... In: Journal of the American College of Cardiology, Vol. 68, No. 13: pp. 1435-1448 ... RESULTS We identified 52 genomic loci, of which 32 are novel, that are reliably associated with 1 or more QRS phenotypes at p ... We validated the regulatory function of a novel variant in the SCN5A/SCN10A locus in vitro and in vivo. CONCLUSIONS Taken ... OBJECTIVES This meta-analysis sought to gain insights into the genetic determinants of myocardial mass. METHODS We carried out ...
We found extensive genetic overlap. Depression shared 68% of genetic variants with body mass index and 14% and with systolic ... It is unknown if shared genetic factors contribute to these associations. We applied novel statistical tools for polygenic ... Further analyses identified shared genetic variants found in metabolism of alpha-linolenic pathway for type 2 diabetes. ... to quantify genome-wide overlap and to identify shared genetic variants. ...
Access of the Data Via Electronic Mail From Communicating Author Genotype studies at highly polymorphic 15 STR loci were ... Access of the Data Via Electronic Mail From Communicating Author Genotype studies at highly polymorphic 15 STR loci were ... The communities included in the present analysis hold a special attraction for human genetic studies because they practice a ...
Massively parallel single-cell sequencing of genetic loci in diverse microbial populations. View ORCID ProfileFreeman Lan, ... Massively parallel single-cell sequencing of genetic loci in diverse microbial populations ... Massively parallel single-cell sequencing of genetic loci in diverse microbial populations ... Massively parallel single-cell sequencing of genetic loci in diverse microbial populations ...
... Am J Med ... Taken together, these results indicate a locus for efficiency and accuracy of RWR on chromosome 13, and a complex model for ...
Researchers have identified two hidradenitis suppurativa-associated genetic loci linked to the risk of developing the condition ... Genetic loci linked to HS. The study revealed genomic variants pointing to two specific genes: SOX9 and KLF5. The SOX9 gene is ... Two distinct genetic loci that contribute to the risk of an individual developing the chronic skin condition hidradenitis ... The study, which was published in JAMA Dermatology, sought to identify genetic variants associated with HS and to shed light on ...
Comprehensive Genetic Analysis of the Human Lipidome Identifies Novel Loci Controlling Lipid Homeostasis. Date 30 August 2022. ... Comprehensive Genetic Analysis of the Human Lipidome Identifies Novel Loci Controlling Lipid Homeostasis. ... Of the 53 lipid-loci that showed evidence of association (P,1×10-3), 43 loci were associated with at least one lipid ... We integrated lipidomics and genomics to unravel the genetic architecture of lipid metabolism andidentify genetic variants ...
Genetic Meta-Analysis of Diagnosed Alzheimers Disease Identifies New Risk Loci and Implicates Aβ, Tau, Immunity and Lipid ... Genetic Meta-analysis of Diagnosed Alzheimers Disease Identifies New Risk Loci and Implicates Aβ, Tau, Immunity and Lipid ... We confirm 20 previous LOAD risk loci and identify five new genome-wide loci (IQCK, ACE, ADAM10, ADAMTS1 and WWOX). Fine- ... To identify LOAD risk loci, we performed the largest genome-wide association meta-analysis of clinically diagnosed LOAD to date ...
TP53-dependent toxicity of CRISPR/Cas9 cuts is differential across genomic loci and can confound genetic screening ...
First genome-wide association study of esophageal atresia identifies three genetic risk loci at CTNNA3, FOXF1/FOXC2/FOXL1, and ... First genome-wide association study of esophageal atresia identifies three genetic risk loci at CTNNA3, FOXF1/FOXC2/FOXL1, and ... This study represents the first genome-wide association study (GWAS) to identify risk loci for EA/TEF. We used a European case- ... This study represents the first genome-wide association study (GWAS) to identify risk loci for EA/TEF. We used a European case- ...
Data from: Quantitative trait loci from the host genetic background modulate the durability of a resistance gene: a rational ... The resistance breakdown frequency was a highly heritable trait (h²=0.87). Four loci including additive quantitative trait loci ... Quantitative trait loci from the host genetic background modulate the durability of a resistance gene: a rational basis for ... Surprisingly, a genetic trade-off was observed between the durability of PVY resistance controlled by pvr23 and the spectrum of ...
Landscape genetic analyses showed a pattern of IBD for all loci and the panel of NTL, but genetic differentiation estimated at ... 12 loci) or not (NTL; 14 loci) transcribed to RNA. Population genetic differentiation was mostly detected using the panel of ... The study of the factors structuring genetic variation can help to infer the neutral and adaptive processes shaping the ... We typed 1385 individuals at 26 microsatellite loci classified in two groups by considering whether they are located into ...
