DC: More MicroRNA Implicated in Dementia | ALZFORUM
These results are consistent with a loss of function of the GRN gene in the disease, further linking gene dosage effects in ... Once thought to be a simple go-between, RNA is recently attracting much more attention as an important regulator of gene ... The manuscript by Rademakers and colleagues provides evidence that increased binding of miR-659 to the 3UTR of the GRN gene ... Rademakers and colleagues discovered the link between miRNA-659 and progranulin when they sequenced PGRN genes from 378 FTLD ...
ALZFORUM | NETWORKING FOR A CURE
The usual clinical dosage of 300 mg/day was reduced to 75 mg/day, still achieving significant symptom reduction. Whether such a ... Thyroid hormones and retinoids: a possible link between genes and environment in schizophrenia. Brain Res Rev. 2006 Jun;51(1): ...
Does Second X Chromosome Boost Women's Resilience Against Alzheimer's? | ALZFORUM
However, a few genes manage to elude this epigenetic crackdown, riffing off transcripts from both Xs. One such gene-in both ... The role of X chromosome-dosage effects, especially the effects of Kdm6a, is compelling. ... However, a small number of genes can escape such X inactivation and thus have higher expression in females. One such gene is ... The UTX gene escapes X inactivation in mice and humans. Hum Mol Genet. 1998 Apr;7(4):737-42. PubMed. ...