However, genome-wide association studies (GWAS) on genetic factors for GDM are very limited [8]. We are aware of only one ... Studies of the association between dietary factors and the risk of GDM have just emerged over the last decade. There is ... Kwak SH, Kim SH, Cho YM et al (2012) A genome-wide association study of gestational diabetes mellitus in Korean women. Diabetes ... What do the intervention studies that demonstrated success in preventing GDM have in common? The few studies that did ...

... the designed replication study underpowered since we are only interested in the positive associations from the primary study ... If an association can be confirmed in a replication study, it will have a high confidence to be true positive. To design a ... replication study, traditional approaches calculate power by treating replication study as another independent primary study. ... These approaches do not use the information given by primary study. Besides, they need to specify a minimum detectable effect ...

... including the recent insights highlighted by lineage-tracing studies in mice and genetic/genomics data obtained from humans. We ... Abdennour M, Reggio S, Le Naour G et al (2014) Association of adipose tissue and liver fibrosis with tissue stiffness in morbid ... A recent study showed that VAT but not SAT arises from cells expressing the Wilms tumour 1 gene (Wt1) late in mouse gestation ... In a study in mice, an 8 week HFD led to formation of new adipocytes in VAT, associated with activation and proliferation of ...

... larger recent meta-analytic genome-wide association study identified genetic loci for digit ratio as well as associations with ... The Present Study. However, UFRs hormonal associations were never tested before, leaving a gap between the postulate of a ... While for example the Odense Androgen Study (Nielsen et al., 2010) did not find negative associations between CAG repeat ... As stated above, the study was part of a larger one-on-one contest study, involving the necessity for simultaneous presence of ...

Exhaustive analysis of studies containing approximately 450,000 SNPs and 5,000 samples requires only 2 hours using a desktop ... We have identified SNP pairs that have considerably stronger association with disease than their individual component SNPs that ... re-detect most significant SNP-pairs and additionally detect many pairs absent from the literature that show strong association ... currently observed in genome-wide association studies (GWAS). However, even the simplest bivariate analysis is still held back ...

... as a study in an Alaskan Inuit population found an association between plasma fatty acid levels and genetic variants of the ... Fan Q, Nie S, Li S et al (2016) Analysis of the genetic association between IL27 variants and coronary artery disease in a ... For the other four biomarkers, we found no previous studies of prospective associations with MACE in type 2 diabetes, although ... Study of Atherosclerosis in Västmanland. Between November 2005 and May 2011, the Study of Atherosclerosis in Västmanland (SAVa ...

Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic ... Liu XG, Tan LJ, Lei SF et al (2009) Genome-wide association and replication studies identified TRHR as an important gene for ... Yalcin B, Nicod J, Bhomra A et al (2010) Commercially available outbred mice for genome-wide association studies. PLoS Genet 6: ... Tonjes A, Koriath M, Schleinitz D et al (2009) Genetic variation in GPR133 is associated with height: genome wide association ...

... are common neurodevelopmental disorders with moderately strong genetic components and lifelong implica ... In our study design, we emphasized replication of genetic associations in independent cohorts, as opposed to reliance on ... We examined different severity levels because past studies in the DYX2 locus have shown differences in genetic association ... Golding J, Pembrey M, Jones R, ALSPAC Study Team (2001) ALSPAC-the Avon Longitudinal Study of Parents and Children. I. Study ...

... have been an important tool for susceptibility gene discovery in genetic disorders and investigating the interplay among ... Genome-wide association studies (GWAS) have been an important tool for susceptibility gene discovery in genetic disorders and ... Such interactions between two or more loci is called epistasis and it has a major role in complex genetic traits. ...

This marker set will be applicable for evaluating the genetic structure for association mapping, DNA fingerprinting, and ... This study provides one of the first quantitative views of population genetic variation in bottle gourd. ... Decker-Walters, D., Staub, J., Lopez-Sese, A., & Nakata, E. (2001). Genetic Resources and Crop Evolution, 48, 369-380. ... Transferability of Cucumber Microsatellite Markers Used for Phylogenetic Analysis and Population Structure Study in Bottle ...

