Direct autoregulation and gene dosage compensation by POU-domain transcription factor Brn3a.
... Trieu M., Ma A., Eng S.R., ... Conversely, transgenic overexpression of Brn3a in the trigeminal ganglion suppresses the expression of the endogenous gene. ... demonstrating that autoregulation can compensate for the loss of one allele by increasing transcription of the remaining gene ...http://www.uniprot.org/citations/12441296
null=Effect of the Mi gene on reproduction of Meloidogyne hispanica on tomato genotypes, en=Effect of the |i|Mi|/i| gene on...
... which suggests a possible dosage effect of the Mi gene. The variability observed in the Rf values for MiMi tomato genotypes may ... gene. Ten of the 25 tomato genotypes with ,i,Mi,/i, gene are commercially available. However, only Rapit can be used to control ... Ten heterozygous tomato genotypes (Mimi), nine homozygous (MiMi) at the ,i,Mi,/i, locus and six lacking the ,i,Mi,/i, gene for ... Ten of the 25 tomato genotypes with Mi gene are commercially available. However, only Rapit can be used to control the three ...http://booksandjournals.brillonline.com/content/journals/10.1163/138855411x566449
北京大学医学部机构知识库(IR@PKUHSC): Association Between Interferon Regulatory Factor 6 Gene Polymorphisms and Nonsyndromic Cleft Lip With...
There was an obvious dosage effect of allele A at rs642961. The transmission of a major allele (G) of rs2235371 and a minor ... Zhou, Qian,et al."Association Between Interferon Regulatory Factor 6 Gene Polymorphisms and Nonsyndromic Cleft Lip With or ... Association Between Interferon Regulatory Factor 6 Gene Polymorphisms and Nonsyndromic Cleft Lip With or Without Cleft Palate ... Association Between Interferon Regulatory Factor 6 Gene Polymorphisms and Nonsyndromic Cleft Lip With or Without Cleft Palate ...http://ir.bjmu.edu.cn/handle/400002259/61352
Publications - CBG
Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus. Nature: 2011, 478(7367);97-102 [ ... CUBN is a gene locus for albuminuria. J. Am. Soc. Nephrol.: 2011, 22(3);555-70 [PubMed:21355061] [WorldCat.org] [DOI] ... The evolution of gene expression levels in mammalian organs. Nature: 2011, 478(7369);343-8 [PubMed:22012392] [WorldCat.org] [ ... Variant within the promoter region of the CHRNA3 gene associated with FTN dependence is not related to self-reported ...https://www2.unil.ch/cbg/index.php?title=Publications&oldid=2432
Archive | mBio
Transcriptional Regulation Buffers Gene Dosage Effects on a Highly Expressed Operon in Salmonella A feature of bacterial ... Michael J. Coffey, Laura F. Dagley, Simona Seizova, Eugene A. Kapp, Giuseppe Infusini, David S. Roos, Justin A. Boddey, Andrew ... Structural and Nonstructural Genes Contribute to the Genetic Diversity of RNA Viruses With the advent of advanced sequencing ... Gene Essentiality Analyzed by In Vivo Transposon Mutagenesis and Machine Learning in a Stable Haploid Isolate of Candida ...https://mbio.asm.org/content/9/5
Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term...
Malignant transformation initiated by Mll-AF9: gene dosage and critical target cells. Cancer Cell. 13:432-440. doi:10.1016/j. ... 7, I and J), suggesting that LT-HSC function is critically dependent on Evi1 gene dosage. In a noncompetitive setting, although ... our data strongly support a model in which Evi1 gene dosage is a critical determinant of HSC self-renewal potential. ... A gene atlas of the mouse and human protein-encoding transcriptomes. Proc. Natl. Acad. Sci. USA. 101:6062-6067. doi:10.1073/ ...http://jem.rupress.org/content/early/2011/11/10/jem.20110447
Professor Shareen Doak
Doak, S. Jenkins, S. Hurle, R. Varma, M. Hawizy, A. Kynaston, H. & Parry, J. (2007). Bone morphogenic factor gene dosage ... Doak, S. Jenkins, G. Parry, E. Griffiths, A. Shah, V. Baxter, J. & Parry, J. (2003). Characterisation of p53 status at the gene ... Doak, S. & Zaïr, Z. (2011). Real-Time Reverse-Transcription Polymerase Chain Reaction: Technical Considerations for Gene ... Doak, S. (2004). Differential expression of the MAD2, BUB1 and HSP27 genes in Barrett's oesophagus-their association with ...http://www.swansea.ac.uk/staff/medicine/learningandteaching/doaksh/name,164193,en.php
Loss or gain of genetic material: A weighty issue - Healthcanal.com : Healthcanal.com
Full bibliographic informationJacquemont, S. et al., "Mirror extreme BMI phenotypes associated with gene dosage at the ... Scientists discover new gene expression mechanism with possible role in human disease ... Unexpected outcomes sound warning for treatment of genetic diseases using gene editing in embryos ... depending on the number of copies of the genes that an individual has. The CRG researchers Xavier Estivill, Mónica Gratacós and ...https://www.healthcanal.com/genetics-birth-defects/20233-loss-or-gain-of-genetic-material-a-weighty-issue.html
Diploidization - Wikipedia
