The TP53 gene (also known as p53) is crucial in ensuring the conservation of the genome. Deubiquitinating enzymes play an ... "TP53 gene". MedlinePlus. U.S. National Library of Medicine. Retrieved May 18, 2021. "p53". Wikipedia. Retrieved May 18, 2021. ... In healthy cells, p53 activates the E3 ubiquitin ligase MDM2 which in turn ubiquitinates p53. This creates a negative feedback ... Once stabilized, p53 can exert its tumor suppression function. Downstream pathways of p53 act to either halt cell cycle ...

These effects seem to be largely mediated by mutations at guanine in codon 249 of the p53 gene, a tumor suppressing gene, and ... us), National Center for Biotechnology Information (1998-01-01). The p53 tumor suppressor protein. National Center for ... March 2004). "Clustered pathway genes in aflatoxin biosynthesis". Appl. Environ. Microbiol. 70 (3): 1253-62. Bibcode:2004ApEnM ... at several guanine residues in the 12th and 13th codons of the ras gene, a gene whose product controls cellular proliferation ...

Genes of the p53 family are known to be complex. The viral oncoproteins (e.g. Adenovirus E1B) that efficiently inhibit p53 ... The p73 gene encodes a protein with a significant sequence homology and a functional similarity with the tumor suppressor p53. ... The over-expression of p73 in cultured cells promotes a growth arrest and/or apoptosis similarly to p53. The p73 gene has been ... p73, also known as tumor protein 73 (TP73), protein was the first identified homologue of the tumor suppressor gene, p53. Like ...

Gene knockdown is achieved by reducing the expression of a particular gene in a cell. In the case of protein-coding genes, this ... Most of these effects are due to activation of p53-mediated apoptosis and can be suppressed by co-injection of an anti-p53 ... This entire process is referred to as gene expression; it is the process by which the information in a gene, encoded as a ... a quantifiable method for gene knockdown". Genesis. 30 (3): 154-6. doi:10.1002/gene.1053. PMID 11477696. Kloosterman WP, ...

Ouchi T, Monteiro AN, August A, Aaronson SA, Hanafusa H (March 1998). "BRCA1 regulates p53-dependent gene expression". Proc. ... BRCA1 is a human tumor suppressor gene (also known as a caretaker gene) and is responsible for repairing DNA. BRCA1 and BRCA2 ... "Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure". Genes Dev. 16 (5): 583-93. doi ... "Functional and physical interactions between BRCA1 and p53 in transcriptional regulation of the IGF-IR gene". Horm. Metab. Res ...

"BRCA1 regulates p53-dependent gene expression." (1998) Proc. Natl. Acad. Sci 95: 2302. A. August, S. Gibson, Y. Kawakami, T. ... This work was the first to show that this protein could regulate the transcription of genes and could potentially regulate the ...

Paunesku, Tatjana; Zhang, Yueru; Gemmell, M. Anne; Woloschak, Gayle E. (2000). "p53 gene deletions in radiation-induced tumors ...

Further, up-regulation of p73 (TP73), a homolog of p53, and deletion of the p53 pathway gene p14arf/p16/INK4A (CDKN2A) have ... Fink, KL; Rushing, EJ; Schold Jr, SC; Nisen, PD (1996). "Infrequency of p53 gene mutations in ependymomas". Journal of Neuro- ... While p53 (TP53) mutations are not often observed in pediatric ependymoma, the p53 pathway is suggested to play a role in ... However, gene mutations linked to the familial syndromes are rarely found in sporadic cases of ependymoma. For example, NF2 ...

This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 ... "Entrez Gene: TP53I3 tumor protein p53 inducible protein 3". Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to ... P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite ... 2004). "UV-dependent alternative splicing uncouples p53 activity and PIG3 gene function through rapid proteolytic degradation ...

Roth JA, Swisher SG, Meyn RE (October 1999). "p53 tumor suppressor gene therapy for cancer". Oncology. 13 (10 Suppl 5): 148-54 ... carry a balanced genetic translocation in which part of the NTRK3 gene is fused to part of the ETV6 gene to form a fusion gene ... the ER can regulate gene expression by interacting with estrogen response elements within the promotor of specific genes. The ... This fusion gene encodes a chimeric protein termed ETV6-NTRK3. The NTRK3 part of ETV6-NTRK3 protein has up-regulated tyrosine ...

Cell cycle arrest is carried out by the p53-pRb pathway. Activated p53 turns on genes for p21. P21 is a CDK inhibitor that ... Hyperphosphorylated pRb can no longer bind E2F, E2F is released and cyclin A genes, and other crucial genes for S phase, are ... Genes on human chromosome 13, Genes on human chromosome 4, Cell cycle, Proteins, Cell cycle regulators). ... Transcription of cyclin A is indirectly regulated by the tumor suppressor protein p53. P53 is activated by DNA damage and turns ...

