Multi-stage genome-wide association study identifies new susceptibility locus for testicular germ cell tumour on chromosome...
Genetic Loci; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Humans; Linkage Disequilibrium; Male ... Recent genome-wide association studies (GWAS) and subsequent meta-analyses have identified over 25 SNPs at 18 loci, together ... Multi-stage genome-wide association study identifies new susceptibility locus for testicular germ cell tumour on chromosome ... we identified a novel locus at 3q25.31 (rs1510272) demonstrating association with TGCT [per-allele odds ratio (OR) = 1.16, 95% ...http://www.forskningsdatabasen.dk/catalog/272500784
Genome-wide epistatic expression quantitative trait loci discovery in four human tissues reveals the importance of local...
Mapping the genetic architecture of gene expression in human liver. PLoS Biol. 2008;6(5):e107.View ArticlePubMed CentralPubMed ... The genetic landscape of the cell. Science. 2010;327(5964):425-31.View ArticlePubMedGoogle Scholar. ... Genetic analysis of genome-wide variation in human gene expression. Nature. 2004;12(430):743-7.View ArticleGoogle Scholar. ... Genetic interactions in four human tissues. We implemented two search space strategies to detect epistatic eQTLs in the four ...https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-015-1300-3
Isolation of novel microsatellite loci in Orchesella villosa (Arthropoda, Collembola). | IRIS Università degli Studi di Siena
The potential application of these loci to test the effects of environmental contamination on the genetic structure of exposed ... The potential application of these loci to test the effects of environmental contamination on the genetic structure of exposed ... All microsatellite loci showed high levels of polymorphism. The mean number of different alleles at each locus across ... All microsatellite loci showed high levels of polymorphism. The mean number of different alleles at each locus across ...https://usiena-air.unisi.it/handle/11365/38192
Genome-wide association study of lung function decline in adults with and without asthma | RTI
Conclusions: Genetic heterogeneity of lung function might be extensive. Our results suggest that genetic determinants of ... Thirty loci were followed up by in silico replication (1,160 asthmatic and 10,858 nonasthmatic participants: Atherosclerosis ...https://www.rti.org/publication/genome-wide-association-study-lung-function-decline-adults-and-without-asthma
Patent WO2009132089A2 - A method to identify asian soybean rust resistance quantitative trait loci ... - Google Patents
More specifically, the invention includes a method for breeding soybean plants containing quantitative trait loci that are ... The invention further includes germplasm and the use of germplasm containing quantitative trait loci (QTL) conferring disease ... genetic marker alleles can be used to identify plants that contain the desired genotype at one marker locus, several loci, or a ... but that genetic material contains the ASR resistance locus of interest.. Plants containing one or more ASR resistance loci ...http://www.google.com.au/patents/WO2009132089A2?cl=en
Descripción: Characterization of Expression Quantitative Trait Loci in Pedigrees from Colombia and Costa Rica Ascertained for...
Genetic variation at twentythree microsatellite loci in sixteen human populations por: Deka, Ranjan, et al. Publicado: (2015) ... As part of a study to identify genetic loci contributing to bipolar disorder and other quantitative traits in members of 26 ... Genotype profiles for the Costa Rican population at 7 PCR-based loci por: Morera Brenes, Bernal, et al. Publicado: (2014) ... The observation that variants regulating gene expression (expression quantitative trait loci, eQTL) are at a high frequency ...http://repositoriosiidca.csuca.org/Record/RepoKERWA30398
"Quantitative trait locus analysis of unsaturated fatty acids in a rec" by Xianzhi Wang, Guo-Liang Jiang et al.
... for unsaturated fatty acids and to evaluate the genetic effects of single QTL and QTL combinations in soybean. A population of ... Comparisons of two-locus and three-locus combinations indicated that cumulative effects ofQTLswere significant for all the ... The objectives of this study were to identify quantitative trait loci (QTLs) ... Comparisons of two-locus and three-locus combinations indicated that cumulative effects ofQTLswere significant for all the ...https://digitalcommons.unl.edu/agronomyfacpub/813/
Significance Thresholds for Quantitative Trait Locus Mapping Under Selective Genotyping | Genetics
Since the imputation method performs an averaging operation over genetic model parameters, the LOD under random genotyping, in ... 1992 Selective genotyping for determination of linkage between a marker locus and a quantitative trait locus. Theor. Appl. ... Broman, K. W., 2003 Mapping quantitative trait loci in the case of a spike in the phenotype distribution. Genetics 163: 1169- ... Feenstra, B., I. M. Skovgaard and K. W. Broman, 2006 Mapping quantitative trait loci by an extension of the Haley-Knott ...http://www.genetics.org/content/177/3/1963
Evidence for a rare prostate cancer-susceptibility locus at chromosome 1p36. In Swedish families with hereditary prostate...
