Glial cell line-derived neurotrophic factor receptor alpha 2 (GFRA2) gene is associated with tardive dyskinesia Renan P Souza 1 ... Glial cell line-derived neurotrophic factor receptor alpha 2 (GFRA2) gene is associated with tardive dyskinesia Renan P Souza ... Methods: We tested whether variants in the GDNF receptor alpha 2 (GFRA2) gene could play a role in TD susceptibility evaluating ... Analysis of genetic variations in the dopamine D1 receptor (DRD1) gene and antipsychotics-induced tardive dyskinesia in ...

... Publication , Journal ... "Regulation of T cell receptor alpha gene assembly by a complex hierarchy of germline Jalpha promoters." Nat Immunol 6, no. 5 ( ... "Regulation of T cell receptor alpha gene assembly by a complex hierarchy of germline Jalpha promoters." Nat Immunol, vol. 6, no ... Regulation of T cell receptor alpha gene assembly by a complex hierarchy of germline Jalpha promoters. Nat Immunol. 2005 May;6( ...

... in zebrafish is expressed in radial glial cells and is strongly stimulated by estrogens (E2); thus, it can be used in vivo as a ... Interaction of estrogen receptors alpha and beta with estrogen response elements. Mol Cell Endocrinol 181(1-2):151-16311476949 ... Differential response of estrogen receptor alpha and estrogen receptor beta to partial estrogen agonists/antagonists. Mol ... Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern. J Clin Endocrinol Metab 82:4258- ...

Cell Line, Tumor; Estrogen Receptor alpha; Estrogens/analysis*; Female; Gene Expression; Gene Expression Regulation, Neoplastic ... induces estrogen receptor alpha and prolactin receptor expression and increases estrogen responsiveness in breast cancer cells. ... we studied effects on cell growth, PRLR, ER alpha, and PgR levels, and estrogen target genes. Induced endogenous hPRL, but not ... increased ER alpha levels as well as estrogen responsiveness in these cells, suggesting that effects on breast cancer ...

His research concerned the regulation of interleukin 7 receptor alpha-chain gene expression in T cells. He was a recipient of a ... His project was involved with modeling human hematopoietic stem cell gene therapy in nonhuman primates. ... His project was involved with modeling human hematopoietic stem cell gene therapy in nonhuman primates. ... Her research involved studies of gene therapy and brain/vascular stem cell interactions. ...

TNF-alpha activates TNFRSF1A. The extracellular portion of the gene undergoes cleavage and subsequent shedding from the cell ... 80, 81] The mutated protein expressed in vitro had no affinity with the IL-1 receptor, and stimulation of the patients cells ... Mutations in the IL1RN gene result in a prematurely truncated protein that is not secreted, resulting in patient cells being ... 50] including reduced cell surface expression of mutant receptors, an abnormal oligomerization or misfolding with retention in ...

Cutaneous T-cell lymphoma is a term that was created in 1979 at an international workshop sponsored by the National Cancer ... 44] T-cell receptor genes are clonally rearranged; clonally integrated HTLV-1 genes are present and are useful in ... Panniculitis-like T-cell lymphoma shows an alpha/beta+, CD3+, CD4-, CD8+ T-cell phenotype, with expression of cytotoxic ... interleukin-2 receptor; M = M cell; NCAM = neural cell adhesion molecule; NK = natural killer; RBC = red blood cell; T = T cell ...

Both CTCF-dependent and -independent insulators are found between the mouse T cell receptor alpha and Dad1 genes.. Magdinier F ... Mol Cell (2004 Nov 5) 16:453-63. Abstract/Full Text. Transcription of Ig germline genes in single human B cells and the role of ... The human insulin gene displays transcriptionally active epigenetic marks in islet-derived mesenchymal precursor cells in the ... Insulin promoter in human pancreatic β cells contacts diabetes susceptibility loci and regulates genes affecting insulin ...

T-cell receptor alpha locus is a protein that in humans is encoded by the TRA gene, also known as TCRA or TRA@. It contributes ... "Entrez Gene: TRA@ T cell receptor alpha locus". Kenwrick S, Levinson B, Taylor S, et al. (1993). "Isolation and sequence of two ... "The chromosomal location of T-cell receptor genes and a T cell rearranging gene: possible correlation with specific ... 1985). "Analysis of cDNA clones specific for human T cells and the alpha and beta chains of the T-cell receptor heterodimer ...