Apoptosis-stimulating of p53 protein 1 is a protein that in humans is encoded by the PPP1R13B gene. This gene encodes a member ... They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this ... Hershko T, Chaussepied M, Oren M, Ginsberg D (2005). "Novel link between E2F and p53: proapoptotic cofactors of p53 are ... "Mdm2 and mdmX prevent ASPP1 and ASPP2 from stimulating p53 without targeting p53 for degradation". Oncogene. 24 (23): 3836-41. ...

"Entrez Gene: PCBP4 poly(rC) binding protein 4". Taylor WR, Stark GR (2001). "Regulation of the G2/M transition by p53". ... This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis ... Zhu J, Chen X (2000). "MCG10, a novel p53 target gene that encodes a KH domain RNA-binding protein, is capable of inducing ... Poly(rC)-binding protein 4 is a protein that in humans is encoded by the PCBP4 gene. This gene encodes a member of the KH ...

Armstrong, Sue (3 May 2016). P53 : the gene that cracked the cancer code. London. ISBN 978-1-4729-1052-3. OCLC 929031485.{{cite ... There, she characterized important functions of p53 needed for tumor suppression and that they were lost when p53 is mutated in ... Her research is focused on tumor suppressor protein p53 and its role as an oncogene when it is mutated in breast cancer. Born ... 1]^ Hunter, Karen (15 November 1997). "Her In-Gene-Uity Pays Work Reveals Cancer Cure". Bargonetti-Chavarria, Jill (2002-03-22 ...

... disruption of HAUSP gene stabilizes p53". Nature. 428 (6982): 1 p following 486. doi:10.1038/nature02501. PMID 15058298. S2CID ... Normally, p53 levels are kept low in part due to Mdm2-mediated ubiquitylation and degradation of p53. In response to oncogenic ... EBNA1 can compete with p53 for binding USP7. Stabilization by USP7 is important for the tumor suppressor function of p53. In ... HAUSP can deubiquitinate p53 and protect p53 from Mdm2-mediated degradation, indicating that it may possess a tumor suppressor ...

The p53 gene codes for the tumor suppressor p53 proteins. A mutation in this gene can lead to formation of tumors. Five p53 ... One mechanism by which 4-ABP causes bladder cancer is a mutation in the p53 gene, which are seen in thirty to sixty percent of ... evidence from its DNA binding spectrum in human p53 gene". Carcinogenesis. 23 (10): 1721-1727. doi:10.1093/carcin/23.10.1721. ...

This gene encodes a proline-rich protein. Studies of the related mouse gene suggest that this gene is regulated by p53 and may ... Lo PK, Chen JY, Lo WC, Chen BF, Hsin JP, Tang PP, Wang FF (Feb 2000). "Identification of a novel mouse p53 target gene DDA3". ... "Entrez Gene: PSRC1 proline/serine-rich coiled-coil 1". Kathiresan S, Melander O, Guiducci C, et al. (2008). "Six new loci ... Lo PK, Wang FF (Nov 2002). "Cloning and characterization of human and mouse DDA3 genes". Biochim Biophys Acta. 1579 (2-3): 214- ...

The AIFM2 gene contains a putative p53-binding element in intron 5, suggesting that its gene expression can be activated by p53 ... is a protein that in humans is encoded by the AIFM2 gene, also known as p53-responsive gene 3 (PRG3), on chromosome 10. This ... Wu M, Xu LG, Su T, Tian Y, Zhai Z, Shu HB (September 2004). "AMID is a p53-inducible gene downregulated in tumors". Oncogene. ... Wu M, Xu LG, Su T, Tian Y, Zhai Z, Shu HB (September 2004). "AMID is a p53-inducible gene downregulated in tumors". Oncogene. ...

"Entrez Gene: TP53BP1 tumor protein p53 binding protein 1". Bouwman P, Aly A, Escandell JM, Pieterse M, Bartkova J, van der ... Lai H, Lin L, Nadji M, Lai S, Trapido E, Meng L (2002). "Mutations in the p53 tumor suppressor gene and early onset breast ... Tumor suppressor p53-binding protein 1 also known as p53-binding protein 1 or 53BP1 is a protein that in humans is encoded by ... "Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure". Genes & Development. 16 (5): ...

Lehmann, AR (2001). "The xeroderma pigmentosum group D (XPD) gene: One gene, two functions, three diseases". Genes & ... its aberrant association with p53 down-regulates the function of p53, leading to a reduction in p53-dependent apoptosis and ... There are 28 genes in this pathway. Individuals with defects in these genes often have developmental defects and exhibit ... All these disorders can be caused by mutations in a single gene, XPD, or in other genes. Cockayne syndrome (CS) is a rare ...

... a p53-inducible gene, regulates p53-dependent apoptosis". Mol Cell. 8 (1): 85-94. doi:10.1016/S1097-2765(01)00284-2. PMID ... Tumor protein p53-inducible nuclear protein 1 is a protein that in humans is encoded by the TP53INP1 gene. In mice this protein ... "Entrez Gene: TP53INP1 tumor protein p53 inducible nuclear protein 1". Tomasini, Richard; Samir Amina Azizi; Carrier Alice; ... Hershko T, Chaussepied M, Oren M, Ginsberg D (2005). "Novel link between E2F and p53: proapoptotic cofactors of p53 are ...

