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*  Glycogen Synthase Kinase 3 (GSK-3) | NEB
... is a serine/threonine protein kinase and one of several protein kinases, which phosphorylate glycogen synthase. It is also ... is a serine/threonine protein kinase and one of several protein kinases, which phosphorylate glycogen synthase. It is also ... Protein Kinases Information. Applications: Protein Phosphatases & Kinases. * Properties and Usage Unit Definition. One unit is ... 1X NEBuffer™ for Protein Kinases (PK) 50 mM Tris-HCl 10 mM MgCl2 0.1 mM EDTA 2 mM DTT 0.01% Brij 35 (pH 7.5 @ 25°C) ...
https://www.neb.com/products/P6040-Glycogen-Synthase-Kinase-3-GSK-3
*  Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein - Publikationsserver der...
Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein ... Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein. The Journal of biological ... glycogen synthase kinase 3beta interaction protein) as an AKAP. GSKIP directly interacts with PKA and GSK3beta (glycogen ... A-kinase anchoring proteins (AKAPs) include a family of scaffolding proteins that target protein kinase A (PKA) and other ...
https://epub.uni-regensburg.de/30633/
*  Endocrine disturbances related to the use of lithium
By inhibiting GSK3B (glycogen synthase kinase B), an enzyme that degrades B-catenin, lithium can simulate a functional ... In addition, it modulates pathways that regulate neuronal plasticity, such as glycogen synthase kinase 3β, cAMP-dependent ... glycogen synthase kinase 3β), and promoting the suppression of chromogranin A, which represents a novel potential strategy for ... kinase and protein kinase C (7).. Because of lithium narrow therapeutic range and possible overdose potential, small elevations ...
http://www.scielo.br/scielo.php?pid=S0004-27302012000300001&script=sci_arttext
*  Glycogen Phosphorylase - Phosphorylase, Glycogen Summary Report | CureHunter
In mammals, the major isozymes of glycogen phosphorylase are found in muscle, liver and brain tissue. ... An enzyme that catalyzes the degradation of GLYCOGEN in animals by releasing glucose-1-phosphate from the terminal alpha-1,4- ... glycogen synthase (GS), glycogen phosphorylase (GP), and total glycogen content were measured in liver and quadriceps muscle of ... glycogen phosphorylase) and a marker of anaerobic ATP resynthesis (creatine kinase). ". ...
http://www.curehunter.com/public/keywordSummaryD024981-Glycogen-Phosphorylase-Phosphorylase--Glycogen.do
*  Glycogen synthase kinase-3 alpha (P49840) | InterPro | EMBL-EBI
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
http://www.ebi.ac.uk/interpro/protein/P49840
*  GSK3B (glycogen synthase kinase 3 beta)
... glycogen synthase kinase 3 beta), Authors: Dinesh Kumar Thotala, Eugenia M Yazlovitskaya. Published in: Atlas Genet Cytogenet ... GSK3B Kinase-like_dom_sf Prot_kinase_dom Protein_kinase_ATP_BS Ser/Thr_kinase_AS ... Glycogen synthase kinase-3 beta; a new target in pancreatic cancer?. Garcea G, Manson MM, Neal CP, Pattenden CJ, Sutton CD, ... GSK3B (glycogen synthase kinase 3 beta). Written. 2010-04. Dinesh Kumar Thotala, Eugenia M Yazlovitskaya. ...
http://atlasgeneticsoncology.org/Genes/GC_GSK3B.html
*  Glycogen synthase kinase-3 beta (human) | Protein Target - PubChem
Protein target information for Glycogen synthase kinase-3 beta (human). Find diseases associated with this biological target ...
https://pubchem.ncbi.nlm.nih.gov/protein/P49841
*  Gsk3b - Glycogen synthase kinase-3 beta - Rattus norvegicus (Rat) - Gsk3b gene & protein
... in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta- ... by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN ... contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen ... Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt ...
