Loading...
*  Correlation between rs2108622 locus of CYP4F2 gene single nucleotide polymorphism and warfarin dosage in Iranian cardiovascular...
The rs2108622 SNP of the CYP4F2 gene and its effect on warfarin dosing in these patients was accessed. Results: The results of ... our study showed a correlation between age and warfarin dosage. The overall frequency of the CC and TT allele of rs2108622 was ... "Correlation between rs2108622 locus of CYP4F2 gene single nucleotide polymorphism and warfarin dosage in Iranian cardiovascular ... Correlation between rs2108622 locus of CYP4F2 gene single nucleotide polymorphism and warfarin dosage in Iranian cardiovascular ...
http://ijpr.sbmu.ac.ir/article_2074.html
*  Advances in understanding chromosome silencing by the long non-coding RNA Xist. - Oxford Neuroscience
The Xist gene produces a non-coding RNA that functions as the primary switch for X-inactivation, coating the X chromosome from ... X chromosome inactivation (X-inactivation) is a classical model for epigenetic gene regulation in mammals and has been studied ... one of the two X chromosomes becomes genetically silenced to compensate for dosage imbalance of X-linked genes between XX ... one of the two X chromosomes becomes genetically silenced to compensate for dosage imbalance of X-linked genes between XX ...
https://www.neuroscience.ox.ac.uk/publications/366790
*  Advances in understanding chromosome silencing by the long non-coding RNA Xist | lncRNA Blog
... one of the two X chromosomes becomes genetically silenced to compensate for dosage imbalance of X-linked genes between XX ... The Xist gene produces a non-coding RNA that functions as the primary switch for X-inactivation, coating the X chromosome from ... X chromosome inactivation (X-inactivation) is a classical model for epigenetic gene regulation in mammals and has been studied ... breast cancer cancer chromatin colorectal cancer database epigenetic epigenetics gastric cancer gencode gene expression gene ...
http://www.lncrnablog.com/advances-in-understanding-chromosome-silencing-by-the-long-non-coding-rna-xist/
*  Epigenetics Protocols | SpringerLink
Photocrosslinking Oligonucleotide Hybridization Assay for Concurrent Gene Dosage and CpG Methylation Analysis ...
https://link.springer.com/book/10.1385/1592598285
*  Anti-beta Actin antibody [mAbcam 8226] - Loading Control (ab8226) References
Jang SW et al. Identification of drug modulators targeting gene-dosage disease CMT1A. ACS Chem Biol 7:1205-13 (2012). PubMed: ... Hill MJ et al. Knockdown of the schizophrenia susceptibility gene TCF4 alters gene expression and proliferation of progenitor ... Larti F et al. A defect in the CLIP1 gene (CLIP-170) can cause autosomal recessive intellectual disability. Eur J Hum Genet N/A ... Yan L et al. Differential effects of AdOx on gene expression in P19 embryonal carcinoma cells. BMC Neurosci 13:6 (2012). PubMed ...
http://www.abcam.com/beta-actin-antibody-mabcam-8226-loading-control-ab8226-references.html
*  Adhesion of Monocytes to Arterial Endothelium and Initiation of Atherosclerosis Are Critically Dependent on Vascular Cell...
A Vcam1 gene-dosage-dependent effect on atherosclerotic plaque formation was noted in mice of both sexes (Figure 2). In males, ... Vcam1 gene dosage affected endothelial VCAM-1 expression and the subsequent monocyte adherence to lesion-prone areas of the ... VCAM-1 staining of endothelial cells in lesion-prone areas of the aortic arch was gene-dosage dependent. The extent of ... Heterozygous Vcam1 D4D mice revealed a Vcam1 gene-dosage effect and had intermediate, yet significant, reductions in these ...
