Interleukin-18 (rs187238) and glucose transporter 4 (rs5435) polymorphisms in Euro-Brazilians with type 1 diabetes | Abstract
Type 1 diabetes (T1D) is an autoimmune disease with a strong genetic component that has been associated with several genetic ... Type 1 diabetes; Genetic susceptibility; Interleukin-18 gene; Glucose transporter 4 gene; Polymorphisms; SNP , Download:. Full ... of all human body glucose uptake mediated by glucose transporters (Malodobra-Mazur et al., 2016). A deficiency of the insulin- ... Glucose transporter 4 (GLUT4) is known to be an insulin-responsive glucose transporter and has been associated with various ...
Sestrin2 prevents age-related intolerance to ischemia and reperfusion injury by modulating substrate metabolism
Glucose Transporter Type 4 * Nuclear Proteins * Slc2a4 protein, mouse * Peroxidases * Sesn2 protein, mouse ... Nanhu Quan 1 2 , Wanqing Sun 1 2 , Lin Wang 1 2 , Xu Chen 2 , Jonathan S Bogan 3 4 , Xinchun Zhou 5 , Courtney Cates 2 , Quan ... the AMPK downstream glucose uptake and the rate of glucose oxidation were significantly impaired in aged hearts during ischemia ... Sesn2-knockout hearts demonstrate a cardiac phenotype and response to ischemic stress that is similar to wild-type aged hearts ...
Epigenetics of physical exercise - Wikipedia
Additionally, exercise also increases expression of glucose transporter type 4 (GLUT4), which will also help with diabetes ... also identified two types of myocyte cells, Type I and Type II. Each of the different types of cells in skeletal muscle was ... Type I fibers are slow twitch, endurance fibers. This data agrees with human data that says the amount of type I fibers is ... Physical exercise can cause various types of epigenetic alterations, but there are four prominent types that affect cognition ...
ALMS1 and Alström syndrome: a recessive form of metabolic, neurosensory and cardiac deficits | Journal of Molecular Medicine
Indications that ALMS1 influences endocytic recycling suggested that it could have a role in glucose transporter type 4 (GLUT4 ... Wang Z, Li V, Chan GC, Phan T, Nudelman AS, Xia Z, Storm DR (2009) Adult type 3 adenylyl cyclase-deficient mice are obese. PLoS ... Also of note, sperm flagella, which are structurally similar to cilia, are reduced in number and length compared to wild-type [ ... Leto D, Saltiel AR (2012) Regulation of glucose transport by insulin: traffic control of GLUT4. Nat Rev Mol Cell Biol 13:383- ...
GLUT1 deficiency syndrome: MedlinePlus Genetics
Phenotypic spectrum of glucose transporter type 1 deficiency syndrome (Glut1 DS). Curr Neurol Neurosci Rep. 2013 Apr;13(4):342 ... Wang D, Pascual JM, De Vivo D. Glucose Transporter Type 1 Deficiency Syndrome. 2002 Jul 30 [updated 2018 Mar 1]. In: Adam MP, ... This gene provides instructions for producing a protein called the glucose transporter protein type 1 (GLUT1). The GLUT1 ... Glucose transporter-1 deficiency syndrome: the expanding clinical and genetic spectrum of a treatable disorder. Brain. 2010 Mar ...
Nutrients | Free Full-Text | Acute Metabolic Responses to Glucose and Fructose Supplementation in Healthy Individuals: A Double...
... glucose and fructose (GluFru) and sucralose on blood glucose response in healthy individuals. Fifteen healthy individuals (five ... Peak blood glucose levels were significantly lower following the ingestion of Fru compared to the supplementation of Glu and ... The aim of this study was to investigate the impact of glucose (Glu), fructose (Fru), ... which during exercise is transferred to the cell directly via glucose transporter type 4 (GLUT-4) (glucose) or at rest via GLUT ...
3,3′‐Diindolylmethane Enhances Glucose Uptake Through Activation of Insulin Signaling in 3T3‐L1 Adipocytes | Request PDF
Diindolylmethane Enhances Glucose Uptake Through Activation of Insulin Signaling in 3T3‐L1 Adipocytes , Objective Indole‐3‐ ... IR significantly decreased glucose uptake, cell surface glucose transporter type 4 (GLUT4) levels, and Akt phosphorylation, ... DIM also enhanced glucose uptake by increasing expression of glucose transporter 4 in adipocytes. This was associated with DIM‐ ... DDI increased insulin-stimulated glucose uptake, and expression and translocation of glucose transporter 4 in adipocytes ...
