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*  Meta-analysis of Genome Wide Association Studies Identifies Genetic Markers of Late Toxicity Following Radiotherapy for...
Meta-analysis of Genome Wide Association Studies Identifies Genetic Markers of Late Toxicity Following Radiotherapy for ... data from four genome-wide association studies from prostate cancer radiotherapy cohorts including 1564 men to identify genetic ... The results show that heterogeneous radiotherapy cohorts can be combined to identify new moderate-penetrance genetic variants ... associations were tested using multivariable regression, adjusting for clinical and patient-related risk factors. A fixed- ...
https://repository.icr.ac.uk/handle/internal/89
*  Genetic contributions to variation in general cognitive function : a meta-analysis of genome-wide association studies in the...
Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the ... We conducted a meta-analysis of genome-wide association studies of 31 cohorts (N = 53 949) in which the participants had ... the Atherosclerosis Risk in Communities Study (N = 6617) and the Health and Retirement Study (N = 5976). The proportion of ... We investigated the genetic contribution to variation in this important, health-and well-being-related trait in middle-aged and ...
http://www.diva-portal.org/smash/record.jsf?pid=diva2:808973
*  Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study - Nottingham...
Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study ... To better understand the genetic basis of dementia with Lewy bodies, we have done a genome-wide association study with the aim ... Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study. Lancet ... of identifying genetic risk factors for this disorder.. Methods In this two-stage genome-wide association study, we collected ...
http://eprints.nottingham.ac.uk/48193/
*  Benefits of a healthy diet greater in people at high genetic risk for obesity | BMJ
... finds a study in The BMJ today. The researchers say their findings ... diet to prevent long term weight gain are greater in people at high genetic risk for obesity than in those with low genetic ... Genetic predisposition to obesity is no barrier to successful weight management The benefits of sticking to a healthy ... As with many genetic association studies, the effect of genetic predisposition was small, they write. However the findings "do ...
http://www.bmj.com/company/newsroom/benefits-of-a-healthy-diet-greater-in-people-at-high-genetic-risk-for-obesity/
*  High‐Throughput Single Nucleotide Polymorphisms Genotyping Technologies
... wide association studies have successfullyidentified many novel genetic loci for various human complex diseases and ... Genome‐wide association studies have successfully identified many novel genetic loci for various human complex diseases and ... Bhangale TR, Rieder MJ and Nickerson DA (2008) Estimating coverage and power for genetic association studies using near‐ ... Bioinformatics and Genetic Disease , Techniques and Tools in Clinical Genetics , Gene Mapping by Disease Association , Linkage ...
http://www.els.net/WileyCDA/ElsArticle/refId-a0021631.html
*  Internet Medical Journal: Multivariate meta-analysis of the association of G-protein beta 3 gene (GNB3) haplotypes with...
Six genetic association studies encompassing 16,068 participants were identified. Individual participant data were obtained for ... The objective of the present study was to review previous investigations on the association of haplotypes in the G-protein β3 ... Multivariate meta-analysis of the association of G-protein beta 3 gene (GNB3) haplotypes with cardiovascular phenotypes. ... Study-specific results were combined through a random-effects multivariate meta-analysis. After carefully adjustments for ...
http://www.medjournal.com/2014/02/multivariate-meta-analysis-of.html
*  Genetic Association Studies - Current Protocols
Population Stratification in Genetic Association Studies. Jacklyn N. Hellwege, Jacob M. Keaton, Ayush Giri, Xiaoyi Gao, Digna R ... Collection of Clinical and Epidemiological Data for Genetic Linkage and Association Studies. Lindsay Farrer, Mark Logue. ... Genetic Mapping. Jonathan L. Haines. Published online: April 2016. Using the PhenX Toolkit to Add Standard Measures to a Study ... Calculation and Use of the Hardy‐Weinberg Model in Association Studies. Kelli Ryckman, Scott M. Williams. Published online: ...
http://www.currentprotocols.com/WileyCDA/CurPro3Category/L1-2200,L2-2210.html
*  A Systematic Meta-Analysis of Genetic Association Studies for Diabetic Retinopathy | Diabetes
Although NPDR and PDR are commonly subanalyzed in genetic studies, very few studies have reported on genetic associations with ... Future genetic studies should also include genome-wide association studies to identify diabetic retinopathy susceptibility loci ... A Systematic Meta-Analysis of Genetic Association Studies for Diabetic Retinopathy. Sotoodeh Abhary, Alex W. Hewitt, Kathryn P. ... A Systematic Meta-Analysis of Genetic Association Studies for Diabetic Retinopathy. Sotoodeh Abhary, Alex W. Hewitt, Kathryn P. ...
http://diabetes.diabetesjournals.org/content/58/9/2137
*  Genetic Association Study Identifies HSPB7 as a Risk Gene for Idiopathic Dilated Cardiomyopathy
Therefore, this study is an important step towards revealing insight in the genetic background of the sporadic form of dilated ... Identification of genetic disease markers in at-risk persons could play an important role in preventive health care. Several ... Here, we examine the role of common genetic variants on the sporadic form of dilated cardiomyopathy. By screening about 2,000 ... 2010) Genetic Association Study Identifies HSPB7 as a Risk Gene for Idiopathic Dilated Cardiomyopathy. PLoS Genet 6(10): ...