http://atvb.ahajournals.org/content/21/10/1662
*  Actin Depolymerizing Factors Cofilin1 and Destrin Are Required for Ureteric Bud Branching Morphogenesis | proLékaře.cz
The gene dosage of Cfl1 and Dstn in the ureteric bud is important for normal branching patterns. Since Cfl1 and Dstn are ... This effect of reduced gene dosage suggests that the level of total ADF expression (cofilin1 + destrin) in UB cells is ... Článek Tight Regulation of the Gene of the KplE1 Prophage: A New Paradigm for Integrase Gene Regulation ... Tight Regulation of the Gene of the KplE1 Prophage: A New Paradigm for Integrase Gene Regulation ...
https://www.prolekare.cz/casopisy/plos-genetics/2010-10/actin-depolymerizing-factors-cofilin1-and-destrin-are-required-for-ureteric-bud-branching-morphogenesis-45088
*  Postmitotic diversification of olfactory neuron types is mediated by differential activities of the HMG‐box transcription...
Gene dosage experiments that we performed favor the competition model.. The sox‐2(ky707) mutation causes a glycine to glutamic ... mutants depends on the AWC identity specification genes and the AWCON maintenance genes, but is independent of any of the genes ... Gene dosage experiments suggest a competition model. The data presented so far demonstrate two main features of AWB and AWC ... Three AWB identity markers, the str‐1 and sru‐38 GPCR genes and the lim‐4 LIM homeobox gene, failed to be expressed in ky707 ...
http://emboj.embopress.org/content/34/20/2574.export
*  The non-dosage compensated Lsp1 α gene of Drosophila melanogaster escapes acetylation by MOF in larval fat body nuclei, but is...
An X-linked reporter gene bracketed by Lsp1 α flanking regions was dosage compensated. One of the genes flanking Lsp1 α is ... gene has long been known to be not dosage compensated. Here we have examined possible explanations for why the Lsp1 α gene is ... The most likely explanation for why Lsp1 α is not dosage compensated is that the gene has not evolved a mechanism to ... This gene shows a modest enrichment for H4K16ac but only at the part of the gene most distant from Lsp1 α. Phylogenetic ...
https://bmcmolbiol.biomedcentral.com/articles/10.1186/1471-2199-8-35
*  Cellular prion protein (PrPC) protects neuronal cells from the effect of huntingtin aggregation | Journal of Cell Science
Manson, J. C., Hope, J., Clarke, A. R., Johnston, A., Black, C. and MacLeod, N. (1995). PrP gene dosage and long term ... A mouse prion gene with the hamster epitope tag (a gift from S. Priola, Rocky Mountain Lab, MT) and a hamster prion gene (a ... Recent results from the Collinge laboratory showed that disruption of the prion gene in scrapie-infected mice reversed any ... by disrupting the prion gene in a scrapie-infected mouse, they reversed the spongiosis, cognitive defects and neurological ...
http://jcs.biologists.org/content/120/15/2663
*  Mechanistic Roles of Noncoding RNAs in Lung Cancer Biology and Their Clinical Implications
K. S. S. Enfield, G. L. Stewart, L. A. Pikor et al., "MicroRNA gene dosage alterations and drug response in lung cancer," ... gene dosage alterations affecting lncRNA expression have yet to be reported.. 4.2. Epigenetic Mechanisms. Epigenetic influences ... The first lncRNAs identified were the imprinted H19 gene and X-inactive-specific transcript (XIST) critical to X chromosome ... were shown to directly target both DNMT3A and DNMT3B, two genes that are often overexpressed in lung cancer [60], resulting in ...
https://www.hindawi.com/journals/gri/2012/737416/
*  Polygenic mutations in the cytotoxicity pathway increase susceptibility to develop HLH immunopathology in mice | Blood Journal
Secondly, the gene dosage effect suggests that the addition of monoallelic mutations in genes within this pathway, and possibly ... This sensitivity to gene dosage has several implications for human disease. Firstly, the cumulative effects of mutations in ... and the number and severity of the features vary as a function of the gene dosage. ... 41 Prospective studies analyzing the different HLH-related genes systematically and the combination of the genes' variants in ...
