Frontiers | Regular Exercise, Subjective Wellbeing, and Internalizing Problems in Adolescence: Causality or Genetic Pleiotropy?...
The association largely reflects the effects of common genetic factors on these traits. ... The association largely reflects the effects of common genetic factors on these traits. ... because genetic confounding is excluded. Data on these phenotypes were available in a sample of 6,317 adolescent twins and ... because genetic confounding is excluded. Data on these phenotypes were available in a sample of 6,317 adolescent twins and ...https://www.frontiersin.org/articles/10.3389/fgene.2012.00004/full
Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits | Genome Medicine | Full Text
... the lead genetic variant per independent locus was extracted and a genetic score was calculated for each disease/trait as the ... So far, little is known about a genetic overlap between AMD and other complex diseases or disease-relevant traits. For each of ... Of the respective disease/trait variance, the 60 genetic scores explained on average 4.8% (0.27-20.69%) and 16 of them were ... By restricting the analysis to 1824 variants initially used to compute the 60 genetic scores, we identified 28 novel AMD risk ...https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-017-0418-0
Frontiers | Phenome-wide association studies demonstrating pleiotropy of genetic variants within FTO with and without...
Here we used an electronic health record (EHR)-based PheWAS to explore pleiotropy of genetic variants in the fat mass and ... Here we used an electronic health record (EHR)-based PheWAS to explore pleiotropy of genetic variants in the fat mass and ... These results suggest that genetic variants in FTO may have pleiotropic associations, some of which are not mediated by obesity ... have demonstrated utility in validating genetic associations derived from traditional genetic studies as well as identifying ...https://www.frontiersin.org/articles/10.3389/fgene.2014.00250/full
Lipoprotein subclass profiling reveals pleiotropy in the genetic variants of lipid risk factors for coronary heart disease: a...
Lipoprotein subclass profiling reveals pleiotropy in the genetic variants of lipid risk factors for coronary heart disease: a ... Response: Lipoprotein subclass profiling reveals pleiotropy in the genetic variants of lipid risk factors for coronary heart ...https://www.ncbi.nlm.nih.gov/pubmed/24055740
Genetic pleiotropy in complex traits and diseases: implications for genomic medicine Authors: Jacob Gratten and Peter M. ... Genetic and epigenetic analysis of schizophrenia in blood-a no-brainer? Several recent studies have investigated either genetic ... Advances in genetic analysis have revealed new complexities in the interpretation of genetic variants. Correct assessment of a ... Genetic and epigenetic studies of adiposity and cardiometabolic disease Over 300 million adults are obese, but little is known ...https://www.biomedcentral.com/collections/commentariesfromgenomemedicine
A hypothesis linking the energy demand of the brain to obesity risk | PNAS
Evidence for Genetic Pleiotropy Linking Reduced Size of Brain Structures to the BMI. Related work is showing that inverse ... Further evidence for genetic pleiotropy linking increased BMI with reduced brain structures comes from a large family-based ... Evidence for Genetic Pleiotropy Linking Reduced Size of Brain Structures to the BMI ... Identification of pleiotropic genetic effects on obesity and brain anatomy. Hum. Hered. 75, 136-143 (2013).. ...https://www.pnas.org/content/116/27/13266
Pleiotropic Mutations Are Subject to Strong Stabilizing Selection | Genetics
We complement this quantitative genetic analysis of developmental pleiotropy with an analysis of molecular genetic pleiotropy ( ... Molecular genetic pleiotropy and selection. Finally, we complimented our quantitative genetic analyses of developmental ... Molecular genetic pleiotropy and selection. Information on the products of a gene, such as obtained from annotations in the GO ... 2009 Abundant genetic variation + strong selection = multivariate genetic constraints: a geometric view of adaptation. Annu. ...http://www.genetics.org/content/197/3/1051
Uncovering Buffered Pleiotropy: A Genome-Scale Screen for mel-28 Genetic Interactors in Caenorhabditis elegans | G3: Genes |...