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1001167
*  Genetic Association Studies: Time for a New Paradigm? | Cancer Epidemiology, Biomarkers & Prevention
Genetic Association Studies: Time for a New Paradigm? Message Subject (Your Name) has forwarded a page to you from Cancer ... Recently, CEBP published a new editorial policy for association studies of genetic variants and disease (1). The policy gives ... Genetic variation and cancer: improving the environment for publication of association studies. Cancer Epidemiol Biomarkers ... To illustrate this idea, suppose that a study evaluates m tests of association. Each of these associations can be classified ...
http://cebp.aacrjournals.org/content/14/6/1359.1
*  Power Estimates for Voxel-Based Genetic Association Studies Using Diffusion Imaging | SpringerLink
The quest to discover genetic variants that affect the human brain will be accelerated by screening brain images from large ... Purcell, S., et al.: Genetic power calculator: design of linkage and association genetic mapping studies of complex traits. ... Kozlitina, J., et al.: Power of genetic association studies with fixed and random genotype frequencies. Ann. Hum. Genet. 74(5 ... Ambrosius, W.T., et al.: Power for genetic association studies with random allele frequencies and genotype distributions. Am. J ...
https://link.springer.com/chapter/10.1007%2F978-3-319-02475-2_21
*  Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study. - PubMed - NCBI
Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. ... a genetic association study.. Cleynen I1, Boucher G2, Jostins L3, Schumm LP4, Zeissig S5, Ahmad T6, Andersen V7, Andrews JM8, ... Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study ... Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study ...
https://www.ncbi.nlm.nih.gov/pubmed/26490195
*  Challenges to Doing Genetic Association Studies in Transplantation - Salomon - 2012 - American Journal of Transplantation -...
Finally, doing any genetic association study, particularly prospective, therapy-controlled genetic studies, requires relatively ... Challenges to Doing Genetic Association Studies in Transplantation. Authors. *. D. R. Salomon. Corresponding author. * ... But in genetic association terms, one challenge is to inform these inevitable clinical changes by study strategies with the ... It is also important to emphasize here that there is little to no value in genetic association studies that simply prove that a ...
http://onlinelibrary.wiley.com/doi/10.1111/j.1600-6143.2012.04267.x/full?globalMessage=0
*  Molecular Vision: Genetic association study of mitochondrial polymorphisms in neovascular age-related macular degeneration
Genetic association study of mitochondrial polymorphisms in neovascular age-related macular degeneration. Julien Tilleul,1,2 ... Most of the genetic factors identified so far involve the nuclear genome. Recently, two studies in North America and Australia ... Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC ... In our study, we have not confirmed the association between several mitochondrial polymorphisms and neovascular age-macular ...
http://www.molvis.org/molvis/v19/1132/
*  Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study
We tested for genotype-phenotype associations across 156 154 genetic variants. We generated genetic risk scores by combining ... a genetic association study. In: Lancet, Vol. 387, Nr. 10014: S. 156-167 ... The genetic risk score representing all known risk alleles for inflammatory bowel disease showed strong association with ... Genetic studies have identified 163 susceptibility loci for inflammatory bowel disease, mostly shared between Crohn's disease ...
https://epub.ub.uni-muenchen.de/44629/
*  STrengthening the REporting of Genetic Association studies (STREGA)-an extension of the STROBE statement - Oxford Scholarship
... and cohort studies. Given the relevance of general epidemiologic principles for genetic association studies, recommendations ... are proposed in an extension of the STROBE Statement called the STrengthening the REporting of Genetic Association studies ( ... The epidemiology community has recently developed the STrengthening the Reporting of OBservational studies in Epidemiology ( ... Statement have a strong foundation because they are based on empirical evidence on the reporting of observational studies, and ...
http://www.oxfordscholarship.com/view/10.1093/acprof:oso/9780195398441.001.0001/acprof-9780195398441-chapter-10
*  Genetic, Association Studies | Stroke
Novel Susceptibility Loci for Moyamoya Disease Revealed by a Genome-Wide Association Study Lian Duan, Ling Wei, Yanghua Tian, ... 2018 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited. The American Heart Association is a ... Genetic Predisposition to Ischemic StrokeA Polygenic Risk Score Tsuyoshi Hachiya, Yoichiro Kamatani, Atsushi Takahashi, Jun ... White Matter Hyperintensities Are Under Strong Genetic Influence Perminder S. Sachdev, Anbupalam Thalamuthu, Karen A. Mather, ...
