Impact on antibody responses of B-cell-restricted transgenic expression of a viral gene inhibiting activation of NF-κB and NFAT...  Impact on antibody responses of B-cell-restricted transgenic expression of a viral gene inhibiting activation of NF-κB and NFAT...
... we have assessed the impact in vivoof the evasion gene A238L of African swine fever virus, an inhibitor of both NF-κB- and NFAT ... Impact on antibody responses of B-cell-restricted transgenic expression of a viral gene inhibiting activation of NF-κB and NFAT ... Genes Dev 17(18):2205-2232. doi: 10.1101/gad.1102703 CrossRefPubMedGoogle Scholar ... The A238L gene was selectively expressed in mouse B lymphocytes using the promoter and enhancer sequences of the mouse Ig μ ...
more infohttps://link.springer.com/article/10.1007%2Fs00705-015-2419-x
A safe packaging line for gene transfer: separating viral genes on two different plasmids. | Journal of Virology  A safe packaging line for gene transfer: separating viral genes on two different plasmids. | Journal of Virology
A safe packaging line for gene transfer: separating viral genes on two different plasmids.. D Markowitz, S Goff, A Bank ... A safe packaging line for gene transfer: separating viral genes on two different plasmids. ... A safe packaging line for gene transfer: separating viral genes on two different plasmids. ... A safe packaging line for gene transfer: separating viral genes on two different plasmids. ...
more infohttps://jvi.asm.org/content/62/4/1120?ijkey=a451996fbf9de75cc55ee6fbd55d305c41fc2390&keytype2=tf_ipsecsha
Prohibitin Viral Gene Transfer Protects Hippocampal CA1 Neurons From Ischemia and Ameliorates Postischemic Hippocampal...  Prohibitin Viral Gene Transfer Protects Hippocampal CA1 Neurons From Ischemia and Ameliorates Postischemic Hippocampal...
Prohibitin Viral Gene Transfer Protects Hippocampal CA1 Neurons From Ischemia and Ameliorates Postischemic Hippocampal ... Prohibitin Viral Gene Transfer Protects Hippocampal CA1 Neurons From Ischemia and Ameliorates Postischemic Hippocampal ... Prohibitin Viral Gene Transfer Protects Hippocampal CA1 Neurons From Ischemia and Ameliorates Postischemic Hippocampal ... Prohibitin Viral Gene Transfer Protects Hippocampal CA1 Neurons From Ischemia and Ameliorates Postischemic Hippocampal ...
more infohttp://stroke.ahajournals.org/content/early/2014/03/11/STROKEAHA.113.003577.short?rss=1
Transcriptional activation of cloned human beta-globin genes by viral immediate-early gene products.  - PubMed - NCBI  Transcriptional activation of cloned human beta-globin genes by viral immediate-early gene products. - PubMed - NCBI
The viral gene products can be provided by constitutively expressed, integrated viral genes in established cell lines, by viral ... Transcriptional activation of cloned human beta-globin genes by viral immediate-early gene products.. Green MR, Treisman R, ... In contrast, beta-globin transcription in the presence of viral immediate-early gene products requires only 36 bp of 5'- ... Thus both cis and trans-acting viral factors activate beta-globin gene transcription in transient expression experiments, but ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/6313220?dopt=Abstract
Polymers | Free Full-Text | Low Molecular Weight pDMAEMA-block-pHEMA Block-Copolymers Synthesized via RAFT-Polymerization:...  Polymers | Free Full-Text | Low Molecular Weight pDMAEMA-block-pHEMA Block-Copolymers Synthesized via RAFT-Polymerization:...
The aim of this study was to investigate non-viral pDNA carriers based on diblock-copolymers consisting of poly(2-(dimethyl ... Low Molecular Weight pDMAEMA-block-pHEMA Block-Copolymers Synthesized via RAFT-Polymerization: Potential Non-Viral Gene ... "Low Molecular Weight pDMAEMA-block-pHEMA Block-Copolymers Synthesized via RAFT-Polymerization: Potential Non-Viral Gene ... Potential Non-Viral Gene Delivery Agents? Polymers 2011, 3, 693-718. AMA Style. Samsonova O, Pfeiffer C, Hellmund M, Merkel OM ...
more infohttp://www.mdpi.com/2073-4360/3/2/693
siRNA Treatment Slashes Viral Gene Expression by 80%  siRNA Treatment Slashes Viral Gene Expression by 80%
... News Mar 31, 2017 , Original story from Tomsk Polytechnic University (TPU) ... thereby reducing the viral gene expression," says one of the main co-authors of the research Alexander Timin, a JRF of the ... First Successful Gene Therapy Trial Reported for People with Hemophilia A News Dec 14, 2017 ... This leads to degradation of "viral" RNA, preventing its translation on ribosomes into a protein encoded by it, ...
