Bioinformatics analysis identified shared differentially expressed genes as potential biomarkers for Hashimoto's thyroiditis...
Gene expression data acquisition. Two expression profiling array datasets (GSE29315 and GSE6004) were downloaded from Gene ... The Gene Ontology Consortium. Nat Genet. 2000;25:25-9 27. Kanehisa M, Goto S. KEGG: kyoto encyclopedia of genes and genomes. ... The gene expression data were normalized to those of β-actin. In this study, cycle threshold (Ct) values below 35 were included ... RNA sequencing identifies multiple fusion transcripts, differentially expressed genes, and reduced expression of immune ...
STARD12/14 are diagnostic and prognostic biomarkers of lung adenocarcinoma associated with epigenetic regulation, immune...
STARD14 and m6A related gene mRNA expression levels. The differential expression of m6A related genes in low and high STARD12/ ... The expression of STARD14 was bound with lower infiltration of CD8+T cells as well as marker genes expression, which indicated ... B) Violin plots of differential expression of m6A relative genes between high and low STARD12/14 expression groups. (C) Forest ... B) Violin plots of differential expression of ferroptosis relative genes between high and low STARD12/14 expression groups. (C) ...
Rhododendron oldhamii leaf extract improves fatty liver syndrome by increasing lipid oxidation and decreasing the lipogenesis...
25]. The gene expressions of 7 genes (SREBP1, ACC, FAS, CPT1α, PPARα and PPARγ) using complementary DNA from liver tissue was ... Changes in mRNA expression levels of lipogenesis (SREBP1, ACC and FAS) and lipid oxidation (CPT1α, PPARα and PPARγ) genes in ... Interesting, R. oldhamii leaf EtOAc fraction markedly decreased SREBP1 gene expression and increased CPT1α, PPARα and PPARγ in ... The mRNA expression patterns of genes encoding enzymes involved in lipogenesis (SREBP1, ACC and FAS) and lipid oxidation (CPT1α ...
Preventative Effects of Sodium Alginate on Indomethacin-induced Small-intestinal Injury in Mice [Abstract]
Keywords: gene expression, mucin, nonsteroidal anti-inflammatory drugs, small intestine, sodium alginate. ... mRNA expression of Muc1-4 was increased in indomethacin-induced SII, and these increases were prevented by sodium alginate. ... intestinal shortening was associated with reduced histological severity of mucosal injury and ameliorated mRNA expression of ...
Impact of remote ischaemic preconditioning on cerebral oxygenation during total knee arthroplasty
The remote ischemic preconditioning stimulus modifies inflammatory gene expression in humans. Physiol Genomics. 2004;19:143-50 ... Regular Article: Cellular prion protein directly interacts with and enhances lactate dehydrogenase expression under hypoxic ...
Interdependencies among Selected Pro-Inflammatory Markers of Endothelial Dysfunction, C-Peptide, Anti-Inflammatory Interleukin...
... this chemokine affects angiogenesis by stimulation of VEGF-A gene expression [16]. A long-term increase in systemic ... Vascular cellular adhesion molecule-1 (VCAM-1) expression in mice retinal vessels is affected by both hyperglycemia and ... Interleukin-10 suppresses tissue factor expression in lipopolysaccharide-stimulated macrophages via inhibition of Egr-1 and a ... Triglyceride-rich lipoprotein modulates endothelial vascular cell adhesion molecule (VCAM)-1 expression via differential ...
C1QBP regulates apoptosis of renal cell carcinoma via modulating xanthine dehydrogenase (XDH) mediated ROS generation
... suggesting that the regulation of XDH gene expression by C1QBP occurred at the transcriptional level. The expression of XDH is ... PCR analysis were synthesized by Hua Da Gene. The primer sequences were shown in Table 1. The expression of target gene was ... The knockdown of gene expression was assessed by western blot and qRT‐PCR. The sequences of XDH siRNA were listed in Table 2. ... Xanthine dehydrogenase downregulation promotes TGFβ signaling and cancer stem cell-related gene expression in hepatocellular ...
Volume 17, Issue 15 - ijms
Potential mechanism of RRM2 for promoting Cervical Cancer based on weighted gene co-expression network analysis Jingtao Wang, ...