Uncovering Buffered Pleiotropy: A Genome-Scale Screen for mel-28 Genetic Interactors in Caenorhabditis elegans. Anita G. ... Uncovering Buffered Pleiotropy: A Genome-Scale Screen for mel-28 Genetic Interactors in Caenorhabditis elegans. Anita G. ... Uncovering Buffered Pleiotropy: A Genome-Scale Screen for mel-28 Genetic Interactors in Caenorhabditis elegans. Anita G. ... Uncovering Buffered Pleiotropy: A Genome-Scale Screen for mel-28 Genetic Interactors in Caenorhabditis elegans ...http://www.g3journal.org/content/4/1/185
Pleiotropy - Wikipedia
This article is about genetic pleiotropy. For drug pleiotropy, see Pleiotropy (drugs). ... such as gene pleiotropy, developmental pleiotropy, and selectional pleiotropy. Gene pleiotropy occurs when a gene product ... pleiotropy. "Genuine" pleiotropy is when two distinct primary products arise from one locus. "Spurious" pleiotropy, on the ... Pleiotropy describes the genetic effect of a single gene on multiple phenotypic traits. The underlying mechanism is genes that ...https://en.wikipedia.org/wiki/Pleiotropic
Engineered Stem Cells Seek out and Kill HIV in Living Mice, page 1
It's called genetic pleiotropy. You'll notice Asians that begin to consume the Western diet (high in sugar) are generally ... but also upon the particular genetic background of the infected animal. Thus, one can imagine that one may be able to find a ...http://www.abovetopsecret.com/forum/thread830299/pg1&mem=
Almasy L[au] - PubMed - NCBI
Genetic pleiotropy between mood disorders, metabolic, and endocrine traits in a multigenerational pedigree. ... Novel genetic loci associated with hippocampal volume.. Hibar DP, Adams HHH, Jahanshad N, Chauhan G, Stein JL, Hofer E, ... Disentangling the genetic overlap between cholesterol and suicide risk.. Knowles EEM, Curran JE, Meikle PJ, Huynh K, Mathias SR ... Genetic influence on cognitive development between childhood and adulthood.. Mollon J, Knowles EEM, Mathias SR, Gur R, Peralta ...https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Almasy+L%5Bau%5D&dispmax=50
References Anti-alpha Tubulin antibody [DM1A] - Loading Control (ab7291) | Abcam
Drivas TG et al. Basal exon skipping and genetic pleiotropy: A predictive model of disease pathogenesis. Sci Transl Med 7: ... Corrochano S et al. A genetic modifier suggests that endurance exercise exacerbates Huntington's disease. Hum Mol Genet 27:1723 ...https://www.abcam.com/alpha-tubulin-antibody-dm1a-loading-control-ab7291-references.html
Intralocus sexual conflict for fitness | Proceedings of the Royal Society of London B: Biological Sciences
2006 Genetic pleiotropy in Saccharomyces cerevisiae quantified by high-resolution phenotypic profiling. Mol. Genet. Genomics ... 1998 Pleiotropy and the preservation of perfection. Science 279, 1210-1213. doi:10.1126/science.279.5354.1210 (doi:10.1126/ ... 2005 Genetic constraints and sexual dimorphism in immune defense. Evolution 59, 1844-1850. doi:10.1111/j.0014-3820.2005.tb01831 ... 2009 Genetic incompatibility drives sex allocation and maternal investment in a polymorphic finch. Science 323, 1605-1607. doi: ...http://rspb.royalsocietypublishing.org/content/early/2011/12/06/rspb.2011.2340
Wiley Online Library: Search Results Page
Genetic Pleiotropy for Resting Metabolic Rate with Fat-Free Mass and Fat Mass: The Québec Family Study. Obesity Research. ...http://onlinelibrary.wiley.com/advanced/search/results?articleDoi=10.1038/oby.2007.15&scope=allContent&start=1&resultsPerPage=20
Epigenetics by Benedikt Hallgrimsson Ph.D., Brian K. Hall Ph.D. - Hardcover - University of California Press
Zelditch and Swiderski emphasize the distinction between epigenetic mechanisms and genetic pleiotropy as determinants of ... For Waddington, genetic assimilation was one the main ways in which epigenetic mechanisms were relevant to evolutionary change ... The discussion of genetic assimilation and phenotypic plasticity continues in a very different phylogenetic context in the ... They argue that epigenetic pleiotropy needs to be recognized as a distinct phenomenon, somewhat akin to developmental ...https://www.ucpress.edu/book/9780520267091/epigenetics
The Ethics of Fragile X Genetic Screening and Testing Across the Lifespan. Acharya, K. ...https://uic.pure.elsevier.com/en/persons/kruti-acharya
Genetische Risiken und Therapieentwicklung bei Netzhautdegenerationen, medizinische genetik | 10.1007/s11825-017-0134-6 |...
