Ataxia telangiectasia gene mutations in leukaemia and lymphoma | Journal of Clinical Pathology
Banin S, Moyal, L, Shieh S, et al. Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science 1998;281:1674-7. ... The ATM gene in human lymphoid malignancies. The ATM gene is assigned to 11q22.3.5 Chromosome loss at 11q22-23 is a frequent ... The importance of inactivation of the ATM gene in T-PLL is now clear.34, 36, 37 How frequently inactivation of this gene occurs ... THE ATM GENE IN HUMAN LYMPHOMA. Further support for the proposal that inactivation of the ATM gene may be of importance to the ...
Epstein-Barr virus and Burkitt lymphoma | Journal of Clinical Pathology
... the gene encoding p53. It has long been known that cells lacking p53 and ARF activity are resistant to MYC-driven apoptosis.90 ... Role of the p53 tumor suppressor gene in the tumorigenicity of Burkitts lymphoma cells. Cancer Res 1997;57:2508-15. ... p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts. Genes Dev 1991 ... Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis. Genes Dev 1999;13:2658-69. ...
The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis | Journal of Clinical Pathology
A different mechanism of inducing apoptosis is by stabilisation of wild-type p53 by HIF-1. If the cell already has a p53 gene ... it can increase the stability of the product of the tumour suppressor gene p53. In environmental stress or DNA damage, p53 ... or by stabilising wild-type p53-if the cell already has a p53 gene mutation, hypoxia induced apoptosis is prevented ... sequences in the promoter of HIF-1 target genes to initiate gene expression.32 Many genes regulated by HIF-1α are involved in ...
Alterations of MUC1 and MUC3 expression in gastric carcinoma: relevance to patient clinicopathological features | Journal of...
Overexpression of mutant p53 and c-erbB-2 proteins and mutations of the p15 and p16 genes in human gastric carcinoma: with ... Two novel mucin genes down-regulated in colorectal cancer identified by differential display. Cancer Res1999;59:4083-9. ... Mucin gene expression in normal, preneoplastic, and neoplastic human gastric carcinoma. Cancer Res1995;55:2681-90. ... Membrane-bound (MUC1) and secretory (MUC2, MUC3, and MUC4) mucin gene expression in human lung cancer. Tumour Biol1996;17:176- ...
Histological and molecular diversity and heterogeneity of precancerous lesions associated with inflammatory bowel diseases |...
KRAS mutation and p53 mutant-type expression were found in about half cases across all types, while PIK3CA mutation only in ... No BRAF, NRAS or EGFR gene mutation was detected in any type. Certain molecular-morphological correlations were demonstrated; ...
Hereditary thrombophilia in an unselected cohort of venous thrombosis patients in Singapore | Journal of Clinical Pathology
Only one patient was positive for the factor V Leiden mutation and none tested positive for the prothrombin 20210 gene mutation ... factor V Leiden and prothrombin 20210 gene mutations. ...
Prognostic significance of grading (MIB-1 system) in patients with myxoid liposarcoma | Journal of Clinical Pathology
Fewer workers have analysed p53 immunoreactivity and examined the relation between p53 overexpression and clinical outcome.19, ... Chimeric TLS/FUS-CHOP gene expression and the heterogeneity of its junction in human myxoid and round cell liposarcoma. Am J ... Four of the 11 grade 3 tumours overexpressed p53, whereas only one of the 30 grade 1 tumours was p53 positive. ... However, no significant association was found between p53 status and survival (p = 0.20). Overexpression of p53 in myxoid ...