Over-expression of the c-erbB-2 oncogene occurs in a proportion of human adenocarcinomas and in breast carcinoma is associated ... Gene Expression * Humans * Immunohistochemistry * Paget Disease, Extramammary / genetics * Paget Disease, Extramammary / ... c-erbB-2 oncoprotein expression in mammary and extramammary Pagets disease: an immunohistochemical study Histopathology. 1990 ... Over-expression of the c-erbB-2 oncogene occurs in a proportion of human adenocarcinomas and in breast carcinoma is associated ...

Endogenous RPTPkappa associated with EGF receptor and HER2, resulting in suppression of basal and ErbB ligand-induced ... Transforming growth factor {beta} (TGF-{beta})-Smad target gene protein tyrosine phosphatase receptor type kappa is required ... the protein product encoded by the PTPRK gene) protein in tumor and nontumor mammary cells; HER2 overexpression down-regulated ...

Heterodimerization of the erbB-1 and erbB-2 receptors in human breast carcinoma cells: a mechanism for receptor transregulation ... distinguishes ErbB-3 signaling from that of other ErbB/EGFR family members ... Additive effects of c-erbB-2, c-Ha-ras, and transforming growth factor-alpha genes on in vitro transformation of human mammary ... The erbB-2 mitogenic signaling pathway: tyrosine phosphorylation of phospholipase C-gamma and GTPase-activating protein does ...

RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 18 ... Gene symbol: PTPN18). F. 1. Receptor Tyrosine-protein Kinase Erbb-2. (Gene symbol: ERBB2) ...

Zimonjic DB, Alimandi M, Miki T, Popescu NC, Kraus MH (Mar 1995). "Localization of the human HER4/erbB-4 gene to chromosome 2 ... Receptor tyrosine-protein kinase erbB-4 is an enzyme that in humans is encoded by the ERBB4 gene. Alternatively spliced ... "Ligands for ErbB-family receptors encoded by a neuregulin-like gene". Nature. 387 (6632): 509-12. Bibcode:1997Natur.387R.509C. ... ErbB-3 and ErbB-4". Oncogene. 15 (23): 2841-8. doi:10.1038/sj.onc.1201458. PMID 9419975. Fiddes RJ, Campbell DH, Janes PW, ...

Gene Expression Profiling. *Genetic Testing. *Receptor, erbB-2. *High-Throughput Nucleotide Sequencing ... CONCLUSIONS: It is feasible to detect multiple gene mutations with a 22-gene panel in FFPE CRC specimens. TNM stage and total ... As a tumor‑suppressor gene, the liver kinase B1 gene (LKB1, also known as serine/threonine kinase 11, STK11) is closely related ... Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. ...

14 King C R, Kraus M H, Aaronson S A. Amplification of a novel v-erbB-related gene in a human mammary carcinoma. Science. 1985 ... 5 Beckmann M W, Niederacher D, Schnurch H G, Bender H G. The erbB gene family: significance for tumor development, prognosis ... 16 McCann A H, Dervan P A, ORegan M, Codd M B, Gullick W J, Tobin B M. et al . Prognostic significance of c-erbB-2 and ... 18 Nicholson R I, McClelland R A, Finlay P, Eaton C L, Gullick W J, Dixon A R. et al . Relationship between EGF-R, c-erbB-2 ...

Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large ... An involvement of other ErbB family members appears unlikely because dominant-negative mutants of ErbB-1, ErbB-3, or ErbB-4 ... 10, A and B). In contrast, in neurons expressing ΔC-terminal mutants of ErbB-1, ErbB-3, ErbB-4, or a control plasmid, Sema4D ... Plexin-B1 was unable to coimmunoprecipitate with ErbB-1, ErbB-3, or ErbB-4 (unpublished data). ...

The c-erbB-2/HER2 gene is usually reported to be amplified in about 10-30% of breast cancers (12). Its overexpression is more ... Overexpression of c-erbB-2 and absent estrogen receptor status is often associated with aggressive tumours and poor prognosis ( ... C-erbB-2 oncoprotein amplification in infiltrating ductal carcinoma of breast relates to high histological grade and loss of ... ER-positive was seen in 27 of 63 Chinese patients, 10 of 30 Malays and 6 of 12 Indians, while c-erbB-2 was positive in 25 ...

Other names: Human Epidermal Growth Factor Receptor; C-erbB-2 Her-2/neu is an oncogene, which is a type of gene that can ... if the test for the gene is positive as well, this indicates that the patient is likely to have an aggressive tumour. ... Normal cells have two copies of the Her-2/neu gene and low levels of Her-2 protein are produced on the surface of the cells. In ... The test may be used to determine the severity of a patients condition; tumours that are associated with the Her-2/neu gene ...

