Racial Difference in the Relationship of an Angiotensin I-Converting Enzyme Gene Polymorphism to Serum Angiotensin I-...Racial Difference in the Relationship of an Angiotensin I-Converting Enzyme Gene Polymorphism to Serum Angiotensin I-...

... genetic association studies demonstrating relationships in one racial group require confirmation in other racial groups. In ... These include associations with myocardial infarction,9 10 11 12 13 albeit an association that has been inconsistent,14 15 16 ... Whether a similar association of serum ACE with the I/D polymorphism occurs in other racial groups is not known. We studied the ... Results of the present study of white children confirm the previously described association of the ACE gene I/D polymorphism ...
more infohttp://hyper.ahajournals.org/content/27/1/62

Serotonin transporter gene polymorphism and its association with bipolar disorder across different ethnic groups in Malaysia<...Serotonin transporter gene polymorphism and its association with bipolar disorder across different ethnic groups in Malaysia<...

Objectives The risk variants have been shown to vary substantially across populations and a genetic study in a heterogeneous ... The present study showed no significant association between the homozygous short variant of the 5-HTTLPR and bipolar disorder ... The present study showed no significant association between the homozygous short variant of the 5-HTTLPR and bipolar disorder ... The present study showed no significant association between the homozygous short variant of the 5-HTTLPR and bipolar disorder ...
more infohttps://ukm.pure.elsevier.com/en/publications/serotonin-transporter-gene-polymorphism-and-its-association-with-

Genetic Association Studies - Current ProtocolsGenetic Association Studies - Current Protocols

Population Stratification in Genetic Association Studies. Jacklyn N. Hellwege, Jacob M. Keaton, Ayush Giri, Xiaoyi Gao, Digna R ... Collection of Clinical and Epidemiological Data for Genetic Linkage and Association Studies. Lindsay Farrer, Mark Logue. ... Genetic Mapping. Jonathan L. Haines. Published online: April 2016. Using the PhenX Toolkit to Add Standard Measures to a Study ... Calculation and Use of the Hardy‐Weinberg Model in Association Studies. Kelli Ryckman, Scott M. Williams. Published online: ...
more infohttp://www.currentprotocols.com/WileyCDA/CurPro3Category/L1-2200,L2-2210.html

Meta-analysis of genetic association studies on bipolar disorder.  - PubMed - NCBIMeta-analysis of genetic association studies on bipolar disorder. - PubMed - NCBI

Meta-analysis of genetic association studies on bipolar disorder.. Seifuddin F1, Mahon PB, Judy J, Pirooznia M, Jancic D, ... Numerous candidate gene association studies of bipolar disorder (BP) have been carried out, but the results have been ... Individual studies are typically underpowered to detect associations with genes of small effect sizes. We conducted a meta- ... Distribution of 487 candidate gene association studies in BP (case-control and family-based) published in PubMed by year from ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/22573399

A Systematic Meta-Analysis of Genetic Association Studies for Diabetic Retinopathy | DiabetesA Systematic Meta-Analysis of Genetic Association Studies for Diabetic Retinopathy | Diabetes

Although NPDR and PDR are commonly subanalyzed in genetic studies, very few studies have reported on genetic associations with ... Future genetic studies should also include genome-wide association studies to identify diabetic retinopathy susceptibility loci ... A Systematic Meta-Analysis of Genetic Association Studies for Diabetic Retinopathy. Sotoodeh Abhary, Alex W. Hewitt, Kathryn P. ... A Systematic Meta-Analysis of Genetic Association Studies for Diabetic Retinopathy. Sotoodeh Abhary, Alex W. Hewitt, Kathryn P. ...
more infohttp://diabetes.diabetesjournals.org/content/58/9/2137

Genetic Association Study Identifies HSPB7 as a Risk Gene for Idiopathic Dilated CardiomyopathyGenetic Association Study Identifies HSPB7 as a Risk Gene for Idiopathic Dilated Cardiomyopathy

Therefore, this study is an important step towards revealing insight in the genetic background of the sporadic form of dilated ... Identification of genetic disease markers in at-risk persons could play an important role in preventive health care. Several ... Here, we examine the role of common genetic variants on the sporadic form of dilated cardiomyopathy. By screening about 2,000 ... 2010) Genetic Association Study Identifies HSPB7 as a Risk Gene for Idiopathic Dilated Cardiomyopathy. PLoS Genet 6(10): ...
more infohttps://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1001167

