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*  Somatic Cell Fusion - Animal Biotech
These hybrid cells have significant biotechnological applications in many more areas such as: (i) study of control of gene ... Somatic Cell Fusion. In animals fusion of two different cells and production of a hybrid cell have been successfully achieved. ... Bone cells are also known to undergo somatic cell fusion. Cells growing in culture are induced by some of the viruses such as ' ... Some chemicals such as polyethylene glycol also induce somatic cell fusion. It is interesting to note that the cells of ...
http://www.biocyclopedia.com/index/biotechnology/animal_biotechnology/animal_cell_tissue_and_organ_culture/biotech_somatic_cell_culture.php
*  Molecular subtyping of primary prostate cancer reveals specific and shared target genes of different ETS rearrangements. -...
... promising therapeutic targets and can serve as diagnostic markers for molecular subtypes of PCa harboring specific fusion gene ... We found specific deregulation of 57 genes in ERG-positive PCa and 15 genes in ETV1-positive PCa, whereas deregulation of 27 ... We further showed that the expression of seven tumor-associated ERG target genes (PLA1A, CACNA1D, ATP8A2, HLA-DMB, PDE3B, TDRD1 ... We conclude that ETS transcription factors regulate specific and shared target genes and that TDRD1, FKBP10, and GRPR are ...
https://www.nds.ox.ac.uk/publications/817559
*  Immunity Gene Fusions Uncovered in Plants [image] | EurekAlert! Science News
All of these genes are potential candidates for disease resistance in plants as they are implicated as targets for plant ... image shows the relative abundance of gene functions 'fished' out of the plant databases using the NLR sequence. ... Immunity gene fusions uncovered in plants. Earlham Institute. Journal. BMC Biology. Funder. Biotechnology and Biological ... All of these genes are potential candidates for disease resistance in plants as they are implicated as targets for plant ...
https://www.eurekalert.org/multimedia/pub/109065.php
*  Argentina's herds boosted by British and Indian gene fusion - Farmers Weekly
With some 35,000 cattle, the Werthein family's beef business is one of the largest breeding set-ups in Argentina. Nick Fone paid them a visit
http://www.fwi.co.uk/livestock/argentina-s-herds-boosted-by-british-and-indian-gene-fusion.htm
*  ETV6-NTRK3 gene fusion - Wikipedia
ETV6-NTRK3 gene fusion is the translocation of genetic material between the ETV6 gene located on the short arm (designated p) ... fusion gene, ETV6-NTRK3. This new gene consists of the 5' end of ETV6 fused to the 3' end of NTRK3. ETV6-NTRK3 therefore codes ... Wai DH, Knezevich SR, Lucas T, Jansen B, Kay RJ, Sorensen PH (Feb 17, 2000). "The ETV6-NTRK3 gene fusion encodes a chimeric ... Indeed, the ETV6-NTRK3 fusion gene appears to be a critical driver of several types of cancers. It was originally identified in ...
https://en.wikipedia.org/wiki/ETV6-NTRK3_gene_fusion
*  Gene fusion shifts cell activity into high gear, causing some cancer | EurekAlert! Science News
Researchers at Columbia University discovered that a common fusion of two adjacent genes can cause cancer by kicking ... are caused by the fusion of two genes, FGFR3 and TACC3. At the time, it was thought that this gene fusion was limited to a ... Gene fusion shifts cell activity into high gear, causing some cancer Study suggests new approach to treating cancers with this ... These drugs are now being tested in patients with recurrent glioblastoma that contains the gene fusion by one of the paper's co ...
https://www.eurekalert.org/pub_releases/2018-01/cumc-gfs122617.php
*  Enzymatics' Archer Targeted Sequencing Tech Enables Cancer Gene Fusion Analysis, Custom Assays | GenomeWeb
... and has plans to offer additional catalog and custom assays to study fusion transcripts as well as DNA variants. ... Enzymatics has commercialized a new targeted sequencing technology that allows customers to detect cancer-relevant gene fusions ... Enzymatics' Archer Targeted Sequencing Tech Enables Cancer Gene Fusion Analysis, Custom Assays. Mar 11, 2014 ... Home » Enzymatics' Archer Targeted Sequencing Tech Enables Cancer Gene Fusion Analysis, Custom Assays ...