Oncogene ERBB; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1; waved 2 ... EGFR (Epidermal growth factor receptor, HER1, ErbB1) is encoded by the EGFR gene located on chromosome 7 in humans. EGFR ... Protein Aliases: 2.7.10.1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; ... Mutations in the EGFR gene are associated with lung cancer and multiple alternatively spliced transcript variants encode ...

Synthetic gene expression perturbation systems with rapid, tunable, single-gene specificity in yeast. Nucleic Acids Res. 41, ... specific regulation of the erbB-2/HER-2 promoter by using polydactyl zinc finger proteins constructed from modular building ... The RUBY gene encodes a multi-gene product transcriptional unit that encodes enzymes that produce the beet betalain pigment ... d, Ligand-mediated induction of EGFP and mCherry reporter genes for the tandem PYR1*AZIN and PYR1DIAZI circuits. Fluorescence ...

Localization of a novel v-erbB-related gene, c-erbB-2, on human chromosome 17 and its amplification in a gastric cancer cell ... The gene for the HER2 protein (also known as ErbB-2, c-erbB2, or Her2/neu) is a proto-oncogene located on the chromosome 17q. ... Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex. Cancer Cell. 2004;5:317-328. [PubMed] [DOI] [ ... Prognostic significance of p53, nm23, PCNA and c-erbB-2 in gastric cancer. Jpn J Clin Oncol. 2003;33:173-179. [PubMed] [DOI] [ ...

Metastasizing pleomorphic adenoma is 1 of these; the other 2 are carcinoma ex pleomorphic adenoma and true malignant mixed ... In a single case study, Takeuchi et al did not find that the oncogenes and tumor suppressor genes they tested (bcl -2, c-erbB - ... 26] Their findings suggested that deletions of one or more tumor suppressor genes (3p deletions), which are frequently seen in ... 27] In addition, immunohistochemical studies did not document any aberrance in the expression of the tumor suppressor gene ...

Validated for WB, IP, IHC, IF, F. Available in 2 sizes. Highly specific and rigorously validated in-house, HER2/ErbB2 (29D8) ... After cloning the antibody genes into an expression vector, this is then transfected into an appropriate host cell line for ... activity can be activated in the absence of a ligand when overexpressed and through heteromeric associations with other ErbB ... Amplification of the ErbB2 gene and overexpression of its product are detected in almost 40% of human breast cancers (3). ...

The expression of c-erbB-1 and c-erbB-2 in Iranian patients with gastric carcinoma. Pathol Oncol Res. 2002;8:252-256. [PubMed] ... A study of HER2 gene amplification and protein expression in gastric cancer. J Clin Pathol. 2010;63:839-842. [PubMed] ... Correlation of c-erbB-2 protein expression and lymph node status in early gastric cancer. Oncology. 1992;49:363-367. [PubMed] ... Overexpression of c-ErbB-2 protein in gastric cancer by immunohistochemical stain. Oncology. 1996;53:192-197. [PubMed] ...

These effects are, in part, mediated by sustained alterations in gene expression in selected brain regions. The critical ... The early response gene NGFI-C encodes a zinc finger transcriptional activator and is a member of the GCGGGGGCG (GSG) element- ... is expressed in ovarian cancers and the expression correlates with demethylation of CpG sites in the promoter region of c-erbB- ... These effects are, in part, mediated by sustained alterations in gene expression in selected brain regions. The critical ...

Two novel mucin genes down-regulated in colorectal cancer identified by differential display. Cancer Res1999;59:4083-9. ... The first EGF-like domain of rMuc4 is reported to be an intramembrane modulator of the c-erbB-2 receptor tyrosine kinase.9 ... Mucin gene expression in normal, preneoplastic, and neoplastic human gastric carcinoma. Cancer Res1995;55:2681-90. ... Membrane-bound (MUC1) and secretory (MUC2, MUC3, and MUC4) mucin gene expression in human lung cancer. Tumour Biol1996;17:176- ...

Chromosomal assignment of five cancer-associated rat genes: Two thyroid hormone receptor (ERBA) genes, two ERBB genes and the ... Chromosomal assignment of five cancer-associated rat genes: two thyroid hormone receptor (ERBA) genes, two ERBB genes and the ... Myc family of genes; structure, expression and activation in tumor pathogenesis. *NUCLEOTIDE-SEQUENCE OF THE RAT BMYC GENE ... GENE LOCALIZATION ON SORTED CHROMOSOMES - DEFINITIVE EVIDENCE ON THE RELATIVE POSITIONING OF GENES PARTICIPATING IN THE MOUSE ...