Genetic Association Studies: Time for a New Paradigm? | Cancer Epidemiology, Biomarkers & PreventionGenetic Association Studies: Time for a New Paradigm? | Cancer Epidemiology, Biomarkers & Prevention

Genetic Association Studies: Time for a New Paradigm? Message Subject (Your Name) has forwarded a page to you from Cancer ... Recently, CEBP published a new editorial policy for association studies of genetic variants and disease (1). The policy gives ... Genetic variation and cancer: improving the environment for publication of association studies. Cancer Epidemiol Biomarkers ... To illustrate this idea, suppose that a study evaluates m tests of association. Each of these associations can be classified ...
more infohttp://cebp.aacrjournals.org/content/14/6/1359.1

Power Estimates for Voxel-Based Genetic Association Studies Using Diffusion Imaging | SpringerLinkPower Estimates for Voxel-Based Genetic Association Studies Using Diffusion Imaging | SpringerLink

The quest to discover genetic variants that affect the human brain will be accelerated by screening brain images from large ... Purcell, S., et al.: Genetic power calculator: design of linkage and association genetic mapping studies of complex traits. ... Kozlitina, J., et al.: Power of genetic association studies with fixed and random genotype frequencies. Ann. Hum. Genet. 74(5 ... Ambrosius, W.T., et al.: Power for genetic association studies with random allele frequencies and genotype distributions. Am. J ...
more infohttps://link.springer.com/chapter/10.1007%2F978-3-319-02475-2_21

Inherited determinants of Crohns disease and ulcerative colitis phenotypes: a genetic association study.  - PubMed - NCBIInherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study. - PubMed - NCBI

Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Govt; Research Support, U.S. Govt, P.H.S. ... a genetic association study.. Cleynen I1, Boucher G2, Jostins L3, Schumm LP4, Zeissig S5, Ahmad T6, Andersen V7, Andrews JM8, ... Inherited determinants of Crohns disease and ulcerative colitis phenotypes: a genetic association study ... Inherited determinants of Crohns disease and ulcerative colitis phenotypes: a genetic association study ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/26490195

Systematic Reviews of Genetic Association Studies | proLékaře.czSystematic Reviews of Genetic Association Studies | proLékaře.cz

1. Data Sources for Meta-Analysis of Genetic Association Studies Preparation of a Protocol. Like other research studies, ... Little empirical evidence associating study results with study characteristics for genetic association studies exists as yet, ... The most important sources of bias in genetic association studies are less well understood than those in other study designs ... The era of genome-wide association studies has implications for the meta-analysis of genetic associations. Although, in ...
more infohttps://www.prolekare.cz/casopisy/plos-medicine/2009-3/systematic-reviews-of-genetic-association-studies-46784

A genetic association study of CSMD1 and CSMD2 with cognitive functionA genetic association study of CSMD1 and CSMD2 with cognitive function

... Athanasiu, Lavinia ... This association reached the study-wide significance level (p ,= 1.2 Chi 10(-5)). SNP rs10503253 was not significantly ... Additional studies of larger samples with cognitive phenotypes will be needed to further clarify the role of CSMD1 in cognitive ... In conclusion, we studied n = 3437 individuals and found evidence that a variant in CSMD1 is associated with cognitive function ...
more infohttp://umu.diva-portal.org/smash/record.jsf?pid=diva2:1088993&language=sv

Univariate and multivariate statistical tests in genetic association studiesUnivariate and multivariate statistical tests in genetic association studies

... Show full item record ... Genome-wide association studies have identified hundreds of genomic loci associated with a wide range of human conditions and ... In addition to the simulation study I performed the similar analyses for real data from The National FINRISK Study. I used ... However, most of these studies have focused on analysing single traits, even the studies involving multiple related traits. ...
more infohttps://helda.helsinki.fi/handle/10138/229113

Challenges to Doing Genetic Association Studies in Transplantation - Salomon - 2012 - American Journal of Transplantation -...Challenges to Doing Genetic Association Studies in Transplantation - Salomon - 2012 - American Journal of Transplantation -...