https://www.genomeweb.com/sequencing/enzymatics-archer-targeted-sequencing-tech-enables-cancer-gene-fusion-analysis-c
*  JCI - The tumorigenic FGFR3-TACC3 gene fusion escapes miR-99a regulation in glioblastoma
blocking gene regulation of miR-99a and enhancing expression of the fusion gene. The fusion gene was mutually exclusive with ... fusion gene is formed through tandem duplication. (. B. ) Validation of the tandem duplication in fusion-positive patients ... We performed whole transcriptome sequencing to identify fusion genes in glioma and discovered FGFR3-TACC3. fusions in 4 of 48 ... Fusion genes are chromosomal aberrations that are found in many cancers and can be used as prognostic markers and drug targets ...
https://www.jci.org/articles/view/67144/figure/2
*  JCI - The tumorigenic FGFR3-TACC3 gene fusion escapes miR-99a regulation in glioblastoma
blocking gene regulation of miR-99a and enhancing expression of the fusion gene. The fusion gene was mutually exclusive with ... We performed whole transcriptome sequencing to identify fusion genes in glioma and discovered FGFR3-TACC3. fusions in 4 of 48 ... Fusion genes are chromosomal aberrations that are found in many cancers and can be used as prognostic markers and drug targets ... gene fusion is expressed in human cancer and generates an oncogenic protein that promotes tumorigenesis in glioblastoma. ...
https://www.jci.org/articles/view/67144/figure/3
*  nCounter® Vantage 3D™ Gene Fusion Panels | NanoString Technologies
Save time and sample material with multiplexed gene fusion detection in a single tube. Ideal for use with challenging sample ... Lung Panel Gene Fusions The Vantage 3D Lung Fusion Panel includes 63 probes: 35 for specific fusion detection, 24 for ... Leukemia Panel Gene Fusions The Vantage 3D Leukemia Fusion Panel includes 42 probes in total: 27 for specific fusion detection ... nCounter® Vantage 3D™ Leukemia Gene Fusion Panel Includes 42 probes: 27 for specific fusion detection, 12 leukemia biomarkers, ...
https://www.nanostring.com/products/gene-expression-panels/gene-expression-panels-overview/ncounter-gene-fusion-panels
*  CD44-SLC1A2 Gene Fusions in Gastric Cancer | Science Translational Medicine
Fusion genes are chimeric genes formed in cancers through genomic aberrations such as translocations, amplifications, and ... CD44-SLC1A2 Gene Fusions in Gastric Cancer. By Jiong Tao, Nian Tao Deng, Kalpana Ramnarayanan, Baohua Huang, Hue Kian Oh, Siew ... CD44-SLC1A2 Gene Fusions in Gastric Cancer. By Jiong Tao, Nian Tao Deng, Kalpana Ramnarayanan, Baohua Huang, Hue Kian Oh, Siew ... CD44-SLC1A2 Gene Fusions in Gastric Cancer Message Subject. (Your Name) has forwarded a page to you from Science Translational ...
http://stm.sciencemag.org/content/3/77/77ra30
*  Transcriptome Sequencing of 25 Prostate Cancer Tumors IDs Novel Gene Fusions | GenomeWeb
Transcriptome Sequencing of 25 Prostate Cancer Tumors IDs Novel Gene Fusions. Nov 02, 2010 ... Home » Transcriptome Sequencing of 25 Prostate Cancer Tumors IDs Novel Gene Fusions ... Gene-Based Diets Don't Help Weight Loss. A new study in JAMA finds that genetic tests might not be able to determine what diet ...
https://www.genomeweb.com/sequencing/transcriptome-sequencing-25-prostate-cancer-tumors-ids-novel-gene-fusions
*  'Gene fusion' mutation uses 3-way mechanism to drive childhood brain cancers | EurekAlert! Science...
