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*  Lethal gene - definition of lethal gene by The Free Dictionary
lethal gene synonyms, lethal gene pronunciation, lethal gene translation, English dictionary definition of lethal gene. n. a ... gene that under certain conditions causes the death of an organism. Also called le′thal fac`tor, le′thal muta′tion. Noun 1. ... le′thal gene′. n. a gene that under certain conditions causes the death of an organism. Also called le′thal fac`tor, le′thal ... Lethal gene - definition of lethal gene by The Free Dictionary https://www.thefreedictionary.com/lethal+gene ...
https://www.thefreedictionary.com/lethal+gene
*  Lethal Gene Mutation Key to Blocking Cholesterol Processing Uncovered
They found that the gene shares 75 percent of its sequence with a human gene called ANG2 (Another New Gene 2), and also shares ... Lethal Gene Mutation Key to Blocking Cholesterol Processing Uncovered. By Thomas Jefferson University Hospital, Apr 20, 2006 - ... The gene is well conserved across species and no one has discovered its function as yet, which makes it very exciting. The gene ... A number of genes that regulate lipid metabolism have yet to be determined, and there s much to learn about how animals process ...
http://www.rxpgnews.com/biochemistry/Lethal_Gene_Mutation_Key_to_Blocking_Cholesterol_P_4094_printer.shtml
*  The Drosophila melanogaster gene lethal(3)73Ah encodes a ring finger protein homologous to the oncoproteins MEL-18 and BMI-1. ...
Gene. 1995 Oct 3;163(2):203-8. Research Support, Non-U.S. Gov't ... The lethal(3)73Ah gene is located in a densely transcribed ... Gene. 1995 Oct 3;163(2):203-8.. The Drosophila melanogaster gene lethal(3)73Ah encodes a ring finger protein homologous to the ... The Drosophila melanogaster (Dm) gene lethal(3)73Ah, essential at the late pupal stage, encodes a protein with a novel Cys-rich ... Amino-acid sequence comparison revealed a striking homology of the entire lethal(3)73Ah sequence to the gene products of the ...
https://www.ncbi.nlm.nih.gov/pubmed/7590267?dopt=Abstract
*  Why Are Dominant Lethal Genes Rare - portsettpon - dayviews.com
Lethal,,,Allele,,,Lecture,,,.,,,LETHAL,,,GENE,,,,ABSOLUTE,,,LETHAL,,,[DOMINANT,,,],,,AND,,,SUB-,,,LETHAL,,,GENE,,,[RECESSIVE ... genes,,much,,rarer,,than,,lethal,,recessive,,genes?,,ChaCha,,Answer:,,For,,most,,genes,,,you,,have,,two,,copies,,of,,each,,gene ... lethal.Why,do,dominant,lethal,alleles,occur,rarely?,.,It,is,how,evolution,eliminates,the,lethal,genes.,.Why,,are,,dominant,, ... lethal,gene,could,.Why,are,dominant,lethal,genes,rare?,genome,,environment.,Development,of,a,multicellular,organism,from,a, ...
http://dayviews.com/portsettpon/524007645/
*  Method for treating a metastatic carcinoma using a conditionally lethal gene - Patent # 5997859 - PatentGenius
... construct which directs the expression of a gene product (e.g., HSVTK) that activates a compound with little or no cytotoxicity ... said gene being expressed in said metastaticcarcinoma, said gene encoding a conditionally lethal gene product which activates a ... Thus, conditionally lethal genes from transcriptional promoter elements responsive to these viral "immediate early" gene ... Alternatively, a singlevector which directs the expression of both a cytotoxic gene or gene product, and a gene which encodes ...
http://www.patentgenius.com/patent/5997859.html
*  Red Tide is a Lethal Replikins Gene Disorder | BioSpace
Red Tide is a Lethal Replikins Gene Disorder - read this article along with other careers information, tips and advice on ... lethal gene structural conservation, mutations, and rapid replication. Joint work* on advance detection provides time and gene ... Red Tide is a Lethal Replikins Gene Disorder. Published: Dec 03, 2018 ... 0.001 in 2016 and 2017 to contain two years pre-outbreak increasing highest concentration range of lethal Gene Replikin ...
https://www.biospace.com/article/releases/red-tide-is-a-lethal-replikins-gene-disorder/
*  Changing Channels-Modifier Gene Renders Mutation Lethal | ALZFORUM
A case in point is the mouse sodium channel modifier 1 (SCNM1), a gene that can turn a chronic disorder into a lethal disease. ... In the C57BL/6 background, a mutation in the sodium channel gene 8a (Scn8a) is lethal, and pups die after a month. In the ... Some diseases, such as familial Alzheimer's disease (FAD), arise from a mutation in a single gene. In sporadic AD, however, ... complex interactions among multiple genes underlie the phenotype, and under these circumstances genetic background may strongly ...
https://www.alzforum.org/news/research-news/changing-channels-modifier-gene-renders-mutation-lethal
*  Body clock gene may help lethal spread of breast cancer | New Scientist
... and now a gene associated with the body clock seems to makes its spread more likely in mice ... Body clock gene may help lethal spread of breast cancer. The precise links between circadian rhythms and cancer's spread are ... which codes for a protein that binds to and controls the activity of other genes within a cell. The team then used gene-editing ... Loss of a gene related to Arnt12 does seem to be associated with an increase in lung cancer, an effect that is enhanced when ...
https://www.newscientist.com/article/2106849-body-clock-gene-may-help-lethal-spread-of-breast-cancer/
*  The Ceratitis capitata homologue of the Drosophila sex-determining gene sex-lethal is structurally conserved, but not sex...
