... greatly facilitating the evolutionary studies of gene regulation after gene duplication or speciation. Gene duplications can ... The gene duplication rate in C. elegans is on the order of 10−7 duplications/gene/generation, that is, in a population of 10 ... Gene duplication (or chromosomal duplication or gene amplification) is a major mechanism through which new genetic material is ... It can be defined as any duplication of a region of DNA that contains a gene. Gene duplications can arise as products of ...
Homozygous tandem duplication within the gene encoding the beta-subunit of rod phosphodiesterase as a cause for autosomal ... According to the data presented here, the PDEB gene is not the main gene responsible for ARRP, but accounts for about 5% of the ... Molecular characterization of the gene in that family (a consanguineous pedigree) revealed a homozygous 71-bp tandem ... we screened a panel of 19 families for linkage to markers within or close to the PDEB gene. Homozygosity was also tested in ...
Emerging Human Metapneumovirus Gene Duplication Variants in Patients with Severe Acute Respiratory Infection, China, 2017-2019 ... Emerging Human Metapneumovirus Gene Duplication Variants in Patients with Severe Acute Respiratory Infection, China, 2017-2019 ...
We provide a detailed study of the differences between alternative splicing and gene duplication and discuss potential ... The former reflects the ability of many genes to express different products, while the latter results in several copies of the ... same gene that are similar but not identical. In spite of these obvious differences, recent computational studies as well as ... and gene duplication (GD) followed by sequence divergence constitute two fundamental biological processes contributing to ...
What are Genome Evolution, Mutations, Gene Duplications, Gene Losses, and Inversions?. Rogério de Leon Pereira ... Types of Gene- Structural, Constitutive, Regulatory, Jumping, Overlapping, Split gene#Bio knowledge ... HHMI BioInteractive: The Making of the Fittest: The Birth and Death of Genes ...
Pancreatic cancer: Gene duplication explains tumor aggressiveness. Until now, scientists have failed to establish a link ... In cases where a tumor had not doubled the mutated KRAS gene copy, the researchers discovered duplications in other cancer ... Such genes are referred to as oncogenes. The team headed by Roland Rad made a surprising discovery: The mutant gene was often ... For their experiments, the researchers mutated one of the two copies of the KRAS gene in mice. The gene plays a key role in ...
The butterfly plant arms-race escalated by gene and genome duplications. *Mark ... and the role of gene and genome duplications as a substrate for novel traits.,/p,}}, author = {{Edger, Patrick P. and Heidel- ... key innovations are associated with gene and genome duplications. Furthermore, we show that the origins of both chemical ... key innovations are associated with gene and genome duplications. Furthermore, we show that the origins of both chemical ...
Whole-genome duplications (WGDs) have shaped the gene repertoire of many eukaryotic lineages. The redundancy created by WGDs ... Duharcourt Lab - Dynamics of gene loss following ancient whole-genome duplication in the cryptic Paramecium complex. 15 May ... Dynamics of gene loss following ancient whole-genome duplication in the cryptic Paramecium complex ... In addition, post-WGD gene loss has been slower in Paramecium than in other species having experienced genome duplication, ...
We first describe the mathematical model of evolution by tandem duplication and introduce duplication histories and duplication ... We then provide a simple recursive algorithm which determines whether or not a given rooted phylogeny can be a duplication ... Identity between most parsimonious duplication trees and most parsimonious phylogenies for the same data, combined with the ... shows strong evidence that our reconstruction procedure providesgood insights into the duplication histories of these loci. ...
Here, we consider the problem of reconciling a gene tree with a species network via duplication and loss events. Two variants ... the first one finds the best tree in the network with which to reconcile the gene tree, and the second one finds the best ... Reconciliation methods explain topology differences between a species tree and a gene tree by evolutionary events other than ... reconciliation between the gene tree and the whole network. ... In the gene tree reconciliation problem, G represents a gene ...