KLF6 inhibited oral cancer migration and invasion via downregulation of mesenchymal markers and inhibition of MMP-9 activities
Expression and significance of Kruppel-like factor 6 gene in osteosarcoma. Int Orthop. 2012;36:2107-11 ... KLF6 functions as a tumor suppressor gene and increases p21 expression via p53-independent pathway [3]. The loss of KLF6 ... Upper panel: the expression level , 2. Lower panel: the expression level ≧2. (B)A Kaplan-Meier survival curve for the oral ... Ectopic KLF6 expression decreased the migration and invasion of oral cancer cells. KLF6 also suppressed the expression and ...
Association of plasma fatty acid-binding protein 3 with estimated glomerular filtration rate in patients with type 2 diabetes...
Obesity-related glomerulopathy: insights from gene expression profiles of the glomeruli derived from renal biopsy samples. ... Consistently, an accumulation of macrophages and induction of MCP-1 expression have also been associated with FABP3 expression ... which consequently induce an increased expression of FABP3 [13]. Moreover, Nauta et al. reported that damage to distal renal ...
Reproduction of the Antitumor Effect of Cisplatin and Cetuximab Using a Three-dimensional Spheroid Model in Oral Cancer
Impact of the 3D microenvironment on phenotype, gene expression, and EGFR inhibition of colorectal cancer cell lines. PLoS One ... Schmidt M, Scholz CJ, Polednik C, Roller J. Spheroid-based 3-dimensional culture models: Gene expression and functionality in ... Both oral cancer cell lines showed expression of E-cadherin, whereas EGFR expression was significantly higher in HSC-3 than in ... Increased expression of Dsg2 in malignant skin carcinomas: A tissue-microarray based study. Cell Adh Migr. 2009;3:148-54 ...
Nicotinamide mononucleotides alleviated neurological impairment via anti-neuroinflammation in traumatic brain injury
We detected the expressions of TNF-α and IL-1β by RT-qPCR. The finding illustrated that the expression of TNF-α and IL-1β genes ... 5B and Table S1). Hierarchical cluster analysis of 792 reversed genes shows that gene expression has been significantly ... a series of genes were selected to detect their expression levels using RT-qPCR. As showed in Fig. 6, 10 genes (Ccl2, Trl2, ... C) Expression heatmap of 792 reversed genes. D and E) GO enrichment analysis and KEGG enrichment analysis based on the reversed ...
Expressions of EphA2 and EphrinA-1 in early squamous cell cervical carcinomas and their relation to prognosis
Over-expression of Eph and ephrin genes in advanced ovarian cancer: ephrin gene expression correlates with shortened survival. ... Expression of p27, p21, and p16 protein in early squamous cervical cancer and its relation to prognosis. Gynecol Oncol. 2003;89 ... Expression of EphA2 and EphrinA-1 in vulvar carcinomas and its relation to prognosis. J Clin Pathol. 2007;60:1086-91 ... Expression of EphA2 is prognostic of disease-free interval and overall survival in surgically treated patients with renal cell ...
Novel contributors to B cell activation during inflammatory CNS demyelination; An oNGOing process
Another pathway activated after BAFF/BAFF-R binding is the canonical that upregulates the expression of various genes, such as ... Expression and function of TNF family member B cell-activating factor in the development of autoimmune arthritis. Int Immunol. ... CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation. Proc Natl Acad Sci U S A ... Time course and spatial profile of Nogo-A expression in experimental autoimmune encephalomyelitis in C57BL/6 mice. J ...
Correlation between genetic polymorphism of angiopoietin-2 gene and clinical aspects of rheumatoid arthritis
Osteopontin inhibition of miR-129-3p enhances IL-17 expression and monocyte migration in rheumatoid arthritis. Biochim Biophys ... The Angiopoietin-2 (Ang2) gene encodes angiogenic factor, and the polymorphisms of Ang2 gene predict risk of various human ... The Mas study proposed Ang2 gene as a susceptibility gene for neovascular age-related macular degeneration and polypoidal ... Correlation between CCL4 gene polymorphisms and clinical aspects of breast cancer. Int J Med Sci. 2018;15:1179-1186 ...