Our findings support the use of differential allelic expression in blood as a surrogate for breast tissue in future studies on ... a suitable surrogate test tissue must be identified for future studies. We measured differential allelic expression of 12 ... As access to large numbers of fresh breast tissue to perform such studies is difficult, ... Recent genome-wide association studies (GWAS) have identified variants that account for an additional 5.9% of the genetic risk ...

... researchers have found utilizing data from large-scale genetic association studies can help investigate associations between ... A) Several studies suggest that SARS-CoV-2 can directly infect cardiac cells of the myocardium and may cause heart damage by a ... In a study of 416 patients in ICU, 20% had evidence of cardiac injury, which was associated with a five-fold increase in the ... A case study in Brazil was the first to document SARS-CoV-2 viral particles in the heart of a child with multisystem ...

... the association signal primarily arises from de novo protein-truncating variants, as opposed to the more common missense ... Whole-exome sequencing studies have been useful for identifying genes that, when mutated, affect risk for autism spectrum ... 5e). This clustering of different association signals from genetic association scores and their transcriptomic/interactomic ... genes with two de novo likely gene-disrupting mutations or a gene uniquely implicated by a genome-wide association study. This ...

Toxoplasma gondii has a highly clonal genetic structure classified into three major genetic types, I, II, and III, plus ... Genetic association and expression studies indicate a role of toll-like receptor 8 in pulmonary tuberculosis. PLoS Genet 4(10): ... Toxoplasma gondii has a highly clonal genetic structure classified into three major genetic types, I, II, and III, plus ... Toxoplasma gondii has a highly clonal genetic structure, with three major genetic types, I, II, and III, plus additional ...

Neonatal, nodulocystic, and conglobate acne have proven genetic influences [2]. Postadolescent acne is related with a first- ... was the first who studied the role of heredity in acne. ... Genetic control of sebum excretion and acne - a twin study. Br ... Association between serum insulin growth factor-I (IGF-I) and a simple sequence repeat in IGF-I gene: implications for genetic ... Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese poulations. Hum Mol Genet. 2009;18:4897-904. ...

Subclinical hypothyroidism and its association with lupus nephritis: a case control study in a large cohort of Chinese systemic ... environmental and genetic associations. Ann Rheum Dis. 2011;70(Suppl 2):A88-9. ... Characteristics of rheumatoid arthritis and its association with major comorbid conditions: cross-sectional study of 502 649 UK ... Although poly-autoimmunity is frequently described in SLE, the association with type 1 DM is uncommon. An association between ...

We aimed to assess associations between parental social media comparison (PSMC)-the degree to which individuals compare their ... Silberg, J. L., Maes, H., & Eaves, L. J. (2010). Genetic and environmental influences on the transmission of parental ... Associations between Comparison on Social Media and Depressive Symptoms: A Study of Young Parents. *Jaime E. Sidani. ORCID: ... and informed consent was obtained from all individual participants included in the study. All procedures performed in studies ...

However, studies of ASD cases versus controls have been limited by post-mortem timing and severely small sample sizes. Reports ... We also tested for enrichment of ASD EWAS CpGs for being targets of meQTL associations using available SNP genotype data in the ... Discovery-oriented EWAS for ASD using blood samples will likely need even larger samples and unified genetic data to further ... DNA from 968 blood samples from children in the Study to Explore Early Development (SEED 1) was used to generate epigenome-wide ...

This study is registered with the Australian New Zealand Clinical Trials Registry (ACTRN12617000643370). Registered on 3 May ... Some observational studies suggest exercise intensity may be important for inducing cognitive improvements; however, this has ... The objective of the current study was to evaluate the effect of systematically manipulated high-intensity and moderate- ... studies examining the impact of exercise interventions on cognition have produced inconsistent findings. ...

... and associations with genetic and cardiovascular risk factors. Dement Geriatr Cogn Disord Extra. 2016;6:529-40. ... and the Tromsø Study. The Tromsø Study (www.tromsostudy.com) is a prospective cohort study with primarily Caucasian ... In the present study, we linked information on drug use from NorPD with data on neurological health from the Tromsø study [15 ... Study design. This is an observational study where we relied on data from two existing databases: NorPD (www.norpd.no) ...

