Glycocholic Acid Summary Report | CureHunter
The glycine conjugate of CHOLIC ACID. It acts as a detergent to solubilize fats for absorption and is itself absorbed. ... Glycochenodeoxycholic Acid (Glycochenodeoxycholate) 3. Technetium Tc 99m Diethyl-iminodiacetic Acid 4. Aminopyrine ( ... Bile Acids and Salts: 3397*Cholic Acids: 8*Glycocholic Acid: 105*Glycodeoxycholic Acid: 68 ... Glycocholic Acid. Subscribe to New Research on Glycocholic Acid The glycine conjugate of CHOLIC ACID. It acts as a detergent to ...http://www.curehunter.com/public/keywordSummaryD006000-Glycocholic-Acid.do
Human Metabolome Database: Showing metabocard for Chenodeoxycholic acid glycine conjugate (HMDB0000637)
Glycochenodeoxycholic acid. HMDB. Glycylchenodeoxycholate. HMDB. Glycylchenodeoxycholic acid. HMDB. N-(3a,7a-Dihydroxy-5b- ... Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid. ... Chenodeoxycholic acid glycine conjugate is an acyl glycine and a bile acid-glycine conugate. It is a secondary bile acid ... The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl ...http://www.hmdb.ca/metabolites/HMDB0000637
Bile acid-induced necrosis in primary human hepatocytes and in patients with obstructive cholestasis (Journal Article) |...
... of the model bile acid glycochenodeoxycholic acid (GCDC). Treatment with GCDC resulted in necrosis with no increase in ... Accumulation of bile acids is a major mediator of cholestatic liver injury. Recent studies indicate bile acid composition ... 60 APPLIED LIFE SCIENCES; AMINOTRANSFERASES; APOPTOSIS; BILE; BILIARY TRACT; CHOLIC ACID; CONCENTRATION RATIO; GLYCINE; HUMAN ... Individual bile acid levels were determined in serum and bile by UPLC/QTOFMS in patients with extrahepatic cholestasis with, or ...https://www.osti.gov/scitech/biblio/22465712
Frontiers | Bile Acids in Neurodegenerative Disorders | Frontiers in Aging Neuroscience
... the relevant bile acids, their origin, and the precise molecular mechanism(s) by which they confer neuroprotection are not ... the relevant bile acids, their origin, and the precise molecular mechanism(s) by which they confer neuroprotection are not ... Bile acids, a structurally related group of molecules derived from cholesterol, have a long history as therapeutic agents in ... Bile acids, a structurally related group of molecules derived from cholesterol, have a long history as therapeutic agents in ...https://www.frontiersin.org/articles/10.3389/fnagi.2016.00263/full
OC-079 FGF19 expression is highly responsive to bile acids compared to other bile acid regulatory genes within the human ileum ...
... chenodeoxycholic acid [CDCA] or glyco-chenodeoxycholic acid [GCDCA]) or without (control explants). 3 Duodenal and colonic ... OC-079 FGF19 expression is highly responsive to bile acids compared to other bile acid regulatory genes within the human ileum ... OC-079 FGF19 expression is highly responsive to bile acids compared to other bile acid regulatory genes within the human ileum ... FGF19 is the human orthologue of FGF15 and is thought to have roles in the regulation of bile acid pool sizes and BA ...http://gut.bmj.com/content/61/Suppl_2/A34.2
Serum bile acid profiling reflects enterohepatic detoxification state and intestinal barrier function in inflammatory bowel...
