JCI - PTG gene deletion causes impaired glycogen synthesis and developmental insulin resistance
... we generated mice possessing a heterozygous deletion of the PTG gene. Because the PTG gene is intronless, the entire coding ... PTG gene deletion causes impaired glycogen synthesis and developmental insulin resistance. Sean M. Crosson,1 Ahmir Khan,2 John ... The heterozygous deletion of the PTG gene indicates that this protein plays a vital role in glycogen metabolism. The steady- ... Homozygous deletion of the PTG gene was embryonic lethal, as the genotyping of more than 100 pups derived from heterozygous ...
Ph MGI Mouse Gene Detail - MGI:97571 - patch deletion region
J:99 Gruneberg H, et al., Two closely linked genes in the mouse. Genet Res. 1960;1(1):69-90 ... Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse ... Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. ... Tumor Biology (MTB)), Gene Ontology (GO) Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, ...
TP53 gene mutations and 17p deletions in human astrocytomas
Recent molecular genetic analyses of astrocytomas have demonstrated frequent chromosome 17 deletions involving the telomeric ... TP53 gene mutations and 17p deletions in human astrocytomas Genes Chromosomes Cancer. 1991 Sep;3(5):323-31. doi: 10.1002/gcc. ... Recent molecular genetic analyses of astrocytomas have demonstrated frequent chromosome 17 deletions involving the telomeric ... and none of either the grade I astrocytomas or oligodendrogliomas demonstrated distinct point mutations involving the TP53 gene ...
A frame-shift deletion in the survival motor neuron gene in Spanish spinal muscular atrophy patients
The region on chromosome 5q13 encompassing the disease gene is particularly unstable and prone to large-scale … ... The other patients showed either deletions of the SMN gene (49/54) or a gene conversion event changing SMN exon 7 into its ... A frame-shift deletion in the survival motor neuron gene in Spanish spinal muscular atrophy patients Nat Genet. 1995 Nov;11(3): ... The region on chromosome 5q13 encompassing the disease gene is particularly unstable and prone to large-scale deletions whose ...
09/02/2022: Lab Alert: MPXV TNF Receptor Gene Deletion May Lead to False Negative Results with Some MPXV Specific LDTs
... ... CDC will update the published primer and probe sequence information to alert test developers of this TNF receptor gene deletion ... At this point, the TNF receptor gene deletion is rare. Molecular laboratory developed tests (LDTs) designed using the CDC ... Use a multiplex assay that targets multiple viral genes, or an assay that targets an essential viral gene which is unlikely to ...
Gene Deletion | Profiles RNS
"Gene Deletion" by people in this website by year, and whether "Gene Deletion" was a major or minor topic of these publications ... "Gene Deletion" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This deletion may be detected using cytogenetic techniques and can also be inferred from the phenotype, indicating a deletion ... Below are the most recent publications written about "Gene Deletion" by people in Profiles. ...
Identification of a new DMD gene deletion by ectopic transcript analysis. | Journal of Medical Genetics
The detailed genetic analysis of the Duchenne/Becker muscular dystrophy gene is hindered by the large number of exons involved ... sequences from complex genes and illustrate its potential by the identification of a hitherto undescribed single exon deletion. ...
The D allele of angiotensin I-converting enzyme gene insertion/deletion polymorphism is associated with the severity of...
Therefore, we investigated the possible association of ACE gene insertion/deletion (I/D) polymorphism and the severity of ... The ACE gene I/D polymorphism was genotyped using a PCR method. Results : The frequencies of DD genotype, D allele carrier- ... Niemiec P, Zak I, Wita K. The D allele of angiotensin I-converting enzyme gene insertion/deletion polymorphism is associated ... Niemiec, P., Zak, I. and Wita, K. (2008) The D allele of angiotensin I-converting enzyme gene insertion/deletion polymorphism ...
Chromosome 7p22 deletion - symptoms directly caused by the loss of gene ACTB - Chromosome Disorder Outreach, Inc
7p22 deletion - a deletion within the short arm of chromosome 7 - causes a number of symptoms, including developmental delay, ... Although 7p22 deletions have been described previously, ACTB loss has not be proven to be the root of the symptoms. The article ... Chromosome 7p22 deletion and associated symptoms directly caused by the loss of gene ACTB. ... Chromosome 7p22 deletion and associated symptoms directly caused by the loss of gene ACTB. ...
Association between TP53 gene deletion and protein expression in esophageal squamous cell carcinoma and its prognostic...
Moreover, the present study also detected TP53 gene deletion. TP53 gene deletion rates were 31.8 and 47.9% in the tumor tissues ... as well as gene deletion and amplification (21,22). It has been reported that deletion of the TP53 gene plays an important role ... TP53 gene deletion was negatively associated with overall survival. Patients with TP53 gene deletion had a worse prognosis (P, ... FISH was used to detect TP53 gene deletion in patients with ESCC of Kazakh background, which suggested that TP53 gene deletion ...
