Overexpression of CD44 in acquired tamoxifen-resistant breast cancer cells augments their migratory response to heregulin beta...
Both standard and v3 isoforms of CD44 were overexpressed in TamR cells at both gene and protein levels (mean fold increase in ... Expression of CD44 (standard and v3 isoforms) were confirmed by RT-PCR and western blotting and their association with erbB ... These data demonstrate a role for CD44 as a modulator of erbB receptor function in endocrine-resistant breast cancer cells, ... Treatment of TamR cells with heregulin resulted in phosphorylation of erbB receptors together with a number of downstream ...https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr1918
Clinical Utility of Serum Human Epidermal Growth Factor Receptor Type 2 Testing as a Marker of Therapeutic Response In Tissue...
Akiyama T, Sudo C, Ogawara H, Toyoshima K, Yamamoto T (1986) The product of the human c-erbB-2 gene: a 185-kilodalton ... Yamauchi H, Stearns V, Hayes DF (2001) When is a tumor marker ready for prime time? A case study of c-erbB-2 as a predictive ... HER2 overexpression occurs in 20.0-30.0% of breast cancers, usually as a result of gene amplification [4,5], and is associated ... Fehm T, Gebauer G, Jäger W (2002) Clinical utility of serial serum c-erbB-2 determinations in the follow-up of breast cancer ...https://www.clinmedjournals.org/articles/ijccr/international-journal-of-cancer-and-clinical-research-ijccr-4-089.php?jid=ijccr
The incidence of EML4-ALK rearrangements, EGFR mutation | Open-i
Genes, erbB-1/genetics*. *Lung Neoplasms/epidemiology*/genetics*. *Receptor Protein-Tyrosine Kinases/genetics* ... Affiliation: 1] State Key Laboratory of Oncology in South China, Guangzhou, China  Collaborative Innovation Center for ... Affiliation: 1] State Key Laboratory of Oncology in South China, Guangzhou, China  Collaborative Innovation Center for ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC4248273_srep07268-f5&req=4
Michael Cascio - Publications - Oregon Health & Science University
Epithelioid sarcoma expresses epidermal growth factor receptor but gene amplification and kinase domain mutations are rare. ... Raess, P. W., Cascio, M. J., Fan, G., Press, R., Druker, B. J., Brewer, D. & Spurgeon, S. E. Jan 1 2017 In : American Journal ... Cascio, M. J. & DeLoughery, T. G. Mar 1 2017 In : Medical Clinics of North America. 101, 2, p. 263-284 22 p.. Research output: ... Cascio, M. J. & Jen, K. Y. Jan 1 2018 In : Current Opinion in Hematology. 25, 1, p. 29-36 8 p.. Research output: Research - ...https://ohsu.pure.elsevier.com/en/persons/michael-cascio/publications/
CiNii 論文 - RECENT ADVANCES IN THE MOLECULAR GENETICS OF UROGENITAL TUMORS ...