In Swedish families with hereditary prostate cancer, linkage to the HPC1 (ital) locus on chromosome 1q24-25 is restricted to ... Evidence for a rare prostate cancer-susceptibility locus at chromosome 1p36. ... Subjects list: Research, Usage, Genetic aspects, Prostate cancer, Chromosome mapping, Genetic disorders, Linkage (Genetics) ... A potential hereditary prostate cancer (PC) susceptibility locus has been shown to be on chromosome 1p36. Data from a genomic ...http://www.readabstracts.com/Biological-sciences/Evidence-for-a-rare-prostate-cancer-susceptibility-locus-at-chromosome-1p36.html
Ml-stat-talks] Wed 9/21: Barbara Englehardt on genome-wide associations
The goal of the second study was to identify a genetic locus that regulates gene expression differently in the presence of ... Here, we developed multiple models of differential regulation and computed Bayes factors to identify such genetic loci. In both ... or studies to identify genetic variants that are associated with a particular phenotype or disease, can be performed trivially ... studies, we identified loci with potential associations that also have interesting implications in terms of the mechanism of ...https://lists.cs.princeton.edu/pipermail/ml-stat-talks/2011-September/000095.html
Characterization and multiplex genotyping of alpaca tetranucleotide microsatellite markers
Allele numbers ranged from 6 (Locus P135) to 12 (loci P149 and PCTD17). There was no evidence of linkage disequilibrium at any ... Microsatellite data have been analysed in thousands of genetic studies on extant species but the technology can be problematic ... Microsatellite data have been analysed in thousands of genetic studies on extant species but the technology can be problematic ... locus (p = 0.064 - 1). Deviation from Hardy-Weinberg equilibrium was observed in three loci after Bonferroni correction (PCTD17 ...https://espace.curtin.edu.au/handle/20.500.11937/35649
Quantitative Trait Locus and Genetical Genomics Analysis Identifies Putatively Causal Genes for Fecundity and Brooding in the...
Due to their polygenic architectures, such traits are difficult to investigate with genetic mapping. Therefore, little is known ... We found 12 loci for different aspects of egg fecundity. We then combined the genomic confidence intervals of these loci with ... Overlaps between egg loci and expression loci, and trait-gene expression correlations identify 29 candidates from bone and five ... Quantitative Trait Locus and Genetical Genomics Analysis Identifies Putatively Causal Genes for Fecundity and Brooding in the ...http://www.diva-portal.org/smash/record.jsf?pid=diva2:910411
Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study - Nottingham...
They also provide some evidence for a novel candidate locus, namely CNTN1 (rs7314908; OR 1·51, 1·27-1·79; p=2·21 × 10-⁶); ... Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study ... So far, to our knowledge, no large-scale genetic study of dementia with Lewy bodies has been done. To better understand the ... genetic basis of dementia with Lewy bodies, we have done a genome-wide association study with the aim of identifying genetic ...http://eprints.nottingham.ac.uk/48193/
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants....
Our results support the hypothesis that rare coding variants can pinpoint causal genes within known genetic loci and illustrate ... Although wet and dry AMD subtypes exhibit predominantly shared genetics, we identify the first genetic association signal ... that applying the approach systematically to detect new loci requires extremely large sample sizes. ...https://scholars.duke.edu/display/pub1111001
IJMS | Free Full-Text | Characterization of Novel Di-, Tri-, and Tetranucleotide Microsatellite Primers Suitable for Genotyping...