"Gene fusions are common in cancers, and we think it's likely that some will be found to work via combinatorial mechanisms like ... Gene fusion' mutation uses 3-way mechanism to drive childhood brain cancers Study co-led by Penn scientists highlights ... Gene fusion' mutation uses 3-way mechanism to drive childhood brain cancers. University of Pennsylvania School of Medicine ... Investigating further, the team found that the MYB-QKI gene fusions appeared to be driving these brain tumors in three ...
https://www.eurekalert.org/pub_releases/2016-02/uops-fm020216.php
*  Researchers Studying PARP Inhibitor, Hormone Therapy in Prostate Cancer Patients with Gene Fusion | GenomeWeb
Researchers Studying PARP Inhibitor, Hormone Therapy in Prostate Cancer Patients with Gene Fusion. May 29, 2013 ... Home » Researchers Studying PARP Inhibitor, Hormone Therapy in Prostate Cancer Patients with Gene Fusion ...
https://www.genomeweb.com/clinical-genomics/researchers-studying-parp-inhibitor-hormone-therapy-prostate-cancer-patients-gen
*  TMPRSS2-ERG gene fusions induce prostate tumorigenesis by modulating microRNA miR-200c. - PubMed - NCBI
TMPRSS2-ERG gene fusions induce prostate tumorigenesis by modulating microRNA miR-200c.. Kim J1, Wu L1, Zhao JC1, Jin HJ1, Yu J ... Words of wisdom: Re: TMPRSS2-ERG gene fusions induce prostate tumorigenesis by modulating microRNA miR-200c. [Eur Urol. 2014] ... TMPRSS2-ERG Gene Fusions induce prostate tumorigenesis through modulating microRNA miR-200c ... TMPRSS2-ERG Gene Fusions induce prostate tumorigenesis through modulating microRNA miR-200c ...
https://www.ncbi.nlm.nih.gov/pubmed/24186205
*  Regulated expression of lacZ gene fusions in tobacco
... TH Teeri, H Lehväslaiho, M Franck, J Uotila, P Heino, ET Palva, Marc Van ... "Regulated Expression of lacZ Gene Fusions in Tobacco." In Primary and Secondary Metabolism of Plant Cell Cultures II, ed. ... "Regulated Expression of lacZ Gene Fusions in Tobacco." Primary and Secondary Metabolism of Plant Cell Cultures II. Ed. Wolfgang ... 1989). Regulated expression of lacZ gene fusions in tobacco. In W. G. Kurz (Ed.), Primary and secondary metabolism of plant ...
https://biblio.ugent.be/publication/1910779
*  Poly-gene fusion transcripts and chromothripsis in prostate cancer. - Canada's Michael Smith Genome Sciences Centre
... each containing sequence from three different genes, originating from different parts of the genome. One such poly-gene fusion ... Furthermore, we detected poly-gene fusion transcripts in the prostate cancer cell line LNCaP, suggesting they may represent a ... The implication that multigenic changes can give rise to poly-gene fusion transcripts is potentially of great significance to ... You are here: Home / Platforms / Scientific Publications / Poly-gene fusion transcripts and chromothripsis in prostate cancer. ...
http://www.bcgsc.ca/platform/publications/poly-gene-fusion-transcripts-and-chromothripsis-in-prostate-cancer
*  Frequent sun exposure may cue gene fusion found in skin cancer. ecancer - News
A fusion gene is a single composite gene that is the result of the combination of two formerly independent genes. ... Fusion genes may be found in various types of connective tissue tumours, and some treatments have been developed that inhibit ... However, no fusion gene had been identified for cSCC before the Kumamoto University research team began their search. ... It may be possible, for example, to assess the fusion genes in a cancerous lesion and apply a customised therapy based on the ...
http://ecancer.org/news/13021-frequent-sun-exposure-may-cue-gene-fusion-found-in-skin-cancer.php
*  Small Molecule Disrupts Abnormal Gene Fusion Associated with Leukemia | Center for Cancer Research - National Cancer Institute
In separate experiments, AML driven by the related fusion gene NUP98-JARID1A was found to also be sensitive to disulfiram. ... Disulfiram inhibits the binding of the NUP98-PHF23 fusion gene product to DNA of blood-forming cells, preventing the ... Gene expression profiles revealed overexpression of Hoxa/b, Meis1, and Bahcc1 genes in NP23 tissues. In addition, BAHCC1 ... and his colleagues generated transgenic mice that expressed the NP23 fusion gene in all hematopoietic tissues, and used global ...