An immunohistologic evaluation of c-erbB-2 gene product in patients with urinary bladder carcinoma. SATO K. ... 腎盂尿管癌における c-erbB-2, p53遺伝子産物過剰発現と Ki-67による細胞増殖動態の検討 橋本 博 , 須江 洋一 , 徳光 正行 , 佐賀 祐司 , 八竹 直 ... A novel insertional mutation at the third zinc finger coding region of the WT1 gene in Denys-Drash syndrome OGAWA O. ... Enhanced expression of c-myc and epidermal growth factor receptorhttp://ci.nii.ac.jp/naid/10008458527
Role of Neuregulin-1/ErbB Signaling in Cardiovascular Physiology and Disease | Circulation
Liu X, Hwang H, Cao L, Buckland M, Cunningham A, Chen J, Chien KR, Graham RM, Zhou M. Domain-specific gene disruption reveals ... ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling. EMBO J. 1997; 16: ... Whereas inhibition of ErbB signaling is a powerful treatment for mammary and perhaps other carcinomas, activation of ErbB ... Clinical studies in breast cancer with novel ErbB inhibitors are currently underway. Novel oncological indications for ErbB ...http://circ.ahajournals.org/content/116/8/954
ERRFI1 - Wikipedia
"Entrez Gene: ERRFI1 ERBB receptor feedback inhibitor 1". Benzinger, Anne; Muster Nemone; Koch Heike B; Yates John R; Hermeking ... "Inhibition of ErbB-2 mitogenic and transforming activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 ... ERBB receptor feedback inhibitor 1 is a protein that in humans is encoded by the ERRFI1 gene. MIG6 is a Cytoplasmic protein ... Fiorini M, Ballaro C, Sala G, Falcone G, Alema S, Segatto O (Sep 2002). "Expression of RALT, a feedback inhibitor of ErbB ...https://en.wikipedia.org/wiki/ERRFI1
Faculty of Pharmaceutical Sciences - Research Output - Kyushu University
Y-box binding protein YBX1 and its correlated genes as biomarkers for poor outcomes in patients with breast cancer. Shibata, T ... The activation of SRC family kinases and focal adhesion kinase with the loss of the amplified, mutated EGFR gene contributes to ... Improved quality of life in patients with no-option critical limb ischemia undergoing gene therapy with DVC1-0101. matsumoto, T ... Therapeutic angiogenesis: Recent and future prospects of gene therapy in peripheral artery disease. Tanaka, M., Taketomi, K. & ...https://kyushu-u.pure.elsevier.com/en/organisations/faculty-of-pharmaceutical-sciences-2/publications/
Multivariate survival analysis of clinicopathologic features in surgical stage I endometrioid carcinoma including analysis of...
Expression of erbB-1 and erbB-2 genes in normal and pathological human endometrium.. *Magdalena Brys. , Andrzej Semczuk. , ... HER 2 / neu : an increasingly important therapeutic target . Part 2 : Distribution of HER 2 / neu overexpression and gene ...https://www.semanticscholar.org/paper/Multivariate-survival-analysis-of-clinicopathologi-Nazeer-Ballouk/cc81e04bfa747b44c1ef394853d48498411e425b
ENSDARG00000086098 - Zebrafish Mutation Project - Wellcome Sanger Institute
ERBB receptor feedback inhibitor 1 [Source:HGNC Symbol;Acc:18185]. Mouse Orthologue:. Errfi1. Mouse Description:. ERBB receptor ... If you would like to be informed when the status of this gene changes (for example, a new allele is generated or an allele is ... You can look for mutant lines by browsing a complete list or by searching for a particular gene ...https://www.sanger.ac.uk/sanger/Zebrafish_Zmpgene/ENSDARG00000086098
List of MeSH codes (G14) - Wikipedia
... genes, erba MeSH G14.340.024.340.383.500.791.295 --- genes, erbb MeSH G14.340.024.340.383.500.791.295.300 --- genes, erbb-1 ... genes, nef MeSH G14.340.400.500.667 --- genes, pol MeSH G14.340.400.500.735 --- genes, px MeSH G14.340.400.500.775 --- genes, ... genes, viral MeSH G14.340.400.500.172 --- genes, env MeSH G14.340.400.500.258 --- genes, gag MeSH G14.340.400.500.345 --- genes ... genes, helminth MeSH G14.340.357.500 --- genes, insect MeSH G14.340.365.500 --- genes, plant MeSH G14.340.375.500 --- genes, ...https://en.wikipedia.org/wiki/List_of_MeSH_codes_(G14)
The metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), inhibits stress-induced autophagy in cancer cells.. ... Down-regulates the ErbB Family of Receptors to Inhibit Downstream Oncogenic Signaling Pathways.. Authors:. Zaklina Kovacevic ... The Metastasis Suppressor, N-MYC Downstream-regulated Gene-1 (NDRG1), ... Autophagy 2016 ;12(1):1-222. kb Emory University, School of Medicine , Department of Microbiology and Immunology , Atlanta , GA ...https://www.pubfacts.com/author/Dong-Hun+Bae
MAPs and POEP of the roads from prokaryotic to eukaryotic kingdoms. - Semantic Scholar
The DNA sequence analyses of MAP genes from the above organisms reveal sequence homologies with other prokaryotic MAPs as well ... The DNA sequence analyses of MAP genes from the above organisms reveal sequence homologies with other prokaryotic MAPs as well ... Overexpression of a Hevea brasiliensis ErbB-3 Binding protein 1 Gene Increases Drought Tolerance and Organ Size in Arabidopsis ...https://www.semanticscholar.org/paper/MAPs-and-POEP-of-the-roads-from-prokaryotic-to-Datta/26c3242fd4b09777525a842992dfb0fe387566fe
... the binding target genes were classified into Gene Ontology (GO) groups. The GO analysis results for 892 coenriched genes ... 2016) Overexpression of a Hevea brasiliensis ErbB-3 Binding protein 1 gene increases drought tolerance and organ size in ... Seven genes were up-regulated [log2 (OX/NR) , 2] and two genes were down-regulated [log2 (OX/NR) , −1] by TsNAC1 (Table I). The ... A total of 892 genes were highly enriched in both sets, and 22.16% of these gene peaks were located in the promoter region (a ...http://www.plantphysiol.org/content/176/1/742
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to...