Finally, doing any genetic association study, particularly prospective, therapy-controlled genetic studies, requires relatively ... Challenges to Doing Genetic Association Studies in Transplantation. Authors. *. D. R. Salomon. Corresponding author. * ... But in genetic association terms, one challenge is to inform these inevitable clinical changes by study strategies with the ... It is also important to emphasize here that there is little to no value in genetic association studies that simply prove that a ...
more infohttp://onlinelibrary.wiley.com/doi/10.1111/j.1600-6143.2012.04267.x/full?globalMessage=0

Making Sense of Puzzling Genetic Association Studies | Annals of Internal Medicine | American College of PhysiciansMaking Sense of Puzzling Genetic Association Studies | Annals of Internal Medicine | American College of Physicians

Making Sense of Puzzling Genetic Association Studies: A Team Approach Free Jennifer S. Lee, MD, PhD; Margaret A. Tucker, MD ... In genetic association studies, Mendelian randomization also helps to minimize reporting or selection bias. Mendelian ... Making Sense of Puzzling Genetic Association Studies: A Team Approach. Ann Intern Med. 2006;145:302-304. doi: 10.7326/0003-4819 ... By forming a collaborative consortium, the Genetic Markers for Osteoporosis (GENOMOS) study was able to assess the association ...
more infohttps://annals.org/aim/fullarticle/727659/making-sense-puzzling-genetic-association-studies-team-approach

Molecular Vision: Genetic association study of mitochondrial polymorphisms in neovascular age-related macular degenerationMolecular Vision: Genetic association study of mitochondrial polymorphisms in neovascular age-related macular degeneration

Genetic association study of mitochondrial polymorphisms in neovascular age-related macular degeneration. Julien Tilleul,1,2 ... Most of the genetic factors identified so far involve the nuclear genome. Recently, two studies in North America and Australia ... Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC ... In our study, we have not confirmed the association between several mitochondrial polymorphisms and neovascular age-macular ...
more infohttp://www.molvis.org/molvis/v19/1132/

Interpretation of Genetic Association Studies: Markers with Replicated Highly Significant Odds Ratios May Be Poor ClassifiersInterpretation of Genetic Association Studies: Markers with Replicated Highly Significant Odds Ratios May Be Poor Classifiers

We focus on the clinical validity of genetic testing with an emphasis on two popular statistical methods for evaluating markers ... The hope is that genetic testing will benefit patients and their families, and encourage positive lifestyle changes and guide ... The scientific community should be cautious to avoid overstating the value of association findings in terms of personalized ... Our analyses and examples show that strong association, although very valuable for establishing etiological hypotheses, does ...
more infohttps://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1000337

Inherited determinants of Crohns disease and ulcerative colitis phenotypes: a genetic association studyInherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study

We tested for genotype-phenotype associations across 156 154 genetic variants. We generated genetic risk scores by combining ... a genetic association study. In: Lancet, Vol. 387, Nr. 10014: S. 156-167 ... The genetic risk score representing all known risk alleles for inflammatory bowel disease showed strong association with ... Genetic studies have identified 163 susceptibility loci for inflammatory bowel disease, mostly shared between Crohns disease ...
more infohttps://epub.ub.uni-muenchen.de/44629/

STrengthening the REporting of Genetic Association studies (STREGA)-an extension of the STROBE statement - Oxford ScholarshipSTrengthening the REporting of Genetic Association studies (STREGA)-an extension of the STROBE statement - Oxford Scholarship

... and cohort studies. Given the relevance of general epidemiologic principles for genetic association studies, recommendations ... are proposed in an extension of the STROBE Statement called the STrengthening the REporting of Genetic Association studies ( ... The epidemiology community has recently developed the STrengthening the Reporting of OBservational studies in Epidemiology ( ... Statement have a strong foundation because they are based on empirical evidence on the reporting of observational studies, and ...
more infohttp://www.oxfordscholarship.com/view/10.1093/acprof:oso/9780195398441.001.0001/acprof-9780195398441-chapter-10

Genetic, Association Studies | StrokeGenetic, Association Studies | Stroke

Novel Susceptibility Loci for Moyamoya Disease Revealed by a Genome-Wide Association Study Lian Duan, Ling Wei, Yanghua Tian, ... 2018 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited. The American Heart Association is a ... Genetic Predisposition to Ischemic StrokeA Polygenic Risk Score Tsuyoshi Hachiya, Yoichiro Kamatani, Atsushi Takahashi, Jun ... White Matter Hyperintensities Are Under Strong Genetic Influence Perminder S. Sachdev, Anbupalam Thalamuthu, Karen A. Mather, ...
more infohttp://stroke.ahajournals.org/collection/genetic-association-studies

Bayesian Model Uncertainty and Prior Choice with Applications to Genetic Association
         StudiesBayesian Model Uncertainty and Prior Choice with Applications to Genetic Association Studies