more infohttps://www.technologynetworks.com/genomics/news/sirna-treatment-slashes-viral-gene-expression-by-80-286989
Non-viral gene therapy for bone tissue engineering  Non-viral gene therapy for bone tissue engineering
read more By administering BMP-2 plasmid DNA instead of protein, cells can take up the gene, produce and release BMP-2 ... However future safety and efficacy studies at orthotopic locations, will determine whether this gene delivery strategy is ready ... Non-viral gene therapy for bone tissue engineering. DSpace/Manakin Repository. Non-viral gene therapy for bone tissue ...
more infohttps://dspace.library.uu.nl/handle/1874/282736
Frontiers | Optogenetic dissection of neuronal circuits in zebrafish using viral gene transfer and the Tet system | Frontiers...  Frontiers | Optogenetic dissection of neuronal circuits in zebrafish using viral gene transfer and the Tet system | Frontiers...
... viral gene delivery and the iTet-Off system, to express transgenes in the brain of zebrafish. High-level gene expression in ... High-level gene expression in neurons was achieved by Sindbis and Rabies viruses. The Tet system produced strong and specific ... The Tet system therefore provides the opportunity to generate libraries of diverse expression patterns similar to gene trap ... The Tet system therefore provides the opportunity to generate libraries of diverse expression patterns similar to gene trap ...
more infohttps://www.frontiersin.org/articles/10.3389/neuro.04.021.2009/full
Class I MHC-restricted cytotoxic T lymphocyte recognition of cells infected with human cytomegalovirus does not require...  Class I MHC-restricted cytotoxic T lymphocyte recognition of cells infected with human cytomegalovirus does not require...
... proteins introduced into the cell after viral penetration and efficient recognition occurs in the absence of de novo viral gene ... cytotoxic T lymphocyte recognition of cells infected with human cytomegalovirus does not require endogenous viral gene ... cytotoxic T lymphocyte recognition of cells infected with human cytomegalovirus does not require endogenous viral gene ... cytotoxic T lymphocyte recognition of cells infected with human cytomegalovirus does not require endogenous viral gene ...
more infohttps://www.jimmunol.org/content/146/8/2795?ijkey=8f7254f64b14dd65e656af3da8d556b3ebfc2585&keytype2=tf_ipsecsha
Lytic Replication of Epstein-Barr Virus in the Peripheral Blood: Analysis of Viral Gene Expression in B Lymphocytes During...  Lytic Replication of Epstein-Barr Virus in the Peripheral Blood: Analysis of Viral Gene Expression in B Lymphocytes During...
... leading to the expression of a limited set of viral genes. These latent genes are EBV nuclear antigens (EBNA), 1, 2, 3A, 3B, 3C ... An Epstein-Barr virus-producer line Akata: Establishment of the cell line and analysis of viral DNA. Virus Genes 1991;5:147. ... The viral replicative cycle is almost certainly initiated, but it appears to be aborted before expression of late gene products ... Lytic Replication of Epstein-Barr Virus in the Peripheral Blood: Analysis of Viral Gene Expression in B Lymphocytes During ...
more infohttp://www.bloodjournal.org/content/89/5/1665?ijkey=eff8d17be91c35e8adce66725c492b1034c8155b&keytype2=tf_ipsecsha&sso-checked=true
Gene behavior distinguishes viral from bacterial infections | Science News  Gene behavior distinguishes viral from bacterial infections | Science News
Researchers have identified signatures of viral infection, a distinction that may help doctors tell whether bacteria or a virus ... Gene behavior distinguishes viral from bacterial infections. New approach could gauge response to flu vaccine. ... CASING A CULPRIT Certain gene behavior changes in people can reveal whether an infection is caused by a virus, such as the H1N1 ... To find the viral fingerprints, computational immunologist Purvesh Khatri of Stanford University and colleagues combed through ...
more infohttps://www.sciencenews.org/article/gene-behavior-distinguishes-viral-bacterial-infections
Optimising non-viral gene delivery in a tumour spheroid model. | UK CF Gene Therapy Consortium  Optimising non-viral gene delivery in a tumour spheroid model. | UK CF Gene Therapy Consortium
The current investigation systematically examines the efficiency of several non-viral gene transfer agents to transfect ... new insights into tumour-specific factors affecting non-viral gene transfer and highlights the difficulties in delivering genes ... 22 kDa linear PEI provided optimal gene delivery, with gene expression peaking at 46 h. Despite being the optimal vector tested ... Gene delivery in an MCTS model comprised entirely of quiescent cells demonstrated that in addition to being inaccessible to the ...
more infohttp://www.cfgenetherapy.org.uk/publications/publication/232
Insertion of a new gene of viral origin into bone marrow cells of mice | Science  Insertion of a new gene of viral origin into bone marrow cells of mice | Science
Insertion of a new gene of viral origin into bone marrow cells of mice ... Insertion of a new gene of viral origin into bone marrow cells of mice ... Insertion of a new gene of viral origin into bone marrow cells of mice ... Insertion of a new gene of viral origin into bone marrow cells of mice ...
more infohttp://science.sciencemag.org/content/208/4447/1033
Presentation of CMV immediate-early antigen to cytolytic T lymphocytes is selectively prevented by viral genes expressed in the...  Presentation of CMV immediate-early antigen to cytolytic T lymphocytes is selectively prevented by viral genes expressed in the...