Studies within the critical window when seroconversion frequently occurs in infants with high genetic risk will provide key ... Similarly, mutation of the type 1 diabetes genome-wide association study gene Rnls, which controls UPR signalling, led to ... Inshaw JRJ, Sidore C, Cucca F et al (2021) Analysis of overlapping genetic association in type 1 and type 2 diabetes. ... This stress response also shows a number of genetic associations with type 1 diabetes [70]. Although upregulation of HLA Class ...

Tsuboi T, Endo S. Genetic studies of febrile convulsions: analysis of twin and family data. Epilepsy Res Suppl. 1991;4:119-28. ... The association between iron deficiency and febrile seizures in childhood. Clin Pediatr. 2009;48(4):420-6. ... van den Berg BJ, Yerushalmy J. Studies on convulsive disorders in young children: I. Incidence of febrile and nonfebrile ... A prospective study of recurrent febrile seizures. N Engl J Med. 1992;327(16):1122-7. ...

Clearly it would be informative to examine the associations also in individuals with normal weight. The fact that the study ... Early metabolic features of genetic liability to type 2 diabetes: Cohort study with repeated metabolomics across early life. ... 2.1 Participants and study design. This study is a follow-up study of women participating in a single-center dietary ... although the association was dependent on the pre-pregnancy BMI. In a large previous study of non-pregnant women, higher levels ...

Large-scale studies on community ecology are highly desirable but often difficult to accomplish due to the considerable ... Large-scale studies on community ecology are highly desirable but often difficult to accomplish due to the considerable ... The distribution of genetic variation within a community provides another axis of information which is complementary to the ... Association of the relative abundance of spider species from seven different families in mock communities of 46 different ...

In this study, using faecal samples from patients with IBD, we show through diversity analysis of the microbial community ... More than 215 IBD-associated loci have been identified so far from various genome-wide association studies (GWAS) [7]. It has ... Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7. ... Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across ...

2022). These studies highlight the grand potential of KO-models from the IMPC to study the genetic influence and complementary ... Dpp8, a gene with no human disease association, causes at depletion significantly increased total body fat amount with ... Aging in mice is increasingly being studied, but differences in study design and background make it difficult to draw general ... In the context of this study, we would like to thank the IMPC for data gathering and annotation, the wrangler and data analysts ...

... a Mendelian randomization study in the copenhagen general population study of 53221 adults. Journal of Internal Medicine, 269, ... Willage, B. (2018). The effect of weight on mental health: New evidence using genetic IVs. Journal of Health Economics, 57, 113 ... Clark and Etilé (2011) explored the association of sub-optimal BMI levels and life satisfaction controlling for spouses BMI ... This study has been realized using the data collected by the Swiss Household Panel (SHP), which is based at the Swiss Center of ...

... offers powerful methods for detecting and modeling associations often in data with large feature spaces and complex ... associations. Many useful tools/packages (e.g. scikit-learn) have been developed to make the various elements of data handling ... Uppu, S., Krishna, A.: Tuning hyperparameters for gene interaction models in genome-wide association studies. In: International ... In: Trujillo, L., Winkler, S.M., Silva, S., Banzhaf, W. (eds) Genetic Programming Theory and Practice XIX. Genetic and ...

Devils have unusually low genetic diversity for a mammal (Jones et al., 2004), which is consistent with a founder effect when ... Decline in population size in a 160-km2 study site at Freycinet, Eastern Tasmania. Population size estimated from closed ... perhaps in association with disease (Guiler, 1964, 1992). This idea was used as the basis of a model (Bradshaw and Brook, 2005 ... Pradel R (1996) Utilization of capture-mark-recapture for the study of recruitment and population growth rate. Biometrics 52: ...

... because the majority of studies do not report the genetic mating system. We also categorized the study environment in which the ... testing genetic associations among personality and life history. Behav Ecol 24:35-941 ... where u is the overall mean lnRR; sk[i] is the study-specific random effect, k, applied to effect size, i; ap[i] is the ... This indicates that future studies should take into account the mating system and study environment when trying to understand ...