The Ceratitis capitata homologue of the Drosophila sex-determining gene sex-lethal is structurally conserved, but not sex- ... The Ceratitis capitata homologue of the Drosophila sex-determining gene sex-lethal is structurally conserved, but not sex- ... The Ceratitis capitata homologue of the Drosophila sex-determining gene sex-lethal is structurally conserved, but not sex- ... The Ceratitis capitata homologue of the Drosophila sex-determining gene sex-lethal is structurally conserved, but not sex- ...
http://dev.biologists.org/content/125/8/1495
*  The good, the bad and the lethal: gene expression and metabolomics reveal physiological mechanisms underlying chronic thermal...
The good, the bad and the lethal: gene expression and metabolomics reveal physiological mechanisms underlying chronic thermal ... The good, the bad and the lethal: gene expression and metabolomics reveal physiological mechanisms underlying chronic thermal ... In this study, we conducted biochemical measurements (RT-qPCR of select genes and targeted, quantitative metabolomic profiling ... Patterns of gene expression were similar to those observed in acute ramping experiments reported previously: larvae reared at ...
https://stroudcenter.org/publications/gene-expression-metabolomics-reveal-physiological-mechanisms-underlying-chronic-thermal-effects-mayfly-larvae/
*  Binding of Superantigen Toxins into the CD28 Homodimer Interface Is Essential for Induction of Cytokine Genes That Mediate...
... to induce a lethal cytokine storm, and peptides that prevent this binding can suppress superantigen lethality. ... of Superantigen Toxins into the CD28 Homodimer Interface Is Essential for Induction of Cytokine Genes That Mediate Lethal Shock ...
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1001149
*  Scientists Isolate Genes that Made 1918 Flu Lethal | Infection Control Today
To find the gene or genes that enabled the virus to invade the lungs, Kawaoka and his group blended genetic elements from the ... One exception, however, included a complex of three genes that, acting in concert with another key gene, allowed the virus to ... That gene makes hemagglutinin, a protein found on the surface of the virus and that confers on viral particles the ability to ... Using the relic genes, Kawaoka's group was able to generate viruses that carry different combinations of the 1918 virus and ...
https://www.infectioncontroltoday.com/influenza/scientists-isolate-genes-made-1918-flu-lethal
*  A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor. | Sigma-Aldrich
A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor.. [Nicholas C Turner, Christopher J ... Inhibitors of poly (ADP-ribose)-polymerase-1 (PARP) are highly lethal to cells with deficiencies in BRCA1, BRCA2 or other ... To discover new determinants of sensitivity to these drugs, we performed a PARP-inhibitor synthetic lethal short interfering ... These results highlight the potential of synthetic lethal siRNA screens with chemical inhibitors to define new determinants of ...
https://www.sigmaaldrich.com/catalog/papers/18388863
*  Scientists isolate genes that made 1918 flu lethal
... December 29, 2008 By Terry Devitt ... To find the gene or genes that enabled the virus to invade the lungs, Kawaoka and his group blended genetic elements from the ... One exception, however, included a complex of three genes that, acting in concert with another key gene, allowed the virus to ... That gene makes hemagglutinin, a protein found on the surface of the virus and that confers on viral particles the ability to ...
https://news.wisc.edu/scientists-isolate-genes-that-made-1918-flu-lethal/
*  Long-term treatment success using gene therapy to correct a lethal metabolic disorder | EurekAlert! Science News
... long-lasting reductions in bilirubin levels in a mouse model of CNS1 and is described in an Open Access article in Human Gene ... A new gene therapy approach to correcting this metabolic error achieved significant, ... Excessive and often lethal blood levels of bilirubin can result from mutations in a single gene that are the cause of the ... IMAGE: Human Gene Therapy, the Official Journal of the European Society of Gene and Cell Therapy, British Society for Gene and ...
https://www.eurekalert.org/pub_releases/2014-10/mali-lts100914.php
*  In highly lethal type of leukemia, cancer gene predicts treatment response | EurekAlert! Science News
Those whose leukemia cells carried mutations in a nefarious cancer gene called TP53 consistently achieved remission after ... Patients with the most lethal form of acute myeloid leukemia (AML) -- based on genetic profiles of their cancers -- typically ... In highly lethal type of leukemia, cancer gene predicts treatment response Patients whose cancer cells carry TP53 mutations ... In Highly Lethal Type of Leukemia, Cancer Gene Predicts Treatment Response (IMAGE) view more ...
https://www.eurekalert.org/pub_releases/2016-11/wuso-ihl111816.php
*  Aggressive, Lethal Brain Cancer Tied To Gene Mutation, Study Finds
... Brain InjuryAggressive, Lethal Brain Cancer Tied To Gene ... "Although each gene plays a specific role in the cell, sometimes errors in the DNA cause two ordinary genes to fuse into a ... looking specifically for gene fusions. The most common fusion they observed involved the genes FGFR (fibroblast growth factor ... "But we may be able to discover a number of other gene fusions, each accounting for a small percentage of tumors, and each with ...
https://tbilaw.com/blog/aggressive-lethal-brain-cancer-tied-to-gene-mutation-study-finds/
*  Project: Identification and cloning, by the use of a mouse molecular genetic approach, of new genes protecting against lethal...
