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Mutations of p53 gene can be detected in the plasma of patients with large bowel carcinoma. | Journal of Clinical Pathology  Mutations of p53 gene can be detected in the plasma of patients with large bowel carcinoma. | Journal of Clinical Pathology
RESULTS: p53 gene mutations were not found in the control specimens. They were found in both the primary tumour and the plasma ... The others were Dukes' C and Dukes' D. CONCLUSIONS: p53 gene mutations can be detected in the plasma of some patients with ... Mutations of p53 gene can be detected in the plasma of patients with large bowel carcinoma. ... Mutations of p53 gene can be detected in the plasma of patients with large bowel carcinoma. ...
more infohttp://jcp.bmj.com/content/51/8/611
How Tumor-Suppressor Gene p53 Keeps Cancer at Bay - Scientific American  How Tumor-Suppressor Gene p53 Keeps Cancer at Bay - Scientific American
The p53 gene monitors biochemical signals in cells that can indicate DNA damage or mutations. Upon detection of cancer ... When that gene is broken, DNA damage cannot be repaired because p53 is continually exported to the cytoplasm and getting ... Researchers have known for some time that the tumor-suppressor gene p53 plays a vital role in the body's struggle to stave off ... "In half of all tumor cells p53 is not working, sometimes because a kinase gene responsible for phosphorylation is mutated. ...
more infohttps://www.scientificamerican.com/article/how-tumor-suppressor-gene/
Medical Xpress - p53 gene  Medical Xpress - p53 gene
Study sheds light on dark side of tumor suppressor gene, p53. The gene p53 is the most commonly mutated gene in cancer - it is ... p53 (also known as protein 53 or tumor protein 53), is a transcription factor which in humans is encoded by the TP53 gene. p53 ... The gene p53 functions normally as a cancer suppressor, but mutated versions of the gene have been implicated in the ... Genetic variant of p53 gene linked to breast cancer risk in premenopausal African American women. Scientists at The Wistar ...
more infohttps://medicalxpress.com/tags/p53+gene/
The Emerging p53 Gene Family  The Emerging p53 Gene Family
Perturbation of p53 protein function is a common, if not universal, finding in human cancer.Tumor suppression by p53 is due, at ... In contrast to p53, neither p73 nor p51 appears to be frequently mutated in human cancers on the basis of the limited studies ... Finally, unlike p53, cells produce multiple p73 and p51 isoforms as a result of alternative splicing, and production of p73 and ... Nonetheless, data on differences between these proteins and p53 are emerging. For example, p73 is not induced by DNA damage and ...
more infohttps://insights.ovid.com/jnci/199904070/00005042-199904070-00003
Establishment of Methylation-Specific PCR for the Mouse p53 Gene  Establishment of Methylation-Specific PCR for the Mouse p53 Gene
Y. Gondo, K. Nakamura, K. Nakao et al., "Gene replacement of the p53 gene with the lacZ gene in mouse embryonic stem cells and ... Establishment of Methylation-Specific PCR for the Mouse p53 Gene. Ryuji Okazaki,1 Akira Ootsuyama,1 Yasuhiro Yoshida,2 and ... P. Hainaut and M. Hollstein, "p53 and human cancer: the first ten thousand mutations," Advances in Cancer Research, vol. 77, pp ... P. G. Corn, S. J. Kuerbitz, M. M. van Noesel et al., "Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia ...
more infohttps://www.hindawi.com/journals/mbi/2011/938435/ref/
p53 gene mutations in human epithelial skin cancers.  - PubMed - NCBI  p53 gene mutations in human epithelial skin cancers. - PubMed - NCBI
... techniques for the presence of p53 and RAS gene mutations. Whereas 48% (9/19) of the BCCs tested presented a mutated p53 gene, ... p53 gene mutations in human epithelial skin cancers.. Molès JP1, Moyret C, Guillot B, Jeanteur P, Guilhou JJ, Theillet C, ... all showing a mutated p53 gene) presented specific nuclear staining. In contrast to other reported data we could not detect any ... In addition to molecular detection, we searched for p53 protein accumulation, by immunocytochemical staining, in a subset of 23 ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/8437842?dopt=Abstract
Polimorfismo do códon 72 do gene p53 e risco de infecções persistentes por papiloma...  Polimorfismo do códon 72 do gene p53 e risco de infecções persistentes por papiloma...
