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*  Lactobacillus plantarum ldhL gene: overexpression and deletion. | Journal of Bacteriology
L-LDH activity was increased up to 13-fold through this gene dosage effect. However, this change had hardly any effect on the ... Lactobacillus plantarum ldhL gene: overexpression and deletion.. T Ferain, D Garmyn, N Bernard, P Hols, J Delcour ... Lactobacillus plantarum ldhL gene: overexpression and deletion. Message Subject (Your Name) has forwarded a page to you from ... Inactivation of the gene resulted in the absence of L-LDH activity and in exclusive production of the D isomer of lactate. ...
https://jb.asm.org/content/176/3/596
*  History Gene amplification is a frequent manifestation of genomic instability that - Therapeutic Applications of Kinase...
Gene dosage depends upon elements that regulate both gene gene and amplification reduction. Micronuclei (MNs) derive from ... History Gene amplification is a frequent manifestation of genomic instability that. October 21, 2016. c-Raf ... History Gene amplification is a frequent manifestation of genomic instability that plays a role in tumour progression and ... There is evidence that NHEJ is usually involved in junction formation between amplicon microhomologies during gene ...
http://www.antibodyassay.com/index.php/2016/10/21/history-gene-amplification-is-a-frequent-manifestation-of-genomic-instability-that/
*  Protocols and Video Articles Authored by Thomas Bourgeron (Translated to Italian)
Key Role for Gene Dosage and Synaptic Homeostasis in Autism Spectrum Disorders Trends in Genetics : TIG. Aug, 2010 , Pubmed ID ... These mutations concern only a small number of individuals, but they shed light on one gene dosage-sensitive synaptic pathway ... Second, the majority of the mutations apparently affect a single allele, suggesting a key role for gene dosage in ... The analysis of rare variations of 8 candidate genes among the 27 genes located in this region suggested SEZ6L2 as a compelling ...
https://www.jove.com/author/Thomas_Bourgeron?language=Italian
*  Leukemia development initiated by deletion of RBP-J: mouse strain, deletion efficiency and cell of origin | Disease Models &...
1998). Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator ... 2006). Testing gene function early in the B cell lineage in mb1-Cre mice. Proc. Natl. Acad. Sci. USA 103, 13789-13794. doi: ... which replaces the intact renin gene. Thus, animals with two copies of Cre recombinase will have both renin genes deleted. ... The T-cell lymphomas developed late in life and occurred in a non-cell-autonomous manner (the RBP-J gene was intact). The ...
http://dmm.biologists.org/content/11/12/dmm036731
*  Research Scientist in Bioinformatics | GenomeWeb
The laboratory addresses questions of gene dosage, aneuploidy, sex chromosome evolution, and sex determination to ultimately ... dosage compensation, and genome evolution. Proficiency with multiple scripting languages, high-throughput sequencing analysis, ... understand the relationship between gene dose, genome balance, and phenotype. The research scientist will take part in de novo ... A research scientist position in bioinformatics and computational biology is available in the Malone Laboratory of Gene Dosage ...
https://www.genomeweb.com/resources/jobs/research-scientist-bioinformatics
*  WikiGenes - Monosomy
Gene dosage effect in acquired monosomy 7: distinct behaviour of beta-glucuronidase and phosphoserine phosphatase. Minelli, A ... Gene dosage effect in acquired monosomy 7: distinct behaviour of beta-glucuronidase and phosphoserine phosphatase [17]. ... wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary ... PHOG, a candidate gene for involvement in the short stature of Turner syndrome. Ellison, J.W., Wardak, Z., Young, M.F., Gehron ...
https://www.wikigenes.org/e/mesh/e/9357.html
*  Fungal Gene Expression on Demand: an Inducible, Tunable, and Metabolism-Independent Expression System for Aspergillus niger |...
Gene dosage- and concentration-dependent luciferase activities on an MTP scale. (A) One thousand spores of different strains ... 2A). When 50 μg/ml Dox was present, mluc expression was induced in a gene dosage-dependent manner: luciferase activity was much ... Gene dosage- and concentration-dependent luciferase activities on a bioreactor scale. (A) Growth rates determined from ... As a reporter gene, we used the luciferase gene mluc, encoding a reporter that is sensitive and nondestructive and has a short ...
https://aem.asm.org/content/77/9/2975
*  PhD Viva | Indian Institute of Technology Delhi
... process optimization and gene dosage strategy 26/10/2017 TARUNA BANSALA Department of Textile Technology Studies on Graphene ...
http://www.iitd.ac.in/phd_viva_voce?page=14
*  Could a New Down Syndrome Mouse Model Also Be Useful for Alzheimer Research? | ALZFORUM
App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome ... Since the trisomy includes one human APP gene in the context of two mouse genes, you have (with regard to Aβ) essentially a ... Part of the long-term strategy we had (very long-term, as it turned out) is to breed to candidate gene knockout mice, so we can ... Cindy, sorry, we have not looked at APP by Western blot, but we do know that the human gene is expressed at the RNA level. ...