Functions, pathophysiology and current insights of exosomal endocrinology (Review)
... downregulation of glucose transporter type 4, and disruption of insulin receptor signaling (72). ... local signals between the same type of cells, paracrine, i.e., local signals between different types of cells, or endocrine, i. ... Type 2 diabetes mellitus is a metabolic disease that has been associated with both obesity and presence of exosomes (68). This ... Xiao Y, Zheng L, Zou X, Wang J, Zhong J and Zhong T: Extracellular vesicles in type 2 diabetes mellitus: Key roles in ...
Classic glucose transporter type 1 deficiency syndrome - About the Disease - Genetic and Rare Diseases Information Center
Find symptoms and other information about Classic glucose transporter type 1 deficiency syndrome. ... Classic glucose transporter type 1 deficiency syndrome. Other Names: Classic GLUT1 deficiency syndrome; Classic GLUT1-DS; De ... Classic glucose transporter type 1 deficiency syndrome is a genetic disease. This means that one or more genes have differences ... About Classic glucose transporter type 1 deficiency syndrome. Many rare diseases have limited information. Currently GARD aims ...
Genetic Variation of the GLUT10 Glucose Transporter (SLC2A10) and Relationships to Type 2 Diabetes and Intermediary Traits |...
The SLC2A10 gene encodes the GLUT10 facilitative glucose transporter, which is expressed in high amounts in liver and pancreas ... Genetic Variation of the GLUT10 Glucose Transporter (SLC2A10) and Relationships to Type 2 Diabetes and Intermediary Traits ... a glucose transporter in the type 2 diabetes-linked region of chromosome 20q12-13.1.. Mol Genet Metab ... a glucose transporter in the type 2 diabetes-linked region of chromosome 20q12-13.1.. Mol Genet Metab ...
Frontiers | Sex-Specific Skeletal Muscle Fatigability and Decreased Mitochondrial Oxidative Capacity in Adult Rats Exposed to...
... and increased prevalence of metabolic diseases such as type 2 diabetes mellitus. Postnatal hyperoxia exposure in rodents is a ... and increased prevalence of metabolic diseases such as type 2 diabetes mellitus. Postnatal hyperoxia exposure in rodents is a ... there was a significant interaction between sex and treatment group in protein expression of glucose transporter type 4 (GLUT4 ... By phosphorylating glucose transported into cells, the hexokinases play a key role in glucose disposition by committing glucose ...
HSPA12A unstabilizes CD147 to inhibit lactate export and migration in human renal cell carcinoma
Glucose transporter 1; GLUT4: Glucose transporter type 4; HK2: Hexokinase 2; PFKFB3: 6-phosphofructo-2-kinase/fructose-2:6- ... CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression. EMBO J. 2000 ... CD147 augmented monocarboxylate transporter-1/4 expression through modulation of the Akt-FoxO3-NF-kappaB pathway promotes ... Prognostic Indications of Elevated MCT4 and CD147 across Cancer Types: A Meta-Analysis. Biomed Res Int. 2015;2015:242437 ...
Treatment of chronic renal insufficiency with losartan and traditional Chinese drug for invigorating spleen and kidney
Effects of Chinese herbal medicine Yiqi Zengmin Formula on expression of glucose transporter 4 in skeletal muscle in type 2 ... Systematic review on methodology of randomized controlled trials of post-marketing Chinese patent drugs for treatment of type 2 ... Logistic regression analysis on relationships between traditional Chinese medicine constitutional types and overweight or ... 4]. Jian-sheng Li, Ya Li, Su-yun Li, Yuan-yuan Wang, Li Deng, Yan-ge Tian, Su-li Jiang , Ying Wang. Long-term effects of Tiaobu ...
Hormones and Hormone Action | Greenspan's Basic & Clinical Endocrinology, 10e | AccessBiomedical Science | McGraw Hill Medical
Thyroid hormones and glycaemic indices in euthyroid, hyperthyroid, hypothyroid, all type 2 diabetics and non-diabetic subjects ...