1. Coordinate inter-genomic gene expression: Duplicated genes often result in increased dosage of gene products. Doubled ... It has been hypothesized that dosage balance may play a key role in shaping the evolutionary fates of duplicated genes (1). ... The main goals of diploidization are: 1. To ensure proper gene dosage 2. To maintain stable cellular division processes. It ... First, the eliminated copy restores the normal gene dosage in the diploid organism (1). Second, the changes in chromosomal ...https://en.wikipedia.org/wiki/Diploidization
Table of Contents - September 01, 2017, 175 (1) | Plant Physiology
5-Aminolevulinic Acid Dehydratase Gene Dosage Affects Programmed Cell Death and Immunity Qichao Chai, Xiaoguang Shang, Shuang ... SCYL2 Genes Are Involved in Clathrin-Mediated Vesicle Trafficking and Essential for Plant Growth Ji-Yul Jung, Dong Wook Lee, ... Multiplexed Gene Editing and Protein Overexpression Using a Tobacco mosaic virus Viral Vector Will B. Cody, Herman B. Scholthof ... Gene Regulatory Networks for the Haploid-to-Diploid Transition of Chlamydomonas reinhardtii Sunjoo Joo, Yoshiki Nishimura, Evan ...http://www.plantphysiol.org/content/175/1?current-issue=y
ErbB2/Neu-Induced, Cyclin D1-Dependent Transformation Is Accelerated in p27-Haploinsufficient Mammary Epithelial Cells but...
Neu-induced mammary transformation in vivo is modulated by p27 gene dosage.We generated MMTV-neu/p27+/+, MMTV-neu/p27+/−, and ... we have tested whether p27 gene dosage alters ErbB2/Neu- and cyclin D1-induced mammary cell transformation in culture and in ... Deletion of the p27Kip1 gene restores normal development in cyclin D1-deficient mice. Proc. Natl. Acad. Sci. USA 98:194-199. ... As many genes involved in mammary gland morphogenesis are often dysregulated during tumorigenesis, it is conceivable that p27 ...https://mcb.asm.org/content/22/7/2204?ijkey=bbc6e714334ef8acad64d7200cf3d0f5e869902a&keytype2=tf_ipsecsha
Proliferation of aneuploid human cells is limited by a p53-dependent mechanism | JCB
Trisomy has been shown to create gene dosage imbalances in both budding yeast and mammals (Torres et al., 2007; Williams et al ... Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis. Genes Dev. 14: ... monosomy would also generate gene dosage imbalances. This provides a likely explanation for why our data show activation of the ... which would limit the capacity of aneuploidy-induced gene dosage imbalances to activate the p53 pathway. Alternatively, some ...http://jcb.rupress.org/content/188/3/369
5-Aminolevulinic Acid Dehydratase Gene Dosage Affects Programmed Cell Death and Immunity. Chai et al. Plant Physiol. 2017 175 ( ...http://www.plantphysiol.org/highwire/payment/process/ppv/139137?jcode=plantphysiol&type=ppv&ppv_type=article&url=http%3A/www.plantphysiol.org/content/early/2017/07/27/pp.17.00816
Current Prospects in Optic Nerve Protection and Regeneration: Sixth ARVO/Pfizer Ophthalmics Research Institute Conference |...
Libby RT Li Y Savinova OV . Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage. PLoS Genet. 2005; ... Genes that appear upregulated in early glaucomatous damage include immediate response genes such as Atf3, neurotrophic factor, ... Duration of gene silencing after administration of the RNAi should also be evaluated. Compensatory changes in endogenous gene ... and cytokine genes, and genes involved in the regulation of the cell cycle, extracellular matrix, and cytoskeleton. 17 It is ...https://iovs.arvojournals.org/article.aspx?articleid=2188599
DNA copy number evolution in Drosophila cell lines | Genome Biology | Full Text
For example, we found that proto-oncogenes were over-represented in one cell line (S2-DRSC), whereas tumor suppressor genes ... consistent with the gene balance hypothesis. Second, while most copy number changes were cell line-specific, we identified some ... The sum of these trans-effects in gene networks can antagonize the dosage effect and result in gene-specific dosage ... Gene dosage effects and compensation. The amount of transcript produced from genes with a given copy number is a function of ...https://genomebiology.biomedcentral.com/articles/10.1186/gb-2014-15-8-r70
Characterization of an inducible promoter in different DNA copy number conditions | BMC Bioinformatics | Full Text
The system is composed by a luxR constitutive expression cassette and a RFP gene regulated by the luxI promoter, which is ... Kittleson JT, Cheung S, Anderson JC: Rapid optimization of gene dosage in E. coli using DIAL strains. Journal of Biological ... The luxR gene is constitutively produced by the tetR promoter and the strong ribosome binding site B0034. The gene encoding for ... Boyd D, Weiss D, Chen J, Beckwith J: Towards single-copy gene expression systems making gene cloning physiologically relevant: ...https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-13-S4-S11
Persistence, suppression and re-expression of pigment formation in somatic cell hybrids between mouse melanoma cells and non...