Genetic polymorphism of the αs1-casein locus in five populations of goats from Mexico ... Genetic polymorphism of the αs1-casein locus in five populations of goats from Mexico ...
It is proposed that certain C. difficile toxinotypes with distinct pathogenicity locus (PaLoc) variants are associated with ... Molecular characterization of pathogenicity locus (PaLoc) and tcdC genetic diversity among tcdABClostridioides difficile ... Genetic diversity of the tcdC gene was determined by the sequencing of the gene. Of the 50 C. difficile isolates investigated, ... The present study demonstrates that the majority of clinical tcdAB isolates of C. difficile frequently harbor tcdC genetic ...
Most of these loci are novel, but several overlapped with known genetic risk factors for other ocular diseases. Strong ... GWAS of corneal biomechanics identifies over 200 novel associated loci providing additional insight into the genetic aetiology ... GWAS of corneal biomechanics identifies over 200 novel associated loci providing additional insight into the genetic aetiology ... GWAS of corneal biomechanics identifies over 200 novel associated loci providing additional insight into the genetic aetiology ...
While equine MHC class II DRA and DQA loci have received attention, the genetic diversity and effects of selection on DRB and ... This study aimed to provide the first in-depth analysis of the MHC class II DRB and DQB loci in the Equidae family. Three DRB ... Site-specific selection analysis predicted genes evolving under positive selection both at DRB and DQB loci. No selected amino ... is a genetic region containing highly polymorphic genes with immunological functions. MHC class I and class II genes encode ...
Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with ... Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with ... Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with ... Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with ...
... and phosphorylation of potato tuber starch are starch-related traits studied at the genetic level. In this paper, we perform a ... for the first time genomic regions associated with starch granule morphology and to increase number of known genome loci ... Genetic loci determining potato starch yield and granule morphology revealed by genome-wide association study (GWAS). Vadim K. ... Genetic loci determining potato starch yield and granule morphology revealed by genome-wide association study (GWAS) PeerJ 8: ...
Genetic variants at the 16p13 locus confer risk for eosinophilic esophagitis.. Go back to Publications ... Chromosomes, Human, Pair 16; DNA-Binding Proteins; Eosinophilic Esophagitis; Genetic Loci; Humans; Lectins, C-Type; Membrane ... we have identified an additional EoE risk locus at 16p13 and highlight a shared and unique genetic etiology of EoE with a ... and III genes and nearly all other loci using a highly powered study design with dense genotyping throughout the locus. ...
A catalog of genetic loci associated with kidney function from analyses of a million individuals... 18. janúar 2021 Wuttke M, ...
Genome-wide analysis identifies molecular systems and 149 genetic loci associated with income 16 December 2019 ... These loci show clear evidence of functionality, with transcriptional differences identified across multiple cortical tissues, ... Using a method to meta-analyze data from genetically-correlated traits, we identify an additional 120 income-associated loci. ... Following training in Genetics at the University of Cambridge and Genetic Epidemiology at the University of Sheffield, Adam ...
Topography of genetic loci in tissue samples: towards new diagnostic tool using interphase FISH and high‐resolution image ... Our results show that the topography of genetic loci determined in 3D‐fixed cell tissue corresponds to that obtained for 2D‐ ... The investigations of trisomic loci in HT‐29 cells revealed that the location of the third genetic element is not different ... It suggests that the arrangement of genetic loci in cell nucleus is conserved in different types of human cells. ...
Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps. Nature Genetics , 48 ... Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps ... Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps. ... Applying fine-mapping analysis to 233 known and new loci associated with the 20 traits, we resolve the associations of 59 loci ...
Fine-Mapping of Genetic Loci Linked to REM-Density in the Munich Vulnerability Study ... 2010). Fine-Mapping of Genetic Loci Linked to REM-Density in the Munich Vulnerability Study. Biological Psychiatry, 67(9 Suppl. ... Fine-Mapping of Genetic Loci Linked to REM-Density in the Munich Vulnerability Study ...
Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 ... Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 ...
... but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated ... we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci ... Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the ... Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, ...
Previous studies have linked over 100 genomic loci to age-at-menarche but that work was restricted to common autosomal ... we identify common X-chromosome loci at IGSF1 (rs762080, P=9.4 × 10−13) and FAAH2 (rs5914101, P=4.9 × 10−10). Highlighted genes ... More than 100 loci have been identified for age at menarche by genome-wide association studies; however, collectively these ... Web-based, participant-driven studies yield novel genetic associations for common traits. PLoS Genet. 6, e1000993 (2010). ...