O produto do gene E6 se liga ao produto do gene supressor de tumor p53 levando a sua degradação pela via de proteólise ... The E6 gene product interacts with the tumor suppressor p53 gene product, resulting in its degradation via ubiquitin dependent ... The p53 gene is a tumor suppressor that funcions in the regulation of the cell cycle. It presents a number of distinct ... O gene p53 é um supressor tumoral com função de regulação do ciclo celular que apresenta vários polimorfismos distintos em ...
more infohttp://www.teses.usp.br/teses/disponiveis/46/46131/tde-14052018-121907/pt-br.php
Gene p53 mutations are restricted to poorly differentiated and undifferentiated carcinomas of the thyroid gland.  - PubMed -...  Gene p53 mutations are restricted to poorly differentiated and undifferentiated carcinomas of the thyroid gland. - PubMed -...
The p53 gene was analyzed in tumor specimens obtained from 52 patients with various types of carcinoma of the thyroid gland by ... Gene p53 mutations are restricted to poorly differentiated and undifferentiated carcinomas of the thyroid gland.. Donghi R1, ... The p53 gene was shown to be unaffected in all differentiated tumors by single-strand conformation polymorphism analysis. ... The comparative analysis of the p53 gene, in both the more and the less differentiated area of this tumor, clearly showed that ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/8473515?dopt=Abstract
rAd-p53 Gene Therapy for Advanced Malignant Thyroid Tumors - Tabular View - ClinicalTrials.gov  rAd-p53 Gene Therapy for Advanced Malignant Thyroid Tumors - Tabular View - ClinicalTrials.gov
Radiation: p53 gene therapy with radioactive iodine p53 gene therapy with concurrent radioactive iodine pre-surgery p53 gene ... Drug: rAd-p53 gene pre-surgery p53 gene treatment: 10exp12 virus particles per 3 days for 5 times ... Drug: p53 gene therapy p53 gene treatment: 10exp12 virus particles per 3 days for 10 times ... rAd-p53 Gene Therapy for Advanced Malignant Thyroid Tumors. The safety and scientific validity of this study is the ...
more infohttps://clinicaltrials.gov/ct2/show/record/NCT00902122
COTI-2 Found to Correct Specific p53 Gene Mutation in Human Ovarian Cancer Cells  COTI-2 Found to Correct Specific p53 Gene Mutation in Human Ovarian Cancer Cells
... restored the normal protein configuration of the R175H p53 gene mutation and did not affect normal p53 protein," said Dr. Wayne ... The gene mutation specific normalization of p53 protein configuration was observed at a very low concentration (10 nmol/l) that ... COTI-2 Found to Correct Specific p53 Gene Mutation in Human Ovarian Cancer Cells. ... stops cancer cells from replicating by correcting the effects of specific genetic errors affecting the p53 gene. COTI's ...
more infohttps://finance.yahoo.com/news/coti-2-found-correct-specific-141500810.html
rAd-p53 Gene Therapy for Advanced Malignant Thyroid Tumors - Full Text View - ClinicalTrials.gov  rAd-p53 Gene Therapy for Advanced Malignant Thyroid Tumors - Full Text View - ClinicalTrials.gov
Drug: rAd-p53 gene Procedure: surgery Drug: p53 gene therapy Radiation: p53 gene therapy with radioactive iodine Phase 4 ... p53 gene therapy plus radioactive iodine. Radiation: p53 gene therapy with radioactive iodine p53 gene therapy with concurrent ... Drug: rAd-p53 gene pre-surgery p53 gene treatment: 10exp12 virus particles per 3 days for 5 times ... Drug: p53 gene therapy p53 gene treatment: 10exp12 virus particles per 3 days for 10 times ...