Digestive duplication cyst of the tongue. Synonyms: Enteric duplication cyst of the tongue , Foregut duplication cyst of the ... Digestive duplication cyst of the tongue?. Our RARE Concierge Services Guides are available to assist you by providing ... Digestive duplication cyst of the tongue. Get in touch with RARE Concierge.. Contact RARE Concierge ... Donate to Global Genes 28 Argonaut, Suite 150. Aliso Viejo, CA 92656. Phone: (+1) 949-248-RARE (7273) ...
... January 8, 2019 By Eric Hamilton For news media ... Grasses have multiple copies of the florigen gene, thanks to an ancient duplication in their genomes. One of those copies has ... The team found that the duplicate, named FTL9, has evolved to act as a sort of inverse of its parent gene florigen. Where ... The researchers pinpointed the cause of that variation to a single letter change in a single gene that is one of 14 duplicates ...
The zebra finch MHC exhibits a complex structure and history involving gene duplication and fragmentation. The zebra finch MHC ... Our analyses of the zebra finch MHC suggest a complex history involving chromosomal fission, gene duplication and translocation ... evidence and the genome assembly itself place core MHC genes on as many as four chromosomes with TAP and Class I genes mapping ... Lastly, we find strong evidence of selection acting on sites within passerine MHC Class I and Class II genes. The zebra finch ...
Cortical gene expression is affected by inheritance pattern of chromosome 15q duplication. Genetics plays a substantial role in ... In those with the maternally inherited duplication, we found that there were significant changes in the genes related to ... Both the maternal and paternal duplication groups shared changes in genes related to synapses and cell homeostasis. More work ... Project Title: Cortical gene expression is affected by inheritance pattern of chromosome 15q duplication ...
Ancestral duplications and highly dynamic opsin gene evolution in percomorph fishes. Fabio Cortesia*, Zuzana Musilová, Sara M. ... Ancestral duplications and highly dynamic opsin gene evolution in percomorph fishes. In: Proceedings of the National Academy of ... Ancestral duplications and highly dynamic opsin gene evolution in percomorph fishes. Proceedings of the National Academy of ... Ancestral duplications and highly dynamic opsin gene evolution in percomorph fishes. / Cortesia, Fabio; Musilová, Zuzana; Stieb ...
... gene, and result in defective central nervous system (CNS) myelination (see the image below).... ... they are at opposite ends of a clinical spectrum of X-linked diseases caused by mutations of the same gene, the proteolipid ... Gene duplications. Approximately 60-70% of cases of Pelizaeus-Merzbacher disease result from duplications of the region of the ... Inclusion of other genes in the duplicated region, or inclusion of aberrations of genes at the duplication endpoints, may ...
Data published in Inoue et al (2015): Inoue J, Sato Y, Sinclair R, Tsukamoto K, Nishida M. 2015. Rapid genome reshaping by multiple-gene loss after whole-genome duplication in teleost fish suggested by mathematical modeling. Proceedings of the National Academy of Sciences of the United States of America 112(48):14918-14923
In agreement with GSS activity localization in vivo, we identified six genes encoding arylsulfatase-like enzymes with a ... PcGSS evolved from arylsulfatase-like genes by gene duplication and neofunctionalization. To investigate the evolutionary ... PxGSS genes are located in tandem in a conserved lepidopteran arylsulfatase gene cluster comprising SulfB, SulfC, and SulfD, ... Analysis of PcSulf and PcGSS gene expression in the gut and remaining body tissues. To determine whether PcSulf and PcGSS genes ...
The Institute of Evolutionary Science of Montpellier (ISEM - University of Montpellier, CNRS, IRD, EPHE, CIRAD, INRAP) has been focusing research on biodiversity origins and dynamics and the associated evolutionary mechanisms. ...
My comment: RNA-directed DNA methylation and gene duplication are nutrient-dependent. That missing fact links the presence of ... That claim is made because the exclusive relationship between the link from nutrient uptake and gene duplication "…could not be ... Divergence of Gene Body DNA Methylation and Evolution of Plant Duplicate Genes. Excerpt 1) "A recent study demonstrated that ... gene duplication, hypomethylated, metabolism, morphological, mutations, natural selection, Nutrient-dependent, organized ...
