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*  Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity |...
Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity. Tae- ... Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity ... Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity ... Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity ...
http://clincancerres.aacrjournals.org/content/early/2015/08/10/1078-0432.CCR-14-2413.figures-only
*  Recent Advances in Autism Spectrum Disorders: Applications of Whole Exome Sequencing Technology
WES allows scanning the mutations/variations in genes commonly observed in many diseases with genetic heterogeneity.72 As a ... WES may be considered as an efficient technique in diseases which demonstrate genetic heterogeneity.3842 GWAS of ... In addition, linkage studies may also fail due to the genetic and phenotypic heterogeneity in Mendelian diseases. Exome ... Their results provided strong evidence in favor of CHD8 and KATNAL2 genes were likely to be important genetic risk factors. In ...
http://psychiatryinvestigation.org/journal/view.php?number=257&viewtype=pubreader
*  Genetic heterogeneity of Icelanders
... genetic inheritance" in the popular press. This supposed genetic homogeneity was a major factor in the establishment of deCODE ... It is doubtful that population changes during past calamities had much effect on the genetic variability of Icelanders. ... In fact, it is mainly because mtDNA is a non-recombining genetic unit that many errors are easily identified by phylogenetic ... Professor Árnason explains in his article: "Recently, statements have been made about a special 'genetic homogeneity' of the ...
https://www.innovations-report.com/html/reports/life-sciences/report-16211.html
*  Genetic Heterogeneity of Heart-Hand Syndromes | Circulation
Despite the marked genetic heterogeneity of heart-hand syndromes, genetic heterogeneity of Holt-Oram syndrome itself is at most ... Genetic Heterogeneity of Heart-Hand Syndromes. Craig T. Basson, Scott D. Solomon, Barbara Weissman, Calum A. MacRae, Andrew K. ... Genetic Heterogeneity of Heart-Hand Syndromes. Craig T. Basson, Scott D. Solomon, Barbara Weissman, Calum A. MacRae, Andrew K. ... Genetic Heterogeneity of Heart-Hand Syndromes. Craig T. Basson, Scott D. Solomon, Barbara Weissman, Calum A. MacRae, Andrew K. ...
http://circ.ahajournals.org/content/91/5/1326.full
*  Genetic Heterogeneity between Berbers and Arabs
... Lara R Arauna, Universitat Pompeu Fabra, Barcelona, Spain David Comas, ... Arauna, Lara R, and Comas, David(Sep 2017) Genetic Heterogeneity between Berbers and Arabs. In: eLS. John Wiley & Sons Ltd, ... This complex demographic landscape has yielded a large degree of genetic heterogeneity among North African populations. Recent ... 2015) Genetic Heterogeneity in Algerian Human Populations. PLoS One 10 (9): e0138453. ...
http://www.els.net/WileyCDA/ElsArticle/refId-a0027485.html
*  Genetic Heterogeneity of Gaucher Disease: Enzymatic and Immunologic Studies | SpringerLink
1986) Genetic Heterogeneity of Gaucher Disease: Enzymatic and Immunologic Studies. In: Freysz L., Dreyfus H., Massarelli R., ... G.A. Grabowski, J. Goldblatt, T. Dinur, J. Kruse, L. Svennerholm, S. Gatt, and R.J. Desnick, Genetic heterogeneity in Gaucher ... J. Sorge, T. Gelbart, C. West, B. Westwood, and E. Beutler, Heterogeneity in type I Gaucher disease demonstrated by restriction ...
https://link.springer.com/chapter/10.1007/978-1-4684-5212-9_87
*  New study rebuts claims about Icelandic genetic heterogeneity
... to argue for the relative genetic heterogeneity of Icelanders in his analysis of mitochondrial DNA (mtDNA) sequences, are poor ... This latest research article, 'A Reassessment of Genetic Diversity in Icelanders: Strong Evidence from Multiple Loci for ... and uses population genetics simulations to demonstrate that genetic drift, not admixture (as claimed by E. Árnason), has been ... both greatly expands sample sizes from individual populations and the number of genetic loci analysed, ...
http://www.innovations-report.com/html/reports/life-sciences/report-20667.html
*  'genetic heterogeneity' Protocols and Video...
Detecting Somatic Genetic Alterations in Tumor Specimens by Exon Capture and Massively Parallel Sequencing', 'gDNA Enrichment ... and Genetic Analysis', 'Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles', ' ... Genetic Barcoding with Fluorescent Proteins for Multiplexed Applications', 'Purifying the Impure: Sequencing Metagenomes and ... Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers', ' ...
https://www.jove.com/keyword/genetic+heterogeneity
*  Genetic heterogeneity - Wikipedia
Initial research on genetic heterogeneity was conducted using genetic linkage analyses, which map genetic loci of related ... Genetic heterogeneity occurs through the production of single of similar phenotypes through different genetic mechanisms. There ... Disorders on the Autism spectrum have high levels of genetic heterogeneity and result from multiple genetic pathways including ... Marked genetic heterogeneity is correlated to multiple levels of causation in many common human diseases including cystic ...