We searched for mutations in the EGFR gene in primary tumors from patients with non-small-cell lung cancer who had a response ... Genes, erbB-1*. *Heterozygote. *Humans. *Lung Neoplasms/drug therapy. *Lung Neoplasms/genetics* ... A subgroup of patients with non-small-cell lung cancer have specific mutations in the EGFR gene, which correlate with clinical ... Somatic mutations were identified in the tyrosine kinase domain of the EGFR gene in eight of nine patients with gefitinib- ...https://www.ncbi.nlm.nih.gov/pubmed/15118073
PSMC3 - Wikipedia
... a BRCA1 locus-related gene". Gene. 248 (1-2): 99-107. doi:10.1016/S0378-1119(00)00141-4. PMID 10806355. ... The gene PSMC3 encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity ... "Entrez Gene: PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3". "Uniprot: P17980 - PRS6A_HUMAN". Le Tallec B, ... A pseudogene has been identified on chromosome 9. The human PSMC3 gene has 12 exons and locates at chromosome band 11p11.2. The ...https://en.wikipedia.org/wiki/PSMC3
Dr Danuta Kalinowski - The University of Sydney
... down-regulates the ErbB family of receptors to inhibit downstream oncogenic signaling pathways. Journal of Biological Chemistry ... N-myc downstream-regulated gene 1 (NDRG1), inhibits stress-induced autophagy in cancer cells. Journal of Biological Chemistry, ... down-regulates the ErbB family of receptors to inhibit downstream oncogenic signaling pathways. Journal of Biological Chemistry ... N-myc downstream-regulated gene 1 (NDRG1), inhibits stress-induced autophagy in cancer cells. Journal of Biological Chemistry, ...http://sydney.edu.au/medicine/people/academics/profiles/danuta.kalinowski.php
Dr Sumit Sahni - The University of Sydney
Sahni, S., Merlot, A., Krishnan, S., Jansson, P., Richardson, D. (2014). Gene of the month: BECN1. Journal of Clinical ... down-regulates the ErbB family of receptors to inhibit downstream oncogenic signaling pathways. Journal of Biological Chemistry ... Sahni, S., Merlot, A., Krishnan, S., Jansson, P., Richardson, D. (2014). Gene of the month: BECN1. Journal of Clinical ... down-regulates the ErbB family of receptors to inhibit downstream oncogenic signaling pathways. Journal of Biological Chemistry ...http://sydney.edu.au/medicine/people/academics/profiles/sumit.sahni.php
RCSB PDB - Protein Feature View - ERBB receptor feedback inhibitor 1 - Q9UJM3 (ERRFI HUMAN)
This protein in other organisms (by gene name): B2RDX9 - Homo sapiens 0 * Q99JZ7 - Mus musculus no matching PDB entries ...http://www.rcsb.org/pdb/protein/B2RDX9
NDRG1 - Wikipedia
Protein NDRG1 is a protein that in humans is encoded by the NDRG1 gene. This gene is a member of the N-myc downregulated gene ... Down-regulates the ErbB Family of Receptors to Inhibit Downstream Oncogenic Signaling Pathways". J. Biol. Chem. 291 (3): 1029- ... doi:10.1016/j.gene.2008.03.002. PMID 18455888. "Entrez Gene: NDRG1 N-myc downstream regulated gene 1". Kachhap SK, Faith D, ... 2002). "Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family". Mol ...https://en.wikipedia.org/wiki/NDRG1
The novel dithiocarbamate, DpdtC suppresses HER2-overexpressed cancer cells by up-regulating NDRG1 via inactivation of HER2-ERK...
