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*  Glycogen Synthase Kinase 3 (GSK-3) | NEB
... is a serine/threonine protein kinase and one of several protein kinases, which phosphorylate glycogen synthase. It is also ... Glycogen Synthase Kinase 3 (GSK-‑3) is a serine/threonine protein kinase and one of several protein kinases, which ... Protein Kinases Information. Applications: Protein Phosphatases & Kinases. * Properties and Usage Unit Definition. One unit is ... 1X NEBuffer™ for Protein Kinases (PK) 50 mM Tris-HCl 10 mM MgCl2 0.1 mM EDTA 2 mM DTT 0.01% Brij 35 (pH 7.5 @ 25°C) ...
https://www.neb.com/products/P6040-Glycogen-Synthase-Kinase-3-GSK-3
*  Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein - Publikationsserver der...
Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein ... Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein. The Journal of biological ... glycogen synthase kinase 3beta interaction protein) as an AKAP. GSKIP directly interacts with PKA and GSK3beta (glycogen ... A-kinase anchoring proteins (AKAPs) include a family of scaffolding proteins that target protein kinase A (PKA) and other ...
https://epub.uni-regensburg.de/30633/
*  Glycogen Phosphorylase - Phosphorylase, Glycogen Summary Report | CureHunter
In mammals, the major isozymes of glycogen phosphorylase are found in muscle, liver and brain tissue. ... An enzyme that catalyzes the degradation of GLYCOGEN in animals by releasing glucose-1-phosphate from the terminal alpha-1,4- ... glycogen synthase (GS), glycogen phosphorylase (GP), and total glycogen content were measured in liver and quadriceps muscle of ... glycogen phosphorylase) and a marker of anaerobic ATP resynthesis (creatine kinase). ". ...
http://www.curehunter.com/public/keywordSummaryD024981-Glycogen-Phosphorylase-Phosphorylase--Glycogen.do
*  CP-91149 |Glycogen phosphorylase inhibitor | Hello Bio
... high quality Glycogen phosphorylase inhibitor from Hello Bio, a trusted supplier for life science researchers worldwide ... Also inhibits glucagon-stimulated glycogenolysis (IC50 = 2.1 µM) and activates glycogen synthase. Displays growth inhibitory ... Synthetic glycogen phosphorylase (GP) inhibitor (IC50 = 0.5 µM). Approx 5-to 10- fold less potent in the absence of glucose. ... Inhibition of glycogen phosphorylase (GP) by CP-91,149 induces growth inhibition correlating with brain GP expression.. Schnier ...
https://www.hellobio.com/cp-91149.html
*  Glycogen synthase kinase-3 alpha (P49840) | InterPro | EMBL-EBI
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
http://www.ebi.ac.uk/interpro/protein/P49840
*  GSK3B (glycogen synthase kinase 3 beta)
... glycogen synthase kinase 3 beta), Authors: Dinesh Kumar Thotala, Eugenia M Yazlovitskaya. Published in: Atlas Genet Cytogenet ... Glycogen synthase kinase-3 beta (GSK3B) was named due to its ability to phosphorylate and inactivate glycogen synthase. GSK3B ... GSK3B Kinase-like_dom_sf Prot_kinase_dom Protein_kinase_ATP_BS Ser/Thr_kinase_AS ... Glycogen synthase kinase-3 beta; a new target in pancreatic cancer?. Garcea G, Manson MM, Neal CP, Pattenden CJ, Sutton CD, ...
http://atlasgeneticsoncology.org/Genes/GC_GSK3B.html
*  Glycogen synthase kinase-3 beta (human) | Protein Target - PubChem
Protein target information for Glycogen synthase kinase-3 beta (human). Find diseases associated with this biological target ...
https://pubchem.ncbi.nlm.nih.gov/protein/P49841
*  Gsk3b - Glycogen synthase kinase-3 beta - Rattus norvegicus (Rat) - Gsk3b gene & protein
... in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta- ... by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN ... contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen ... Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt ...
https://www.uniprot.org/uniprot/P18266
*  Gsk3a - Glycogen synthase kinase-3 alpha - Mus musculus (Mouse) - Gsk3a gene & protein
Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen ... by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed ... Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating ... Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt ...