Presentation of CMV immediate-early antigen to cytolytic T lymphocytes is selectively prevented by viral genes expressed in the ... was selectively prevented during the subsequent expression of viral early genes. The surface expression of MHC class I ... Recognition by cytolytic T lymphocytes of the phosphoprotein pp89, the immunodominant viral antigen expressed in the immediate- ...
more infohttps://epub.ub.uni-muenchen.de/6734/
The development of cationic polymers for non-viral gene delivery syste by Amaraporn Wongrakpanich  "The development of cationic polymers for non-viral gene delivery syste" by Amaraporn Wongrakpanich
Gene therapy is the process of delivering genetic material, such as DNA (encoding for an important protein) into a patient's ... Gene therapy is the process of delivering genetic material, such as DNA (encoding for an important protein) into a patient's ... Gene therapy is the process of delivering genetic material, such as DNA (encoding for an important protein) into a patient's ... We found that this PGAA can form polyplexes with DNA and could be used in gene therapy. At the present time, mechanisms by ...
more infohttps://ir.uiowa.edu/etd/1935/
Regulators Discover a Hidden Viral Gene in Commercial GMO Crops  : Conscious Life News  Regulators Discover a Hidden Viral Gene in Commercial GMO Crops : Conscious Life News
Researchers have discovered a hidden viral gene lurking in many commercial GMO crops, raising possible concerns about its ... Gene VI, like most plant viral genes, produces a protein that is multifunctional. It has four (so far) known roles in the viral ... This is because there are clear indications that this viral gene (called Gene VI) might not be safe for human consumption. It ... This attribute of Gene VI raises two obvious biosafety concerns: 1) Gene VI will lead to aberrant gene expression in GMO crop ...
more infohttp://consciouslifenews.com/hidden-viral-gene-gmo-crops/1148194/
Strategies to test nuclear localization of non-viral gene delivery vec by Garrett Richard Rettig  "Strategies to test nuclear localization of non-viral gene delivery vec" by Garrett Richard Rettig
We focused on pursuing in vitro and in vivo methods by which to test non-viral vectors for increases in gene expression based ... Several strategies have been explored to demonstrate an increase in reporter gene expression from this type of non-viral vector ... The hypothesis of this work was to incorporate a nuclear localizing sequence into a non-viral delivery vector, demonstrate ... The complexity of achieving this goal is increased when considering an in vivo system for improving gene transfer efficiency. ...
more infohttps://ir.uiowa.edu/etd/212/
Viral gene inhibition of class I major histocompatibility antigen expression: not a general mechanism governing the...  Viral gene inhibition of class I major histocompatibility antigen expression: not a general mechanism governing the...
Viral gene inhibition of class I major histocompatibility antigen expression: not a general mechanism governing the ... Viral gene inhibition of class I major histocompatibility antigen expression: not a general mechanism governing the ... Viral gene inhibition of class I major histocompatibility antigen expression: not a general mechanism governing the ... Viral gene inhibition of class I major histocompatibility antigen expression: not a general mechanism governing the ...
more infohttps://jvi.asm.org/content/62/8/2755/figures-only
A gene deletion that up-regulates viral gene expression yields an attenuated RSV vaccine with improved antibody responses in...  A gene deletion that up-regulates viral gene expression yields an attenuated RSV vaccine with improved antibody responses in...
A gene deletion that up-regulates viral gene expression yields an attenuated RSV vaccine with improved antibody responses in ... A gene deletion that up-regulates viral gene expression yields an attenuated RSV vaccine with improved antibody responses in ... A gene deletion that up-regulates viral gene expression yields an attenuated RSV vaccine with improved antibody responses in ... A gene deletion that up-regulates viral gene expression yields an attenuated RSV vaccine with improved antibody responses in ...
more infohttps://stm.sciencemag.org/content/7/312/312ra175
Low-frequency ultrasound increases non-viral gene transfer to the mouse lung. | UK CF Gene Therapy Consortium  Low-frequency ultrasound increases non-viral gene transfer to the mouse lung. | UK CF Gene Therapy Consortium
... increases non-viral gene transfer to the mouse lung. US is greatly attenuated in the lung due to large energy losses at the air ... We have thus, established that low-frequency US can enhance lung gene transfer with naked pDNA and this enhancement is more ... It did, however, increase naked pDNA gene transfer by approximately 4 folds. Importantly, this was achieved in the absence of ... Low-frequency ultrasound increases non-viral gene transfer to the mouse lung.. Xenariou S, Liang HD, Griesenbach U, Zhu J, ...
more infohttp://cfgenetherapy.org.uk/publications/publication/189