This Week in PNAS: Oct 27, 2015 | GenomeWeb
... the researchers narrowed in on a novel mutation in the tumor suppressor gene PTEN that appeared to boost the pro-tumor activity ... Craig Venter and colleagues point out that library preparation methods can impact the taxonomic groups and microbial genes ... exploring the feasibility of finding individual driver genes using unbiased computational and experimental validation methods. ...
CNV-Adjusted Analysis Points to Prognostically Informative Meningioma Methylation Groups | GenomeWeb
... contrast to meningiomas arising in neurofibromatosis type 2 patients missing an NF2 gene coding for the Merlin tumor suppressor ... the group investigated further with CRISPR-based gene editing and other functional experiments. ...
This Week in PNAS: Oct 15, 2014 | GenomeWeb
Characteristic mutations to the tumor suppressor gene TP53 do not seem to dial up copy-number changes in individuals with the ... and cell cycle control genes. In an effort to understand human papillomavirus contributions to head and neck cancer, a ...
Gastric Cancer Analysis in Young Populations Identifies Four Subtypes | GenomeWeb
Small Study of Gene Editing to Treat Sickle Cell Disease In a Novartis-sponsored study in the New England Journal of Medicine, ... Our proteogenomic analyses provide signaling pathways correlated with somatic mutations, oncogene and tumor suppressor ... Further, they found 11,938 genes were expressed in the tumor and adjacent normal samples, on average, in the mRNA data. The ... These peptides were mapped to 10,295 protein-coding genes, on average.. The researchers also compared previous genomic analyses ...