https://www.uniprot.org/uniprot/P18266
*  Gsk3a - Glycogen synthase kinase-3 alpha - Mus musculus (Mouse) - Gsk3a gene & protein
Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen ... by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed ... Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating ... Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt ...
http://www.uniprot.org/uniprot/Q2NL51
*  Glycogen Synthase Kinase-3β Is a Negative Regulator of Cardiomyocyte Hypertrophy | JCB
Three MAP kinases (SAPKs, ERKs, and p38), protein kinase A, casein kinase Iα in cooperation with MAP kinase/ERK kinase-1, and ... 1997) Regulation of protein kinase B and glycogen synthase kinase-3 by insulin and β-adrenergic agonists in rat epididymal fat ... OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. Proc. Natl ... 1998) Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization. Genes Dev 12:3499-3511, pmid: ...
http://jcb.rupress.org/content/151/1/117?ijkey=9c8fad12ee5717a468a3291df938b88f928b37c8&keytype2=tf_ipsecsha
*  Glycogen Synthase Kinase-3 (GSK3) - AM26737PU-N | acris-antibodies.com
Glycogen Synthase Kinase-3 (GSK3), 0.1 mg. GSK-3 has been highly conserved during evolution, and homolog genes have been ... Recommended Secondary Antibodies for Glycogen Synthase Kinase-3 (GSK3) (11 products). Catalog No.. Host. Clone/Iso.. Pres.. ... Product Description for Glycogen Synthase Kinase-3 (GSK3). Mouse anti Drosophila, Human, Porcine, Rat Glycogen Synthase Kinase- ... Glycogen synthase kinase 3 regulates cell fate in Dictyostelium. Cell. 1995 Jan 13;80(1):139-48. PubMed PMID: 7813009. ...
https://www.acris-antibodies.com/antibodies/primary-antibodies/glycogen-synthase-kinase-3-gsk3-am26737pu-n.htm
*  Role of Glycogen Synthase Kinase-3β in Neuronal Apoptosis Induced by Trophic Withdrawal | Journal of Neuroscience
1997) Regulation of protein kinase B and glycogen synthase kinase-3 by insulin and beta-adrenergic agonists in rat epididymal ... 1996) Regulation of mitochondrial pyruvate dehydrogenase activity by tau protein kinase I/glycogen synthase kinase 3beta in ... OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. Proc Natl ... 1992) Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau. FEBS Lett 314:315-321. ...
https://www.jneurosci.org/content/20/7/2567?ijkey=780a9439a6ccd8727b55370a331ec8b7df65045d&keytype2=tf_ipsecsha
*  Homozygous deletion of glycogen synthase kinase 3β bypasses senescence allowing Ras transformation of primary murine...
We show that homozygous deletion of glycogen synthase kinase (GSK) 3β (GSK3β−/−) bypasses senescence induced by mutant RasV12 ... Homozygous deletion of glycogen synthase kinase 3β bypasses senescence allowing Ras transformation of primary murine ... Homozygous deletion of glycogen synthase kinase 3β bypasses senescence allowing Ras transformation of primary murine ... Homozygous deletion of glycogen synthase kinase 3β bypasses senescence allowing Ras transformation of primary murine ...
https://www.pnas.org/content/105/13/5248
*  Glycogen synthase kinase-3 (GSK-3) regulates TGF-β(1) -induced differentiation of pulmonary fibroblasts.
Glycogen synthase kinase-3 (GSK-3) regulates various intracellular signaling pathways; its role in TGF-β(1) -induced ... The effect of GSK-3 inhibition on α-sm-actin expression was similar in fibroblasts from individuals with and without COPD. ... Neither smad, NF-κB, nor ERK1/2 were involved in the inhibitory actions of GSK-3 inhibition by SB126763 on myofibroblast ... Moreover, silencing of GSK-3 by siRNA or pharmacological inhibition by CT/CHIR99021 fully inhibited the TGF-β(1) -induced ...
http://www.biomedsearch.com/nih/Glycogen-synthase-kinase-3-GSK/23297769.html
*  Frontiers | Glycogen Synthase Kinase-3 is an Intermediate Modulator of Serotonin Neurotransmission | Frontiers in Molecular...
