David F. Stern, PhD > Stern Lab | Pathology | Yale School of...
Amin DN, Perkins AS, Stern DF: Gene expression profiling of ErbB receptor and ligand-dependent transcription. Oncogene. 2004 ... Amin DN, Tuck D, Stern DF: Neuregulin-regulated gene expression in mammary carcinoma cells. Exp Cell Res. 2005 Sep 10. PMID: ... ERBB2 works in close partnership with other members of the EGF receptor (ERBB family) of tyrosine kinases, so we also study ... Neuregulin 1-activated ERBB4 interacts with YAP to induce Hippo pathway target genes and promote cell migration. Haskins JW, ...http://medicine.yale.edu/lab/stern/people/df_stern-2.profile
Clinical Utility of Serum Human Epidermal Growth Factor Receptor Type 2 Testing as a Marker of Therapeutic Response In Tissue...
Human Epidermal growth factor Receptor type 2 (HER2) is over expressed in 20.0-30.0% of breast cancers and is currently ... Yamauchi H, Stearns V, Hayes DF (2001) When is a tumor marker ready for prime time? A case study of c-erbB-2 as a predictive ... HER2 overexpression occurs in 20.0-30.0% of breast cancers, usually as a result of gene amplification [4,5], and is associated ... Fehm T, Gebauer G, Jäger W (2002) Clinical utility of serial serum c-erbB-2 determinations in the follow-up of breast cancer ...https://www.clinmedjournals.org/articles/ijccr/international-journal-of-cancer-and-clinical-research-ijccr-4-089.php?jid=ijccr
Epidermal growth factor receptor inhibitor with fluorouracil, leucovorin, and irinotecan as an alternative treatment for...
Expression profiles of ErbB family receptors and prognosis in primary transitional cell carcinoma of the urinary bladder. Clin ... Further analysis of the urothelial carcinoma of the urinary tract was carried out, and the results showed a wild-type KRAS gene ... Analysis of codons 12 and 13 of the KRAS gene in the excised colorectal cancer tissues revealed that they were mutation- ... They also found that urothelial carcinoma had more frequent mutations in chromatin regulatory genes. The current findings all ...https://jmedicalcasereports.biomedcentral.com/articles/10.1186/s13256-016-0879-6
Evaluation of C-ErbB-2 Overexpression and Her-2/neu Gene Copy Number Heterogeneity in Barrett's Adenocarcinoma
... neu gene is accompanied by overexpression of its cell surface receptor product, c‐erbB‐2 protein. To investigate the degree of ... Evaluation of C-ErbB-2 Overexpression and Her-2/neu Gene Copy Number Heterogeneity in Barrett's Adenocarcinoma. Axel Walch,1 ... In conclusion, we observed marked intratumoural heterogeneity of c‐erbB‐2 protein overexpression and Her‐2/neu gene copy number ... The observed heterogeneity could hamper the exact diagnostic determination of the c‐erbB‐2 status in small biopsies and ...https://www.hindawi.com/journals/acp/2000/947249/abs/
Cyclooxygenase-2 (COX2) gene silencing with siRNA could enhance DNA vaccination to inhibit established ErbB-2 carcinomas |...
... gene silencing with siRNA could enhance DNA vaccination to inhibit established ErbB-2 carcinomas. ... gene silencing with siRNA could enhance DNA vaccination to inhibit established ErbB-2 carcinomas ... The gene silencing efficacy of both plasmids was checked by transfecting COX2 over-expressing A17 cells. The plasmids were used ... The gene silencing efficacy of both plasmids was checked by transfecting COX2 over-expressing A17 cells. The plasmids were used ...https://pubblicazioni.unicam.it/handle/11581/250358
KAKEN - Research Projects | Study of mechanisms of development and growth in hormone (especially estrogen) dependent uterine...