Genetic pleiotropy between age-related macular degeneration (AMD) and sixteencomplex diseases and traits ... An atlas of genetic correlations across human diseases and traits. Bulik-Sullivan, B; Finucane, HK; Anttila, V; Gusev, A; Day, ... Modelling the genetic risk in age-related macular degeneration. Grassmann, F; Fritsche, LG; Keilhauer, CN; Heid, IM; Weber, BHF ... Clinical and genetic factors associated with progression of geographic atrophy lesions in age-related macular degeneration ...https://www.deepdyve.com/lp/springer_journal/genetische-risiken-und-therapieentwicklung-bei-netzhautdegenerationen-Qwp4baJ0N9
Blood Pressure and Cerebral White Matter Share Common Genetic Factors in Mexican Americans | Hypertension
We also tested whether regional pattern in genetic pleiotropy is modulated by the phylogeny of WM development. BP and high- ... Genetic Analyses. Two sets of analyses were performed to study the magnitude and regional variations in shared genetic variance ... Beverage genetic analysis calculates the magnitude and significance of genetic correlation coefficient (ρG), which is the ... Bivariate genetic correlation analysis was used to calculate the genetic overlap between several BP measurements (pulse ...http://hyper.ahajournals.org/content/57/2/330
Protocols and Video Articles Authored by Anders Blomberg
Jun, 2006 , Pubmed ID: 16534619 Genetic pleiotropy, the ability of a mutation in a single gene to give rise to multiple ... Genetic Pleiotropy in Saccharomyces Cerevisiae Quantified by High-resolution Phenotypic Profiling Molecular Genetics and ... allowing further genetic manipulation by synthetic genetic array (SGA)-based, high-throughput methods. We show two such ... We also refute the existence of phenotypic islands along chromosomes but report on a remarkable loss both of pleiotropy and of ...https://www.jove.com/author/Anders_Blomberg
Tyrosine Hydroxylase, the Rate-Limiting Enzyme in Catecholamine Biosynthesis | Circulation
Pleiotropy: Bivariate Genetic Analyses Pleiotropy (genetic covariance for 2 correlated, heritable traits14) was estimated as ... We documented such pleiotropy statistically using bivariate genetic analyses.15 Genetic pleiotropy is an integral component of ... we undertook bivariate genetic analyses15 in search of pleiotropy or the coordinate effect of a single gene on multiple traits ... Genetic analysis of the age at menopause by using estimating equations and Bayesian random effects models. Stat Med. 2000; 19: ...http://circ.ahajournals.org/content/116/9/993
Genetic architecture and pleiotropy shape costs of Rps2-mediated resistance in Arabidopsis thaliana *Alice MacQueen ... Rights & permissionsfor article Genetic architecture and pleiotropy shape costs of ,i,Rps2,/i,-mediated resistance in ,i, ... Genome-wide patterns of genetic variation in worldwide Arabidopsis thaliana accessions from the RegMap panel * Joy Bergelson ... The molecular genetic basis of herbivory between butterflies and their host plants *Sumitha Nallu ...http://www.nature.com/search?author=%22Joy%20Bergelson%22&error=cookies_not_supported&code=3e84ab3a-181a-44f8-84e8-6a0d6e3c75b4
PAR-17-252: From Genomic Association to Causation: A Convergent Neuroscience Approach for Integrating Levels of Analysis to...
Additionally, phenotypic heterogeneity and genetic pleiotropy are known phenomena in neuropsychiatric disorders that pose a ... If addressing genetic/genomic level of analysis, describe how the role of known genetic risk factors for neuropsychiatric ... the genetic architecture of mental disorders by identifying robust and reliable genetic associations across the allelic ... If the project includes a genetic level of analysis, does it signify an important advancement in explaining genetic causality ...https://grants.nih.gov/grants/guide/pa-files/PAR-17-252.html
Find Research Outputs - Fujita Health University
Genetic and animal model analyses reveal the pathogenic role of a novel deletion of RELN in schizophrenia. Sobue, A., Kushima, ... Genetic variation determines VEGF-A plasma levels in cancer patients. Innocenti, F., Jiang, C., Sibley, A. B., Etheridge, A. S ... Genetic Variants in CPA6 and PRPF31 Are Associated With Variation in Response to Metformin in Individuals With Type 2 Diabetes ... Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases. Kanai, M., ...https://pure.fujita-hu.ac.jp/en/publications/?format=&page=6
Associations between attention-deficit/hyperactivity disorder and autoimmune diseases are modified by sex: a population-based...
In sum, if sex-specific genetic pleiotropy, or other sex-specific mechanisms, underlie any associations between ADHD and ... some tentative genetic associations between ADHD and the immune system have been noted. For example, a study on genetic ... Wang K, Gaitsch H, Poon H, Cox NJ, Rzhetsky A (2017) Classification of common human diseases derived from shared genetic and ... Another potential mechanism could be that there is a tendency for more genetic variants positively associated with both ADHD ...https://link.springer.com/article/10.1007%2Fs00787-017-1056-1
No questions in Phenotype - lookformedical.com
Genetic Markers (0) * Genetic Pleiotropy (0) * Penetrance (0) * Phylogeny (0) * Ploidies (0) ...https://lookformedical.com/answers/en/phenomena-and-processes/genetic-phenomena/phenotype