... and animal behavioral studies showing that serotonin regulates the activation states of brain glycogen synthase kinase-3 (GSK3 ... and animal behavioral studies showing that serotonin regulates the activation states of brain glycogen synthase kinase-3 (GSK3 ... Jope, R. S., and Johnson, G. V. W. (2004). The glamour and gloom of glycogen synthase kinase-3. Trends Biochem. Sci. 29, 95-102 ... Glycogen synthase kinase-3 is an intermediate modulator of serotonin neurotransmission. Abigail M. Polter and Xiaohua Li* ...
https://www.frontiersin.org/articles/10.3389/fnmol.2011.00031/full
*  Glycogen Synthase Kinase 3 (GSK-3) and Its Inhibitors: Drug Discovery and Development | Pharmaceutical & Medicinal Chemistry |...
Glycogen Synthase Kinase 3 (GSK-3) and Its Inhibitors: Drug Discovery and Development. Ana Martinez (Editor), Ana Castro ( ... Structures of Glycogen Synthase Kinase 3. 5. Kinase-Kinase and Site-Site Interactions in the Phosphorylation of Tau by GSK-3. ... 7. Glycogen Synthase Kinase-3: A Target for Novel Mood Disorder Treatments. 8. GSK3 and Stem Cells. 9. Glycogen Synthase Kinase ... Glycogen Synthase Kinase 3 (GSK-3) and Its Inhibitors: Drug Discovery and Development. ...
https://www.wiley.com/en-us/Glycogen+Synthase+Kinase+3+%28GSK+3%29+and+Its+Inhibitors%3A+Drug+Discovery+and+Development-p-9780471770015
*  Glycogen Synthase Kinase-3β Inhibition Ameliorates Cardiac Parasympathetic Dysfunction in Type 1 Diabetic Akita Mice | Diabetes
Glycogen synthase from rabbit skeletal muscle. Amino acid sequence at the sites phosphorylated by glycogen synthase kinase-3, ... Role of glycogen synthase kinase-3 in cell fate and epithelial-mesenchymal transitions. Cells Tissues Organs 2007;185:73-84pmid ... Glycogen synthase kinase (GSK) 3β is a serine/threonine kinase originally identified as an enzyme that phosphorylates and ... Glycogen Synthase Kinase-3β Inhibition Ameliorates Cardiac Parasympathetic Dysfunction in Type 1 Diabetic Akita Mice. ...
http://diabetes.diabetesjournals.org/content/63/6/2097
*  Inhibition of Glycogen Synthase Kinase 3β Attenuates Neurocognitive Dysfunction Resulting from Cranial Irradiation | Cancer...
Kinase-inactive glycogen synthase kinase 3β promotes Wnt signaling and mammary tumorigenesis. Cancer Res 2005; 65: 5792-801. ... Central role of glycogen synthase kinase-3β in endoplasmic reticulum stress-induced caspase-3 activation. J Biol Chem 2002; 277 ... Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation. Nature 2000; 406: 86-90. ... Glycogen synthase kinase-3 in neurodegeneration and neuroprotection: lessons from lithium. Curr Alzheimer Res 2007; 4: 21-31. ...
http://cancerres.aacrjournals.org/content/68/14/5859.long
*  Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic β-cell function via glycogen synthase kinase-3β. - PubMed ...
Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic β-cell function via glycogen synthase kinase-3β.. Jurczyk A ... Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic β-cell function via glycogen synthase kinase-3β ... Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic β-cell function via glycogen synthase kinase-3β ... Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic β-cell function via glycogen synthase kinase-3β ...
https://www.ncbi.nlm.nih.gov/pubmed/26546129
*  Glycogen Synthase Kinase 3 (GSK3) Inhibitor, SB-216763, Promotes Pluripotency in Mouse Embryonic Stem Cells
Here, we show that SB-216763, a glycogen synthase kinase-3 (GSK3) inhibitor, can maintain mouse embryonic stem cells (mESCs) in ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0039329
*  Sensors | Free Full-Text | Rapid Detection of Glycogen Synthase Kinase-3 Activity in Mouse Sperm Using Fluorescent Gel Shift...
Assaying the glycogen synthase kinase-3 (GSK3) activity in sperm is of great importance because it is closely implicated in ... Rapid Detection of Glycogen Synthase Kinase-3 Activity in Mouse Sperm Using Fluorescent Gel Shift Electrophoresis. Hoseok Choi ... Choi, H.; Choi, B.; Seo, J.T.; Lee, K.J.; Gye, M.C.; Kim, Y.-P. Rapid Detection of Glycogen Synthase Kinase-3 Activity in Mouse ... Assaying the glycogen synthase kinase-3 (GSK3) activity in sperm is of great importance because it is closely implicated in ...
https://www.mdpi.com/1424-8220/16/4/551
*  Ascl1a/Dkk/β-catenin signaling pathway is necessary and glycogen synthase kinase-3β inhibition is sufficient for zebrafish...
Ascl1a/Dkk/β-catenin signaling pathway is necessary and glycogen synthase kinase-3β inhibition is sufficient for zebrafish ... Ascl1a/Dkk/β-catenin signaling pathway is necessary and glycogen synthase kinase-3β inhibition is sufficient for zebrafish ... Ascl1a/Dkk/β-catenin signaling pathway is necessary and glycogen synthase kinase-3β inhibition is sufficient for zebrafish ... Ascl1a/Dkk/β-catenin signaling pathway is necessary and glycogen synthase kinase-3β inhibition is sufficient for zebrafish ...
https://www.pnas.org/content/108/38/15858?ijkey=07fdb5a9e9bf281eca5ef6d8a1351d54de72baaf&keytype2=tf_ipsecsha
*  Regulate Axon Branching by the Cyclic GMP Pathway via Inhibition of Glycogen Synthase Kinase 3 in Dorsal Root Ganglion Sensory...
... dependent protein kinase regulates CCAAT enhancer-binding protein beta functions through inhibition of glycogen synthase kinase ... Regulate Axon Branching by the Cyclic GMP Pathway via Inhibition of Glycogen Synthase Kinase 3 in Dorsal Root Ganglion Sensory ... Regulate Axon Branching by the Cyclic GMP Pathway via Inhibition of Glycogen Synthase Kinase 3 in Dorsal Root Ganglion Sensory ... Regulate Axon Branching by the Cyclic GMP Pathway via Inhibition of Glycogen Synthase Kinase 3 in Dorsal Root Ganglion Sensory ...
http://www.jneurosci.org/content/29/5/1350
*  Lithium Chloride Promotes Apoptosis in Human Leukemia NB4 Cells by Inhibiting Glycogen Synthase Kinase-3 Beta [Abstract]
Lithium Chloride Promotes Apoptosis in Human Leukemia NB4 Cells by Inhibiting Glycogen Synthase Kinase-3 Beta. Int J Med Sci ... Lithium Chloride Promotes Apoptosis in Human Leukemia NB4 Cells by Inhibiting Glycogen Synthase Kinase-3 Beta Liu Li1,2, Hao ... Moreover, LiCl significantly increased the level of Ser9-phosphorylated glycogen synthase kinase 3β(p-GSK-3β), and decreased ... Keywords: Lichium chloride, GSK-3β, leukemia cells, proliferation, apoptosis This is an open access article distributed under ...
http://www.medsci.org/v12p0805