Preliminary study of oncogene expressions in endometrial cancers-aberrant estrogen receptor gene and erbB-2-' Eur J Gynecol. ( ... Publications] Fujimoto J,et al.: 'Danazol decreases transcription of estrogen receptor gene in human monocytes.' Gen.Pharmac.26 ... Publications] Fujimoto J,et al.: 'Danazol Decreases Transcription of Estrogen Receptor Gene in Human Monocytes' Gen.Pharmac.26 ... Publications] Fujimoto J.,et al.: 'Danazol decreases transcription of estrogen receptor gene in human monocyte.' Gen. Pharmac. ...https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06671638/
TCF/LEF and CREB binding sites coexist in the promoters of some β-catenin target genes, such as cyclin D1 ( 40), TCRα ( 41), ... c-erbB-2 gene product directly associates with β-catenin and plakoglobin. Biochem Biophys Res Commun 1995; 208: 1067-72. ... The transcriptional coactivator CBP interacts with β-catenin to activate gene expression. J Cell Biol 2000; 149: 249-54. ... Eng C. Familial papillary thyroid cancer-many syndromes, too many genes? J Clin Endocrinol Metab 2000; 85: 1755-7. ...http://cancerres.aacrjournals.org/content/69/5/1867
MEK inhibition leads to PI3K/AKT activation by relieving a negative feedback on ERBB receptors. Cancer Res 2012;72:3228-37. ... 9, 10), activating EGFR mutations have rarely been reported, and EGFR gene copy number and KRAS mutational status were not ... Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell 1988;53:549-54. ... Prognostic significance of c-erbB-2 gene expression in pancreatic cancer patients. Neoplasma 2001;48:188-91. ...http://cancerres.aacrjournals.org/content/73/7/2221
Plakoglobin - Wikipedia
The JUP gene contains 13 exons spanning 17 kb on chromosome 17q21. Plakoglobin is a member of the catenin family, since it ... Kanai Y, Ochiai A, Shibata T, Oyama T, Ushijima S, Akimoto S, Hirohashi S (Mar 1995). "c-erbB-2 gene product directly ... Plakoglobin, also known as junction plakoglobin or gamma-catenin, is a protein that in humans is encoded by the JUP gene. ... Arnemann J, Spurr NK, Wheeler GN, Parker AE, Buxton RS (Jul 1991). "Chromosomal assignment of the human genes coding for the ...https://en.wikipedia.org/wiki/Plakoglobin
HER2/neu - Wikipedia
Molecular cloning of the gene showed that HER2, Neu, and ErbB-2 are all encoded by the same orthologs. ERBB2, a known proto- ... Olayioye MA, Graus-Porta D, Beerli RR, Rohrer J, Gay B, Hynes NE (September 1998). "ErbB-1 and ErbB-2 acquire distinct ... erbB-3 (neuregulin-binding; lacks kinase domain), and erbB-4. All four contain an extracellular ligand binding domain, a ... ErbB-2 was named for its similarity to ErbB (avian erythroblastosis oncogene B), the oncogene later found to code for EGFR. ...https://en.wikipedia.org/wiki/HER2/neu
Geldanamycin: the prototype of a class of antitumor drugs targeting the heat shock protein 90 family of molecular chaperones
Amplification of a novel v-erbB-related gene in a human mammary carcinoma. Science. 1985;229:974-976. [PubMed] ... Goldman R, Levy RB, Peles E, Yarden Y. Heterodimerization of the erbB-1 and erbB-2 receptors in human breast carcinoma cells: a ... Crit Rev Eukaryot Gene Expr. 1994;4:1-18. [PubMed]. *Magnuson NS, Beck T, Vahidi H, Hahn H, Smola U, Rapp UR. The raf-1 serine/ ... Genes Dev. 13:817-826. [PubMed]. *Ilic D, Furuta Y, and Kanazawa S. et al. 1995. Reduced cell motility and enhanced focal ...http://pubmedcentralcanada.ca/pmcc/articles/PMC434387/?lang=en-ca
Changes of telomere length with aging - Takubo - 2010 - Geriatrics & Gerontology International - Wiley Online Library
Odagiri E, Kanda N, Jibiki K et al. Reduction of telomeric length and c-erbB-2 gene amplification in human breast cancer, ... Next article in issue: Role of methylation of the hMLH1 gene promoter in the development of gastric and colorectal carcinoma in ... Next article in issue: Role of methylation of the hMLH1 gene promoter in the development of gastric and colorectal carcinoma in ... pylori has the proven ability to trigger gene mutation and cancer progression.36 Our results suggest that telomere shortening ...http://onlinelibrary.wiley.com/doi/10.1111/j.1447-0594.2010.00605.x/full
CiNii 論文 - RECENT ADVANCES IN THE MOLECULAR GENETICS OF UROGENITAL TUMORS ...