... fasting plasma glucose (FPG), C-peptide (C-pep) and glycated haemoglobin (HbAlc), used in the management of type 2 is not well ... The presence of abnormal levels of thyroid hormones influenced glycaemic indices in type 2 population. This implies that ... This cross-sectional study examined the relationship between thyroid hormones and glycaemic indices in type 2. Positive ... Abnormal thyroid hormone levels have been reported in type 2, but the relationship between thyroid hormone levels and glycaemic ...
Medicine - Scholarly Works - University of Arizona
Glucose Transporter Type 4 100% * Citrate (si)-Synthase 90% * Skeletal Muscle 53% ... Glucose response curve and type 2 diabetes risk in latino adolescents. Kim, J. Y., Mandarino, L. J., Coletta, D. K. & Shaibi, G ... Glucose control and vascular complications in veterans with type 2 diabetes. Duckworth, W., Abraira, C., Moritz, T., Reda, D., ... Glucose uptake in rat soleus: Effect of acute unloading and subsequent reloading. Henriksen, E. J. & Tischler, M. E., 1988, In ...
Jun Ninomiya-Tsuji - Citation Index - NCSU Libraries
Glucose / metabolism; Glucose Transporter Type 4 / metabolism; Intracellular Signaling Peptides and Proteins / metabolism; MAP ... Type I / deficiency; Receptors, Tumor Necrosis Factor, Type I / metabolism; Time Factors; Tumor Necrosis Factor-alpha / ... Collagen Type I / metabolism; Collagen Type IV / metabolism; Extracellular Matrix / metabolism; Fibronectins / metabolism; ... MeSH headings : Animals; Apoptosis / genetics; Biomarkers; Bone Morphogenetic Protein Receptors, Type I / genetics; Bone ...
Pesquisa | Portal Regional da BVS
... glucose transporter type 4; IBMX: 3-isobutyl-1-methylxanthine; LPL: lipoprotein lipase; MSC: mesenchymal stem cells; α-MEM: α ... which was similar in the wild-type and knockout groups. Expression of genes encoding Mg2+ channels and transporters such as ... Human CNNM2 is not a Mg(2+) transporter per se. Sponder, Gerhard; Mastrototaro, Lucia; Kurth, Katharina; Merolle, Lucia; Zhang ... These transporters include Na+ -dependent B0 AT1 and ATB0,+ and the Na+ -independent exchanger b0,+ /rBAT in the apical ...
OPUS 4 | Functional expression of the human glucose transporters GLUT2 and GLUT3 in yeast offers novel screening systems for...
... whose growth defect on glucose can be rescued by the functional expression of human transporters. The simplicity of handling ... Furthermore, single amino acid substitutions at specific positions of the transporter sequence appear to positively affect the ... facilitate glucose transport in specific tissues. Their malfunction or misregulation is associated with serious diseases, ... which appears to negatively affect the trafficking of the transporter in the heterologous expression system. ...
Reproduction | 0021 | SFEBES2009 | Society for Endocrinology BES 2010 | Endocrine Abstracts
Abnormally low glucose transporter 4 (GLUT4) expression has been shown in adipocytes from subjects with PCOS1 and skeletal ... Recently, we described immunopositive staining for MC3-R in the testes of wild-type mice and reported that the testicular ... Monocarboxylate transporters 8 and 10 (MCT8 and MCT10) are effective plasma membrane TH transporters expressed in the human ... The role of thyroid hormone transporters MCT8 and MCT10 in the EVT-like cell line HTR8-SVneo. Choudhury Juhela , Loubiere ...
WebmedCentral.com :: Bioinformatics Editor - Prof. Kazuo Ishii
... and Yousuke Ebina Identification of Two Enhancer Elements in the Gene Encoding the Type 1 Glucose Transporter from the Nouse ... and Yosuke Ebina Platelet-Derived Growth Factor Triggers Translocation of the Insulin-Regulatable Glucose Transporter (Type 4) ... Ebina Possible Domains Responsible for Intracellular Targeting and Insulin-Dependent Translocation of Glucose Transporter Type ... and Yousuke Ebina Epidermal Growth Factor Triggers the Translocation of Insulin-responsive Glucose Transporter (GLUT4). ...