Markerless Gene Deletion by Floxed Cassette Allelic Exchange Mutagenesis in Chlamydia trachomatis | Protocol (Translated to...
Aquí se describe un método para la eliminación de genes dirigida y sin marcadores en Chlamydia trachomatis mediante... ... La principal ventaja de esta técnica es que permite la deleción de genes dirigidos sin infligir efectos polares sobre genes ... Knock-in de genes por CRISPR/Cas9 y clasificación celular en líneas deacrófagos y células T… ... Knock-in de genes por CRISPR/Cas9 y clasificación celular en líneas deacrófagos y células T… ...
Table 2 - Plasmodium falciparum pfhrp2 and pfhrp3 Gene Deletions in Malaria-Hyperendemic Region, South Sudan - Volume 29,...
pfhrp2 deletion. pfhrp3 deletion. pfhrp2/3 double deletion. Wild-type. No.. Frequency, % (95% CI). No.. Frequency, % (95% CI). ... Plasmodium falciparum pfhrp2 and pfhrp3 Gene Deletions in Malaria-Hyperendemic Region, South Sudan Irene Molina-de la Fuente1, ... Deletions for pfhrp2 and pfhrp3 include both single and double deletions. All analyses used a 95% CI and a p value of ,0.05 for ... Plasmodium falciparum pfhrp2 and pfhrp3 Gene Deletions in Malaria-Hyperendemic Region, South Sudan. ...
Large Intronic Deletion of the Fragile Site Gene PRKN Dramatically Lowers Its Fragility Without Impacting Gene Expression -...
Large Intronic Deletion of the Fragile Site Gene PRKN Dramatically Lowers Its Fragility Without Impacting Gene Expression. ... Large Intronic Deletion of the Fragile Site Gene PRKN Dramatically Lowers Its Fragility Without Impacting Gene Expression ... We find that gene expression of PRKN is largely unaffected by this intronic deletion. Strikingly, the intronic deletion, which ... These extremely large genes do not encode large proteins, but the extreme sizes of the genes originate from vast introns. ...
Recurrent deletion of a region containing exon 24 of the RB1 gene caused by non-homologous recombination between a LINE-1HS and...
Screening non-deletion alpha-thalassaemia mutations in the HBA1 and HBA2 genes by high-resolution melting analysis - FORTH /...
Genetic deletion of the inflammation-regulated microRNA miR-146a increases exon-skipping mediated dystrophin restoration in...
Gene Tools, LLC 1001 Summerton Way Philomath, OR 97370 USA Ph.: (541) 929-7840 , Fax: (541) 929-7841. Contact Us ... Genetic deletion of the inflammation-regulated microRNA miR-146a increases exon-skipping mediated dystrophin restoration in ... Duchenne muscular dystrophy (DMD) is a progressive muscle disease caused by loss of function mutations in the Dystrophin gene ... These data demonstrate genetic deletion of miR-146a is sufficient to increase dystrophin rescue via exon skipping. Our data ...
Novel intra-genic large deletions of CTNNB1 gene identified in WT desmoid-type fibromatosis - The Desmoid Tumor Research...
Novel intra-genic large deletions of CTNNB1 gene identified in WT desmoid-type fibromatosis. ... Novel intra-genic large deletions of CTNNB1 gene identified in WT desmoid-type fibromatosis ... In conclusion, a minority of DT is WT for either CTNNB1, APC or any other gene involved in the WNT pathway. In this subgroup ... In the two WT cases, two novel alterations were detected: a complex deletion of APC and a pathogenic mutation of LAMTOR2. ...
Deletion of exons 9 & 10 of the Presenilin 1 gene in a patient with early-onset AD generates longer amyloid seeds - JPND...
"Deletion of exons 9 and 10 of the Presenilin 1 gene in a patient with Early-onset Alzheimer Disease generates longer amyloid ... Deletion of exons 9 & 10 of the Presenilin 1 gene in a patient with early-onset AD generates longer amyloid seeds. ... Home » JPND Publications » Deletion of exons 9 & 10 of the Presenilin 1 gene in a patient with early-onset AD generates longer ...
Targeted deletions of complement lectin pathway genes improve outcome in traumatic brain injury | Research Square
... modeled by controlled cortical impact in wild-type mice and in mice carrying gene-targeted deficiencies of individual ... Targeted gene deletions include: the recognition subcomponents ficolin-A, CL-11, MBL-C and MBL-A, both individually and ... Targeted deletions of complement lectin pathway genes improve outcome in traumatic brain injury ... modeled by controlled cortical impact in wild-type mice and in mice carrying gene-targeted deficiencies of individual ...