http://www.uniprot.org/uniprot/Q2NL51
*  Inhibitors of glycogen synthase 3 kinase - Energy Innovation Portal
Compounds of formula 1: ##STR00001## wherein R.sub.1 is alkyl, cycloalkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl, substituted with 0 3 substituents selected from lower alkyl, halo, hydroxy, lower alkoxy, amino, lower alkyl-amino, and nitro; R.sub.2 is hydroxy, amino, or lower alkoxy; R.sub.3 is H, lower alkyl, lower acyl, lower alkoxy-acyl, or amino-acyl; R.sub.4 is H or lower alkyl; and pharmaceutically acceptable salts and esters thereof; are effective inhibitors of GSK3.
https://techportal.eere.energy.gov/patent.do/ID=14823
*  Glycogen synthase kinase - Wikipedia
Glycogen synthase kinase is an enzyme. Types include: GSK1 GSK2 GSK-3 GSK3A GSK3B Glycogen synthase kinase at the US National ...
https://en.wikipedia.org/wiki/Glycogen_synthase_kinase
*  Glycogen Synthase Kinase-3β Is a Negative Regulator of Cardiomyocyte Hypertrophy | JCB
OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. Proc. Natl ... Three MAP kinases (SAPKs, ERKs, and p38), protein kinase A, casein kinase Iα in cooperation with MAP kinase/ERK kinase-1, and ... Glycogen synthase kinase-3 (GSK-3)1 is a highly conserved protein kinase that is believed to play a critical role in ... 1995) Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature. 378:785-789, pmid:8524413. ...
http://jcb.rupress.org/content/151/1/117?ijkey=9c8fad12ee5717a468a3291df938b88f928b37c8&keytype2=tf_ipsecsha
*  Glycogen Synthase Kinase-3 (GSK3) - AM26737PU-N | acris-antibodies.com
Glycogen Synthase Kinase-3 (GSK3), 0.1 mg. GSK-3 has been highly conserved during evolution, and homolog genes have been ... Product Description for Glycogen Synthase Kinase-3 (GSK3). Mouse anti Drosophila, Human, Porcine, Rat Glycogen Synthase Kinase- ... Glycogen Synthase Kinase-3 (GSK3) antibody See related secondary antibodies. Search for all "Glycogen Synthase Kinase-3 (GSK3)" ... Recommended Secondary Antibodies for Glycogen Synthase Kinase-3 (GSK3) (11 products). Catalog No.. Host. Clone/Iso.. Pres.. ...
https://www.acris-antibodies.com/antibodies/primary-antibodies/glycogen-synthase-kinase-3-gsk3-am26737pu-n.htm
*  Role of Glycogen Synthase Kinase-3β in Neuronal Apoptosis Induced by Trophic Withdrawal | Journal of Neuroscience
OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. Proc Natl ... 1993) Glycogen synthase kinase 3 beta is identical to tau protein kinase I generating several epitopes of paired helical ... 1998) Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-kinase/Akt cell survival pathway. J Biol Chem 273:19929- ... 1994) Glycogen synthase kinase-3 beta is a dual specificity kinase differentially regulated by tyrosine and serine/threonine ...
https://www.jneurosci.org/content/20/7/2567?ijkey=780a9439a6ccd8727b55370a331ec8b7df65045d&keytype2=tf_ipsecsha
*  Frontiers | Glycogen Synthase Kinase-3 is an Intermediate Modulator of Serotonin Neurotransmission | Frontiers in Molecular...
... and animal behavioral studies showing that serotonin regulates the activation states of brain glycogen synthase kinase-3 (GSK3 ... and animal behavioral studies showing that serotonin regulates the activation states of brain glycogen synthase kinase-3 (GSK3 ... Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A. Proc. Natl. Acad. Sci. U.S.A. 97, 11960- ... Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378, 785-789. ...
https://www.frontiersin.org/articles/10.3389/fnmol.2011.00031/full
*  Homozygous deletion of glycogen synthase kinase 3β bypasses senescence allowing Ras transformation of primary murine...
We show that homozygous deletion of glycogen synthase kinase (GSK) 3β (GSK3β−/−) bypasses senescence induced by mutant RasV12 ... Homozygous deletion of glycogen synthase kinase 3β bypasses senescence allowing Ras transformation of primary murine ... Homozygous deletion of glycogen synthase kinase 3β bypasses senescence allowing Ras transformation of primary murine ... Homozygous deletion of glycogen synthase kinase 3β bypasses senescence allowing Ras transformation of primary murine ...
https://www.pnas.org/content/105/13/5248
*  Glycogen Synthase Kinase 3 (GSK-3) and Its Inhibitors: Drug Discovery and Development | Pharmaceutical & Medicinal Chemistry |...