Project: Identification and cloning, by the use of a mouse molecular genetic approach, of new genes protecting against lethal ... induced lethal inflammation. TNF plays a central role in a lot of pathologies and induces lethal cardiovascular shock and ... In this project, we want to identify and clone the genes responsible for resistance against Tumor Necrosis Factor (TNF)- ...
https://biblio.ugent.be/project/3G026001
*  Long-term treatment success using gene therapy to correct a lethal metaboli... ( New Rochelle NY October 9 2014-...)
... gene,therapy,to,correct,a,lethal,metabolic,disorder,biological,biology news articles,biology news today,latest biology news, ... CNS1 is an outstanding model for in vivo gene therapy with easily mea...,Long-term,treatment,success,using, ... New Rochelle NY October 9 2014-Excessive and often lethal blo...In a target _blank href http://online.liebertpub.com/doi/full/ ... In "Life-Long Correction of Hyperbilirubinemia with a Neonatal Liver-Specific AAV-Mediated Gene Transfer in a Lethal Mouse ...
http://www.bio-medicine.org/biology-news-1/Long-term-treatment-success-using-gene-therapy-to-correct-a-lethal-metabolic-disorder-38379-1/
*  mel-26 - Protein maternal effect lethal 26 - Caenorhabditis elegans - mel-26 gene & protein
Gene expression databases. Bgee dataBase for Gene Expression Evolution. More...Bgeei. WBGene00003209 Expressed in 5 organ(s), ... based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.,p>,a href='/help/gene_centric_isoform_ ... Gene expression databases. Bgeei. WBGene00003209 Expressed in 5 organ(s), highest expression level in adult organism. ... This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a ...
https://www.uniprot.org/uniprot/Q94420
*  Structure-based systematic isolation of conditional-lethal mutations in the single yeast calmodulin gene. | Genetics
Five were lethal, 6 were lethal only in synthetic medium 13 were temperature-sensitive lethal and 2 had no discernible ... Conditional-lethal mutations of the single calmodulin gene in Saccharomyces cerevisiae have been very difficult to isolate by ... Structure-based systematic isolation of conditional-lethal mutations in the single yeast calmodulin gene.. Y Ohya and D ... Structure-based systematic isolation of conditional-lethal mutations in the single yeast calmodulin gene.. Y Ohya and D ...
http://www.genetics.org/content/138/4/1041?ijkey=92d06964797592024beccd68c1f29ae396b9812a&keytype2=tf_ipsecsha
*  raly - Autoantigenic hnRNP-associated with lethal yellow - Danio rerio (Zebrafish) - raly gene & protein
ZFIN:ZDB-GENE-041010-127. Synonyms:RALYImported. ,p>Information which has been imported from another database using automatic ... p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source ... Autoantigenic hnRNP-associated with lethal yellowImported. ,p>Information which has been imported from another database using ... Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.,p>,a href='/help/gene_name' target='_top ...
http://www.uniprot.org/uniprot/Q6TGV1
*  Sex-lethal, the master sex-determining gene in Drosophila, is not sex-specifically regulated in Musca domestica. - Zurich Open...
Sex-lethal, the master sex-determining gene in Drosophila, is not sex-specifically regulated in Musca domestica. ... Sex-lethal (Sxl) is the master switch gene for somatic sex determination in Drosophila melanogaster. In XX animals, Sxl becomes ... Sex-lethal (Sxl) is the master switch gene for somatic sex determination in Drosophila melanogaster. In XX animals, Sxl becomes ... Meise, M; Hilfiker-Kleiner, D; Dübendorfer, A; Brunner, C; Nöthiger, R; Bopp, D (1998). Sex-lethal, the master sex-determining ...
https://www.zora.uzh.ch/id/eprint/170/
*  2012 News Feature: Rare lethal disorder traced to variant of the PIGA gene on the X chromosome - National Human Genome Research...
Home / Research at NHGRI / DIR News Features / 2012 News Feature: Rare lethal disorder traced to variant of the PIGA gene on ... 2012 News Feature: Rare lethal disorder traced to variant of the PIGA gene on the X chromosome ... Rare lethal disorder traced to variant of the PIGA gene on the X chromosome. Next generation sequencing plays key role in ... 2012 News Feature: Rare lethal disorder traced to variant of the PIGA gene on the X chromosome. #query {background:#565656; ...
https://www.genome.gov/27546978/2012-news-feature-rare-lethal-disorder-traced-to-variant-of-the-piga-gene-on-the-x-chromosome/