A deletion in the gene encoding the CD45 antigen in a patient with SCID<...
We report here that a homozygous 6-bp deletion in the gene encoding CD45 (PTPRC, gene map locus 1q31-32), which results in a ... We report here that a homozygous 6-bp deletion in the gene encoding CD45 (PTPRC, gene map locus 1q31-32), which results in a ... We report here that a homozygous 6-bp deletion in the gene encoding CD45 (PTPRC, gene map locus 1q31-32), which results in a ... We report here that a homozygous 6-bp deletion in the gene encoding CD45 (PTPRC, gene map locus 1q31-32), which results in a ...
Correlates of Prenatal and Early-Life Tobacco Smoke Exposure and Frequency of Common Gene Deletions in Childhood Acute...
Correlates of Prenatal and Early-Life Tobacco Smoke Exposure and Frequency of Common Gene Deletions in Childhood Acute ... "Correlates of Prenatal and Early-Life Tobacco Smoke Exposure and Frequency of Common Gene Deletions in Childhood Acute ... Correlates of Prenatal and Early-Life Tobacco Smoke Exposure and Frequency of Common Gene Deletions in Childhood Acute ... "Correlates of Prenatal and Early-Life Tobacco Smoke Exposure and Frequency of Common Gene Deletions in Childhood Acute ...
Gene deletion - Open Source Truth
chromosomal deletion Archives - Global Genes
Deletion of Hydrophobin Genes in Aspergillus Niger
Genes were removed using pairs of cas9 plasmids that were designed with sgRNA that targets regions upstream and downstream of ... Future studies should focus on creating a strain with a knockout of all eight hydrophobin genes to assess their function. ... No major differences were found between the wildtype and the deletion strains for all properties. Functional redundancy is ... the gene to be deleted. The knockout strains were assessed on solid and liquid shaken cultures for growth, spore dispersal and ...
Relaxin-3 receptor (Rxfp3) gene deletion reduces operant sucrose- but not alcohol-responding in mice
... gene deletion reduces operant sucrose- but not alcohol-responding in mice ... OperantEthanolGene DeletionMaleMiceMice, Inbred C57BLMice, KnockoutMotivationRandom AllocationReceptors, G-Protein-Coupled ... Relaxin-3 receptor (Rxfp3) gene deletion reduces operant sucrose- but not alcohol-responding in mice. ... we investigated the effect of Rxfp3 gene deletion in C57BL/6J mice on sucrose and alcohol self-administration and cue-induced ...
Deletion of iNOS gene impairs mouse fracture healing
... and maximal and total energy were determined.Deletion of the iNOS gene decreased the total and maximum energy absorption of the ... In this study, we evaluated the specific contribution of iNOS to fracture healing by using iNOS gene therapy in iNOS-deficient ... However, the clinical utility of NOS gene therapy to enhance fracture healing will need further evaluation. ... and maximal and total energy were determined.Deletion of the iNOS gene decreased the total and maximum energy absorption of the ...
Research reveals how UV rays activate skin cancer
Mice with gene deletion remained healthy. The researchers hypothesized that a gene called Hgma2 is expressed in the skin when ... The mice that had the stem cell mutations and an intact Hgma2 gene developed melanomas, while the mice with the mutations and ... One group of mice had only the mutations, while the other group had mutations and the Hgma2 gene deleted. ... They may also have found a way to stop skin cancer in its tracks using a gene target. ...
MTAP Gene Deletion (Concept Id: C5554617) - MedGen - NCBI
A molecular abnormality referring to the loss of at least one copy of the MTAP gene. ... MTAP gene deletion in endometrial cancer.. Wong YF, Chung TK, Cheung TH, Nobori T, Chang AM. Gynecol Obstet Invest 1998;45(4): ... Methylthioadenosine phosphorylase gene deletions are common in osteosarcoma.. García-Castellano JM, Villanueva A, Healey JH, ... Methylthioadenosine phosphorylase gene deletions are common in osteosarcoma.. García-Castellano JM, Villanueva A, Healey JH, ...
Negative chemotaxis of Ligilactobacillus agilis BKN88 against gut-derived substances | Scientific Reports
L. agilis BKN88 contains five putative chemoreceptor genes (mcp1-mcp5). Chemotaxis assays using a series of chemoreceptor ... Construction of MCP-encoding or CheA-encoding gene deletion mutants. Putative MCP-encoding or CheA-encoding genes in L. agilis ... gadBC genes), arginine deiminase (ADI) system (arcABC genes), and urease system (ureABC genes) were not detected in L. agilis. ... except for two cheW genes, in a single gene cluster (motility operon) and five putative MCP-encoding genes (mcp1-mcp5). mcp1 ...