BETA-2-MICROGLOBULINNKT15 T CELL RECEPTOR ALPHA-CHAINNKT15 T CELL RECEPTOR BETA-CHAINT-CELL SURFACE GLYCOPROTEIN CD1D2-( ... 3HUJ: Crystal Structure Of Human Cd1d-Alpha-Galactosylceramide In Complex With Semi-Invariant Nkt Cell Receptor. ... N-{(1s,2r,3s)-1-[(Alpha-D-Galactopyranosyloxy)methyl]-2,3-Dihydroxyheptadecyl}hexacosanamide. ...

The FOLR1 gene provides instructions for making a protein called folate receptor alpha. This protein is found within the cell ... Folate receptor alpha is thought to play a major role in bringing folate from the bloodstream into brain cells. It transports ... where it attaches (binds) to folate, allowing the vitamin to be brought into the cell. Folate receptor alpha is produced in ... which means both copies of the gene in each cell have mutations. The parents of an individual with an autosomal recessive ...

Engineered T cells expressing tumor-specific T-cell receptors (TCRs) are emerging as a mode of personalized cancer ... Genes, T-Cell Receptor alpha Actions. * Search in PubMed * Search in MeSH ... Rapid Identification and Evaluation of Neoantigen-reactive T-Cell Receptors From Single Cells Biman C Paria 1 , Noam Levin, ... Rapid Identification and Evaluation of Neoantigen-reactive T-Cell Receptors From Single Cells Biman C Paria et al. J Immunother ...

... target genes in human peripheral blood mononuclear cells (PBMCs) associated with non-alcoholic fatty liver disease (NAFLD) ... Expression of PPARα and its target genes was determined in PBMCs. The levels of liver cell damage markers, total cholesterol ( ... There is an up-expression of PPARα target genes in the PBMCs of NAFLD patients, possibly leading to changes in β-oxidation and ... and liver cell damage markers were significantly increased in the OF group (P < 0.05). In the OF group, PPARα target ...

A pair of large-scale genetic studies has revealed 2 genes that influence the risk of getting multiple sclerosis (MS). The ... Both receptors are known to influence the way that T cells patrol the body for pathogens. Both IL2R-alpha and IL7R-alpha have ... IL7R-alpha). The genome-wide scan also found 2 SNPs in the gene for interleukin 2 receptor-alpha (IL2R-alpha) associated with ... Both studies revealed an association between MS and a single SNP in the gene for interleukin 7 receptor-alpha ( ...

Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages.. Mombaerts P; Clarke ... MHC-restricted T cell receptor signaling is required for alpha beta TCR replacement of the pre T cell receptor.. Croxford AL; ... 6. Role of Bcl-2 in alpha beta T cell development in mice deficient in the common cytokine receptor gamma-chain: the ... The Ets-1 transcription factor is required for complete pre-T cell receptor function and allelic exclusion at the T cell ...

Gene. Trav6-3. T cell receptor alpha variable 6-3. 0. 96. 3. 0. ... Gene type: gene segment; Gene Name: Trav6-3. Provider Wellcome ... Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, ... J:259852 Mouse Genome Informatics and the WTSI Mouse Genomes Project, MGI Strain Genome Feature and Gene Model Load. Database ... Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse ...

Hormonal regulation of estrogen receptor alpha and beta gene expression in human granulosa-luteal cells in vitro.. Chiang CH; ... Estrogen receptor beta--an independent prognostic marker in estrogen receptor alpha and progesterone receptor-positive breast ... discrimination of responses involving estrogen receptor α/estrogen receptor β, G protein-coupled estrogen receptor, or estrogen ... Expression and regulation of the estrogen receptors in PC-3 human prostate cancer cells.. Pisolato R; Lombardi AP; Vicente CM; ...

... alleles of the alpha chain of the T-cell receptor gene are frequently rearranged. This conclusion was based, in part, on Figure ... Examination of the original film indicates that there was no evidence that the second alpha-chain rearranges in mature T-cells ... submitted for publication to the journal Cell (Cell manuscript), but was later withdrawn. ORI accepted the C.I.T. conclusion ... Kumar made a number of other materially misleading statements in the Cell manuscript that were not supported by the primary ...

