Loading...
*  Adipose tissue - Wikipedia
"Adipose is a conserved dosage-sensitive antiobesity gene". Cell Metabolism. 6 (3): 195-207. doi:10.1016/j.cmet.2007.08.001. PMC ... Although its discoverers dubbed this gene the adipose gene, it is not a gene responsible for creating adipose tissue. ... Gene defects in the leptin gene (ob) are rare in human obesity.[78] As of July, 2010, only 14 individuals from five families ... Main article: Genetics of obesity § Genes. The thrifty gene hypothesis (also called the famine hypothesis) states that in some ...
https://en.wikipedia.org/wiki/Adipose
*  PAX6 - Wikipedia
1994). "PAX6 gene dosage effect in a family with congenital cataracts, aniridia, anophthalmia and central nervous system ... regulation of gene expression. • positive regulation of gene expression. • pallium development. • oligodendrocyte cell fate ... "Genes and Mapped Phenotypes." National Center for Biotechnology Information. U.S. Pax6 is a gene in prenatal development ... "Genes & Development. 28 (17): 1879-1884. doi:10.1101/gad.246140.114. ISSN 0890-9369. PMC 4197948 . PMID 25184676.. ...
https://en.wikipedia.org/wiki/PAX6
*  Circadian clock - Wikipedia
developed a novel strategy termed "Gene Dosage Network Analysis" (GDNA) to describe network features in the human circadian ... initiates transcription of target genes such as the core clock genes 'period' genes (PER1, PER2, and PER3) and two cryptochrome ... The first genes identified in the plant clock were TOC1, CCA1 and LHY. The peak expression of the CCA1 and LHY genes occurs at ... Characterization of a subset of these genes demonstrated a dosage-dependent effect on oscillator function. Protein interaction ...
https://en.wikipedia.org/wiki/Circadian_clock
*  Diploidization - Wikipedia
1. Coordinate inter-genomic gene expression: Duplicated genes often result in increased dosage of gene products. Doubled ... It has been hypothesized that dosage balance may play a key role in shaping the evolutionary fates of duplicated genes (1). ... The main goals of diploidization are: 1. To ensure proper gene dosage 2. To maintain stable cellular division processes. It ... First, the eliminated copy restores the normal gene dosage in the diploid organism (1). Second, the changes in chromosomal ...
https://en.wikipedia.org/wiki/Diploidization
*  Peripheral neuropathy - Wikipedia
Gabriel JM, Erne B, Pareyson D, Sghirlanzoni A, Taroni F, Steck AJ (December 1997). "Gene dosage effects in hereditary ...
https://en.wikipedia.org/wiki/Peripheral_neuropathy
*  X-inactivation - Wikipedia
Since individuals of either sex will receive two copies of every gene in a pseudoautosomal region, no dosage compensation is ... in females that are heterozygous at the involved gene or genes than in females that are homozygous at that gene or those genes. ... meaning that the Tsix gene overlaps the Xist gene and is transcribed on the opposite strand of DNA from the Xist gene.[31] Tsix ... Expressed genes on the inactive X chromosome[edit]. A fraction of the genes along the X chromosome escape inactivation on the ...
https://en.wikipedia.org/wiki/X-chromosome_inactivation
*  X-inactivation - Wikipedia
Since individuals of either sex will receive two copies of every gene in a pseudoautosomal region, no dosage compensation is ... in females that are heterozygous at the involved gene or genes than in females that are homozygous at that gene or those genes ... meaning that the Tsix gene overlaps the Xist gene and is transcribed on the opposite strand of DNA from the Xist gene. Tsix is ... The silencing of genes along the Xi occurs soon after coating by Xist RNA. Like Xist, the Tsix gene encodes a large RNA which ...
https://en.wikipedia.org/wiki/X-inactivation
*  Barbara J. Meyer - Wikipedia
... discovery of the master control gene involved in sex determination; and studies of gene regulation, particularly dosage ... Still studying gene regulation, but turning to sex determination, Meyer discovered the master gene involved in sex ... Clustered DNA Motifs Mark X Chromosomes for Repression by a Dosage Compensation Complex. [P. McDonel, J. Jans, B. Peterson, B. ... Genet, 1996 Barbara J. Meyer, Dennis G. Kleid, and Mark Ptashne, "Lambda Repressor Turns Off Transcription of Its Own Gene", ...
https://en.wikipedia.org/wiki/Barbara_J._Meyer
*  FOXE3 - Wikipedia
"Foxe3 is required for morphogenesis and differentiation of the anterior segment of the eye and is sensitive to Pax6 gene dosage ... This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.. *v ... "Entrez Gene: forkhead box E3".. *^ Doucette L, Green J, Fernandez B, Johnson G, Parfrey P, Young T (2011). "A novel, non-stop ... Gene ontology. Molecular function. • DNA binding. • sequence-specific DNA binding. • transcription factor activity, sequence- ...