... sensitive and technically simple tools for assaying genetic variability in plant pathogenic fungi. ... Primers for di-, tri-, and tetranucleotide loci were designed directly from the recently published genomic sequence of ... and tetranucleotide loci were designed directly from the recently published genomic sequence of Mycospherlla graminicola and ... Use of the MLPA Assay in the Molecular Diagnosis of Gene Copy Number Alterations in Human Genetic Diseases ...http://www.mdpi.com/1422-0067/13/3/2951/xml
Extended Bayesian LASSO for Multiple Quantitative Trait Loci Mapping and Unobserved Phenotype Prediction | Genetics
Under the genotype coding assumed here, βj represents the genetic effect associated with locus j (j = 1, … , p) or more ... across loci, whereas locus-specific effects meant to enforce differential shrinkage across loci are obtained as deviations from ... Crucially for us here, λj is defined in terms of a measure, δ, of model sparsity, which is common to all loci, and a locus- ... Consequently, the degree of shrinkage is made locus specific through differences in the variances across loci. These variance ...http://www.genetics.org/content/186/3/1067
Identification of HKDC1 and BACE2 as Genes Influencing Glycemic Traits During Pregnancy Through Genome-Wide Association Studies...
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 2010;42:105-116 ... The locus with strongest association in the GWAS was 10q22.1 with 2HPG. This locus, which showed a relatively narrow region of ... Genetic Investigation of ANthropometric Traits (GIANT) Consortium, *Asian Genetic Epidemiology Network-Type 2 Diabetes (AGEN- ... among the first genetic loci shown to be associated with FPG (25), was also associated with FPG in pregnant women. PPP1R3B, ...http://diabetes.diabetesjournals.org/content/62/9/3282.full
Genetic Loci Linked to Brain Aging Features | GenomeWeb
NEW YORK (GenomeWeb) - The genetic loci that influence age-related epigenetic marks in the human brain may overlap with parts ...https://www.genomeweb.com/microarrays-multiplexing/genetic-loci-linked-brain-aging-features
Mapping the genetic locus for triglycerides
... 29.04.2008. Story appearing in May issue of JLR. Researchers have mapped out a ... While this genetic locus does contain 375 known genes, the researchers highlighted three genes that are especially promising ...http://www.innovations-report.com/html/reports/life-sciences/report-108940.html
Genetic Loci | Harvard Catalyst Profiles | Harvard Catalyst
"Genetic Loci" by people in Harvard Catalyst Profiles by year, and whether "Genetic Loci" was a major or minor topic of these ... For example the locus 6p21 is found within band 21 of the P-arm of CHROMOSOME 6. Many well known genetic loci are also known by ... Genetic loci are usually identified with a shorthand notation that indicates the chromosome number and the position of a ... "Genetic Loci" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject ...https://connects.catalyst.harvard.edu/Profiles/display/Concept/Genetic%20Loci
MHAC Gene - GeneCards | MHAC Genetic Locus
Genetic Locus), Microhydranencephaly, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards ... MHAC (Microhydranencephaly) is a Genetic Locus. Diseases associated with MHAC include Microhydranencephaly. ... The novel genetic disorder microhydranencephaly maps to chromosome 16p13.3-12.1. (PMID: 10762554) Kavaslar GN … Tolun A ( ...http://www.genecards.org/cgi-bin/carddisp.pl?gene=MHAC
FUSE Gene - GeneCards | FUSE Genetic Locus
Genetic Locus), Polykaryocytosis Promoter, including: function, proteins, disorders, pathways, orthologs, and expression. ...http://www.genecards.org/cgi-bin/carddisp.pl?gene=FUSE
DYT22 Gene - GeneCards | DYT22 Genetic Locus
Genetic Locus), Dystonia 22, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The ...http://www.genecards.org/cgi-bin/carddisp.pl?gene=DYT22
MYP9 Gene - GeneCards | MYP9 Genetic Locus
Genetic Locus), Myopia 9, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human ... MYP9 (Myopia 9) is a Genetic Locus. Diseases associated with MYP9 include Myopia 9 and Myopia. ... A susceptibility locus for myopia in the normal population is linked to the PAX6 gene region on chromosome 11: a genomewide ...http://www.genecards.org/cgi-bin/carddisp.pl?gene=MYP9
ARCODS Gene - GeneCards | ARCODS Genetic Locus
Genetic Locus), Ariculocondylar Syndrome, including: function, proteins, disorders, pathways, orthologs, and expression. ...https://www.genecards.org/cgi-bin/carddisp.pl?gene=ARCODS