An evolutionarily conserved transcription factor and critical regulator of development, CTCF is ideal acknowledged for its DNA ... To analyze the p Stat5 response quantitatively for each and every FLAG Stat5 expression level, we sub divided the p Stat5 ... firstly the overlapped genes have been discovered amongst the responsive gene modules plus the miRNA target gene sets. Then the ... We identified TAK1 as a positive mediator of autophagy through the suppression of S6K1 phosphorylation and showed that the ...
Escárcega RO, Fuentes-Alexandro S, García-Carrasco M, Gatica A, Zamora A. The transcription factor nuclear factor-kappa B and ... Comprehensive gene expression analysis of prostate cancer reveals distinct transcriptional programs associated with metastatic ... Terakawa N, Kanamori Y, Yoshida S. Loss of PTEN expression followed by Akt phosphorylation is a poor prognostic factor for ... Constitutive activation of STAT3 and STAT5 is present in the majority of nasopharyngeal carcinoma and correlates with better ...
Mammary gland factor; MGF; Signal transducer and activator of transcription 5A; STA5A_HUMAN; STAT 5; STAT 5A; STAT5; STAT5A; ... Serine phosphorylation is also required for maximal transcriptional activity (By similarity). Tyrosine phosphorylated in ... The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth ... Note: Translocated into the nucleus in response to phosphorylation.. Extracellular region or secreted. Cytosol. Plasma membrane ...
... interacts with signal transducer and activator of transcription 5 (STAT5) in activating Aurora-A gene expression. Nucleic Acids ... Following DNA damage the transcription factor p53 is activated, which results in transcription of the Cdk inhibitor p21 and ... Katayama H, Sasai K, Kawai H, Yuan ZM, Bondaruk J, Suzuki F, Fujii S, Arlinghaus RB, Czerniak BA, Sen S: Phosphorylation by ... where Aurora-A directly phosphorylates p53 to augment p53 protein turnover and transcriptional activity [38]. In addition, a ...
Naive CD4+ "helper" T cells can differentiate into multiple effector subsets, each defined by the transcription factors (TFs) ... 1B), IL-15 induced phosphorylation of Jak1, Akt, and ERK1/2 (Fig. 1C) with delayed kinetics for ERK1/2 phosphorylation. ... IL-2, IL-25, IL-33, TSLP, Notch, STAT3, STAT5, and IRF4 [1-4]. Because many of these are associated with alternative T-cell ... Based on insights from a multigene signature approach evaluating a broad range of inflammation-related genes we focused here on ...
Al though it has been shown that EPO induces tyrosine phosphorylation of Stat3 in addition to a likely purpose for this gene ... On top of that, JUN, MYC, and RELA signify mem bers of every from the transcription factor households recognized inside the ... Transcriptional integration of upstream signaling Examination of M6 unveiled an enrichment for TFs together with other nuclear ... which suggests that it existed within a phosphorylated state fairly not like STAT5, which others have proven to get located ...
... promoting gene transcription.[7][17] Regulation. Under normal conditions, type I IFN levels are homeostatically regulated to ... IFNAR agonism results in transcriptional changes, with the potential to increase or suppress the transcription of over 2000 ... Hertzog PJ, Williams BR (June 2013). "Fine tuning type I interferon responses". Cytokine & Growth Factor Reviews. 24 (3): 217- ... STAT5, and STAT6 may play a role in certain cell types[16]) via their SH2 domains. Once recruited, STAT proteins are ...
... since the nuclear translocation and subse quent transcriptional activity of STAT5 is contingent on phosphorylation, we ... developed in safety Extreme insulin signalling can shorten lifespan by reduc ing a vital stress resistance transcription factor ... the diurnal signature plainly overlapped with a large set of essential genes that form an adipose module within a gene gene ... remedy with TKI decreased phosphorylation of STAT5 and of ERK1 two but didnt comparably have an impact on phosphorylation of ...
DNAme usually represses gene transcription through recruiting repressor complexes or precluding transcription factors [65]. ... M. Shi, S. Yang, X. Zhu et al., "The RAGE/STAT5/autophagy axis regulates senescence in mesangial cells," Cellular Signalling, ... These kinases subsequently activate P53 and its transcriptional target p21CIP1/WAF1. In turn, p21CIP1/WAF1 inhibits cyclin- ... dependent kinase 2- (CDK2-) mediated phosphorylation of the retinoblastoma protein (Rb). The hypophosphorylated Rb binds to the ...
... and the constitutive factor CTF/NF-1 is required for efficient hormonal regulation of the thyroperoxidase gene transcription. ... SBMA pathology and phosphorylation of the androgen receptor. Funderburk, S.; Shatkina, L.; Mink, S.; Weis, Q.; Cato, A. C. B. ... Membrane localization and rapid non-transcriptional action of the androgen receptor. Mink, S.; Shatkina, L.; Nestl, A.; Cato, A ... Expression level-dependent contribution of glucocorticoid receptor domains for functional interaction with STAT5. Doppler, W.; ...