DCs-based therapies: potential strategies in severe SARS-CoV-2 infection
Second, specific virulence genes of CoV influence the cytokines production of DCs. Some expression of proteins on CoV appears ... infected with MERS-CoV were in the absence of expression of IFN-β [45]. Furthermore, the fact is the genes encoding HLA class ... Expression of C-type lectin receptors by subsets of dendritic cells in human skin. International immunology. 2004;16:877-87 ... Prokaryotic expression, refolding, and purification of fragment 450-650 of the spike protein of SARS-coronavirus. Protein Expr ...
Advances and challenges in the prevention and treatment of COVID-19
... gene expression, and nucleic acid synthesis.44-46. In vitro model evaluations show that resveratrol significantly inhibits MERS ... Pathogenic influenza viruses and coronaviruses utilize similar and contrasting approaches to control interferon-stimulated gene ... protein expression.46 Nucleocapsid (N) protein is a multifunctional protein essential for CoV replication.47 In addition, ... interleukin2 and the transcription of genes.58 CsA can inhibit the replication of almost all species of coronavirus in a dose- ...
ProEx C as Diagnostic Marker for Detection of Urothelial Carcinoma in Urinary Samples: A Review
Gene expression profiles of primary HPV 16 and HPV 18 infected early stage cervical cancers and normal cervical epithelium: ... The gene encoding TOP2A is the target for numerous anticancer agents; mutations in this gene have been related with the ... Morphologic expression of urothelial carcinoma in situ: a detailed evaluation of its histologic patterns with emphasis on ... Expression of ProEx C in Primary and Metastatic Urothelial Carcinoma. Diagn Cytopathol. 2015;43(3):181-187 ...
Dopamine receptor D2 genetic variations is associated with the risk and clinicopathological variables of urothelial cell...
... and Gene Expression Omnibus (GEO) datasets revealed correlations of the expression of DRD2 with an invasive tumor, tumor ... Polymorphisms within the DRD2 gene were shown to be associated with lung and colon cancers. The purpose of this study was to ... Keywords: Dopamine receptor D2 gene, Polymorphism, Susceptibility, Clinicopathologic development, Urothelial cell carcinoma ... explore effects of DRD2 gene polymorphisms on the susceptibility to and clinicopathological characteristics of urothelial cell ...
PM2.5 Upregulates MicroRNA-146a-3p and Induces M1 Polarization in RAW264.7 Cells by Targeting Sirtuin1
Comprehensive understanding of PM2.5 on gene and microRNA expression patterns in zebrafish (Danio rerio) model. Sci Total ... Inhaled particulate matter causes expression of nuclear factor (NF)-kappaB-related genes and oxidant-dependent NF-kappaB ... The mRNA expression of miR-146a-3p was detected by qRT-PCR. (B-C) Relative expression of miR-146a-3p normalized against the U6 ... The mRNA expressions of M1 and M2 markers were quantified by qRT-PCR. The results showed that the mRNA expressions of M1 ...
The Emerging Portrait of Glial Cell Line-derived Neurotrophic Factor Family Receptor Alpha (GFRα) in Cancers
GFRα1 expression is upregulated in a significant proportion of human breast cancers [29-31]. Abundant expression of GFRα1 was ... Moreover, gene analysis indicated that a GDNF response gene set predicts poor prognosis and has predictive value in breast ... When ARTN treatment was administered, MMP-2 expression increases, and E-cadherin expression decreases [48]. Most notably, ARTN/ ... Impact of GFRA1 gene reactivation by DNA demethylation on prognosis of patients with metastatic colon cancer. World journal of ...
FasL Expression on Human Nucleus Pulposus Cells Contributes to the Immune Privilege of Intervertebral Disc by Interacting with...
Association of lpr gene with graft-vs.-host disease-like syndrome. The Journal of experimental medicine. 1985;162:1-18 ... FasL expression of NP cells in different levels from degenerative and normal NP. A. qRT-PCR analysis of FasL expression. B. ... Secondly, we only up-regulated the FasL expression of NP cells by lentiviral vector without down-regulating the expression. ... Fas ligand gene transfer prolongs rat renal allograft survival and down-regulates anti-apoptotic Bag-1 in parallel with ...