... taurocholic acid, and glycochenodeoxycholic acid were as significantly increased as the secondary BAs LCA, ursodeoxycholic acid ... taurocholic acid, and glycochenodeoxycholic acid were as significantly increased as the secondary BAs LCA, ursodeoxycholic acid ... Finally, we found that in ileocecal resected CD patients, the unconjugated primary BAs, cholic acid and chenodeoxycholic acid, ... Finally, we found that in ileocecal resected CD patients, the unconjugated primary BAs, cholic acid and chenodeoxycholic acid, ...http://www.zora.uzh.ch/id/eprint/32468/
Glycochenodeoxycholic Acid-[d9] - IsoSciences
Glycochenodeoxycholic Acid-[d9] Home / Products / Bile Acids / Bile Acid Conjugates / Glycochenodeoxycholic Acid-[d9]. ...https://isosciences.com/shop/bile-acids/glycochenodeoxycholic-acid-d9/
Glycochenodeoxycholic acid | GoldBio
Glycochenodeoxycholic acid (GCDC) is a bile salt that is used as an anionic detergent to solubilize lipids. In other ... GCDC is also used in applications analyzing the damage done to DNA by other bile acids. ...https://www.goldbio.com/product/118295/glycochenodeoxycholic-acid
Glycochenodeoxycholic acid - Wikipedia
Glycochenodeoxycholic acid is a bile salt formed in the liver from chenodeoxycholic acid and glycine, usually found as the ... Nucleic Acids Res. 39 (Database issue): D1035-41. doi:10.1093/nar/gkq1126. PMC 3013709 . PMID 21059682. Wishart DS; Knox C; Guo ...https://en.wikipedia.org/wiki/Glycochenodeoxycholic_acid
Lipidomic Approaches to Determining Drug Response Phenotypes in Cardiovascular Disease - Kaddurah-daouk, Rima F.
... chenodeoxycholic acid, glycocholic acid, glycochenodeoxycholic acid, glycoursodeoxycholic acid, taurocholic acid, and ... lauric acid, myristic acid, pentadecanoic acid, palmitic acid, stearic acid, arachidic acid, behenic acid and lignoceric acid. ... linoleic acid, arachidonic acid, oleic acid, and erucic acid. Particular classes of fatty acids include omega-3 fatty acids (e. ... docosanoic acid, tetracosanoic acid, 9-tetradecenoic acid, 9-hexadecenoic acid, 111-octadecenoic acid, 9-octadecenoic acid, 11- ...http://www.freepatentsonline.com/y2009/0197242.html
hdhA - 7-alpha-hydroxysteroid dehydrogenase - Escherichia coli (strain K12) - hdhA gene & protein
Catalyzes the oxidation of the 7-alpha-hydroxy group of primary bile acids such as cholate, chenodeoxycholate and ... DB02123 Glycochenodeoxycholic Acid. ,p>This section describes post-translational modifications (PTMs) and/or processing events ... bile acid catabolic process Source: EcoCycInferred from direct assayi*2007545 ... It always involves more than one amino acid and includes all residues involved in nucleotide-binding.,p>,a href='/help/np_bind ...https://www.uniprot.org/uniprot/P0AET8
Sodium/bile acid cotransporter - DrugBank
Deoxycholic Acid. approved. unknown. substrate. Details. DB02123. Glycochenodeoxycholic Acid. experimental. unknown. substrate ... Sodium/bile acid cotransporter. Details. Name. Sodium/bile acid cotransporter. Kind. protein. Organism. Human. Polypeptides. ... Ursodeoxycholic acid. approved, investigational. unknown. substrateinhibitor. Details. DB04348. Taurocholic Acid. experimental ... Cholic Acid. approved. unknown. substrateinhibitor. Details. DB00887. Bumetanide. approved. unknown. substrateinhibitor. ...https://www.drugbank.ca/biodb/bio_entities/BE0003644
Exendin-4, a glucagon-like peptide 1 receptor agonist, protects cholangiocytes from apoptosis | Gut
A) Glycochenodeoxycholic acid (GCDCA; 400 μmol/l) induced a significant increase in caspase 3 activity that was prevented by ... Chenodeoxycholic acid and taurochenodexycholic acid induce anti-apoptotic cIAP-1 expression in human hepatocytes. J ... Ursodeoxycholic acid may inhibit deoxycholic acid-induced apoptosis by modulating mitochondrial transmembrane potential and ... glycochenodeoxycholic acid (GCDCA, 400 μmol/l),15 16 in the absence or presence of a 30 min preincubation with exendin-4 (100 ...https://gut.bmj.com/content/58/7/990?ijkey=c095c1f3b373b1fbda5e9345d33768bcf454fb53&keytype2=tf_ipsecsha
human metabolite (CHEBI:77746)
hyodeoxycholic acid Mass :392.57200 Formula : C24H40O4 glycochenodeoxycholic acid Mass :449.62336 Formula : C26H43NO5 ... iduronic acid Definition : A member of the class of iduronic acids that is the major uronic acid component of the dermatan ... glucaric acid Mass :210.13880 Formula : C6H10O8 indole Definition : Either of two isomeric forms comprising a benzene ring ... decanoic acid Mass :172.265 Formula : C10H20O2 6-(2-amino-2-carboxyethyl)-4-hydroxybenzothiazole Mass :238.26300 Formula : ...http://www.ebi.ac.uk/chebi/chebiOntology.do?chebiId=77746
Combinatorial chemopreventive effect of butyric acid, nicotinamide and calcium glucarate against the 7,12-dimethylbenz(a...
