Rifaximin beneficially altered intestinal ammonia generation by regulating intestinal glutaminase expression independent of gut ...
CB-839 is a novel, orally bioavailable inhibitor of glutaminase, a key enzyme in the metabolism of glutamine. Cancer cells ... Project Title: Glutamine Metabolism in Prostate Cancer: Preclinical and Clinical Evaluation of Dual Inhibition of Glutaminase ... in prostate cancer for treatment of mCRPC and identify biomarkers that predict response to the combination of glutaminase plus ...
Phosphate-dependent glutaminase (PDG) is the key enzyme for NH3 production, and its activity is increased by acidosis and ...
Glutaminase. YAP/TAZ. [9, 10]. Endothelial-to-mesenchymal transition. Can be induced by haemodynamic changes associated with ...
Identification of a Loss-of-Function Mutation in the Context of Glutaminase. Deficiency and Neonatal Epileptic Encephalopathy. ... Identification of a Loss-of-Function Mutation in the Context of Glutaminase Deficiency and Neonatal Epileptic Encephalopathy. ...
Escherichia coli carbamoyl-phosphate synthetase: domains of glutaminase and synthetase subunit interaction. Guillou, F., Rubino ...
We have previously shown that inhibition of glutaminase 1, which catalyzes the rate-limiting step of glutamine catabolism, ...
Conclusion: These results suggest that the attenuation of upregulated hippocampal glutaminase by JHU-083 represents a new ... Glutamine Antagonist JHU-083 Normalizes Aberrant Hippocampal Glutaminase Activity and Improves Cognition in APOE4 Mice. ... isolated from hippocampi of adult APOE4 knock-in mice to evaluate the effect of JHU-083 treatment on LPS-induced glutaminase ( ...
Glutaminase activity and generation of ammonia in stored cellular blood products (especially platelets) may conceivably lead to ...
2018) Distinct regulation of Th17 and Th1 cell differentiation by Glutaminase-Dependent metabolism Cell 175:1780-1795. ...
P. Gao, I. Tchernyshyov, T. C. Chang et al., "C-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and ...
This leads to increased expression in Purkinje neurons of TNFα, IL-1b, HMGB1 and glutaminase. This altered neurotransmission ...
... hen egg-white lysozyme and human glutaminase C (Illava et al., 2021. ; Milano et al., 2022. ). ...
S. Zhao, et al, "BAG3 promotes autophagy and glutaminolysis via stabilizing glutaminase", Cell Death & Disease, 2019, 284(10). ... Promotion of autophagy and glutaminolysis via stabilization of glutaminase by BAG3. BAG3 is a protein involved in the ... In cells overexpressing BAG3, glutaminase (GLS) succinylation is promoted, which prevents ubiquitination and subsequent ...
Distinct regulation of Th17 and Th1 cell differentiation by glutaminase-dependent metabolism ...
Huang F, Zhang Q, Ma H, Lv Q, Zhang T. Expression of glutaminase is upregulated in colorectal cancer and of clinical ... potential biomarker characterising both colorectal cancer cells and senescent cells is the mitochondrial enzyme glutaminase 1 ( ...
The pathways for glutamine metabolism can include reactions catalysed by aspartate aminotransferase, glutaminase, succinate ...
The cycle is completed with the transport of glutamine to presynaptic neurons, where it is deaminated by glutaminase to reform ...
Expression of mitochondrial HMGCoA synthase and glutaminase in the colonic mucosa is modulated by bacterial species. Eur J ...
Glutaminase. Model: iEC042_1314. Reaction:. gln__L_p + h2o_p → glu__L_p + nh4_p ...
Glutaminase inhibition impairs CD8 T cell activation in STK11/Lkb1 deficient lung cancer. Lung. Mouse. Cancer. The Walter and ...
A popular hypothesis in oncology research over the past few years is that immunotherapy works synergistically with glutaminase ...
The absence of glutaminase and urease would prevent the serious side effects currently seen with the use of bacteria-derived L- ... However, the newly isolated Antarctic fungi was found to have L-Asparaginase free of glutaminase and urease.. The potency of ... However, L-Asparaginase is always associated with two other enzymes -- glutaminase and urease -- which cause adverse side ...
Sensitisation of Ehrlich Ascitic Tumour Cells to Methotrexate by Inhibiting Glutaminase FRANCISCO J. ALONSO, JUAN A. SEGURA, ... Sensitisation of Ehrlich Ascitic Tumour Cells to Methotrexate by Inhibiting Glutaminase (free) ...
... drug prescriptions and tissue-Trans-Glutaminase (tTG) serum levels. At baseline, all patients had poor Quality of Life and VAS ... Anti-IgA tissue Trans-Glutaminase subtype 2 (tTG) antibodies were measured with an ELISA kit from Phadia Diagnostics (Upsala, ... drug prescriptions and tissue-Trans-Glutaminase (tTG) serum levels. ...
KEAP1/NFE2L2 mutations predict lung cancer radiation resistance that can be targeted by glutaminase inhibition. Cancer ... Finally, we show that glutaminase inhibition preferentially radiosensitizes KEAP1 mutant cells via depletion of glutathione and ...
Phosphofructokinase (PFK) and glutaminase (GLS) activities are key regulatory steps that balance HBP with central metabolism. ...
Neuroprotective effect of hydrogen sulfide against glutamate-induced oxidative stress is mediated via the p53/glutaminase 2 ... Neuroprotective effect of hydrogen sulfide against glutamate-induced oxidative stress is mediated via the p53/glutaminase 2 ...
... glutaminase 1 inhibitor) plus metformin/phenformin. Of additional importance, this combined treatment has potent efficacy in ...
... and glutaminase). On all days of gestation, rates of BCAA transamination were much greater than rates of branched-chain α- ...