http://www.alzforum.org/webinars/could-new-down-syndrome-mouse-model-also-be-useful-alzheimer-research
*  The AMEDEO Literature Guide
Gene dosage reductions of Trf1 and/or Tin2 induce telomere DNA damage and lymphoma formation in aging mice.. Leukemia. 2017 Nov ...
http://amedeo.com/medicine/lym/leuk.htm
*  Assessing HER2 amplification by IHC, FISH, and real-time polymerase chain reaction analysis (real-time PCR) following LCM in...
Antibodies, Monoclonal, Humanized; Female; Gene Amplification; Gene Dosage; Gene Expression Regulation, Neoplastic; Humans; ...
http://www.forskningsdatabasen.dk/catalog/247835527
*  FfAME:org :: Patricia Moussatche
We demonstrate that IZH2 and IZH3 gene dosage affects resistance to polyene antifungal drugs. Moreover, we provide additional ... The nuclear receptor for progesterone functions as a ligand-activated transcription factor, directly regulating gene expression ...
http://ffame.org/pmoussatche.php
*  FfAME:org :: Patricia Moussatche's Publications
We demonstrate that IZH2 and IZH3 gene dosage affects resistance to polyene antifungal drugs. Moreover, we provide additional ... Preventing SA accumulation by expression of the nahG gene reduced subsequent ethylene production and altered the development of ... The nuclear receptor for progesterone functions as a ligand-activated transcription factor, directly regulating gene expression ...
http://ffame.org/pmoussatche.allpubs.php
*  KAKEN - Research Projects | Analysis of novel molecular targets of cancer stem cells by systems analysis (KAKENHI-PLANNED...
Journal Article] A genetic study of the effects of reduced Frs2alpha gene dosage in exostoses development and cartilage ... Journal Article] A genetic study of the effects of reduced Frs2alpha gene dosage in exostoses development and cartilage ... Journal Article] Gene set enrichment analysis provides insignt into novel signaling pathways in breast cancer stem cells2010. * ... Journal Article] A state space representation of VAR models with sparse learning for dynamic gene networks2010. *. Author(s). 後 ...
https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-22130009/
*  Beschreibung: Regulation of microRNA function in rodent hippocampal neurons by an alternative Ube3a transcript
UBE3A loss-of-function mutations cause Angelman syndrome (AS) (Kishino et al., 1997), whereas increased UBE3A gene dosage has ... Salmena et al., 2011) In conclusion, the results from my thesis describe a new gene regulatory mechanism operating in neuronal ... has unique functions in neuronal maturation and a gene regulatory function that strongly differ from functions of the ... been associated with autism-spectrum disorders (ASD) (Glessner et al., 2009). The UBE3A gene encodes an enzyme with ubiquitin ...
http://archiv.ub.uni-marburg.de/ubfind/Record/urn:nbn:de:hebis:04-z2015-0617/Description
*  Mouse genetic corneal disease resulting from transgenic insertional mutagenesis | British Journal of Ophthalmology
Glaser T, Jepeal L, Edwards JG, et al. PAX6 gene dosage effect in a family with congenital cataracts, aniridia, anophthalmia ... Another possibility is that the transgenic insertional mutagenesis affected a regulatory gene, such as Pax6 or a similar gene. ... BIGH3 (transforming growth factor β induced gene) is a gene involved in corneal dystrophies such as lattice and granular ... Skonier J, Neubauer M, Madisen L, et al. cDNA cloning and sequence analysis of βig-h3, a novel gene induced in a human ...
http://bjo.bmj.com/content/88/3/428
*  Epigenetics & Chromatin | Articles
Gene dosage in mammals: characterization of haploid embryonic stem cells Authors: Anton Wutz and Martin Leeb ... DNA methylation and gene expression patterns in breast cancer progression from in situ carcinoma to invasive carcinoma Authors: ... Effect of cell separation on gene expression and DNA methylation profiles in intestinal epithelial cells Authors: M Molitor, J ... Control of antigen receptor gene assembly by cis-element mediated looping Authors: Kinjal Majumder, Olivia Koues, Suhasni ...
https://epigeneticsandchromatin.biomedcentral.com/articles?searchType=journalSearch&sort=PubDate&page=10
*  Protein kinase profiling in miscarriage: implications for the pathogenesis of trisomic pregnancy. | CureHunter
Both gene dosage effects and amplified instability operate simultaneously on the expression of protein kinases in trisomic ... This supports a role for chromosome-specific effects in the pathogenesis of trisomy (gene dosage hypothesis). In addition, both ... Distinct patterns of protein kinase expression were seen in the two trisomic groups, including dosage-dependent over-expression ...