https://ccr.cancer.gov/node/17598
*  Gene fusions may be the 'smoking gun' in prostate cancer development, U-M study finds - ScienceBlog.com
Researchers have found that when two genes fuse together to cause prostate cancer, it blocks the receptor for the hormone ... If we're going to find a more durable therapy, we need to get at the gene fusion," says study author Arul Chinnaiyan, M.D. Ph.D ... Home Earth, Energy & Environment Gene fusions may be the 'smoking gun' in prostate cancer development, U-M... ... Gene fusions may be the 'smoking gun' in prostate cancer development, U-M study finds. May 18, 2010. ...
https://scienceblog.com/34007/gene-fusions-may-be-the-smoking-gun-in-prostate-cancer-development-u-m-study-finds/
*  Identification of Targetable FGFR Gene Fusions in Diverse Cancers | Cancer Discovery
... we identified a variety of FGFR gene fusions in a spectrum of human cancers. FGFR fusions are active kinases. Cells harboring ... Identification of Targetable FGFR Gene Fusions in Diverse Cancers. Yi-Mi Wu, Fengyun Su, Shanker Kalyana-Sundaram, Nickolay ... Identification of Targetable FGFR Gene Fusions in Diverse Cancers. Yi-Mi Wu, Fengyun Su, Shanker Kalyana-Sundaram, Nickolay ... Identification of Targetable FGFR Gene Fusions in Diverse Cancers. Yi-Mi Wu, Fengyun Su, Shanker Kalyana-Sundaram, Nickolay ...
http://cancerdiscovery.aacrjournals.org/content/early/2013/05/10/2159-8290.CD-13-0050
*  Ewing Sarcoma Gene Fusions Can Be Generated via Chromoplexy | Cancer Discovery
Ewing Sarcoma Gene Fusions Can Be Generated via Chromoplexy Message Subject (Your Name) has forwarded a page to you from Cancer ... EWSR1-ETS fusions can arise by a sudden burst of complex, loop-like rearrangements termed chromoplexy. ...
http://cancerdiscovery.aacrjournals.org/content/early/2018/09/07/2159-8290.CD-RW2018-153?cdnewslink
*  New Fusion Gene Plays Role In Some Stomach Cancers - Redorbit
The hybrid gene is a fusion of two separate genes, and is one of the first described in gastric cancer, which is the most ... Finding the error led the scientists to the CD44-SLC1A2 fusion gene, which resulted when two nearby genes blended into one. The ... "This is an extremely exciting area, as it opens up a potential role for fusion genes in solid cancer diagnostics and treatment ... The technology is called genomic breakpoint analysis (GBA), which has been used to identify fusion genes in leukemia, but has ...
http://www.redorbit.com/news/health/2025596/new_fusion_gene_plays_role_in_some_stomach_cancers/
*  JAIRO | Renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions(Xp11.2 RCC)
Renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions(Xp11.2 RCC)Renal cell carcinoma associated with ... Xp11.2 translocations/TFE3 gene fusions(Xp11.2 RCC)AN00161368. "/小川, 杏平/"小川, 杏平 , "/山本, 智子/"山本, 智子 , "/高木, 敏男/"高木, 敏男 , "/近藤, 恒 ...
http://jairo.nii.ac.jp/0109/00023347/en
*  Gene Fusion Markup Language: a prototype for exchanging gene fusion data | BMC Bioinformatics | Full Text
... of gene fusion data in an inter-operable and query-able fashion that will enable biologically intuitive access to gene fusion ... Here we propose a prototype, Gene Fusion Markup Language (GFML) as an initiative to provide a standard format for organizing ... As transcriptome studies have been widely used for gene fusion discoveries, the current non-standard mode of data ... These studies have also identified many novel gene fusion candidates with more detailed resolution than previously achieved. ...
https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-13-269