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dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1. DBD. DNA-binding domain. DMSO. ... Regulation of gene transcription is controlled in part by nuclear receptors that function coordinately with coregulator ... The human constitutive androstane receptor (CAR; NR1I3) is expressed primarily in liver and regulates the expression of genes ... in primary human hepatocytes further demonstrated DAX-1 inhibition of CAR-mediated CITCO induction of the CYP2B6 target gene. ...