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*  Quantitation of MYC Gene Expression in Sporadic Breast Tumors with a Real-Time Reverse Transcription-PCR Assay | Cancer Research
Relationship between MYC mRNA Levels and MYC Gene Copy Numbers.. Among the 134 tumors studied for MYC expression at the RNA ... Among the 10 tumors with extra copies of the MYC gene, there were only 4 cases in which real-time RT-PCR showed MYC gene ... Final results, expressed as N-fold differences in MYC gene expression relative to the TBP gene and the calibrator, termed RMYC ... We also found that MYC gene overexpression was rarely due to an increased MYC gene copy number in breast cancer. This new, ...
http://cancerres.aacrjournals.org/content/59/12/2759
*  Selection against PUMA gene expression in Myc-driven B-cell lymphomagenesis.
... Garrison, Sean P ... A key p53 target gene is PUMA, which encodes a BH3-only proapoptotic protein. Here we demonstrate that Puma deletion in the Emu ... Myc mouse model of Burkitt lymphoma accelerates lymphomagenesis and that approximately 75% of Emu-Myc lymphomas naturally ...
http://umu.diva-portal.org/smash/record.jsf?pid=diva2:209194
*  MYC | SelfDecode | Genome Analysis
CG10798 gene product from transcript CG10798-RB, CG10798-PA, CG10798-PB, class E basic helix-loop-helix protein 39, cmyc, c-MYC ... myc-a, myc-b, MYCC, Myc-PA, Myc-PB, myc proto-oncogene protein, myc-related translation/localization regulatory factor, ... c-myc20, c-Myc-a, c-Myc-b, c-myc-like protein, c-myc proto-oncogene, diminuitive, diminutive, DM, dm/dMyc, Dmel_CG10798, dm/myc ... v-myc avian myelocytomatosis viral oncogene-like protein, v-myc myelocytomatosis viral oncogene homolog, v-myc myelocytomatosis ...
https://www.selfdecode.com/gene/myc/
*  Myc Proto Oncogene Protein (Transcription Factor p64 or Class E Basic Helix Loop Helix Protein 39 or MYC) - Pipeline Review, H2...
Myc Proto Oncogene Protein (Transcription Factor p64 or Class E... ... Transcription Factor p64 or Class E Basic Helix Loop Helix Protein 39 or MYC) - Pipeline Review, H2 2017 report by Global ... 38 Pages Report] Check for Discount on Myc Proto Oncogene Protein ( ... Myc (c-Myc) protein encoded by Myc gene, a regulator gene that code for a transcription factor. The protein plays a role in ...
http://www.reportsnreports.com/reports/1222401-myc-proto-oncogene-protein-transcription-factor-p64-or-class-e-basic-helix-loop-helix-protein-39-or-myc-pipeline-review-h2-2017.html
*  Researchers tackle two difficult-to-treat lymphomas
BCL2 and/or BCL6 genes) and about 20 to 30 percent have double-expressor lymphoma (containing the MYC and BCL2 genes). ... This included an evaluation for chromosomal rearrangements involving the MYC, BCL2 and BCL6 genes, and testing for the presence ... About 5 to 10 percent have double-hit lymphoma (or cancer cells that contain chromosomal rearrangements of the MYC, ... of those genes as proteins in the lymphoma cells.. In total, they examined the tumor tissue and clinical data of 117 patients ...
https://www.cityofhope.org/herrera-clinical-oncology-lymphoma-study
*  HBD fusions - Picard Lab home
Deregulation of common genes by c-Myc and its direct target, MT-MC1. Proc. Natl. Acad. Sci. USA 102, 18968-18973 (2005). Burk, ... A new system for regulated functional gene expression for gene therapy applications: Nuclear delivery of a p16INK4A-estrogen ... Positive and negative regulation of gene expression in eukaryotic cells with an inducible transcriptional regulator. Gene Ther ... Modulation of cyclin gene expression by adenovirus E1A in a cell line with E1A-dependent conditional proliferation. J. Virol. ...