We explored the basis of the combinatorial chemopreventive effect of Butyric acid (BA), Nicotinamide (NA) and Calcium Glucarate ... 16860497 - Involvement of endoplasmic reticulum in glycochenodeoxycholic acid-induced apoptosis in.... 23055997 - Interaction ... We explored the basis of the combinatorial chemopreventive effect of Butyric acid (BA), Nicotinamide (NA) and Calcium Glucarate ... Combinatorial chemopreventive effect of butyric acid, nicotinamide and calcium glucarate against the 7,12-dimethylbenz(a) ...http://www.biomedsearch.com/nih/Combinatorial-chemopreventive-effect-butyric-acid/25478867.html
Human hair production by scalp samples grafted onto nude mice. Biochemical data on normal human hair and the genetic defect...
This study shows that the amino acid composition of hairs collected in situ from human scalp was similar to that of terminal ... 19132499 - The effect of capillarisin on glycochenodeoxycholic acid-induced apoptosis and heme oxy.... ... Amino Acid Sequence. Amino Acids / analysis. Animals. Female. Fetal Tissue Transplantation. Gene Expression. Hair / growth & ... 6997229 - The effect of acetohydroxamic acid on the induction of bacterial ureases.. 6778279 - Limited value of uric acid to ...http://www.biomedsearch.com/nih/Human-hair-production-by-scalp/7528049.html
GCA, glycocholic acid; GCDCA, glycochenodeoxycholic acid; GDCA, glycodeoxycholic acid; HDCA, hyodeoxycholic acid; TCA, ... Role of bile acids and bile acid receptors in metabolic regulation. Physiol Rev 2009;89:147-191pmid:19126757. ... 2). Thus, low total BA levels are associated with changes in amino acid and fatty acid utilization and ketogenesis but not ... In healthy subjects, insulin resistance (IR) was associated with increased 12α-hydroxylated BAs (cholic acid, deoxycholic acid ...http://diabetes.diabetesjournals.org/content/62/12/4184
JCI Insight - Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response
4). CPS, cryprinol sulfate; GCA, glycocholic acid; GCDCA, glycochenodeoxycholic acid; PZS, petromyzonol sulfate; SMS, scymnol ... Bile acid-induced cytokine expression in mouse hepatocytes was time (100 μM TCA) and dose dependent. Hepatocytes were treated ... Mechanisms of bile acid-induced (BA-induced) liver injury in cholestasis are controversial, limiting development of new ... Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response. ...https://insight.jci.org/articles/view/90780/figure/1
Bile Salt Export Pump: Drug-Induced Liver Injury and Assessment Approaches | SpringerLink
Biliary excretion of bile acids by bile salt export pump (BSEP) is the rate-limiting step in... ... Bile acid homeostasis is maintained through the tightly regulated enterohepatic circulation of bile acids. ... Tsuchiya S, Tsuji M, Morio Y et al (2006) Involvement of endoplasmic reticulum in glycochenodeoxycholic acid-induced apoptosis ... Bile acid homeostasis is maintained through the tightly regulated enterohepatic circulation of bile acids. Biliary excretion of ...https://link.springer.com/protocol/10.1007/978-1-4939-7677-5_15
Human Norovirus Replication in Human Intestinal Enteroids as Model to Evaluate Virus Inactivation - Volume 24, Number 8-August...