https://en.wikipedia.org/wiki/FOXE3
*  WDTC1 - Wikipedia
2007). "Adipose is a conserved dosage-sensitive antiobesity gene". Cell Metab. 6 (3): 195-207. doi:10.1016/j.cmet.2007.08.001. ... "ScienceDaily: 'Skinny Gene' Exists". Retrieved 2007-09-05. Lai CQ, Parnell LD, et al. (2009). "WDTC1, the ortholog of ... WDTC1 ("Adipose") is a gene associated with obesity. Model organisms have been used in the study of WDTC1 function. A ... "Infection and Immunity Immunophenotyping (3i) Consortium". Born lucky: Scientists discover "skinny gene" - MSNBC. ...
https://en.wikipedia.org/wiki/WDTC1
*  Adipose tissue - Wikipedia
2007). "Adipose is a conserved dosage-sensitive antiobesity gene". Cell Metabolism. 6 (3): 195-207. doi:10.1016/j.cmet.2007.08. ... Although its discoverers dubbed this gene the adipose gene, it is not a gene responsible for creating adipose tissue. Pre- ... Gene defects in the leptin gene (ob) are rare in human obesity. As of July, 2010, only 14 individuals from five families have ... WAT from the transgenic animals exhibited a brown fat gene program and had decreased WAT specific gene expression compared to ...
https://en.wikipedia.org/wiki/Adipose_tissue
*  1q21.1 duplication syndrome - Wikipedia
It is assumed to be a dosage-sensitive gene. When this gene is not available in the 1q21.1 area it leads to microcephaly. ... HYDIN2 is a recent duplication (found only in humans) of the HYDIN gene found on 16q22.2. GJA5 has been identified as the gene ... New genes are expected in the gaps. Because the gaps are still a topic of research, it is hard to find the exact start and end ... Genes related to 1q21.1 deletion in the TAR area are HFE2, TXNIP, POLR3GL, LIX1L, RBM8A, PEX11B, ITGA10, ANKRD35, PIAS3, NUDT17 ...
https://en.wikipedia.org/wiki/1q21.1_duplication_syndrome
*  1q21.1 deletion syndrome - Wikipedia
It is assumed to be a dosage-sensitive gene. When this gene is not available in the 1q21.1 area, it leads to microcephaly. ... HYDIN2 is a recent duplication (found only in humans) of the HYDIN gene found on 16q22.2. Research on the genes CHD1L and ... New genes are expected in the gaps. Because the gaps are still a topic of research, it is hard to find the exact start and end ... Genes related to 1q21.1 deletion in the distal area are PDE4DIP, HYDIN2, PRKAB2, PDIA3P, FMO5, CHD1L, BCL9, ACP6, GJA5, GJA8, ...
https://en.wikipedia.org/wiki/1q21.1_deletion_syndrome
*  Thalamus - Wikipedia
Acampora, D; Avantaggiato, V; Tuorto, F; Simeone, A (1997). "Genetic control of brain morphogenesis through Otx gene dosage ... In zebrafish, it was shown that the expression of two SHH genes, SHH-a and SHH-b (formerly described as twhh) mark the MDO ... Hirata, T.; Nakazawa, M; Muraoka, O; Nakayama, R; Suda, Y; Hibi, M (2006). "Zinc-finger genes Fez and Fez-like function in the ... SHH signaling from the MDO induces a posterior-to-anterior wave of expression the proneural gene Neurogenin1 in the major ( ...
https://en.wikipedia.org/wiki/Thalamus
*  Laurence Hurst - Wikipedia
Papp, Balázs; Pál, Csaba; Hurst, Laurence D. (2003). "Dosage sensitivity and the evolution of gene families in yeast". Nature. ... Lercher, M.J.; Urrutia, A.O.; Hurst, L.D. (2002). "Clustering of housekeeping genes provides a unified model of gene order in ... This has resulted in work on housekeeping genes, gene orders, and the evolution of drug resistance in Staphylococcus aureus, ... Similarly, in showing that genomes are arranged into gene expression domains, Hurst revealed that genes can affect the ...
https://en.wikipedia.org/wiki/Laurence_Hurst
*  Causes of schizophrenia - Wikipedia
This results in deletions and duplications of dosage sensitive genes. It has been speculated that CNVs underlie a significant ... Variations near the gene FXYD6 have also been associated with schizophrenia in the UK but not in Japan. In 2008, rs7341475 SNP ... A 2016 study implicated the C4 gene in schizophrenia risk. C4 was found to play a role in synapse pruning, and increased C4 ... Together, these candidate genes pointed to an importance of neurotransmission and immunology as important factors in the ...
https://en.wikipedia.org/wiki/Causes_of_schizophrenia
*  Proline-rich 12 - Wikipedia
Chen, Jianping (2009). Molecular Basis of Gene Dosage Sensitivity (Ph.D.). Rice University. ISBN 9781109217346. Williamson MP ( ... Proline-rich 12 (PRR12) is a protein of unknown function encoded by the gene PRR12. The Homo sapiens PRR12 gene is 34,785 base ... Gene - NCBI". Ncbi.nlm.nih.gov. Retrieved 2014-01-26. "PRR12 Gene - GeneCards , PRR12 Protein , PRR12 Antibody". GeneCards. ... Within its gene neighborhood, PRR12 is flanked by PRRG2 and SCAF1 on the sense strand and RRAS and NOSIP on the antisense ...