http://spotidoc.com/doc/695589/hbd-fusions---picard-lab-home
*  lncRNA MYU plays a critical role in the proliferation and tumorigenicity of colon cancer cells. | lncRNA Blog
c-Myc regulates multiple biological processes through its ability to directly modulate gene expression. Here, researchers from ... These results suggest that the MYU/hnRNP-K/CDK6 pathway functions downstream of Wnt/c-Myc signaling and plays a critical role ... Wnt/β-catenin signaling induces the expression of the transcription factor c-Myc, leading to cell proliferation and ... breast cancer cancer chromatin colorectal cancer database epigenetic epigenetics gastric cancer gencode gene expression gene ...
http://www.lncrnablog.com/lncrna-myu-plays-a-critical-role-in-the-proliferation-and-tumorigenicity-of-colon-cancer-cells/
*  Gene amplification synonyms, gene amplification antonyms - FreeThesaurus.com
Antonyms for gene amplification. 46 synonyms for amplification: increase, boosting, stretching, strengthening, expansion, ... extension, widening, raising, heightening, deepening, lengthening.... What are synonyms for gene amplification? ... PCR technique for relative gene copy number quantification to the determination of the relationship between NKX3.1 loss and MYC ... HER-2/neu gene copy number quantifed by real-time PCR: comparison of gene amplification, heterorygosity, and ...
http://www.freethesaurus.com/gene+amplification
*  Transcription factor LKLF is sufficient to program T cell quiescence via a c-Myc-dependent pathway. | Scholars@Duke
Transcription factor LKLF is sufficient to program T cell quiescence via a c-Myc-dependent pathway.'s profile, publications, ... Conversely, LKLF-deficient peripheral T cells produced by gene targeting showed increased proliferation, increased cell size ... Transcription factor LKLF is sufficient to program T cell quiescence via a c-Myc-dependent pathway. Journal Article ... LKLF appeared to function, at least in part, by decreasing expression of the proto-oncogene encoding c-Myc. Forced expression ...
https://scholars.duke.edu/display/pub720432
*  Genes | Free Full-Text | Modeling and Targeting MYC Genes in Childhood Brain Tumors
Deregulated expression of the MYC family of transcription factors, particularly c-MYC and MYCN genes, has been found in many of ... Elevated c-MYC/MYCN initiates and drives tumorigenesis in many in vivo model systems of pediatric brain tumors. Therefore, ... In this review, we explore the roles of MYC oncoproteins and their molecular targets during the formation, maintenance, and ... We also briefly summarize recent progress in the development of therapeutic approaches for pharmacological inhibition of MYC ...
http://www.mdpi.com/2073-4425/8/4/107
*  c-myc - C-myc - Mus musculus (Mouse) - c-myc gene & protein
IPR003327. Myc-LZ. IPR002418. Tscrpt_reg_Myc. IPR012682. Tscrpt_reg_Myc_N. ... IPR003327. Myc-LZ. IPR002418. Tscrpt_reg_Myc. IPR012682. Tscrpt_reg_Myc_N. ... Gene namesi. Name:c-mycImported. ,p>Information which has been imported from another database using automatic procedures.,/p> , ... tr,Q6WDF1,Q6WDF1_MOUSE C-myc (Fragment) OS=Mus musculus OX=10090 GN=c-myc PE=4 SV=1 ...
http://www.uniprot.org/uniprot/Q6WDF1
*  Reactome | MYC gene:H2B K121ub H3K4me3 nucleosome [nucleoplasm]
MYC gene:H2B K121ub H3K4me3 nucleosome [nucleoplasm] (Bos taurus) MYC gene:H2B K121ub H3K4me3 nucleosome [nucleoplasm] (Canis ... MYC gene:H2B K121ub H3K4me3 nucleosome [nucleoplasm] (Mus musculus) MYC gene:H2B K121ub H3K4me3 nucleosome [nucleoplasm] (Oryza ... SET1 complex trimethylates H3K4 at the MYC gene (Homo sapiens) * MYC gene:H2B K121ub H3K4me3 nucleosome [nucleoplasm] (Homo ... MYC gene:H2B K121ub H3K4me3 nucleosome [nucleoplasm] (Rattus norvegicus) MYC gene:H2B K121ub H3K4me3 nucleosome [nucleoplasm] ( ...