Vimentin deficiency prevents high-fat diet-induced obesity and insulin resistance in mice<...
keywords = "CD36 antigens, Glucose transporter type 4, Insulin resistance, Obesity, Vimentin",. author = "Kim, {Seo Yeon} and ... We performed intraperitoneal glucose tolerance tests and measured CD36, a major fatty acid translocase, and glucose transporter ... We performed intraperitoneal glucose tolerance tests and measured CD36, a major fatty acid translocase, and glucose transporter ... We performed intraperitoneal glucose tolerance tests and measured CD36, a major fatty acid translocase, and glucose transporter ...
Glitazones - Thiazolidinediones - GlobalRPH
The expression of the insulin-regulated glucose transporter GLUT-4 was increased in adipose tissue. Rosiglitazone did not ... a type of nuclear regulatory protein involved in transcription of genes regulating glucose and fat metabolism. These PPARs act ... Management of type 2 diabetes mellitus: initial: (previously receiving rosiglitazone 4 mg/day): Avandamet® 2/500mg po bid. ( ... The final result is better use of glucose by the cells.. Mode of action. Thiazolidinediones or TZDs act by binding to PPARs ( ...
The Roles of Bacterial Products, Lipopolysaccharides and Bacteriocins, in Obesity and its Related Complications
... we will consider obesity with special attention to adipocyte types, microbiota, and microbial products, LPS and bacteriocins. ... In addition, there is evidence that fatty acids interfere with very early stages of Glucose Transporter Type 4 (GLUT4) and ... 2018) The relationship between frequently used glucose-lowering agents and gut microbiota in type 2 diabetes mellitus. J ... Metformin, a drug used to lower glucose in NIDDM patients which possesses pleiotropic effects, improves glucose uptake and ...
Faculty of Pharmacy | Faculty staff | Head Of Academic Depa...
... and glucose transporter type (GLUT)4. The extract also curtailed the hippocampal content of beta amyloid (Aβ)42, glycogen ... glucose transporter type 4 (GLUT4), peroxisome proliferator-activated receptor gamma (PPARγ) and glucagon-like peptide-1 (GLP-1 ... To assess our aim, we determined their effect on body weight, IPGTT, glucose homeostasis (glucose, insulin, HOMA IR), lipid ... Olmesartan attenuates type 2 diabetes-associated liver injury: Cross-talk of AGE/RAGE/JNK, STAT3/SCOS3 and RAS signaling ...
Adenine Inhibits the Growth of Colon Cancer Cells via AMP-Activated Protein Kinase Mediated Autophagy
Exogenous adenine increases the expression and translocation of glucose transporter 4, enhances the cellular glucose uptake, ... adenine has been explored for its anticancer property in several types of cancer cell lines. Adenine has been suggested to ... It is suggested that adenine-induced inhibition of cancer cell growth varies greatly depending on the type of cancer cells. ... and elevates the intracellular ATP level [11]. Adenine has been demonstrated to induce AMPK activation in different types of ...
Urinary Tract Infections (UTI) in Diabetes Mellitus: Overview, Renal Emphysema, Emphysematous Cystitis
Sodium-Glucose Co-Transporter 2 Inhibitors (SGLT2i) Exposure and Outcomes in Type 2 Diabetes: A Systematic Review of Population ... Emphysematous pyelonephritis in type II diabetes: A case report of an undiagnosed ureteric colic. Cases J. 2008 Sep 30. 1 (1): ... In any type of emphysematous UTI, coverage for multiple for antibiotic-resistant organisms (eg, Pseudomonas aeruginosa, ... Gauging the Risk Factors for Asymptomatic Bacteriuria in Type-2 Diabetic Women: A Case-Control Study. Cureus. 2020 Jul 8. 12 (7 ...
Search All Tech Briefings - Page 4 - NIHR
Glucose transporter type 1 deficiency syndrome Glycogen storage disease type 1a GM1 gangliosidosis GM2 gangliosidosis Graft ... Type 1 diabetes Type 2 diabetes Ulcerative colitis Ulcerative proctitis Uncontrolled bleeding Upper limb spasticity Urinary ... Molybdenum cofactor deficiency Type A Monocarboxylate transporter 8 deficiency (Allan-Herndon-Dudley syndrome) Motor neurone ... Mucopolysaccharidosis type IIIB (Sanfilippo B syndrome) Mucopolysaccharidosis type VII Multiple myeloma (MM) Multiple sclerosis ...