7. Glycogen Synthase Kinase-3: A Target for Novel Mood Disorder Treatments. 8. GSK3 and Stem Cells. 9. Glycogen Synthase Kinase ... 1. Glycogen Synthase Kinase-3 - an Introductory Synopsis . 2. Glycogen-Synthase-Kinase-β (GSK-3β) a Key Signaling Enzyme: A ... Structures of Glycogen Synthase Kinase 3. 5. Kinase-Kinase and Site-Site Interactions in the Phosphorylation of Tau by GSK-3. ... Selective And ATP Non Competitive Glycogen Synthase Kinase-3 Inhibitors. 15. 3-Amino Pyrazoles as Potent and Selective Glycogen ...
https://www.wiley.com/en-us/Glycogen+Synthase+Kinase+3+%28GSK+3%29+and+Its+Inhibitors%3A+Drug+Discovery+and+Development-p-9780471770015
*  Glycogen Synthase Kinase-3β Inhibition Ameliorates Cardiac Parasympathetic Dysfunction in Type 1 Diabetic Akita Mice | Diabetes
Glycogen synthase from rabbit skeletal muscle. Amino acid sequence at the sites phosphorylated by glycogen synthase kinase-3, ... Glycogen synthase kinase (GSK) 3β is a serine/threonine kinase originally identified as an enzyme that phosphorylates and ... Coordinated phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 and protein kinase C betaII in the ... Role of glycogen synthase kinase-3 in cell fate and epithelial-mesenchymal transitions. Cells Tissues Organs 2007;185:73-84pmid ...
http://diabetes.diabetesjournals.org/content/63/6/2097
*  Inhibition of Glycogen Synthase Kinase 3β Attenuates Neurocognitive Dysfunction Resulting from Cranial Irradiation | Cancer...
Kinase-inactive glycogen synthase kinase 3β promotes Wnt signaling and mammary tumorigenesis. Cancer Res 2005; 65: 5792-801. ... Selective small-molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. Chem ... Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic-AMP-dependent protein kinase and phosphorylase ... Central role of glycogen synthase kinase-3β in endoplasmic reticulum stress-induced caspase-3 activation. J Biol Chem 2002; 277 ...
http://cancerres.aacrjournals.org/content/68/14/5859.long
*  Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic β-cell function via glycogen synthase kinase-3β. - PubMed ...
Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic β-cell function via glycogen synthase kinase-3β.. Jurczyk A ... Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic β-cell function via glycogen synthase kinase-3β ... Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic β-cell function via glycogen synthase kinase-3β ... Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic β-cell function via glycogen synthase kinase-3β ...
https://www.ncbi.nlm.nih.gov/pubmed/26546129
*  Glycogen Synthase Kinase 3 (GSK3) Inhibitor, SB-216763, Promotes Pluripotency in Mouse Embryonic Stem Cells
Here, we show that SB-216763, a glycogen synthase kinase-3 (GSK3) inhibitor, can maintain mouse embryonic stem cells (mESCs) in ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0039329
*  Sensors | Free Full-Text | Rapid Detection of Glycogen Synthase Kinase-3 Activity in Mouse Sperm Using Fluorescent Gel Shift...
Assaying the glycogen synthase kinase-3 (GSK3) activity in sperm is of great importance because it is closely implicated in ... Rapid Detection of Glycogen Synthase Kinase-3 Activity in Mouse Sperm Using Fluorescent Gel Shift Electrophoresis. Hoseok Choi ... Choi, H.; Choi, B.; Seo, J.T.; Lee, K.J.; Gye, M.C.; Kim, Y.-P. Rapid Detection of Glycogen Synthase Kinase-3 Activity in Mouse ... Assaying the glycogen synthase kinase-3 (GSK3) activity in sperm is of great importance because it is closely implicated in ...
https://www.mdpi.com/1424-8220/16/4/551
*  Marine Drugs | Free Full-Text | Marine Fungi as Producers of Benzocoumarins, a New Class of Inhibitors of Glycogen-Synthase...
The glycogen-synthase-kinase 3 (GSK-3) is an important target in drug discovery. This enzyme is involved in the signaling ... The glycogen-synthase-kinase 3 (GSK-3) is an important target in drug discovery. This enzyme is involved in the signaling ... Marine Fungi as Producers of Benzocoumarins, a New Class of Inhibitors of Glycogen-Synthase-Kinase 3β. Jutta Wiese 1. ... "Marine Fungi as Producers of Benzocoumarins, a New Class of Inhibitors of Glycogen-Synthase-Kinase 3β." Mar. Drugs 14, no. 11: ...
http://www.mdpi.com/1660-3397/14/11/200