https://reactome.org/content/detail/R-HSA-3364034
*  Reducing Myc gene activity extends healthy lifespan in mice | News from Brown
Mice with one rather than the normal two copies of the gene Myc (also found in humans) lived 15 percent longer and had ... Reducing Myc gene activity extends healthy lifespan in mice. January 22, 2015 Media contact: David Orenstein 401-863-1862 ... Mice with one rather than the normal two copies of the gene Myc (also found in humans) lived 15 percent longer and had ... Genome-wide patterns of gene expression showed that Myc heterozygotes had significant differences in pathways related to ...
https://news.brown.edu/articles/2015/01/myc
*  The Myc gene and its possible relation to ageing in mice
MYC. Rattus norvegicus. Myc. External links. Mouse Genome Informatics. Search. Ensembl. Search. Entrez Gene. View on Entrez ... GenAge entry for Myc (Mus musculus). Gene information (ID: 1876). Symbol. Myc. Name. myelocytomatosis oncogene. Organism. Mus ... GenAge human genes. *A homolog of this gene for Homo sapiens is present as MYC ... Gene Expression Projects focused on gene expression profiling of ageing and of dietary manipulations of ageing, such as caloric ...
http://genomics.senescence.info/genes/details.php?id=1876
*  MYC Gene Rearrangements Are Closely Associated with Poor Survival of Diffuse Large B Cell Lymphoma with Hepatitis B Virus...
MYC Gene Rearrangements Are Closely Associated with Poor Survival of Diffuse Large B Cell Lymphoma with Hepatitis B Virus ... Zhihe Liu, Siyun Li, Wei Guo, Yinping Wang, Ming Wang, and Ou Bai, "MYC Gene Rearrangements Are Closely Associated with Poor ...
https://www.hindawi.com/journals/bmri/2017/1967648/cta/
*  Precursor B-Cell Acute Lymphoblastic Leukemia/Lymphoma with L3 Morphology, Philadelphia Chromosome, MYC Gene Translocation, and...
Figure 5: Interphase FISH analysis showing a normal chromosome 9 and 22, MYC gene translocation, and an extra red MYC signal ... A MYC gene rearrangement is most frequently associated with Burkitt lymphoma yet has been reported in other mature and immature ... Additionally, the MYC gene translocation and Philadelphia chromosome were also present. Although cases of ALL with co- ... Interphase FISH analysis for t(9;22) and a MYC gene translocation revealed multiple genetic alterations including: a cell line ...
https://www.hindawi.com/journals/cripa/2013/679892/
*  Fluorescence in situ hybridization for c-myc gene shows | Open-i
Fluorescence in situ hybridization for c-myc gene shows one fusion, one red and one green signal (original magnification ×1000 ... Mentions: C-myc gene rearrangement was detected in 94.6% (87/92) [Figure 4] by FISH. Five cases without c-myc gene ... Mentions: C-myc gene rearrangement was detected in 94.6% (87/92) [Figure 4] by FISH. Five cases without c-myc gene ... Figure 4: Fluorescence in situ hybridization for c-myc gene shows one fusion, one red and one green signal (original ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC4836256_CMJ-128-510-g004&req=4
*  DNA Rearrangement and Expression of the c-myc Gene in a Human Myeloma | Springer for Research & Development
... disease-associated chromosomal translocations that bring into contiguity one of the immunoglobulin gene loci with the c-myc... ... Hollis G.F., Gazdar A.F., Kirsch I.R. (1986) DNA Rearrangement and Expression of the c-myc Gene in a Human Myeloma. In: ... This is supported by the fact that in these tumors only the c-myc gene involved in the translocation is expressed (Taub 1984). ... DNA Rearrangement and Expression of the c-myc Gene in a Human Myeloma. ...
https://rd.springer.com/chapter/10.1007/978-3-642-71562-4_33
*  Expression and Amplification of myc Gene Family in Small Cell Lung Cancer and Its Relation to Biological Characteristics |...
