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*  Globin - Wikipedia
Eight globins are known to occur in vertebrates: androglobin, cytoglobin, globin E, globin X, globin Y, hemoglobin, myoglobin ... The globin fold is found in its namesake globin families as well as in phycocyanins. The globin fold was thus the first protein ... Globin E: a globin responsible for storing and delivering oxygen to the retina in birds Globin-coupled sensors: chimeric, with ... single-domain globins, and two types of chimeric globins, flavohaemoglobins and globin-coupled sensors. Bacteria have all three ...
https://en.wikipedia.org/wiki/Globin
*  Features in the human beta-like globin gene cluster
... 951 1234 DNase hypersensitive site 4 4550 4775 DNase hypersensitive site 3 ... G-gamma-globin gene 34478 34622 Exon 1 34745 34967 Exon 2 35854 36069 Exon 3 37921 38039 Left L1 39414 40985 A-gamma-globin ... 53540 Left L1 54740 56389 delta-globin gene 54740 54881 Exon 1 55010 55232 Exon 2 56131 56389 Exon 3 62137 63742 beta-globin ... 10924 Right Alu 12912 13066 Left L1 14836 15071 Right L1 16918 17218 Left Alu 17940 18231 Right Alu 19486 21080 epsilon-globin ...
http://globin.cse.psu.edu/globin/data/globin.html
*  "Induction of endogenous γ-globin gene expression with decoy oligonucleotide targeting . . ." by Xiaoxin S. Xu, Xin Hong et al.
The human γ-globin genes (both Aγ and Gγ-globin genes) carry three Oct-1 transcription factor consensus sequences within their ... Increasing the expression of the γ-globin gene has great benefits in reducing complications associated with these diseases. The ... We have studied the possibility of inducing γ-globin gene expression using decoy oligonucleotides that target the Oct-1 ... significant increases in the level of the γ-globin mRNA were observed. The results of our western blots further demonstrated ...
https://digitalcommons.wayne.edu/biomedcentral/127/
*  Molecular mechanisms of globin gene regulation and disregulat...
Human globin genes are expressed in tissue and developmental stage specific manners. Variou ... Molecular mechanisms of globin gene regulation and disregulation].: ... Molecular mechanisms of globin gene regulation and disregulation].. Authors * Fukumaki, Y Type. Published Article. Journal. ... Human globin genes are expressed in tissue and developmental stage specific manners. Various experiments including expression ...
https://www.mysciencework.com/publication/show/molecular-mechanisms-globin-gene-regulation-disregulation-7ae9b37a
*  "Nonsense mutations in the human beta globin gene affect mRNA metabolis" by Susan J. Baserga
Decreased β-globin mRNA accumulation can be caused by the presence of a nonsense mutation, independent of its type or location. ... These studies strongly suggest that the presence of a nonsense mutation (but not a missense mutation) in β-globin mRNA ... A number of nonsense and missense mutations of the β globin gene were constructed by oligonucleotide-directed site-specific ... nonsense mutation at the 39th codon of the human β globin gene, the β-39 mutation. Studies of mRNA metabolism in reticulocytes ...
http://elischolar.library.yale.edu/ymtdl/2266/
*  High-level, erythroid-specific expression of the human alpha-globin gene in transgenic mice and the production of human...
... and beta-globin genes and the beta-globin DCR, live mice with low-copy numbers were obtained. Both human globin genes are ... Metabolic labeling experiments showed balanced mouse globin synthesis, but imbalanced human globin synthesis, with an alpha/ ... These results are discussed with relation to the coordinate regulation of alpha- and beta-globin synthesis in erythroid tissues ... we have been able to achieve high-level expression of the human alpha-globin gene in transgenic mice. Expression in fetal liver ...
https://www.neuroscience.ox.ac.uk/publications/13535
*  "Proximity among distant regulatory elements at the beta-globin locus r" by Christopher R. Vakoc, Danielle L. Letting et al.
