print
*  How to Dig Deeper? Improved Enrichment Methods for Mucin Core-1 Type Glycopeptides | Molecular & Cellular Proteomics
Table II Glycopeptides representing the same region, Ser154-Lys175 with variable glycosylation, identified from insulin-like ... How to Dig Deeper? Improved Enrichment Methods for Mucin Core-1 Type Glycopeptides. Z. Darula, J. Sherman and K. F. ... Distribution of glycopeptides from nine abundant proteins in the mixed-bed ion exchange separation fractions. Different site ... HCD (upper panel) and ETD (lower panel) spectra of the E1BCW0 glycopeptide, IQPPPT(HexNAc2)EALLTLPGPT(HexNAc)AAGPAGR. The ...
https://www.mcponline.org/content/11/7/O111.016774/tab-figures-data
*  Advances in chemical ligation strategies for the synthesis of glycopeptides and glycoproteins - Chemical Communications (RSC...
A number of recent advances in the chemical synthesis of glycopeptides and glycoproteins are described, with particular focus ... on the development of peptide ligation strategies and their implementation in the convergent assembly of complex glycopeptides ... glycopeptides. and glycoproteins R. J. Payne and C. Wong, Chem. Commun., 2010, 46, 21 DOI: 10.1039/B913845E ... glycopeptides. and glycoproteins are described, with particular focus on the development of peptide. ligation strategies and ...
http://pubs.rsc.org/en/Content/ArticleLanding/2010/CC/b913845e
*  Study on behaviors and performances of universal N-glycopeptide enrichment methods - Analyst (RSC Publishing)
Selective enrichment of glycopeptides from complex samples prior to MS analysis is essential for successf ... However, the analysis of glycopeptides through MS remains challenging due to the microheterogeneity and macroheterogeneity of ... Study on behaviors and performances of universal N-glycopeptide enrichment methods Y. Xue, J. Xie, P. Fang, J. Yao, G. Yan, H. ... Selective enrichment of glycopeptides from complex samples prior to MS analysis is essential for successful glycoproteome ...
https://pubs.rsc.org/en/content/articlelanding/2018/an/c7an02062g
*  Glycopeptide - Wikipedia
Glycopeptides are peptides that contain carbohydrate moieties (glycans) covalently attached to the side chains of the amino ... The synthesis of glycopeptides provides biological probes for researchers to elucidate glycan function in nature and products ... Carbohydrate chemistry Glycopeptide antibiotics Glycosylation Peptide synthesis Talbot P.; Shur B. D.; Myles D. G. (2003). " ... Linear assembly remains a popular strategy for the synthesis of glycopeptides with many examples in the literature. In the ...
https://en.wikipedia.org/wiki/Glycopeptide
*  Plus it
O-Glycopeptide array print and analysis. (Glyco)peptides and control structures were printed on Schott Nexterion Slide H or ... An O-glycopeptide microarray was developed that detected IgG antibodies to aberrant O-glycopeptide epitopes in patients ... The glycopeptide array was qualified by incubation with glycan and glycopeptide-specific mAbs detected by Cy3-conjugated ... MUC2 glycopeptides were synthesized by similar methods. Glycopeptides and control structures were printed on NHS-activated ...
http://cancerres.aacrjournals.org/content/70/4/1306
*  Glycopeptide antibiotic - Wikipedia
Until 2000?] Glycopeptides used to be the last effective line of defense for cases of MRSA, however several newer classes of ... Glycopeptide antibiotics are a class of drugs of microbial origin that are composed of glycosylated cyclic or polycyclic ... Due to their toxicity, use of glycopeptide antibiotics is restricted to patients who are critically ill, who have a ... Some tissues are not penetrated very well by glycopeptides, and they do not penetrate into the cerebrospinal fluid. Vancomycin ...
https://en.wikipedia.org/wiki/Glycopeptide_antibiotic
*  β-Elimination for Release of O-GalNAc-Linked Oligosaccharides from Glycoproteins and Glycopeptides - Current Protocols in...
UNIT 17.15B β-Elimination for Release of O-GalNAc-Linked Oligosaccharides from Glycoproteins and Glycopeptides. ... β-Elimination for Release of O-GalNAc-Linked Oligosaccharides from Glycoproteins and Glycopeptides. Current Protocols in ...
http://onlinelibrary.wiley.com/doi/10.1002/0471142727.mb1715bs31/abstract
*  Chemoenzymatic synthesis of glycopeptides bearing rare N-glycan sequences with or without bisecting GlcNAc - Chemical Science ...
N-Linked glycopeptides have highly diverse structures in nature. Herein, we describe the first synthesis of rare multi- ... Chemoenzymatic synthesis of glycopeptides bearing rare N-glycan sequences with or without bisecting GlcNAc W. Yang, S. Ramadan ... Chemoenzymatic synthesis of glycopeptides bearing rare N-glycan sequences with or without bisecting GlcNAc ... N-Linked glycopeptides have highly diverse structures in nature. Herein, we describe the first synthesis of rare multi- ...
https://pubs.rsc.org/en/Content/ArticleLanding/SC/2018/C8SC02457J
*  GlycoPep Grader: A web-based utility for assigning the composition of N-linked glycopeptides
... ... In addition to evaluating the peptide portions of a given glycopeptide, the GPG algorithm predicts and scores product ions that ... Thus far, the algorithm has identified the correct compositional assignment from multiple candidate N-glycopeptides in all ... is a freely-available software tool designed to accelerate the process of accurately determining glycopeptide composition from ...
https://kuscholarworks.ku.edu/handle/1808/23590
*  Timing of Initiating Glycopeptide Therapy for Methicillin-Resistant Staphylococcus aureus Bacteremia: The Impact on Clinical...
Timing of Initiating Glycopeptide Therapy for Methicillin-Resistant Staphylococcus aureus Bacteremia: The Impact on Clinical ... C. T. Fang, W. Y. Shau, P. R. Hsueh et al., "Early empirical glycopeptide therapy for patients with methicillin-resistant ... R. Leclercq and P. Courvalin, "Resistance to glycopeptides in enterococci," Clinical Infectious Diseases, vol. 24, no. 4, pp. ...
https://www.hindawi.com/journals/tswj/2013/457435/ref/
*  Timing of Initiating Glycopeptide Therapy for Methicillin-Resistant Staphylococcus aureus Bacteremia: The Impact on Clinical...
Timing of Initiating Glycopeptide Therapy for Methicillin-Resistant Staphylococcus aureus Bacteremia: The Impact on Clinical ... Chen-Hsiang Lee, Chun-Chih Chien, and Jien-Wei Liu, "Timing of Initiating Glycopeptide Therapy for Methicillin-Resistant ...
https://www.hindawi.com/journals/tswj/2013/457435/cta/