... and infected them in the presence of 500 μmol/L of glycochenodeoxycholic acid (GCDCA; Sigma, St. Louis, MO, USA) or with 500 μM ...https://wwwnc.cdc.gov/eid/article/24/8/18-0126_article
Glycochenodeoxycholate sulfotransferase - Wikipedia
"Enzymatic sulfation of glycochenodeoxycholic acid by tissue fractions from adult hamsters". J. Lipid Res. 20 (8): 952-9. PMID ... Other names in common use include bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase, bile acid:PAPS: ... Russell DW (2003). "The enzymes, regulation, and genetics of bile acid synthesis". Annu. Rev. Biochem. 72: 137-74. doi:10.1146/ ...https://en.wikipedia.org/wiki/Glycochenodeoxycholate_sulfotransferase
Diferenciación de especies de Xenarthra (Mammalia) a través de la identificación de sus patrones de ácidos biliares fecales:...
... glycocholic acid, cholic acid, chenodeoxycholic acid, deoxycholic acid, dehydrocholic acid, glycochenodeoxycholic acid and ... TCA: taurocholic acid; GCDCA: glycochenodeoxycholic acid; CA cholic acid; GCA: glycocholic acid; CDCA: chenodeoxycholic acid; ... 1). All species had three known bile acids: taurocholic, glycochenodeoxycholic and lithocholic acids, cholesterol (Fig. 2) and ... glycochenodeoxycholic and lithocholic acids, and cholesterol. Only C. villosus had deoxycholic acid (Rf: 0.30 ± 0.01). Z. ...http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-078X2010000400009&lng=es&nrm=iso&tlng=en
ER Stress Signaling in Hepatic Injury | SpringerLink
Tsuchiya S, Tsuji M, Morio Y, Oguchi K. Involvement of endoplasmic reticulum in glycochenodeoxycholic acid-induced apoptosis in ... Interaction between caspase-8 activation and endoplasmic reticulum stress in glycochenodeoxycholic acid-induced apoptotic HepG2 ... Inborn errors of sulfur-containing amino acid metabolism. J Nutr. 2006;136(6 Suppl):1750S-1754SPubMedGoogle Scholar ... Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis. Endocrinology. 2006 ...https://link.springer.com/chapter/10.1007/978-3-642-00150-5_19
Apoptosis Compound Library-MedchemExpress
Glycocholic acid Citric acid Homoplantaginin Taurochenodeoxycholic acid Glycochenodeoxycholic acid PK11007 4-Hydroxybenzyl ... R)-(-)-Gossypol acetic acid (S)-Gossypol (acetic acid) Pifithrin-α (hydrobromide) Tenovin-6 Tenovin 6 (Hydrochloride) TC-DAPK 6 ... Betulinic acid Empty. c. Empty. Raltitrexed Pifithrin-μ RG7112 Obatoclax Pomalidomide R-7050 CIL56 HA14-1 TW-37 Serdemetan ... Gambogic Acid Polydatin Fisetin Hypaconitine Empty. d. Empty. Sinensetin Columbianadin Astilbin Ginsenoside Rh1 Ginsenoside Rh2 ...https://www.medchemexpress.com/screening/Apoptosis_Compound_Library.html
Glentham Life Sciences - Detergents
Glycochenodeoxycholic acid sodium salt. 16564-43-5. Spec. MSDS. Product data: Molecular Formula:. C26H42NNaO5. ... Key products from this range include Polysorbate 20, Polysorbate 80, Brij 35 (Laureth-23) and Cholic acid.. Listing all ...https://www.glentham.com/en/products/categories/detergents/view-50-all/?page=2