Generally, one can investigate the role of a gene whose product is hypothesized to be involved in the biotransformation, cell ... Schaaf BM, Seitzer U, Pravica V, Aries SP, Zabel P. Tumor necrosis factor-alpha -308 promoter gene polymorphism and increased ... Genetic susceptibility to ozone-induced lung hyperpermeability: role of toll-like receptor 4. Am J Respir Cell Mol Biol 2000;22 ... Polymorphisms in the DNA repair gene XPD: correlations with risk and age at onset of basal cell carcinoma. Cancer Epidemiol ...

T cell receptor alpha gene recombination is supported by a Tcra enhancer and CTCF-dependent chromatin hub. Proc Natl Acad Sci U ... Orchestrating T-cell receptor a gene assembly through changes in chromatin structure and organization. Immunol Res. 2010 PMID: ... Retinoic acid receptor alpha represses a Th9 transcriptional and epigenomic program. Immunity. 2019 PMID: 30650370 ... Shared and restricted T-cell receptor use is crucial for carbamazepine-induced Stevens-Johnson syndrome. J Allergy Clin Immunol ...

Type 1 interferons (alpha and beta) bind to the alpha/ beta receptor. Interferon gamma binds to a different cell surface ... surface receptors and initiate a sequence of intracellular events that lead to the transcription of interferon-stimulated genes ... cells, and the expression of Fc receptors and major histocompatibility antigens. ... ACTIMMUNE was tested in a micronucleus assay for its ability to induce chromosomal damage in bone marrow cells of mice ...

Glucocorticoid receptor alpha isoform-selective regulation of antiapoptotic genes in osteosarcoma cells: a new mechanism for ... Glucocorticoid receptor alpha isoform-selective regulation of antiapoptotic genes in osteosarcoma cells: a new mechanism for ... Glucocorticoids and Tumor Necrosis Factor Alpha Cooperatively Regulate Toll-Like Receptor 2 Gene Expression. Molecular and ... Glucocorticoids and Tumor Necrosis Factor Alpha Cooperatively Regulate Toll-Like Receptor 2 Gene Expression. Molecular and ...

Folate receptor-alpha (FR-alpha) testing: In many ovarian cancers, the cells have high levels of the FR-alpha protein on their ... NTRK gene mutations: Some ovarian cancers might be tested for changes in one of the NTRK genes. Cells with these gene changes ... BRCA1 and BRCA2 gene mutations: BRCA genes are normally involved in DNA repair, and mutations in these genes can cause cells to ... Your doctor will order blood count tests to make sure you have enough red blood cells, white blood cells and platelets (cells ...

View Human GFR alpha -like Antibody (MAB9697-100) datasheet. ... Glial Cell line-derived Neurotrophic Factor Receptor alpha-like ... Custom Services for Cell & Gene Therapies. *Genome Engineering Services. *Custom Cell Culture Media Services ... Background: GFR alpha-like. GFR alpha -like (GDNF receptor-alpha-like) is a distant member of the GDNFR family of proteins (1 ... Detection of GFR alpha -like in HEK293 Human Cell Line Transfected with Human GFR alpha -like by Flow Cytometry. HEK293 human ...

... to a receptor protein that spans the membrane of kidney cells. The protein produced from the KL gene, called alpha-klotho, ... KL gene mutations lead to a shortage of functional alpha-klotho. As a result, the receptor protein is not activated, causing it ... The FGF23 gene provides instructions for making a protein called fibroblast growth factor 23, which is produced in bone cells ... Mutations in the FGF23, GALNT3, or KL gene cause HFTC. The proteins produced from these genes are all involved in the ...

Immune cells express receptors for estrogens (ERα and ER), androgens (AR) and progesterone (PR), and experimental manipulation ... Immune cells express receptors for estrogens (ERα and ERβ), androgens (AR), and progesterone (PR), and experimental ... While elegant studies have defined mechanistic roles for sex hormones and receptors in innate immune cells, much remains to be ... While elegant studies have defined mechanistic roles for sex hormones and receptors in innate immune cells, much remains to be ...

... expression of the inhibitory receptors programmed cell death 1 (PD-1; also known as CD279), lymphocyte-activation gene 3 (LAG-3 ... Programmed Cell Death 1 Receptor * Receptors, Antigen, T-Cell, alpha-beta * Tumor Necrosis Factor Receptor Superfamily, Member ... Tumor Necrosis Factor Receptor Superfamily, Member 9 / genetics * Tumor Necrosis Factor Receptor Superfamily, Member 9 / ... Thus, in addition to the well-documented negative regulatory role of PD-1 in T cells, our findings demonstrate that PD-1 ...