https://en.wikipedia.org/wiki/Genetic_heterogeneity
*  Genetic Heterogeneity in Familial Juvenile Polyposis | Cancer Research
Genetic Heterogeneity in Familial Juvenile Polyposis. Sherry C. Huang, Christine R. Chen, Joel E. Lavine, Sharon F. Taylor, ... Genetic Heterogeneity in Familial Juvenile Polyposis. Sherry C. Huang, Christine R. Chen, Joel E. Lavine, Sharon F. Taylor, ... Genetic Heterogeneity in Familial Juvenile Polyposis. Sherry C. Huang, Christine R. Chen, Joel E. Lavine, Sharon F. Taylor, ... Genetic Heterogeneity in Familial Juvenile Polyposis Message Subject (Your Name) has forwarded a page to you from Cancer ...
http://cancerres.aacrjournals.org/content/60/24/6882
*  Colorectal Cancer Genetic Heterogeneity Delineated by Multi-Region Sequencing
The extent of colorectal cancer (CRC) genetic ITH is not well understood in Chinese patients. Thus, we conducted deep ... Collectively, our analysis identified a substantial level of genetic ITH in CRC, which should be considered for personalized ... Intratumor heterogeneity (ITH) leads to an underestimation of the mutational landscape portrayed by a single needle biopsy and ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0152673
*  Further genetic heterogeneity for autosomal dominant human sutural cataracts
Klopp, N.; Heon, E.; Billingsley, G.; Illig, T.; Wjst, M.; Rudolph, G. und Graw, Jochen (2003): Further genetic heterogeneity ...
https://epub.ub.uni-muenchen.de/16412/index.html
*  Huntington's disease: Genetic heterogeneity in black African patients
Our paper supports the presence of a genetic heterogeneity involving two loci in patients with a clinical HD phenotype, making ... Table IV presents a summary of genetic studies on HD from Africa. Scrimgeour et al.24 and Silber et al.25 reported genetically ... The clinical and genetic data are summarised in Table I. Six patients showed the clinical triad of an autosomal dominant family ... Hayden MR, Beighton P. Genetic aspects of Huntington's chorea. Results of a national survey. Am J Med Genet 1982; 11: 135-141 ...
http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S0256-95742008000300020&lng=pt&nrm=iso&tlng=en
*  Using disease symptoms to improve detection of linkage under genetic heterogeneity. - PubMed - NCBI
Using disease symptoms to improve detection of linkage under genetic heterogeneity.. Bureau A1, Labbe A, Croteau J, Mérette C. ... that the latent class approach can provide a substantial gain in power to detect disease genes over the standard heterogeneity ...
https://www.ncbi.nlm.nih.gov/pubmed/18330904?dopt=Abstract
*  Assessment of Genetic Heterogeneity in Structured Plant Populations Using Multivariate Whole-Genome Regression Models | Genetics
Assessment of Genetic Heterogeneity in Structured Plant Populations Using Multivariate Whole-Genome Regression Models. ... Because the extent of genetic heterogeneity in this data set is large, in general, the W- and MG-GBLUPs performed either ... From a prediction perspective, the choice of method seems to depend on the extent of genetic heterogeneity and on sample size. ... Assessment of Genetic Heterogeneity in Structured Plant Populations Using Multivariate Whole-Genome Regression Models. ...
http://www.genetics.org/content/201/1/323
*  Masahito Hosokawa] Massively parallel single-cell genomics for elucidation of intra-tissue genetic heterogeneity | PRESTO
Masahito Hosokawa] Massively parallel single-cell genomics for elucidation of intra-tissue genetic heterogeneity. ... Masahito Hosokawa] Massively parallel single-cell genomics for elucidation of intra-tissue genetic heterogeneity ... to elucidate intra-tissue genetic heterogeneity at the single-cell resolution. Most tumors display extensive intra-tumor ... For understanding these intra-tissue heterogeneities, ideal single-cell genomics methods should analyze tens of thousands of ...
http://www.jst.go.jp/kisoken/presto/en/project/1112066/15655189.html
*  Abstract 2910: Inter metastatic genetic heterogeneity is a characteristic feature of recurrent pancreatic cancer | Cancer...
Inter metastatic genetic heterogeneity is a characteristic feature of recurrent pancreatic cancer [abstract]. In: Proceedings ... Abstract 2910: Inter metastatic genetic heterogeneity is a characteristic feature of recurrent pancreatic cancer. Hitomi ... Abstract 2910: Inter metastatic genetic heterogeneity is a characteristic feature of recurrent pancreatic cancer ... Abstract 2910: Inter metastatic genetic heterogeneity is a characteristic feature of recurrent pancreatic cancer ...
http://cancerres.aacrjournals.org/content/77/13_Supplement/2910
*  High Degree of Genetic Heterogeneity for Hereditary Cerebellar Ataxias in Australia | Springer for Research & Development
Genetic testing strategies such as next-generation sequencing (NGS) panels and whole genome sequencing (WGS) can be applied to ... Our findings highlight the genetic heterogeneity of HCAs and support the use of NGS approaches for individuals who were ... We aim to determine the yield from genetic testing strategies and the genetic and phenotypic spectrum of HCA in Australia by ... Genetic testing strategies such as next-generation sequencing (NGS) panels and whole genome sequencing (WGS) can be applied to ...