Wilson, Melanie Ann (2010). Bayesian Model Uncertainty and Prior Choice with Applications to Genetic Association Studies. ... Bayesian Model Uncertainty and Prior Choice with Applications to Genetic Association Studies ... the biological application of genetic association studies involving single nucleotide polymorphisms. While the most common ... has higher power to detect association than standard procedures. Using data from the North Carolina Ovarian Cancer Study (NCOCS ...
more infohttps://dukespace.lib.duke.edu/dspace/handle/10161/2482

Inherited determinants of Crohns disease and ulcerative colitis phenotypes : a genetic association studyInherited determinants of Crohn's disease and ulcerative colitis phenotypes : a genetic association study

Inherited determinants of Crohns disease and ulcerative colitis phenotypes: a genetic association study. Cleynen, Isabelle ... We tested for genotype-phenotype associations across 156,154 genetic variants. We generated genetic risk scores by combining ... The genetic risk score representing all known risk alleles for inflammatory bowel disease showed strong association with ... Genetic studies have identified 163 susceptibility loci for inflammatory bowel disease, mostly shared between Crohns disease ...
more infohttp://oru.diva-portal.org/smash/record.jsf?pid=diva2:1063911

Genes  | Free Full-Text | Phenotype-Based Genetic Association Studies (PGAS)-Towards Understanding the Contribution of Common...Genes | Free Full-Text | Phenotype-Based Genetic Association Studies (PGAS)-Towards Understanding the Contribution of Common...

6. Phenotype-Based Genetic Association Studies (PGAS): Proof-of-Principle. First proof-of-principle studies for the PGAS ... Phenotype-Based Genetic Association Studies (PGAS)-Towards Understanding the Contribution of Common Genetic Variants to ... Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study ... which stands for phenotype-based genetic association study. PGAS enables us to explore the contribution of genes/genetic ...
more infohttp://mdpi.com/2073-4425/5/1/97/htm

A Systematic Meta-Analysis of Genetic Association Studies for Diabetic Retinopathy - Semantic ScholarA Systematic Meta-Analysis of Genetic Association Studies for Diabetic Retinopathy - Semantic Scholar

RESEARCH DESIGN AND METHODS All studies investigating the association of genetic variants with the development of diabetic ... A systematic meta-analysis was undertaken to collectively assess genetic studies and determine which previously investigated ... These associations were also found in the white population alone (P , 0.05). Polymorphisms in NOS3, VEGF, ITGA2, and ICAM1 are ... Identification of genetic risk factors in diabetic retinopathy will assist in further understanding of this complex and ...
more infohttps://www.semanticscholar.org/paper/A-Systematic-Meta-Analysis-of-Genetic-Association-Abhary-Hewitt/11b7ce11dd2e5136f383b72038d058d616b2278c

Frontiers | Genetic Association Studies of Suicidal Behavior: A Review of the Past 10 Years, Progress, Limitations, and Future...Frontiers | Genetic Association Studies of Suicidal Behavior: A Review of the Past 10 Years, Progress, Limitations, and Future...

... family-based association studies and (iii) genome-wide association studies (GWAS). Various studies on genetic associations have ... family-based association studies and (iii) genome-wide association studies (GWAS). Various studies on genetic associations have ... The aim of this paper is to review recent genetic association studies in suicidal behaviours including (i) case-control studies ... The aim of this paper is to review recent genetic association studies in suicidal behaviours including (i) case-control studies ...
more infohttps://www.frontiersin.org/articles/10.3389/fpsyt.2016.00158/full

Multi-Ethnic Genetic Association Study of Carotid Intima-Media Thickness Using a Targeted Cardiovascular SNP Microarray | StrokeMulti-Ethnic Genetic Association Study of Carotid Intima-Media Thickness Using a Targeted Cardiovascular SNP Microarray | Stroke

As part of a previous large genome-wide association study, association between a total cholesterol genetic risk profile and IMT ... Multi-Ethnic Genetic Association Study of Carotid Intima-Media Thickness Using a Targeted Cardiovascular SNP Microarray. ... Multi-Ethnic Genetic Association Study of Carotid Intima-Media Thickness Using a Targeted Cardiovascular SNP Microarray ... Multi-Ethnic Genetic Association Study of Carotid Intima-Media Thickness Using a Targeted Cardiovascular SNP Microarray ...
more infohttp://stroke.ahajournals.org/content/40/10/3173