http://www.curehunter.com/public/pubmed23231796.do
*  Fungal Publications
2015) Horizontal gene transfer and gene dosage drives adaptation to wood colonization in a tree pathogen. Proc Natl Acad Sci U ... Gene Atlases of Grass-Microbe Interactions. This proposal seeks to build comprehensive gene atlas maps for diverse bioenergy ... 2017) Widespread adenine N6-methylation of active genes in fungi. Nat Genet 49(6), 964-968. 10.1038/ng.3859. More Details ... 2017) Widespread adenine N6-methylation of active genes in fungi. Nat Genet 49(6), 964-968. 10.1038/ng.3859. More Details ...
https://jgi.doe.gov/our-science/science-programs/fungal-genomics/fungal-publications/
*  Characterization of novel and complex genomic aberrations in glioblastoma using a 32K BAC array
By altering gene dosage levels or disrupting proximal or distant regulatory elements CNVs create human diversity. They ... Many of these genes are already linked to several forms of cancer; others represent new candidate genes that may serve as ... These regions encompassed not only previously reported oncogenes and tumor suppressor genes but also numerous novel genes. In ... 1. Application of Genomic and Expression Arrays for Identification of new Cancer Genes. Open this publication in new window or ...
http://uu.diva-portal.org/smash/record.jsf?pid=diva2:289546
*  2015 Publications
2015) Horizontal gene transfer and gene dosage drives adaptation to wood colonization in a tree pathogen. Proc Natl Acad Sci U ... 2015) Sequencing of 15,622 gene-bearing BACs clarifies the gene-dense regions of the barley genome. Plant J . 10.1111/tpj.12959 ... Gene Atlases of Grass-Microbe Interactions. This proposal seeks to build comprehensive gene atlas maps for diverse bioenergy ... 2015) IMG-ABC: A Knowledge Base To Fuel Discovery of Biosynthetic Gene Clusters and Novel Secondary Metabolites. MBio 6(4). ...
https://jgi.doe.gov/news-publications/publications/2015-publications/
*  The Neurobiology of Autism - Pardo - 2007 - Brain Pathology - Wiley Online Library
Salinger WL, Ladrow P, Wheeler C (2003) Behavioral phenotype of the reeler mutant mouse: effects of RELN gene dosage and social ... Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism. Am J Hum Genet 77 ... Barnby G, Abbott A, Sykes N, Morris A, Weeks DE, Mott R, Lamb J, Bailey AJ, Monaco AP (2005) Candidate-gene screening and ... Gauthier J, Bonnel A, St-Onge J, Karemera L, Laurent S, Mottron L, Fombonne E, Joober R, Rouleau GA (2005) NLGN3/NLGN4 gene ...
http://onlinelibrary.wiley.com/doi/10.1111/j.1750-3639.2007.00102.x/references
*  Search Results - - 648 Results - Digital Library
The effects of growth phase, total transforming DNA concentration, transforming DNA conformation, and gene dosage on ... The pyrR gene product was purified to homogeneity and found to have a monomeric molecular mass of 19 kDa. The pyrR gene is ... Unlike Escherichia coli where the above genes are expressed from a biscistronic operon the two genes in M. jannaschii are ... Pseudomonas putida is the natural host of TOL plasmids, ranging between 50 kbp and 300 kbp in size and encoding genes for the ...
https://digital.library.unt.edu/explore/partners/UNT/browse/?fq=str_degree_department%3ADepartment+of+Biological+Sciences&sort=added_a&start=40
*  ASF1 | SGD
... buffering mRNA synthesis rate against gene dosage changes in S phase; anti-silencing protein, derepresses silent loci when ... Gene Ontology Details Gene Ontology GO Annotations consist of four mandatory components: a gene product, a term from one of the ... The number of putative Regulators (genes that regulate it) and Targets (genes it regulates) for the given locus, based on ... All manually curated literature for the specified gene, organized into topics according to their relevance to the gene (Primary ...
http://www.yeastgenome.org/locus/S000003651
*  All transcript variants in gene KAT6B - Global Variome shared LOVD
decreased gene dosage. PubMed: DDDS 2015, Journal: DDDS 2015. -. -. De novo. -. -. -. 0. -. Johan den Dunnen. ... DB-ID: database ID of variant, grouping multiple observations of the same variant together, starting with the HGNC gene symbol ... All transcript variants in gene KAT6B. The variants shown are described using the NM_012330.3. NM_001256468.1. NM_001256469.1. ... encompassing the entire 18-exon gene. DNA change (cDNA): description of variant at DNA level, based on a coding DNA reference ...
https://databases.lovd.nl/shared/variants/KAT6B?search_var_status=%3D%22Marked%22%7C%3D%22Public%22