more infohttps://clinicaltrials.gov/ct2/show/NCT00902122?cond=%22Li+Fraumeni+syndrome%22&rank=7
Role and Mutational Heterogeneity of the p53 Gene in Hepatocellular Carcinoma | Cancer Research  Role and Mutational Heterogeneity of the p53 Gene in Hepatocellular Carcinoma | Cancer Research
The mutational spectrum of the p53 gene was analyzed in 53 hepatocellular carcinomas. Somatic mutations of the p53 gene were ... around the p53 locus and at 17p13.3 to the telomere). Sixteen of the 17 cases with p53 gene mutations showed LOH around the p53 ... Role and Mutational Heterogeneity of the p53 Gene in Hepatocellular Carcinoma. Naoshi Nishida, Yoshihiro Fukuda, Hiroyuki ... Role and Mutational Heterogeneity of the p53 Gene in Hepatocellular Carcinoma. Naoshi Nishida, Yoshihiro Fukuda, Hiroyuki ...
more infohttp://cancerres.aacrjournals.org/content/53/2/368
Pilot studies on the p53 gene in nipple aspirate fluid from patients with breast cancer | SpringerLink  Pilot studies on the p53 gene in nipple aspirate fluid from patients with breast cancer | SpringerLink
Prosser J, Thompson AM, Granston G, Evans HJ: Evidence that p53 behaves as a tumour suppressor gene in sporadic breast tumours ... In this study we demonstrate that polymerase chain reaction (PCR) amplification of p53 gene DNA is achievable in a proportion ... Pilot studies on the p53 gene in nipple aspirate fluid from patients with breast cancer. ... Motomura K, Koyama H, Noguchi S, Inaji H, Azuma C: Detection of c-erbB-2 gene amplification in nipple discharge by means of ...
more infohttps://link.springer.com/article/10.1023%2FA%3A1006487315587
Cancer related gene p53 not regulated as indicated by previous tissue culture research ( The cellular cascade of molecular...  Cancer related gene p53 not regulated as indicated by previous tissue culture research ( The cellular cascade of molecular...
This study caused a big shift in how we think about p53 explains Sa...,Cancer,related,gene,p53,not,regulated,as,indicated,by, ... The chemical modifications of the p53 protein that we thought were es... ... Cancer related gene p53 not regulated as indicated by previous tissue culture research ... But when the cell senses that its DNA has been damaged, it slows down the degradation of p53, so that p53 protein levels can ...
more infohttp://www.bio-medicine.org/biology-news/Cancer-related-gene-p53-not-regulated-as-indicated-by-previous-tissue-culture-research-864-1/
CiNii 論文 - 
 		
 		
 			
 		 	
 		 		
 		 			Frequent Somatic Mutations of the APC and p53 Genes in Sporadic Ampullary...  CiNii 論文 - Frequent Somatic Mutations of the APC and p53 Genes in Sporadic Ampullary...
Frequent Somatic Mutations of the APC and p53 Genes in Sporadic Ampullary Carcinomas * * IMAI Yasuo ... Mutations in the p53 gene occur in diverse human tumour types NIGRO J. M. ... 5-Methylcytosine as an endogenous mutagen in the human LDL receptor and p53 genes. RIDEOUT W. M. III ... Selective G-to-T mutations of p53 gene in hepatocellular carcinoma from southern Africa BRESSAC B. ...
more infohttps://ci.nii.ac.jp/naid/10008080702
Genetic Interactions between the Wilms' Tumor 1 Gene and the p53 Gene | Cancer Research  Genetic Interactions between the Wilms' Tumor 1 Gene and the p53 Gene | Cancer Research
One of these modifiers is the p53 protein. To investigate a genetic interaction between the p53 gene and the wt1 gene, we have ... Kidney sections of p53-null and wt1het/p53-null mice. A, normal p53-null kidney. B, wt1het/p53-null kidney showing ... Genetic Interactions between the Wilms' Tumor 1 Gene and the p53 Gene Aswin L. Menke, Alan R. Clarke, Andrea Leitch, Annemieke ... The WT1 gene product stabilizes p53 and inhibits p53 mediated apoptosis. Genes Dev., 9: 2143-2156, 1995. ...