http://www.bloodjournal.org/content/127/17/2113?sso-checked=true
*  Plus it
2 and 3). Moreover, the extent of this attenuation was proportional to the RAGE gene dosage (Figs. 2 and 3). Recently, ... The degree of kidney injury was proportional to RAGE gene dosage. Furthermore, we show that low-molecular weight heparin (LMWH ... A: Gene targeting vector and strategy. B and C: Southern blotting of embryonic stem cell DNA and mouse tail DNA digested with ... To perform gene targeting in embryonic stem cells, we constructed a targeting vector containing two loxP sites flanking the neo ...
http://diabetes.diabetesjournals.org/content/55/9/2510
*  CBS Publications
Gene expression analysis identifies global gene dosage sensitivity in cancer. Fehrmann RS, Karjalainen JM, Krajewska M, Westra ... Fatness-associated FTO gene variant increases mortality independent of fatness--in cohorts of Danish men. Zimmermann E, Kring ... Concordance of gene expression in human protein complexes reveals tissue specificity and pathology. Börnigen D, Pers TH, ... A distinct adipose tissue gene expression response to caloric restriction predicts 6-mo weight maintenance in obese subjects. ...
http://www.cbs.dtu.dk/publications/index.php?userid=772
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Conditional knockout of the RNA-binding protein HuR in CD4? T cells reveals a gene dosage effect on cytokine production. ... These results reveal a complex differential posttranscriptional regulation of cytokines by HuR in which gene dosage plays an ... Mammalian gene expression patterns change profoundly in response to low oxygen levels. These changes in gene expression ... genes, regulate lipid metabolism in concert with their host genes. Here, we show that miR-33b also cooperates with SREBP1 in ...
https://www.jove.com/visualize?author=Myriam+Gorospe
*  Effect of Genome Position on Heterologous Gene Expression in Bacillus subtilis: An Unbiased Analysis
... gene orientation with respect to DNA replication direction does not influence gene expression. Our study shows that gene dosage ... However, the copy number of integrated genes depends on their genomic location. This gene dosage effect is rarely addressed in ... We found that there is a strong gene dosage effect in fast growing B. subtilis cells, which can amount to a 5-fold difference ... Two studies in Escherichia coli presented conflicting data on the impact of gene dosage. Here, we investigate how genome ...
http://dare.uva.nl/search?metis.record.id=535261
*  Nutritional Supplements for Down Syndrome
Cystathione beta synthase: Gene dosage effect in trisomy 21. Biochemical and Biophysical Research Communications 128:40-44, ... Homocysteine, factor VII and antithrombin III in subjects with different gene dosage for cystathione beta-synthase. Journal of ... Antioxidants. It has been known for many years that one of the genes overexpressed in Down syndrome is the one producing ... Both formulas have more than 40 ingredients, most of them the same or similar, but with differences in dosage. Various formulas ...
https://www.quackwatch.org/01QuackeryRelatedTopics/down.html
*  Plus it
Our data are compatible with a gene dosage effect. Watson et al. (11) showed that individuals with two GSTP1 105Val alleles ... Methylation of CpG islands in the promoter region of the GSTP1 gene is another mechanism of gene inactivation. GSTP1 ... The Ile105Val polymorphism of the GSTP1 gene was analyzed using the PCR-RFLP technique as described by Harries et al. (22). ... Experimental Design: The Ile105Val polymorphism in the GSTP1 gene was analyzed using a PCR-RFLP technique. Ninety-seven ...
http://clincancerres.aacrjournals.org/content/11/6/2175
*  Signalling and Cell Cycle Laboratory | IRB Barcelona
Gene Dosage Imbalance Contributes to Chromosomal Instability-Induced Tumorigenesis Clemente-Ruiz M, Murillo-Maldonado JM, ...