Makki, M.S.; Heinzel, T.; Englert, C. TSA downregulates Wilms tumor gene 1 (Wt1) expression at multiple levels. Nucleic Acids ... Kanai, Y.; Ochiai, A.; Shibata, T.; Oyama, T.; Ushijima, S.; Akimoto, S.; Hirohashi, S. c-erbB-2 gene product directly ... Benson, E.K.; Mungamuri, S.K.; Attie, O.; Kracikova, M.; Sachidanandam, R.; Manfredi, J.J.; Aaronson, S.A. p53-dependent gene ... Microarray analysis of epigenetic silencing of gene expression in the KAS-6/1 multiple myeloma cell line. Cancer Res., 2004, 64 ...

Genes, erbB-2. Breast Neoplasms. Receptor, ErbB-2. Disease-Free Survival. Tamoxifen. Mammary Neoplasms, Animal. Receptor, ErbB- ...

Vitamin K is an essential cofactor of many coagulation gene products, and thus mutations in the VKORC1 gene compounded with the ... Other similar examples of therapeutic/companion diagnostic pairs include, but are not limited to, c-erbB-2 biomarkers/ ... gene amplification, target capture, and detection. Target genes are amplified in the presence of biotinylated primer pairs, ... A polymorphism in the VKORC1 gene associated with an interindividual variability in the dose-anticoagulant effect of warfarin. ...

c-erbB-2/HER-2/neu (phospho-specific) Antibody Staining Protocol for Immunohistochemistry. ... Name: c-erbB-2/HER-2/neu (phospho-specific) Ab-18 Antibody ... neu and erbB-3. Tyr is the phosphorylation site that is most ... Activation of HER-2 is frequent in ductal carcinoma in situ suggesting that HER-2 signaling plays a critical role in the early ... Description: c-erbB-2 (HER-2/neu) is a 185 kDa receptor tyrosine kinase belonging to the epidermal growth factor receptor ...

... and FACE ErbB-2 (Y1248) use an in cell Western method (cell based assay) that includes ELISA reagents and 2 antibodies to ... monitor levels of both total ErbB-2 and phospho ErbB-2 (Y877) or (Y1248), activated by kinases (phosphorylation). ... Gene Dosage Alterations in Evolution and Ageing (Claudia Keller Valsecchi). * Structural Analysis of Nucleosomes During ... HER-3 or ErbB-3). Although, ErbB-2 does not have any known high-affinity ligands, its kinase activity can be activated without ...

"Gene expression profiling of ErbB receptor and ligand-dependent transcription." Oncogene.. 2004 Feb 19; 23(7):1428-38. ... "Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop." Genes ... "Design of a retrovirus-derived vector for expression and transduction of exogenous genes in mammalian cells." Molecular and ... "Identification of candidate target genes for EVI-1, a zinc finger oncoprotein, using a novel selection strategy." Oncogene.. ...

Receptor tyrosine-protein kinase erbB-2 derived from Recombinant human HER-2 protein fragment (around aa 311-462) (exact ... Metastatic lymph node gene 19 protein, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor ... C-erbB-2/HER-2 is a member of the EGFR family. This MAb is specific and shows minimal cross-reaction with other members of the ... c-erbB-2/HER-2 protein is over-expressed in a variety of carcinomas especially those of breast and ovary. ...

Genes, erbB-2 MeSH Trastuzumab MeSH DeCS ID:. 32062 Unique ID:. D018719 ... It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. ... 2019; for ERB-B2 RECEPTOR TYROSINE KINASES see ERBB RECEPTORS 2017-2019; see PROTO-ONCOGENE PROTEINS C-ERBB-2 1995-1999; for ... It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. ...

Genes, erbB-2; Trastuzumab; Lapatinib; Americans with Disabilities Act; Neoplasms; Tomography, Spiral Computed; Lung Neoplasms. ...

1a+b). These genes were then evaluated in a deconvolution screen where individual siRNAs constituting the original pools were ... The metalloproteinase ADAM17 activates ErbB signalling by releasing ligands from the. The metalloproteinase ADAM17 activates ... This revealed that knockdown of 24 genes mimicked the effects of ADAM17 knockdown on AP-HB-EGF shedding (Supplementary Data 1 ... 1a). Stringent selection criteria identified 645 genes whose knockdown inhibited loss of AP cell-surface staining in response ...

Neoplasias de la Mama/terapia, Metástasis de la Neoplasia/prevención & control, Genes erbB-2/efectos de los fármacos, ... Pan-American Guidelines for the Treatment of SARS-CoV-2/COVID-19: a joint evidence-based guideline of the Brazilian Society of ... La enfermedad por el Coronavirus 2019 (COVID-19) es una patología respiratoria de humanos producida por SARS-CoV-2. El 11 de ... Hospitalised patients with coronavirus disease 2019 (COVID-19) as a result of SARS-CoV-2 infection have a high mortality rate ...