... tool that recognizes most important transcription factors that are changing their activity in a set of samples. ... RNA polymerase II transcription factor binding(GO:0001085). Gene overrepresentation in curated gene sets: canonical pathways ... Genes involved in Factors involved in megakaryocyte development and platelet production. 0.1. 3.8. REACTOME TRANSCRIPTIONAL ... PID IL2 STAT5 PATHWAY. IL2 signaling events mediated by STAT5. 0.2. 3.3. PID CIRCADIAN PATHWAY. Circadian rhythm pathway. ...
Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1. ... Gene silencing of Bim or FOXO3a by siRNA prevents apoptosis induced by RTK inhibitor. (A,B) FDC-P1/FLT3-ITD cells were ... When 4-OHT was added, which leads to transcriptional activity of FOXO3a, fewer cells were maintained in S-phase and more cells ... As expected, phosphorylation of AKT, ERK, and FOXO3a was apparent (Figures 1B,2D). ...
GTRD transcription factor targets gene sets.. *. msigdb:C3:TFT:TFT_LEGACY. TFT_Legacy. ... This might be useful for certain cases, e.g., for a specific transcriptional factor (TF), we take the union of ChIP-seq peaks ... PHOSPHORYLATION 0.012476423 14 ## fold_enrichment p_value p_adjust mean_tss_dist observed_gene_hits ## 1 1.542328 0.03308353 ... STAT5_SIGNALING 0.021152759 25 ## 4 HALLMARK_BILE_ACID_METABOLISM 0.010077105 13 ## 5 HALLMARK_HEDGEHOG_SIGNALING 0.006965189 9 ...
Inside the nucleus, EGFR functions as a co-transcription factor for several genes involved in cell proliferation and ... have been shown to function as co-transcriptional activators for various cancer-promoting genes. However, the regions of each ... IR-induced phosphorylation of nuclear AKT was primarily dependent on HER3 expression and tyrosine kinase activation of ... Combining radiotherapy with MEK1/2, STAT5 or STAT6 inhibition reduces survival of head and neck cancer lines Molecular cancer. ...
Kruppel-like factor 4. HE:. Haematoxylin-eosin. IL-7:. Interleukin-7. STAT5:. Signal transducer and activator of transcription ... Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells. Genes Dev. 2012;26(17): ... Recent studies have found that non-coding RNAs and post transcriptional modification of RNAs have become the active fields of ... oligodendrocyte transcription factor 2 (OLIG2), spalt like transcription factor 2 (SALL2) and SOX2). Of which, SOX2 has a high ...
Ray, Swagat, Catnaigh, Pol and Anderson, Emma C. (2015) Post-transcriptional regulation of gene expression by Unr. Biochemical ... The histone demethylase JMJD2A/KDM4A links ribosomal RNA transcription to nutrients and growth factors availability. Nature ... Millson, Stefan H., Truman, Andrew W. and Piper, Peter W. (2022) Hsp90 and phosphorylation of the Slt2(Mpk1) MAP kinase ... Tel/PDGFRbeta induces stem cell differentiation via the Ras/ERK and STAT5 signaling pathways. Experimental Hematology, 37 (9). ...
Analysis showed function-based networks, shared transcription factor binding sites and signaling pathways for members of the ... pathway membership and common transcription factor binding within and across clusters. RT-qPCR was used with representative ... The candidate genes of interest (GOI) identified from the microarray analysis and clustered by expression pattern across the ... Candidate genes showing distinctive expression patterns in response to ethanol were clustered by pattern and further analyzed ...
... the tumor necrosis factor receptor. Nowadays, monoclonal anti-TNF-α antibody is used for the treatment of these diseases ... Tumor necrosis factor-alpha (TNF-α) is implicated in the process of various autoimmune and inflammatory diseases through ... TRAF2 activates PI3K/Akt/STAT5. Activator protein 1 is a transcription factor, regulating gene expression, involving TRAF2/ ... TNFR2 induces the phosphorylation of kinases through TRAF2, involving the same pathway of NF-κB activation. MAPK activation ...
Whereas p38 activation is critical for the phosphorylation of the transcription factor CREB, PI3K activation is required for ... a class of small noncoding RNA that is an important regulator of transcriptional and posttranscriptional gene expression. Gene ... STAT1 and STAT3, but not STAT2 or STAT5, are also constitutively activated in all SLCL. The ability of the activated STAT ... Further, the transcription factor Forkhead box (FOX) protein 1, (FOXO1) was shown to be a target of miR-182. The aim of this ...