Here, we examined the mechanism for DNA looping at the beta-globin locus. By using chromosome conformation capture (3C), we ... GATA-1 occupies the beta-major globin promoter normally in fetal liver erythroblasts from mice lacking the LCR, suggesting that ... Kinetic studies reveal that GATA-1-induced loop formation correlates with the onset of beta-globin transcription and occurs ... transcription factor GATA-1 and its cofactor FOG-1 are required for the physical interaction between the beta-globin locus ...
http://escholarship.umassmed.edu/pgfe_pp/132/
*  Hemoglobinopathies facts, information, pictures | Encyclopedia.com articles about Hemoglobinopathies
These people, who have two different alleles of the beta globin gene, are said to be heterozygous. The beta globin allele that ... Hemoglobin is made up of heme and globin. Heme is an iron-containing pigment that binds to oxygen. Globin, which holds the heme ... Fetal hemoglobin has a pair of gamma-globin molecules in place of the typical beta-globins of adult hemoglobin. Higher-than- ... or the ß-globin (alpha- and beta-globin) chains. Some of these genetic changes, such as the substitution of valine for glutamic ...
https://www.encyclopedia.com/medicine/diseases-and-conditions/pathology/hemoglobinopathies
*  Hemoglobinopathy Evaluation
... and another portion made up of four globin (protein) chains. The globin chains, depending on their structure, have different ... The types of globin chains that are present are important in the function of hemoglobin and its ability to transport oxygen. ... Thalassemia is a condition in which a gene mutation results in reduced production of one of the globin chains. This can upset ... These genetic changes may result in a reduced production of one of the normal globin chains or in the production of ...
https://labtestsonline.org/tests/hemoglobinopathy-evaluation
*  Dienekes' Anthropology Blog: Lack of β thalassemia mutations in Minoan Cretans
DNA sequencing focused on the Intervening Sequence 1 (IVS-1) of the beta globin gene and its splicing junctions. 63% of the ...
http://dienekes.blogspot.com/2012/11/lack-of-thalassemia-mutations-in-minoan.html
*  Beta-thalassemia: Newborn
Hemoglobin is made up of two proteins, alpha globin and beta globin. ... The beta chain requires a gene from each parent to produce the correct quality and quantity of beta globin. If the gene from ... Normal hemoglobin has two alpha and two beta globin protein chains. A deficiency or absence of the alpha chain results in Alpha ...
http://www.openanesthesia.org/beta-thalassemia_newborn/
*  Erythropoiesis
H. Ni, X.-D. Yang,C.J. Stoeckert, Jr., Maturation and developmental stage-related changes in fetal globin gene expression are ...
http://www.cbil.upenn.edu/EpoDB/bfue_culture.html
*  What Is Genetic Disorder - Alpha Thalassemia - Medicalrealm
Alpha thalassemia occurs due to excess of beta globin chain than alpha glob ... hemoglobin consists of alpha globin chain and beta globin chain. There are two forms of thalassemia. These include alpha ... In normal individual, hemoglobin consists of alpha globin chain and beta globin chain.. There are two forms of thalassemia. ... Alpha thalassemia occurs due to excess of beta globin chain than alpha globin chain. Alpha thalassemia is an autosomal ...
http://www.medicalrealm.net/what-is-genetic-disorder---alpha-thalassemia.html
*  BIOGEN IDEC AND SANGAMO BIOSCIENCES ANNOUNCE GLOBAL COLLABORATION TO DEVELOP TREATMENTS FOR HEMOGLOBINOPATHIES | Biogen Media
... when patients switch from producing functional fetal gamma-globin to a mutant form of adult beta-globin, which results in their ... The mutation in beta-globin that gives rise to SCD causes the red blood cells to form an abnormal sickle or crescent shape ... Mutations in the genes encoding beta-globin, a subunit of the oxygen-carrying protein of red blood cells, lead to the ... There are several forms of beta-thalassemia caused by mutations in the beta-globin gene; broadly the disorder results in ...
http://newsroom.biogen.com/press-release/corporate/biogen-idec-and-sangamo-biosciences-announce-global-collaboration-develop-tr
*  Delta beta thalassemia: a rare hemoglobin variant
The gamma genes on the affected chromosome increase their production of gamma globin, thereby increasing the amount of ...
http://www.bloodresearch.or.kr/journal/view.html?uid=1731&vmd=Full
*  globin - Wiktionary
biochemistry) Any globular protein that incorporates a globin fold. *(biochemistry) One of several polypeptides that are the ... Retrieved from "https://en.wiktionary.org/w/index.php?title=globin&oldid=48058080" ...