more infohttp://cancerres.aacrjournals.org/content/62/22/6615?ijkey=f9b1feda88d7a8a55cd7b2abca44ada9b02e8235&keytype2=tf_ipsecsha
Is the p53 gene truly the guardian of the genome? - The Johns Hopkins News-Letter  Is the p53 gene truly the guardian of the genome? - The Johns Hopkins News-Letter
... highly cited statistic that p53 mutations are found in just over 50 percent of all human cancers suggests that when the gene is ... The p53 gene is widely known as a cancer suppressor gene that reduces the frequency of tumors - but what if that wasn't the ... PUBLIC DOMAIN Recently, researchers discovered that the p53 gene can both stop and accelerate cancer growth. The p53 gene is ... The p53 gene also acts as a checkpoint for cells when undergoing the growth cycle: p53 can check if cell functions are being ...
more infohttps://www.jhunewsletter.com/article/2019/02/is-the-p53-gene-truly-the-guardian-of-the-genome
Metabolic 'reprogramming' by the p53 gene family leads to tumor regression - Healthcanal.com : Healthcanal.com  Metabolic 'reprogramming' by the p53 gene family leads to tumor regression - Healthcanal.com : Healthcanal.com
Scientists have found that altering members of the p53 gene family, known as tumor suppressor genes, causes rapid regression of ... "P53 is altered in most human cancers and p53 reactivation suppresses tumors in vivo in mice. This strategy has proven difficult ... "The p53 family interacts extensively in cellular processes that promote tumor suppression," said Flores. "Thus, a clear ... "We found that IAPP is involved in tumor regression and that amylin, the protein encoded by the IAPP gene, stops a cell's ...
more infohttps://www.healthcanal.com/cancers/57443-metabolic-reprogramming-by-the-p53-gene-family-leads-to-tumor-regression.html
Role of p53 Gene in Metabolism Regulation in Patients With Li-Fraumeni Syndrome  Role of p53 Gene in Metabolism Regulation in Patients With Li-Fraumeni Syndrome
littermates, mice deficient in p53 display a gene dose-dependent decrease in aerobic. exercise capacity, implying that p53 has ... of p53 gene are so common in cancers by potentially conferring metabolic advantages in. tumorigenesis, but they may also give ... We have recently reported that TP53 (encoding p53 protein), one of the most frequently. mutated genes in human cancers, dose ... Metabolic Regulation by Tumor Suppressor p53 in Li-Fraumeni Syndrome. Trial Phase:. N/A. Minimum Age:. 18 Years. Maximum Age:. ...
more infohttp://www.knowcancer.com/cancer-trials/NCT00406445/
Correlative study between apoptotic factors and the expression of p53 gene in hepatocellular carcinoma patients for  Correlative study between apoptotic factors and the expression of p53 gene in hepatocellular carcinoma patients for
... ... Correlative study between apoptotic factors and the expression of p53 gene in hepatocellular carcinoma patients for * ... Correlative study between apoptotic factors and the expression of p53 gene in hepatocellular carcinoma patients for Author(S). ... Correlative study between apoptotic factors and the expression of p53 gene in hepatocellular carcinoma patients for ...
more infohttp://www.philadelphia.edu.jo/newlibrary/eng/english-books/671-english-books/95202-engb-95202
P53-responsive gene 1 - Wikipedia  P53-responsive gene 1 - Wikipedia
P53-responsive gene 1 is a protein that in humans is encoded by the PRG1 gene. "Human PubMed Reference:". "Entrez Gene: P53- ... responsive gene 1". Retrieved 2017-11-07. Ozalp S, Yalcin OT, Tanir HM, Kabukcuoglu S, Erol G (2003). "p53 overexpression as a ... "P53 and K-ras mutations are frequent events in microscopically negative surgical margins from patients with nonsmall cell lung ...