https://www.irbbarcelona.org/ca/research/signalling-and-cell-cycle-laboratory
*  Development and Growth Control Laboratory publications | IRB Barcelona
Gene Dosage Imbalance Contributes to Chromosomal Instability-Induced Tumorigenesis Clemente-Ruiz M, Murillo-Maldonado JM, ...
https://www.irbbarcelona.org/ca/research/development-and-growth-control-laboratory/publications
*  adult pleomorphic rhabdomyosarcoma 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
Gene Dosage. Gene Expression. Humans. Image Interpretation, Computer-Assisted. Male. Middle Aged. Myeloid Cell Leukemia ... MeSH-major] Genes, p53 / physiology. Genes, ras / physiology. Rhabdomyosarcoma / etiology. *KOMP Repository. gene/protein/ ... Marmoset Gene list: Data: Gene Annotation .. *[Source] The source of this record is MEDLINE®, a database of the U.S. National ... and BMP4 genes. Genes Chromosomes Cancer; 2007 Nov;46(11):1028-38. The Lens. Cited by Patents in .. *[Source] The source of ...
http://www.bmlsearch.com/?kwr=adult+pleomorphic+rhabdomyosarcoma+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0
*  grade iv astrocytic tumor of the brain drug therapy 2000:2010[pubdate] *count=100 - BioMedLib™ search engine
Gene Dosage. Glioblastoma / genetics. Humans. Infant. Male. Middle Aged. Neoplasm Recurrence, Local / genetics. Nucleic Acid ... RESULTS: A restricted set of tumor-associated genes was identified for each grade that included genes not previously associated ... profiles is expected to aid in the identification of astrocytoma-associated genes and highly expressed cell surface genes as ... Boon K, Edwards JB, Eberhart CG, Riggins GJ: Identification of astrocytoma associated genes including cell surface markers. BMC ...
http://www.bmlsearch.com/?kwr=grade+iv+astrocytic+tumor+of+the+brain+drug+therapy+2000:2010%5Bpubdate%5D&cxts=100&stmp=b1
*  Single-Cell Based Quantitative Assay of Chromosome Transmission Fidelity | G3: Genes | Genomes | Genetics
... gene dosage sensitivity. (A) A bar plot shows CIN rate of nine strains each having heterozygous deletion of one icCIN gene ( ... Gene Onology (GO) analysis of validated candidate genes. dcCIN genes and icCIN genes were classified using GO Slim Mapper tool ... E) Gene Ontology Slim functional classification of icCIN genes. Only groups with at least two genes are shown with some highly ... B) Gene Ontology Slim functional classification of dcCIN genes, showing only major groups with at least 10 genes with some ...
http://www.g3journal.org/content/5/6/1043.full
*  US6900300B1 - Quadruplex DNA and duplex probe systems - Google Patents
Assays for the direct measurement of gene dosage WO1992016657A1 (en) 1992-10-01. Method of identifying a nucleotide present at ... Although not required, other promoters include, e.g., single stranded binding proteins such as Rec A protein, T4 gene 32 ... Sense and antisense 50-mer ssDNA target sequences, derived from exon 10 of the human cystic fibrosis gene (Nature 380, 207 ( ... 50-mer ssDNA target sequences, derived from exon 10 of the human cystic fibrosis gene (Nature 380, 207 (1996)) and modified ...
https://patents.google.com/patent/US6900300?oq=6%2C044%2C471
*  US20060019278A1 - Marker for prenatal diagnosis and monitoring - Google Patents
More specifically, this invention relies on the discovery that the maspin gene is differentially methylated in fetal DNA and in ... To assess the gene dosage of U-maspin, bisulfite-converted placental tissue DNA was assessed by the MassEXTEND assay. The SNP ... Gene Security Network, Inc.. Methods for cell genotyping US20110092763A1 (en) * 2008-05-27. 2011-04-21. Gene Security Network, ... Gene dosage of U-maspin for 23 normal pregnancies and 2 pregnancies involving a trisomy 18 fetus was determined using the ...
https://patents.google.com/patent/US20060019278A1/en