Regulation of megakaryocytic differentiation of K562 cells by FosB, a member of the Fos family of AP-1 transcription factors. ... As shown in Figure 6A, it was found that the mRNA expression of 3912 genes were decreased and 3770 genes were increased in BaF3 ... Kress TR, Sabo A, Amati B. MYC: connecting selective transcriptional control to global RNA production. Nat Rev Cancer. 2015;15: ... Therefore, imatinib was a paradigm of targeted therapies, which due to that imatinib inhibits the phosphorylation of BCR-ABL ...
... gene families represent species-specific expansions of pregnancy-associated hormones/cytokines. In this review we examine the ... Transcription of GH family genes is regulated by a locus control region located 23 kb upstream of the cluster [43, 57]. Four ... Transcriptional control of trophoblast giant cell-specific gene expression has been investigated using the Rcho-1 trophoblast ... Commonalities in cell-specific and/or temporal-specific aspects of gene expression do not appear to be main factors governing ...
However, the inherent complexity of transcriptional signatures, with thousands of differentially expressed genes, makes them ... We apply our approach to 189 drugs tested in 671 cancer cell lines and observe a connection between gene expression levels of ... Finally, we prove the predictive capability of the modules and demonstrate how they can be used as gene sets in conventional ... Our strategy starts with the calculation of drug-gene correlations and is followed by a pathway-oriented filtering and a ...
Promotes phosphorylation of MAPK8 at Thr-183 and Tyr-185, and of AKT1 at Ser-473.. Gene Name:. FLT4. Uniprot ID:. P35916 ... Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response ... Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential ... chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and ...
Cytokine release, inflammatory pain and gene expression were investigated in challenged PTPH1-WT and KO mice. The present study ... transcription factor AP-1 contributes to TNFα-inducible expression of MCP-1 gene [67-69]. This regulatory mechanism might ... Tyrosine phosphorylation is a central mechanism in the control of key signaling proteins involved in innate immunity. The role ... It has been recently shown that JAK2 and STAT5 are required for LPS-induced IL-6 production [63] and, as already mentioned, ...
... gene promoter: nuclear factors that interact with an element shared by three lymphokine genes - those for GM-CSF, interleukin-4 ... JAK2 then induces tyrosine phosphorylation of STAT5, which activates its DNA-binding ability [47,49] and the ensuing cell ... regulation of interleukin-5 production is thought to result from activation of gene transcription [37]. Interleukin-5 synthesis ... Darnell JE, Kerr AM, Stark GR: Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular ...
However, epigenetic changes in other candidate genes such as brain-derived neurotrophic factor (BDNF) and serotonin transporter ... The results of this review shows that focus to date has been on genes involved in the regulation of hypothalamic-pituitary- ... Further, these epigenetic changes are cell/tissue-specific in regulating expression of genes, providing potential biomarkers ... adrenal (HPA) axis and its correlation to subsequent neurobiology, for example, the role of glucocorticoid receptor gene. ...
The aim of this study was to investigate the role of PTEN gene and environmental risk factors on the progression and prognosis ... nGH-induced STAT5 phosphorylation is low at one-week and maximal at 2.5-weeks of age when compared to young adults, accompanied ... BMS-777607 we hypothesize that ZicL regulates gene transcription in the entire neural tube of the ascidian.". "The S1 mRNA of ... In this study, we focused on the transcriptional mechanisms that regulate CiNut1 expression. We found that an approximately 1.0 ...
Additionally, the TME is influenced by m6A regulatory factors, impacting the progression and prognosis of CRC. In this review, ... FTO downregulated the transcription of m6A downstream target gene MTA1, which inhibits CRC cell growth and metastasis in vivo. ... directly interact with transcription factors to mediate mRNA cyclization; (d) through histone modification, some "writers" are ... Interactions, localization, and phosphorylation of the m (6)A generating METTL3-METTL14-WTAP complex. RNA. 2018;24:499-512. ...
We Rabbit Polyclonal to Cyclin L1 discovered that neutralization of IL-2 abrogated all STAT5 phosphorylation (pSTAT5) in Treg ... The nanobody genes acquired after Sanger sequencing were translated to their amino acid sequence and exposed the characteristic ... The study of host and parasite factors that contribute to the pathogenesis of SMA has been hampered by the lack of an ... However, the PRB transcriptional activity and insensitivity to MPA were irreversible by LY294002 in ARID1A-deficient cells. ...
Humans , Cell Line, Tumor , Cell Proliferation/genetics , Gene Expression Regulation, Neoplastic , Genes, Homeobox , Glioma/ ... And the influencing factors of clinical remission rate were analyzed in CD patients. Paired t test, independent sample t test, ... Conclusion:This study suggests that IL-2/JAK3/STAT5 may be involved in the pathogenesis of AS, and JAK3 mRNA can be used as a ... Objective:To detect the expression of interleukin 2 (IL-2)/Janus kinase 3/signal transduction and transcriptional activator 5 ( ...