more infohttps://en.wikipedia.org/wiki/P53-responsive_gene_1
Detection of p53 Gene in Breast Cancer by Denaturing Gradient Gel Electrophoresis and the DCode System ( 		       Akira...  Detection of p53 Gene in Breast Cancer by Denaturing Gradient Gel Electrophoresis and the DCode System ( Akira...
... p53,Gene,in,Breast,Cancer,by,Denaturing,Gradient,Gel,Electrophoresis,and,the,DCode,System,biological,advanced biology ... One hundred and two genomic DNA sam ples obtained from breast cancers were examined from exon 5, 6, 7 and 8 of the p53 gene. ... Detection of p53 Gene in Breast Cancer by Denaturing Gradient Gel Electrophoresis and the DCode System ... Gene Expression Arrays: Highly Sensitive Detection of Expression Patterns with Improved Tools for Target Amplification. 7. The ...
more infohttp://www.bio-medicine.org/biology-technology/Detection-of-p53-Gene-in-Breast-Cancer-by-Denaturing-Gradient-Gel-Electrophoresis-and-the-DCode-System-1111-1/
Expression of VEGF-A, Otx Homeobox and p53 Family Genes in Proliferative Vitreoretinopathy  Expression of VEGF-A, Otx Homeobox and p53 Family Genes in Proliferative Vitreoretinopathy
... p53, and p63 genes showed the same expression trend (Figure 4). We found higher levels of VEGF-A, Otx2, p53, and p63 genes ... Figure 4: Statistical correlation among VEGF-A, Otx2, p53, and p63 genes and between Otx1 and Otx3 genes. Dispersion plots ... among VEGF-A versus Otx2, p53, and p63; Otx2 versus VEGF-A, p53, and p63; p53 versus VEGF-A, Otx2, and p63, and finally p63 ... Gene levels were detected by quantitative PCR. values representing gene expression are shown on -axis. Black column: adult ...
more infohttps://www.hindawi.com/journals/mi/2013/857380/
An association study of the codon 72 polymorphism in the pro-apoptotic gene p53 and Alzheimer's disease. - Semantic Scholar  An association study of the codon 72 polymorphism in the pro-apoptotic gene p53 and Alzheimer's disease. - Semantic Scholar
... association study between sporadic AD and the common proline/arginine polymorphism at codon 72 in the pro-apoptotic gene p53, ... These findings show no evidence for an association between p53 codon 72 polymorphism and AD in our population. ... Recent studies have demonstrated that p53-associated apoptosis is involved in the pathogenesis of Alzheimer's disease (AD). We ... Association study between P53 and P73 gene polymorphisms and the sporadic late-onset form of Alzheimer's disease. *Renato ...
more infohttps://www.semanticscholar.org/paper/An-association-study-of-the-codon-72-polymorphism-Rosenmann-Meiner/7b2045b8204569b29eb426a6e8de3778407cf094
P53 Gene: Mutation and Immunohistochemical Analysis in Patients with Invasive Ductal Carcinoma of Breast | Science Publications  P53 Gene: Mutation and Immunohistochemical Analysis in Patients with Invasive Ductal Carcinoma of Breast | Science Publications
... the presence of p53 gene alterations has been associated with worse prognosis. This study was attempted to associate p53 gene ... of the p53 gene. Mutations were confirmed by direct DNA sequencing. Samples were also analyzed for expression of p53 ... We support that mutation in p53 gene can be exploited as a prognostic marker for the early diagnosis of breast cancer, although ... Although the occurrence of this mutation was very less, we did not find expression of p53 protein immunohistochemicaly. ...
more infohttp://thescipub.com/abstract/10.3844/ajbbsp.2013.395.403