https://en.wiktionary.org/wiki/globin
*  Globin like (cd01067) | InterPro | EMBL-EBI
Globin_like (cd01067). Accession cd01067 Integration. RsbS co-antagonist protein RsbRA N-terminal domain (IPR014792) Member ...
http://www.ebi.ac.uk/interpro/signature/cd01067
*  Globin - Medical Dictionary / Glossary | Medindia
Globin' - The protein component of hemoglobi, is clearly explained in Medindia s glossary of medical terms ... Globin - Glossary. Written & Compiled by Medindia Content Team. Medically Reviewed by The Medindia Medical Review Team on May ...
https://www.medindia.net/glossary/globin.htm
*  Globin - Lampetra fluviatilis (European river lamprey)
Belongs to the globin family.PROSITE-ProRule annotation. ,p>Manual validated information which has been generated by the ... sp,P02207,GLB_LAMFL Globin OS=Lampetra fluviatilis OX=7748 PE=1 SV=2 ...
http://www.uniprot.org/uniprot/P02207
*  PPT - Globins PowerPoint Presentation - ID:1348492
Globins. Lecture 10/01/2009. The Backbone structure of Myoglobin. 2. Myoglobin: 44 x 44 x 25 Å single subunit 153 amino acid ... Globins & Enzyme Catalysis -Globins & enzyme catalysis. 10/06/2009. the bohr effect. higher ph i.e. lower [h + ] promotes ... EVOLUTION OF GLOBINS -. evolution of globins evolution of visual pigments and related molecules. evolution of gene clusters. ... Globins & Enzyme Catalysis -. 10/06/2009. the bohr effect. higher ph i.e. lower [h + ] promotes tighter binding of oxygen to ...
https://www.slideserve.com/tosca/globins-1348492
*  Globin Gene Therapy | Memorial Sloan Kettering Cancer Center
MSK's innovative globin gene transfer therapy offers the potential to free patients from a lifetime of red blood cell ... which is believed to achieve better expression of β-globin on a per-copy basis, and therefore the potential for superior ... utilizing a lentiviral vector to stably insert a functional β-globin gene, and then infusing the patient with engineered HSCs ...
https://www.mskcc.org/research-advantage/support/technology/available/globin-gene-therapy
*  beta-Globins - beta Globin Summary Report | CureHunter
They include epsilon-globin, gamma-globin, delta-globin and beta-globin. There is also a pseudogene of beta (theta-beta) in the ... Adult HEMOGLOBIN is comprised of two ALPHA-GLOBIN chains and two beta-globin chains. ... Members of the beta-globin family. In humans, they are encoded in a gene cluster on CHROMOSOME 11. ... beta Globin; Non-alpha Globin Chain, Unspecified; Non alpha Globin Chain, Unspecified; beta Globins; beta-Globin ...
http://www.curehunter.com/public/keywordSummaryD055544-beta-Globins-beta-Globin.do
*  Genetic and Epigenetic Mechanisms of β-Globin Gene Switching | SpringerLink
Alteration of balanced expression of globin genes, which usually occurs due to damage to adult β-globin genes, leads to ... The phenomenon of stage-specific transcription of globin genes is referred to as globin gene switching. Mechanisms of ... HS4 core element of the human beta-globin locus control region is required for high-level globin gene expression in definitive ... The hematopoietic regulator TAL1 is required for chromatin looping between the beta-globin LCR and human gamma-globin genes to ...
https://link.springer.com/article/10.1134/S0006297918040090
*  RCSB PDB - Protein Feature View - Globin-F1 - Q7SID0 (GLBF1 EPTBU)
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
http://www.rcsb.org/pdb/protein/Q7SID0
*  Methemoglobinemia, beta-globin type - Genetics Home Reference - NIH
HBB gene mutations that cause methemoglobinemia, beta-globin type change the structure of beta-globin and promote the heme iron ... This gene provides instructions for making a protein called beta-globin. Beta-globin is one of four components (subunits) that ... In adults, hemoglobin normally contains two subunits of beta-globin and two subunits of another protein called alpha-globin. ... Methemoglobinemia, beta-globin type is a condition that affects the function of red blood cells. Specifically, it alters a ...
https://ghr.nlm.nih.gov/condition/methemoglobinemia-beta-globin-type