The results were independent of gene dosage of either parent cell. gamma-irradiation of suppressing partner cells prior to ...http://jcs.biologists.org/content/47/1/207
Mitochondrial DNA Damage and Dysfunction Associated With Oxidative Stress in Failing Hearts After Myocardial Infarction |...
Mitochondrial gene expression in mammalian striated muscle. Evidence that variation in gene dosage is the major regulatory ... 8 As opposed to nuclear-encoded genes, mitochondrial-encoded gene expression is largely regulated by the copy number of mtDNA. ... mRNA genes are shown as the areas labeled with the codes of the corresponding electron transport chain complexes I, III, IV, ... The mtDNA levels were normalized to the abundance of the 18S rRNA gene run on the same gel. The protein levels of transcription ...http://circres.ahajournals.org/content/88/5/529
1997) Sensitivity to Jerky gene dosage underlies epileptic seizures in mice. J. Neurosci. 17:4562-4569. ... 1995) Pattern and time course of immediate early gene expression in rat brain following acute stress. Neuroscience 64:477-505. ... PTZ seems to decrease the potency of GABA-mediated inhibition in brain (26) and, depending on the dosage, can produce myoclonic ... 1992) From ligand binding to gene expression: new insights into the regulation of G-protein-coupled receptors. Trends Biochem ...http://molpharm.aspetjournals.org/content/52/6/1056
Jonathan Pollack | Stanford Medicine Profiles
In lost/gained regions, gene expression profiling detected a gene dosage effect with significant lower/higher average gene ... frequently underlie gene expression changes by increasing or decreasing gene dosage. However, only a subset of genes with ... We analyzed 1,233,780 gene-to-gene data points and found that gene gains typically outnumbered losses (ratio of gains/losses = ... Parallel analysis of gene expression helped delineate potential candidate genes, and unsupervised analysis of gene expression ...https://med.stanford.edu/profiles/jonathan-pollack
PAX6 - Wikipedia
1994). "PAX6 gene dosage effect in a family with congenital cataracts, aniridia, anophthalmia and central nervous system ... regulation of gene expression. • positive regulation of gene expression. • pallium development. • oligodendrocyte cell fate ... "Genes and Mapped Phenotypes." National Center for Biotechnology Information. U.S. Pax6 is a gene in prenatal development ... "Genes & Development. 28 (17): 1879-1884. doi:10.1101/gad.246140.114. ISSN 0890-9369. PMC 4197948 . PMID 25184676.. ...https://en.wikipedia.org/wiki/PAX6
TREM2 Binds Aβ, Reprograms Microglia to Curb Plaques | ALZFORUM
The authors have also performed transcriptomic profiling to identify genes dependent on TREM2 gene dosage. This work helps us ... The results by Lee and colleagues show that extra TREM2 gene dosage is beneficial for memory deficits and AD-associated ... Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease ... When we identify a new gene contributing to a disease this is the ultimate goal, and it's great to see the amazing work that ...https://www.alzforum.org/news/research-news/trem2-binds-av-reprograms-microglia-curb-plaques
Genetic Engineering Spider Silk
An increase in the gene dosage of glycyl-tRNA synthase did not enhance silk production. So it was decided to increase the ... The repeats were joined to the C- and N- termini peptides of the silkworm fibroin heavy chain gene, and placed under the ... In another version of the vector, the spider silk sequence was also joined to a green fluorescent protein gene to aid in ... Silk genes spin composite silk fibres with improved mechanical properties. PNAS 2012, 109, 923-8. ...http://www.i-sis.org.uk/Genetic_Engineering_Spider_Silk.php
Regional neural tube closure defined by the Grainy head-like transcription factors.
The two genes contribute equally to closure 2, where only Grhl gene dosage is limiting. Combined deletion of Grhl2 and Grhl3 ... Using a gene-targeting approach we show that deletion of Grhl2 results in failed closure 3, with mutants exhibiting a split- ... molecular basis for these observations based on the function of the non-neural ectoderm-specific Grainy head-like genes in mice ...https://www.uniprot.org/citations/20654612
Effective quantitative real-time polymerase chain reaction analysis of the parkin gene (PARK2) exon 1-12 dosage | BMC Medical...
... gene exons by comparing the intensity of the amplification signals from some exon of this gene with that of the β-globin gene ( ... Deletions and duplications of single exons or exon groups account for a large proportion of the gene mutations. Direct ... the internal control). We analyzed rearrangements in exons 1-12 of the PARK2 gene in 64 patients from Russia with early-onset ... and reproducible method applicable to the rapid detection of exon rearrangements in the PARK2 gene. It is suitable for the ...https://bmcmedgenet.biomedcentral.com/articles/10.1186/1471-2350-8-6