Genes on human chromosome 17, All stub articles, Human chromosome 17 gene stubs). ... SENP3 may be regulated by Arf-Mdm2-p53 pathway. Yeh ET, Gong L, Kamitani T (2000). "Ubiquitin-like proteins: new wines in new ... "Entrez Gene: SENP3 SUMO1/sentrin/SMT3 specific peptidase 3". v t e (Articles with short description, Short description matches ... SUMO1/sentrin/SMT3 specific peptidase 3, also known as SENP3, is a protein which in humans is encoded by the SENP3 gene. SENP3 ...

Collavin L, Monte M, Verardo R, Pfleger C, Schneider C (Oct 2000). "Cell-cycle regulation of the p53-inducible gene B99". FEBS ... G2 and S phase-expressed protein 1 is an enzyme that in humans is encoded by the GTSE1 gene. The protein encoded by this gene ... "Entrez Gene: GTSE1 G-2 and S-phase expressed 1". Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the ... In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling ...

Momand J, Wu HH, Dasgupta G (January 2000). "MDM2--master regulator of the p53 tumor suppressor protein". Gene. 242 (1-2): 15- ... This states that only one working allele of a tumour suppressor gene is necessary for its function (the mutated gene is ... It has been shown that E2F stimulates expression of pro-apoptotic genes in addition to G1/S transition genes, however, cancer ... Some genes activated during the G1/S transition such as cyclin E are repressed by HDAC during early to mid-G1 phase. This ...

Mutations to the p53 gene are often found in many types of cancers. The MAP4K4 gene contains four binding sites for p53. Upon ... p53 is a tumour suppressor gene and is involved with cellular response to stress. When expressed, the cell cycle is halted in ... Miled C, Pontoglio M, Garbay S, Yaniv M, Weitzman JB (June 2005). "A genomic map of p53 binding sites identifies novel p53 ... Hao JM, Chen JZ, Sui HM, Si-Ma XQ, Li GQ, Liu C, Li JL, Ding YQ, Li JM (March 2010). "A five-gene signature as a potential ...

WRNp also physically interacts with p53, a tumor suppressor gene that stops the formation of tumors and the progression of ... its aberrant association with p53 down-regulates the function of p53, leading to a reduction in p53-dependent apoptosis and ... Gene transcription changes found in WS cells are strikingly similar to those observed in normal aging. At the level of gene ... Harris CC (1996). "Structure and function of the p53 tumor suppressor gene: clues for rational cancer therapeutic strategies". ...

... a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells". Gene. 257 (1): 67-75. doi:10.1016/ ... Tian K, Wang Y, Xu H (May 2007). "WTH3 is a direct target of the p53 protein". Br J Cancer. 96 (10): 1579-86. doi:10.1038/sj. ... "Entrez Gene: RAB6C RAB6C, member RAS oncogene family". Sanger Centre, The; Washington University Genome Sequencing Cente, The ( ... Shan J; Yuan L; Budman DR; Xu HP (2002). "WTH3, a new member of the Rab6 gene family, and multidrug resistance". Biochim. ...

Tumor protein p53-inducible protein 11 is a protein that in humans is encoded by the TP53I11 gene. GRCh38: Ensembl release 89: ... "Entrez Gene: TP53I11 tumor protein p53 inducible protein 11". Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A " ... Liang XQ, Cao EH, Zhang Y, Qin JF (2004). "P53-induced gene 11 (PIG11) involved in arsenic trioxide-induced apoptosis in human ... Liang XQ, Cao EH, Zhang Y, Qin JF (2004). "A P53 target gene, PIG11, contributes to chemosensitivity of cells to arsenic ...

p53-regulated apoptosis-inducing protein 1 is a protein that in humans is encoded by the TP53AIP1 gene. GRCh38: Ensembl release ... "Entrez Gene: P53AIP1 p53-regulated apoptosis-inducing protein 1". Strano S, Monti O, Pediconi N, et al. (2005). "The ... a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53". Cell. 102 (6): 849-62. doi: ... Kövesi G, Szende B (2004). "Changes in apoptosis and mitotic index, p53 and Ki67 expression in various types of oral ...

P53 also directly transcriptionally represses CDK1. Mutations in several genes involved in the G2/M transition are implicated ... Overexpression of both cyclin B and CDK1, oftentimes downstream of loss of tumor suppressors such as p53, can cause an increase ... Taylor WR, Stark GR (April 2001). "Regulation of the G2/M transition by p53". Oncogene. 20 (15): 1803-15. doi:10.1038/sj.onc. ... CDK1 is directly inhibited by three transcriptional targets of p53: p21, Gadd45, and 14-3-3σ. Inactive Cyclin B1/CDK1 is ...