Enhanced expression of c-myc and epidermal growth factor receptor (c-erbB-1) genes in primary human renal cancer YAO M. ... 腎盂尿管癌における c-erbB-2, p53遺伝子産物過剰発現と Ki-67による細胞増殖動態の検討 橋本 博 , 須江 洋一 , 徳光 正行 , 佐賀 祐司 , 八竹 直 ... A novel insertional mutation at the third zinc finger coding region of the WT1 gene in Denys-Drash syndrome OGAWA O. ... Isolation and characterization of a zinc finger polypeptidehttp://ci.nii.ac.jp/naid/10008458527
Dynamic Interaction of PTPμ with Multiple Cadherins In Vivo | JCB
1994) c-erbB-2 gene product associates with catenin in human cancer cells. Biochem Biophys Res Commun 205:73-78, pmid:7999105. ... 1995) E-cadherin as a tumor (invasion) suppressor gene. BioEssays 17:97-99, pmid:7748170.. ... which are related to the product of the segment polarity gene armadillo, bind directly to the cytoplasmic segment of cadherin, ... Figure 2 Association of PTPμ with N-cadherin, E-cadherin, and cadherin-4 in extracts of rat lung. Extracts of rat lung were ...http://jcb.rupress.org/content/141/1/287.long
We sought to determine whether coamplification and overexpression of the topoisomerase IIα gene, near erbB-2 on chromosome 17, ... Other important features of this study are that we determined both overexpression and gene amplification for erbB-2, using a ... we studied both overexpression and gene copy number of both erbB-2 and topoisomerase IIα in a group of 35 patients with LABC ... based on the recent documentation that this gene is often coamplified with erbB-2 in breast cancer and is a well-known target ...http://clincancerres.aacrjournals.org/content/8/4/1061
Proto-oncogenes | definition of Proto-oncogenes by Medical dictionary
viral gene (e.g. in certain retroviruses) inducing host cell neoplasia. on·co·gene (ong'kō-jēn) Any of a family of genes that ... Quantification of c-erbB-2 gene expression in breast cancer by competitive RT-PCR ... on·co·gene. (ong'kō-jēn), 1. Any of a family of genes that normally encodes proteins that are involved in cell growth or ... on·co·gene (on'kō-jēn) Any of a family of genes, which under normal circumstances, code for proteins involved in cell growth or ...http://medical-dictionary.thefreedictionary.com/Proto-oncogenes
CA2069900C - Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor - Google Patents
These findings indicate that increased erbB-3 expression, as in the case of EGF-R and erbB-2, plays a role in some human ... prompting designation of the new gene as erbB-3. It was mapped to human chromosome 12q11-13 and was shown to be expressed as ... Characterization of the cloned DNA fragment mapped the region of v-erbB homology to three exons with closest homology of 64 % ... Markedly elevated erbB-3 mRNA levels were demonstrated in certain human mammary tumor cell lines. ...https://patents.google.com/patent/CA2069900C
Contents for Volume 22 / Issue 2
Gstm1 and Gstt1 Genes are Potential Risk Modifiers for Bladder Cancer. SZ Abdel-Rahman, PhD, WA Anwar, MD, WE Abdel-Aal, MD, HM ... Overexpression of C-erbB-2 protein in poorly differentiated gastric adenocarcinoma was closely associated with increased lymph- ... Prognostic Significance of c-erbB-2 Gene Expression in the Poorly Differentiated Type of Adenocarcinoma of the Stomach. Yutaka ... In patients with null alleles for both the polymorphic glutathione S-transferase genes GSTMI and GSTTI either individually or ...http://cancerprev.org/Journal/Issues/22/2/
Epidermal Growth Factor Receptor Kinase Domain Mutations in Esophageal and Pancreatic Adenocarcinomas | Clinical Cancer Research
EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to ... ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines. Proc Natl Acad ... Gene amplification in esophageal adenocarcinomas and Barrett's with high-grade dysplasia. Clin Cancer Res 2003;9:4819-25. ... Amplification and over-expression of the EGFR and erbB-2 genes in human esophageal adenocarcinomas. Int J Cancer 1993;54:213-9. ...http://clincancerres.aacrjournals.org/content/12/14/4283.long