http://stroke.ahajournals.org/collection/genetic-association-studies
*  Inherited determinants of Crohn's disease and ulcerative colitis phenotypes : a genetic association study
Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study. Cleynen, Isabelle ... We tested for genotype-phenotype associations across 156,154 genetic variants. We generated genetic risk scores by combining ... The genetic risk score representing all known risk alleles for inflammatory bowel disease showed strong association with ... Genetic studies have identified 163 susceptibility loci for inflammatory bowel disease, mostly shared between Crohn's disease ...
http://oru.diva-portal.org/smash/record.jsf?pid=diva2:1063911
*  Genes | Free Full-Text | Phenotype-Based Genetic Association Studies (PGAS)-Towards Understanding the Contribution of Common...
6. Phenotype-Based Genetic Association Studies (PGAS): Proof-of-Principle. First proof-of-principle studies for the PGAS ... Phenotype-Based Genetic Association Studies (PGAS)-Towards Understanding the Contribution of Common Genetic Variants to ... Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study ... which stands for phenotype-based genetic association study. PGAS enables us to explore the contribution of genes/genetic ...
http://mdpi.com/2073-4425/5/1/97/htm
*  A Systematic Meta-Analysis of Genetic Association Studies for Diabetic Retinopathy - Semantic Scholar
RESEARCH DESIGN AND METHODS All studies investigating the association of genetic variants with the development of diabetic ... A systematic meta-analysis was undertaken to collectively assess genetic studies and determine which previously investigated ... These associations were also found in the white population alone (P , 0.05). Polymorphisms in NOS3, VEGF, ITGA2, and ICAM1 are ... Identification of genetic risk factors in diabetic retinopathy will assist in further understanding of this complex and ...
https://www.semanticscholar.org/paper/A-Systematic-Meta-Analysis-of-Genetic-Association-Abhary-Hewitt/11b7ce11dd2e5136f383b72038d058d616b2278c
*  Frontiers | Genetic Association Studies of Suicidal Behavior: A Review of the Past 10 Years, Progress, Limitations, and Future...
... family-based association studies and (iii) genome-wide association studies (GWAS). Various studies on genetic associations have ... family-based association studies and (iii) genome-wide association studies (GWAS). Various studies on genetic associations have ... The aim of this paper is to review recent genetic association studies in suicidal behaviours including (i) case-control studies ... The aim of this paper is to review recent genetic association studies in suicidal behaviours including (i) case-control studies ...
https://www.frontiersin.org/articles/10.3389/fpsyt.2016.00158/full
*  Multi-Ethnic Genetic Association Study of Carotid Intima-Media Thickness Using a Targeted Cardiovascular SNP Microarray | Stroke
As part of a previous large genome-wide association study, association between a total cholesterol genetic risk profile and IMT ... Multi-Ethnic Genetic Association Study of Carotid Intima-Media Thickness Using a Targeted Cardiovascular SNP Microarray. ... Multi-Ethnic Genetic Association Study of Carotid Intima-Media Thickness Using a Targeted Cardiovascular SNP Microarray ... Multi-Ethnic Genetic Association Study of Carotid Intima-Media Thickness Using a Targeted Cardiovascular SNP Microarray ...
http://stroke.ahajournals.org/content/40/10/3173
*  Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization
... Arking, ... Genetic studies of body mass index yield new insights for obesity biology  Locke, Adam E.; Kahali, Bratati; Berndt, Sonja I.; ...
http://www.julkari.fi/handle/10024/116317
*  Genetic Variation in Prostate-Specific Antigen-Detected Prostate Cancer and the Effect of Control Selection on Genetic...
Genome-wide association study identifies a genetic variant associated with risk for more aggressive prostate cancer. Cancer ... We have highlighted that the method of selecting controls in case-control studies of associations of genetic variation with ... Two study populations were used in this analysis. First, participants from the ProtecT study (20), and second the UK Genetic ... A previous study reported a positive association between rs11199874-G and prostate cancer (25). This association could be ...
http://cebp.aacrjournals.org/content/23/7/1356
*  A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease
... Krüger, ... Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, International Cooperation, Male, Meta- ... A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease}, url = {http ... Genetic Predisposition to Disease,Genome-Wide Association Study,Genotype,Humans,International Cooperation,Male,Meta-Analysis as ...
https://lup.lub.lu.se/search/publication/aa038b7b-07d0-42cc-830a-d266785bec48