Gene Deletion. Gene Duplication. Genes, Duplicate. Humans. Likelihood Functions. Models, Genetic. Models, Statistical. ... We found that the expected number of changes (duplication and deletion) per gene for the tumor genomes is significantly higher ... A phylogenetic model for understanding the effect of gene duplication on cancer progression. ... The model assumes that duplication and deletion occur in accordance with a continuous time Markov Chain along the branches of a ...
Is natural selection therefore completely relaxed after duplication? Does one gene evolve more rapidly than the other? Several ... recent genome-wide studies have suggested that duplicate genes are always under purifying selection and do not always evolve at ... Immediately after a gene duplication event, the duplicate genes have redundant functions. ... gene conversion could substantially distort inferences of selection pressures after gene duplication. How prevalent is gene ...
The (in)dependence of alternative splicing and gene duplication.. Title. The (in)dependence of alternative splicing and gene ... Alternative Splicing, Base Sequence, Computer Simulation, DNA, DNA Mutational Analysis, Evolution, Gene Duplication, Genetic, ... Alternative splicing (AS) and gene duplication (GD) both are processes that diversify the protein repertoire. Recent examples ... The amounts of AS and GD per gene are anticorrelated even when accounting for different gene functions or degrees of sequence ...
DISORDERS OF SEX DEVELOPMENT DUE TO 5-ALPHA-REDUCTASE DEFICIENCY , DELETIONS-DUPLICATIONS (MLPA) SRD5A2 GENE ...
Gene duplication. Duplication of a given gene owing to replication errors and resulting in two redundant copies of the original ... Homologous genes that separated because of a gene duplication event.. Immunological synapse. A region that can form between two ... Genome duplication. Duplication of an entire genome that results in an abundance of duplicated genes, most of which are lost. ... PLoS ONE 2, e506 (2007). A detailed and careful study of 36 postsynaptic gene families in poriferans and cnidarians ...
However, gene duplications repeatedly spawned daughter genes in which mutations optimized either isomaltase or maltase activity ... Gene duplications are believed to facilitate evolutionary innovation. However, the mechanisms shaping the fate of duplicated ... Here, we study a large family of fungal glucosidase genes that underwent several duplication events. We reconstruct all key ... and neofunctionalization are helpful to conceptualize the implications of gene duplication, the three mechanisms co-occur and ...
α-Synuclein gene duplication is present in sporadic Parkinson disease: Reply. / Jeon, Beom S.; Ahn, Tae B.; Park, Sung S. ... α-Synuclein gene duplication is present in sporadic Parkinson disease: Reply. Neurology. 2008 Oct 14;71(16). doi: 10.1212/01. ... Jeon, B. S., Ahn, T. B., & Park, S. S. (2008). α-Synuclein gene duplication is present in sporadic Parkinson disease: Reply. ... Jeon, Beom S. ; Ahn, Tae B. ; Park, Sung S. / α-Synuclein gene duplication is present in sporadic Parkinson disease: Reply. In ...
Gene loss and evolutionary rates following whole genome duplication in Teleost fishes. ... Gene loss and evolutionary rates following whole genome duplication in Teleost fishes. Molecular Biology and Evolution, 2006, ...
Gene duplications resulting in over expression of glucokinase are not a common cause of hypoglycaemia of infancy in humans ... Gene duplications resulting in over expression of glucokinase are not a common cause of hypoglycaemia of infancy in humans ...
... tumor suppressor genes, and DNA repair genes. Learn more here. ... The main types of genes that play a role in cancer are ... Gene duplication: Some cells have extra copies of a gene, which might lead to them making too much of a certain protein. ... Tumor suppressor genes. Tumor suppressor genes are normal genes that slow down cell division or tell cells to die at the right ... Genes known as DNA repair genes act like a person who repairs a car. They help fix mistakes in the DNA, or if they cant fix ...