https://rd.springer.com/article/10.1007%2Fs12311-018-0969-7
*  Genetic Heterogeneity in Therapy-Naïve Synchronous Primary Breast Cancers and Their Metastases | Clinical Cancer Research
Genetic Heterogeneity in Therapy-Naïve Synchronous Primary Breast Cancers and Their Metastases. Charlotte K.Y. Ng, Francois- ... Capturing intra-tumor genetic heterogeneity by de novo mutation profiling of circulating cell-free tumor DNA: a proof-of- ... Temporal and spatial genetic heterogeneity in primary breast cancers and synchronous metastatic deposits. Nine treatment-naïve ... Although the heterogeneity between primary tumors and their metastases preferentially affected passenger genetic alterations, ...
http://clincancerres.aacrjournals.org/content/23/15/4402?ijkey=61b97884ca08c38e473cc78d3c3644351531006d&keytype2=tf_ipsecsha
*  Leicester Research Archive: A study of genetic heterogeneity in Albright hereditary osteodystrophy.
Albright hereditary osteodystrophy (AHO) is a disorder characterised by short stature, obesity, subcutaneous calcifications, brachydactyly and mental retardation. AHO can occur with or without resistance to hormones acting via adenylyl cyclase, even within one kindred. Both phenotypic forms can result from identical heterozygous deactivating mutations in the gene encoding Gsa (GNAS1) leading to reduced Gsa acitivity. Parental origin of the mutation is suggested to play a role in the development of hormone resistance. In this study, 27 GNAS1 mutations have been identified, of which 25 were unique, in a cohort of 58 individuals with characteristics of AHO. The mutations were localised throughout the gene although 7/27 (26%) were present in exon 1. All mutations were predicted to lead either to amino acid substitutions in functionally or structurally important domains or to truncated proteins. Parental origin of the mutations was established in 17 parent-to-child transmissions (14/17 maternal and ...
https://lra.le.ac.uk/handle/2381/34457
*  Genetic Heterogeneity and the Establishment of Tissue Systems During Development | Springer for Research & Development
Korochkin L.I., Grossman A. (1981) Genetic Heterogeneity and the Establishment of Tissue Systems During Development. In: Gene ...
https://rd.springer.com/chapter/10.1007/978-3-642-81477-8_7
*  Deletions in the Parkin gene and genetic heterogeneity in a Greek family with early onset Parkinson's disease | SpringerLink
Deletions in the Parkin gene and genetic heterogeneity in a Greek family with early onset Parkinson's disease. ... 4.Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Md., USA ... 1.Gene Mapping Section, Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of ...
https://link.springer.com/article/10.1007%2Fs004390050845
*  Genetic Heterogeneity of Hyperpepsinogenemic I and Normopepsinogenemic I Duodenal Ulcer Disease | Annals of Internal Medicine |...
Genetic Heterogeneity in Wilson Disease: Lessons from Rare Alleles Annals of Internal Medicine; 127 (1): 70-72 ... Genetic Heterogeneity of Hyperpepsinogenemic I and Normopepsinogenemic I Duodenal Ulcer Disease JEROME I. ROTTER, M.D.; GLORIA ... Genetic Heterogeneity of Hyperpepsinogenemic I and Normopepsinogenemic I Duodenal Ulcer Disease. Ann Intern Med. 1979;91:372- ... These data provide direct evidence for genetic heterogeneity of duodenal ulcer disease. ...
http://annals.org/aim/article-abstract/693325/genetic-heterogeneity-hyperpepsinogenemic-i-normopepsinogenemic-i-duodenal-ulcer-disease
*  Genetic heterogeneity in rapid onset dystonia-parkinsonism: description of a new family | Journal of Neurology, Neurosurgery &...
genetic heterogeneity. Rapid onset dystonia-parkinsonism (RDP) is an autosomal dominant movement disorder with reduced ... Genetic heterogeneity in rapid onset dystonia-parkinsonism: description of a new family ... Genetic heterogeneity in rapid onset dystonia-parkinsonism: description of a new family ... Molecular genetic analysis also excluded linkage to the DYT6 locus and the GAG deletion in DYT1, suggesting at least one ...
http://jnnp.bmj.com/content/76/6/860
*  Joubert syndrome: a model for untangling recessive disorders with extreme genetic heterogeneity | Journal of Medical Genetics
genetic heterogeneity. Introduction. Joubert syndrome (JS, OMIM 213300) is a recessive neurodevelopmental disorder ... Genomic analysis of Meckel-Gruber syndrome in Arabs reveals marked genetic heterogeneity and novel candidate genes. Eur J Hum ... Based on the estimated prevalence of JS (∼1/80 000 Northern Europeans3) and the genetic heterogeneity of the disease, we ... These findings illustrate the extreme genetic heterogeneity of JS. Therefore, given that no single gene predominates as a cause ...
http://jmg.bmj.com/content/52/8/514