adult nhl intermediate grade 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
MeSH-major] Gene Amplification. Genes, erbB-2 / genetics. In Situ Hybridization / methods. Lymphoma, Non-Hodgkin / diagnosis. ... Gene or Genome. A1.3. Manufactured Object. A1.3.1. Medical Device. A18.104.22.168. Drug Delivery Device. A1.3.2. Research Device. ... Receptor, ErbB-2 / genetics. *[MeSH-minor] Adult. Aged. Aged, 80 and over. Arabs. Biomarkers, Tumor / analysis. Chromogenic ... Haydeé Cottliar AS, Noriega MF, Narbaitz M, Rodríguez A, Slavutsky IR: Association between telomere length and BCL2 gene ...http://www.bmlsearch.com/?kwr=adult+nhl+intermediate+grade+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0
Patent US7524827 - Methods and compositions for the inhibition of gene expression - Google Patents
The present invention relates to methods and compositions for the inhibition of gene expression. In particular, the present ... gene (SEQ ID NO:29).. FIG. 4. shows the sequences of antigenes to c-erbB-2 used in some embodiments of the present invention. X ... a heterologous gene includes a gene from one species introduced into another species. A heterologous gene also includes a gene ... a viral gene, a bacterial gene, a microbial gene, a fungal gene). ... Ras gene alteration may cause the gene to stay in the "on" ...http://www.google.com/patents/US7524827?dq=6,548,982
Particle shape enhances specificity of antibody-displaying nanoparticles | PNAS
1995) ERBB-2 (HER2/neu) gene copy number, p185HER-2 overexpression, and intratumor heterogeneity in human breast cancer. Cancer ... 2. Nanoparticle uptake in BT-474 (A), SK-BR-3 (B), and MDA-MB-231 (C) cells. Open bars, nanoparticles with no trastuzumab on ... 2C).. The dependence of trastuzumab-induced nanoparticle uptake on shape and cell type is summarized in Fig. 3A. Spheres ... S1 B, i and ii). A small fraction of protein desorbed from particles in 2 h (trastuzumab: 5-10% in PBS and 7-12% in FBS-PBS; ...http://www.pnas.org/content/110/9/3270?ijkey=6171acb46af0fc4b295aaddccdb1482c3b5242b5&keytype2=tf_ipsecsha
Impact of HER2 codon 655 polymorphism and expression of HER2 and HER3 in non small cell lung cancer patients | springermedizin...
G-A polymorphism at amino acid codon 655 of the human erbB-2/HER2 gene. Nucleic Acids Res. 1991;19:5452. PubMedCentralPubMed ... G-A polymorphism at amino acid codon 655 of the human erbB-2/HER2 gene. Nucleic Acids Res. 1991;19:5452. PubMedCentralPubMed ... Grant S, Qiao L, Dent P. Roles of ERBB family receptor tyrosine kinases, and downstream signaling pathways, in the control of ... 2. Colby TV, Koss M, Travis WD. Tumors of the lower respiratory tract. 3rd ed. Washington, DC: Armed Forces Institute of ...https://www.springermedizin.at/impact-of-her2-codon-655-polymorphism-and-expression-of-her2-and/14928712
Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters | Nature Genetics
Howard Chang and colleagues report the identification of long noncoding RNAs transcribed from the promoters of cell-cycle genes ... Influence of TP53 gene alterations and c-erbB-2 expression on the response to treatment with doxorubicin in locally advanced ... Transcription of long noncoding RNAs (lncRNAs) within gene regulatory elements can modulate gene activity in response to ... Genes Dev. 8, 2540-2551 (1994).. **CAS*PubMed*Article*Google Scholar*40.. Morachis, J.M., Murawsky, C.M. & Emerson, B.M. ...https://www.nature.com/articles/ng.848?error=cookies_not_supported&code=c6497d3f-2b71-45a7-916f-adada681d8e8
Involvement of microRNAs in HER2 signaling and trastuzumab treatment | SpringerLink
Gene Ther. 2011;18(12):1121-6. doi: 10.1038/gt.2011.79.CrossRefPubMedPubMedCentralGoogle Scholar ... ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling. EMBO J. 1997;16(7): ... Gene. 2015;556(2):192-8. doi: 10.1016/j.gene.2014.11.053.CrossRefPubMedGoogle Scholar ... Use of 70-gene signature to predict prognosis of patients with node-negative breast cancer: a prospective community-based ...https://link.springer.com/article/10.1007/s13277-016-5405-3