The cell lines and tumors with the amplified myc always expressed their corresponding myc genes. The results suggested that ... myc, N-myc, or L-myc were detected in 16 out of 18 lines (89%) and in five out of six patient tumors (83%), when compared with ... The amplification of the myc gene family was observed in nine out of 18 lines (50%) and five out of 23 patient tumors (22%). ... Expression and Amplification of myc Gene Family in Small Cell Lung Cancer and Its Relation to Biological Characteristics. ...
http://cancerres.aacrjournals.org/content/49/10/2683
*  Identifying Myc target genes (direct and indirect) involved in key features of pancreatic islet tumourigenesis
c-Myc encodes a transcription factor, the onco-protein c-MYC, that acts as a master regulator of genes involved in diverse ... Identifying Myc target genes (direct and indirect) involved in key features of pancreatic islet tumourigenesis ... Discussed here is a study of c-Myc induced target genes involved in pancreatic islet tumourigenesis using a large scale ... The c-Myc oncogene is overexpressed or deregulated in many human cancers, and is often associated with aggressive, poorly ...
https://warwick.ac.uk/fac/sci/moac/people/students/2003/sam_robson/usergroups/myc/
*  PLOS ONE: Cell-Type Independent MYC Target Genes Reveal a Primordial Signature Involved in Biomass Accumulation
Using a model of human B lymphoma cells bearing inducible MYC, we identified a stringent set of direct Myc target genes via ... lung cancers or Ewing sarcomas has the highest correlation with MYC expression. Annotation of this gene signature reveals Myc's ... The MYC oncogene, which produces the Myc transcription factor, is frequently altered in human cancer and is a major regulatory ... We also identified direct Myc targets in human embryonic stem cells (ESCs). We further document that a Myc core signature (MCS ...
https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0026057.g003
*  SAP155-Mediated Splicing of FUSE-Binding Protein-Interacting Repressor Serves as a Molecular Switch for c-myc Gene Expression |...
SAP155-Mediated Splicing of FUSE-Binding Protein-Interacting Repressor Serves as a Molecular Switch for c-myc Gene Expression. ... SAP155-Mediated Splicing of FUSE-Binding Protein-Interacting Repressor Serves as a Molecular Switch for c-myc Gene Expression ... SAP155-Mediated Splicing of FUSE-Binding Protein-Interacting Repressor Serves as a Molecular Switch for c-myc Gene Expression ... SAP155-Mediated Splicing of FUSE-Binding Protein-Interacting Repressor Serves as a Molecular Switch for c-myc Gene Expression ...
http://mcr.aacrjournals.org/content/early/2012/05/22/1541-7786.MCR-11-0462
*  The c-myc gene paradox in Burkitt's lymphoma chromosomal translocation. - Radcliffe Department of Medicine
The c-myc gene paradox in Burkitt's lymphoma chromosomal translocation. Rabbitts TH., Baer R., Davis M., Forster A., Hamlyn PH ...
https://www.rdm.ox.ac.uk/publications/601859
*  C-myc required by the immune system ( c-myc a gene commonly involved in canc...)
MacDonald the study is basic research that may have ...,C-myc,required,by,the,immune,system,biological,biology news articles, ... c-myc a gene commonly involved in cancer onset has been found to hav...In order to rapidly and efficiently respond to new ... C-myc required by the immune system. c-myc a gene commonly involved in cancer onset has been found to hav...In order to rapidly ... c-myc, a gene commonly involved in cancer onset, has been found to have a role in the immune system's normal function according ...
http://www.bio-medicine.org/biology-news/C-myc-required-by-the-immune-system-3443-1/
*  Hydra myc2, a unique pre-bilaterian member of the myc gene family, is activated in cell proliferation and gametogenesis |...
Other members of the vertebrate myc gene family are B-myc, L-myc, N-myc, and s-myc (Eisenman, 2001; Eilers and Eisenman, 2008; ... pBS-hy1/v-myc, pBS-v/hy1-myc, pBS-v-myc, pRCAS-hy1/v-myc, pRCAS-v/hy1-myc, and pRCAS-v-myc have been described (Hartl et al., ... hy2/v-myc, v/hy2-myc, hy1/v-myc, v/hy1-myc). The empty RCAS vector and the RCAS-v-myc construct encoding the 416-amino acid ... Hydra Myc interaction with a potential Myc target gene promoter. Co-expression of myc1, myc2, and CAD in interstitial stem ...
http://bio.biologists.org/content/3/5/397