Evaluating the Prognostic Value of ERCC1 and Thymidylate Synthase Expression and the Epidermal Growth Factor Receptor Mutation...
EGF receptor gene mutations are common in lung cancers from never smokers and are associated with sensitivity of tumors to ... High TS expression can be considered a prognostic factor in negative EGFR-mutated AC-NSCLC, whereas high ERCC1 expression might ... TS expression, rather than ERCC1 expression, was found to be the only independent prognostic factor in malignant pleural ... Scoring of TS and ERCC1 expression. The IHC analysis results of ERCC1 and TS expression were examined, and the scores were ...
Association of Surfactant Protein with Expression of Hoxa5 and Hoxb5 in Rabbit Fetal Lung [Abstract]
Hoxa5 gene may be essential for the expression of SP-A and SP-B in term rabbits. The Hoxb5 gene may be an important factor for ... We compared the expression levels of the Hoxa5, Hoxb5, surfactant protein (SP)-A, and SP-B genes in immature and mature rabbit ... The relative expression ratios of SP-A and SP-B mRNA in the term to preterm groups were 2.45:1 and 2.94:1, respectively. Hoxb5 ... Chung, S.H.; Bae, C.W. Association of Surfactant Protein with Expression of Hoxa5 and Hoxb5 in Rabbit Fetal Lung. Int. J. Med. ...
Volume 10, Issue 9 - ijms
Spatial Localization of Genes Determined by Intranuclear DNA Fragmentation with the Fusion Proteins Lamin KRED and Histone KRED ... Increased Expression of Pattern Recognition Receptors and Nitric Oxide Synthase in Patients with Endometriosis Seung Geun Yeo, ... Survival, Classifications, and Desmosomal Plaque Genes in Non-Small Cell Lung Cancer Laura Boyero, Abel Sánchez-Palencia, Mª ... Clinicopathological Implications of the Expression of Hypoxia-related Proteins in Gastric Cancer Ji-Han Jung, Soyoung Im, Eun ...
Juniperus indica Bertol. extract synergized with cisplatin against melanoma cells via the suppression of AKT/mTOR and MAPK...
JIB extract and combination treatment were shown to reduce FAS protein expression. In addition, the expression of procaspase-8 ... Targeted therapy drugs are used to target specific genes and proteins of cancer cells to precisely identify and attack specific ... JIB extract strongly induced p21 protein expression, which resulted in cell cycle arrest. The expression of downstream cell ... JIB extract or cisplatin only slightly affected ERK and p38 expression. In contrast, JNK expression was distinctly reduced by ...
Volume 12, Issue 1 - ijms
The Expression Levels of Transcription Factors T-bet, GATA-3, RORγt and FOXP3 in Peripheral Blood Lymphocyte (PBL) of Patients ... A Microsatellite Polymorphism in IGF1 Gene Promoter and Timing of Natural Menopause in Caucasian Women Maria Kaczmarek, Joanna ... Associated Genes with Predictive and Prognostic Relevance Chia-Hung Liu, Wan-Chun Tang, Peik Sia, Chi-Chen Huang, Pei-Ming Yang ...
Volume 20, Issue 13 - ijms
Increased Expression of Tetraspanins, ALIX and HSP-70 in the Placenta Tissue of Women with Chronic Venous Disease during ... TMED family genes and their roles in human diseases Lv Zhou, Huaixu Li, Hui Yao, Xingliang Dai, Peng Gao, Hongwei Cheng Int. J ...
Angiotensin Receptor Blockers and Statins Could Alleviate Atrial Fibrosis via Regulating Platelet-Derived Growth Factor/Rac1 ...
Expression of platelet-derived growth factor (PDGF), Rac1 and nuclear factor-kappa B NF-κB in human RAAs. (A-C) Expression of ... Base sequences of primers of target gene had exactly exhibited in Table 1 (Sangon, China). ... C) Quantitative expression of ANP by histogram. (D) Quantitative expression of COL1A1 by histogram. β-actin is an internal ... D) Quantitative expression of AngII (Dc), protein and mRNA volume of PDGF (Da and Db), NF-κB(De) and activated Rac1(Dd) in left ...