https://en.wikipedia.org/wiki/Proline-rich_12
*  45,X/46,XY mosaicism - Wikipedia
Dosage loss of SHOX gene is commonly associated with short stature. Psychomotor development is normal. As the gonads may not be ... These rearrangements of the Y chromosome can lead to partial expression of the SRY gene which may lead to abnormal genitals and ...
https://en.wikipedia.org/wiki/45,X/46,XY_mosaicism
*  Anne Ferguson-Smith - Wikipedia
"Imprinted gene dosage is critical for the transition to independent life". Cell Metabolism. 15 (2): 209-221. doi:10.1016/j.cmet ... Ferguson-Smith, Anne Carla (1989). A genomic analysis of the human homeobox gene loci HOX 1 and HOX 2 (PhD thesis). proquest. ... She moved to the Biology Department at Yale University to undertake a PhD identifying human Hox genes and characterising ... The team identified one of the first endogenous imprinted genes, and showed that the process was epigenetically regulated by ...
https://en.wikipedia.org/wiki/Anne_Ferguson-Smith
*  HLA-DQB1 - Wikipedia
"HLA DQ gene dosage and risk and severity of celiac disease". Clinical Gastroenterology and Hepatology. 5 (12): 1406-12. doi: ... is a human gene and also denotes the genetic locus that contains this gene. The protein encoded by this gene is one of two ... 0302 encode genes that mediate the autoimmune coeliac disease. Homozygotes of DQB1*0201 have a higher risk of developing the ... "Entrez Gene: HLA-DQB1 major histocompatibility complex, class II, DQ beta 1". Lau M, Terasaki PI, Park MS (1994). " ...
https://en.wikipedia.org/wiki/HLA-DQB1
*  Leonard P. Guarente - Wikipedia
Tissenbaum, H.A.; L. Guarente (2001). "Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans". Nature. ... In 1993, Cynthia Kenyon's lab at UCSF discovered that a single-gene mutation in (Daf-2) could double the lifespan of C. elegans ... In 1995 the lab identified the gene SIR4 (Silent information regulator 4) as a longevity regulator. When SIRT4 was mutated in a ... 1995). "Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae". Cell. 80 (3): 485-96. doi:10.1016/0092-8674(95) ...
https://en.wikipedia.org/wiki/Leonard_P._Guarente
*  POU4F1 - Wikipedia
Trieu M, Ma A, Eng SR, Fedtsova N, Turner EE (Jan 2003). "Direct autoregulation and gene dosage compensation by POU-domain ... Trieu M, Ma A, Eng SR, Fedtsova N, Turner EE (Jan 2003). "Direct autoregulation and gene dosage compensation by POU-domain ... This can be explained by gene dosage compensation due to autoregulation, in which expression of the remaining copy of the ... "Entrez Gene: POU4F1 POU domain, class 4, transcription factor 1". Gerrero MR, McEvilly RJ, Turner E, Lin CR, O'Connell S, Jenne ...
https://en.wikipedia.org/wiki/POU4F1
*  Genetic imbalance - Wikipedia
Changes in gene dosage, the number of times a given gene is present in the cell nucleus, can create a genetic imbalance. This ... Diminishing the dosage of most genes produces no obvious change in phenotype. For some genes the phenotypic consequences of a ... For some rare genes, the normal diploid level of gene expression is essential to individual survival; fewer than two copies of ... Genetic imbalance is to describe situation when the genome of a cell or organism has more copies of some genes than other genes ...
https://en.wikipedia.org/wiki/Genetic_imbalance
*  Haploinsufficiency - Wikipedia
The alteration in the gene dosage, which is caused by the loss of a functional allele, is also called allelic insufficiency. An ... The haploinsufficiency is caused by the copy-number variation (CNV) of 28 genes led by the deletion of ~1.6 Mb. These dosage- ... This leads to too many or too few of the dosage sensitive genes. The genomic rearrangements, that is, deletions or duplications ... A mutation in the gene may have erased the production message. One of the two copies of the gene may be missing due to a ...
https://en.wikipedia.org/wiki/Haploinsufficiency
*  Calorie restriction - Wikipedia
Tissenbaum, Heidi A.; Guarente, Leonard (March 8, 2001). "Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis ... "The gene for longevity, if you're a worm". ABC News. 2007. Retrieved 2007-05-03. Gredilla R, Sanz A, Lopez-Torres M, Barja G ( ... Although all three genes are required for the silencing of mating type loci and telomeres, only SIR2 has been implicated in the ... Genes involved in these mechanisms are TOR, PKA, SCH9, MSN2/4, RIM15, and SIR2. Importantly, yeast responses to CR can be ...
https://en.wikipedia.org/wiki/Calorie_restriction