DpdtC suppresses HER2-overexpressed cancer cells by up-regulating NDRG1 via inactivation of HER2-ERK 1/2 signaling, Scientific ... NDRG1, a growth and cancer related gene: regulation of gene expression and function in normal and disease states ... Loss of RALT/MIG-6 expression in ERBB2-amplified breast carcinomas enhances ErbB-2 oncogenic potency and favors resistance to ... tion as a tumor and metastasis suppressor gene in several types of cancer including breast, pancreatic and pros- ...https://www.deepdyve.com/lp/springer_journal/the-novel-dithiocarbamate-dpdtc-suppresses-her2-overexpressed-cancer-mXCgTMfwj0
PTGES3 - Wikipedia
Yoo JY, Hamburger AW (1999). "Interaction of the p23/p198 protein with ErbB-3". Gene. 229 (1-2): 215-221. doi:10.1016/S0378- ... The protein encoded by this gene is also known as p23 which functions as a chaperone which is required for proper functioning ... Prostaglandin E synthase 3 (cytosolic) is an enzyme that in humans is encoded by the PTGES3 gene. ... Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome ...https://en.wikipedia.org/wiki/PTGES3
ERBB3 - Wikipedia
1997). "Ligands for ErbB-family receptors encoded by a neuregulin-like gene". Nature. 387 (6632): 509-12. doi:10.1038/387509a0 ... Yoo JY, Hamburger AW (1999). "Interaction of the p23/p198 protein with ErbB-3". Gene. 229 (1-2): 215-21. doi:10.1016/S0378-1119 ... 1996). "Expression of c-erbB family gene products in adenoid cystic carcinoma of salivary glands: an immunohistochemical study ... Citri A, Skaria KB, Yarden Y (2003). "The deaf and the dumb: the biology of ErbB-2 and ErbB-3". Exp. Cell Res. 284 (1): 54-65. ...https://en.wikipedia.org/wiki/ERBB3
Cyclin D1 - Wikipedia
"ErbB-2 induces the cyclin D1 gene in prostate epithelial cells in vitro and in vivo". Cancer Research. 67 (9): 4364-72. doi: ... The CCND1 gene encodes the cyclin D1 protein. The human CCNDI gene is located on the long arm of chromosome 11 (band 11q13). It ... "Entrez Gene: CCND1 cyclin D1". He Y, Liu Z, Qiao C, Xu M, Yu J, Li G (Jan 2014). "Expression and significance of Wnt signaling ... "CCND1" Gene". GeneCards. "Weizmann Institute of Science". 2013. Retrieved May 6, 2015. Withers DA, Harvey RC, Faust JB, Melnyk ...https://en.wikipedia.org/wiki/Cyclin_D1
Uncategorized - Page 2 - Pharmacodynamic Biomarker Development
... that have a gene amplification and for that reason overexpress ErbB-2, show minimal Notch-1 activity. Conversely, trastuzumab ... Genes triggered by XBP1s and ATF6 possess PF-04691502 mainly complementary and overlapping features, including ER proteins ... 2007). Finally, the TFs downstream from phosphorylated eIF2, ATF4, and CHOP activate exclusive and overlapping units of genes ... popular modifications in gene appearance reflecting a far more adhesive peritoneum had been within peritoneal tissues from ...http://www.woofahs.com/category/uncategorized/page/2/