Lundstrom K (March 2019). "RNA Viruses as Tools in Gene Therapy and Vaccine Development". Genes. 10 (3): 189. doi:10.3390/ ... The central component of a mRNA vaccine is its mRNA construct. The in vitro transcribed mRNA is generated from an engineered ... The in vitro transcribed mRNA has the same structural components as natural mRNA in eukaryotic cells. It has a 5 cap, a 5- ... Wolff JA, Malone RW, Williams P, Chong W, Acsadi G, Jani A, Felgner PL [in German] (March 1990). "Direct gene transfer into ...

December 2006). "The cancer epigenome--components and functional correlates". Genes & Development. 20 (23): 3215-31. doi: ... It has published a census of genes causally implicated in cancer, and a number of whole-genome resequencing screens for genes ... The project involves the systematic screening of coding genes and flanking splice junctions of all genes in the human genome ... Cancer Gene Sequencing Raises New Medical Ethics Issues by Janis C. Kelly. Sep 06, 2013 The Cancer Genome Project CGAP The ...

Nugent CI, Lundblad V (April 1998). "The telomerase reverse transcriptase: components and regulation". Genes & Development. 12 ... A gene is a unit of heredity and is a region of DNA that influences a particular characteristic in an organism. Genes contain ... A gene is a sequence of DNA that contains genetic information and can influence the phenotype of an organism. Within a gene, ... In bacteria, this overlap may be involved in the regulation of gene transcription, while in viruses, overlapping genes increase ...

The Human Connectome Project (HCP) is a five-year project sponsored by sixteen components of the National Institutes of Health ... Eugene; Feinberg, David A; Griffanti, Ludovica; Harms, Michael P; Kelly, Michael; Laumann, Timothy; Miller, Karla L; Moeller, ... "Components of the Human Connectome Project - Behavioral Testing - Connectome". humanconnectome.org. Retrieved 2013-03-08. ... Eugene P; Fitzgibbon, Sean; Westphal, Robert; Carone, Davide; Beckmann, Christian F; Smith, Stephen M (2017). "Hand ...

Ting AH, McGarvey KM, Baylin SB (2006). "The cancer epigenome--components and functional correlates". Genes Dev. 20 (23): 3215- ... The product of gene PD-1 ordinarily represses cytotoxic immune responses. Inhibition of this gene allows a greater immune ... found that passenger genes, with chromosomal proximity to tumor suppressor genes, are collaterally deleted in some cancers. ... Epigenetic repression of DDR genes occurs more frequently than gene mutation in many types of cancer (see Cancer epigenetics). ...

Marked upregulation of genes encoding extracellular matrix components". Circulation Research. 75 (1): 23-32. doi:10.1161/01.res ... This newly formed Smad-Co-Smad complex enters the nucleus where it acts as a transcription factor modulating gene expression. ... Genes & Development. 12 (14): 2144-52. doi:10.1101/gad.12.14.2144. PMC 317013. PMID 9679059. Wang Y, de Waard MC, Sterner-Kock ... "Alterations in cardiac gene expression during the transition from stable hypertrophy to heart failure. ...

This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP ... It interacts with components of the cytoskeleton such as the formin Dia1 (mDia1), with cell adhesion molecules (CAMs), and with ... "Entrez Gene: IQGAP1 IQ motif containing GTPase activating protein 1". White CD, Brown MD, Sacks DB (June 2009). "IQGAPs in ... "IQGAP1: Gene and protein summary". The Human Protein Atlas. Retrieved 2011-05-31. Stradal T, Kranewitter W, Winder SJ, Gimona M ...

2000). "Languages and genes: Modes of transmission observed through the analysis of male-specific and female-specific genes". ... Darlington, CD (1947). "The genetic component of language". Heredity. 1 (3): 269-286. doi:10.1038/hdy.1947.18. Cavalli-Sforza, ... Language family Haplogroup O-M175#Languages families and genes East Asian languages Poloni, Estela S; Semino O, Passarino G, ... Cavalli-Sforza, Luigi Luca; Menozzi P, Piazza A (1994). The history and Geography of Human Genes. Princeton, New Jersey: ...

Release of viral genes and possibly enzymes into the host cell. Replication of viral components using host-cell machinery. ... Assembly of viral components into complete viral particles. Release of viral particles to infect new host cells. One antiviral ... A second approach is to target the processes that synthesize virus components after a virus invades a cell. One way of doing ... Bai J, Rossi J, Akkina R (March 2001). "Multivalent anti-CCR ribozymes for stem cell-based HIV type 1 gene therapy". AIDS Res. ...

Furthermore, the gene for titin contains the largest number of exons (363) discovered in any single gene, as well as the ... Wang K, McClure J, Tu A (August 1979). "Titin: major myofibrillar components of striated muscle". Proceedings of the National ... In 2001, Labeit and colleagues determined the complete sequence of the human titin gene. The human gene encoding for titin is ... The gene duplication events took place independently but were from the same ancestral Ig and FNIII domains. It is said that the ...

VEZT is a gene located on chromosome 12 and encodes for the protein vezatin. Vezatin is a major component of the cadherin- ... Of these, mutations in the VEZT gene have been identified by various Genome-wide association studies (GWAS). The VEZT gene is a ... Mutations of the gene can lead to upregulation or downregulation of the protein which can have detrimental effects on ... Another key component of this junction is the protein myosin VIIA and primarily its interaction with vezatin. Myosins are ...

The RLBP1 gene is located on human chromosome 15, specifically on 15q26. This gene was formerly believed to have 8 exons and 7 ... "In vitro binding of retinol to rat-tissue components". Proceedings of the National Academy of Sciences of the United States of ... A gene element, upstream of the previously thought exon 1 was originally thought to be an enhancer. In reality, this assumed ... People suffering from Bothnia dystrophy have a homozygous C to T base pair substitution in exon 7 of the RLBP1 gene. This leads ...

The gene for A and B transferases is located on chromosome 9. The gene contains seven exons and six introns and the gene itself ... Zhang Z, Stevens LM, Stein D (Jul 2009). "Sulfation of eggshell components by Pipe defines dorsal-ventral polarity in the ... "Detection of common mutations in the GALT gene through ARMS". Gene. 509 (2): 291-4. doi:10.1016/j.gene.2012.08.010. PMID ... The ChAT gene is located on chromosome 10. Decreased expression of ChAT is one of the hallmarks of Alzheimers disease. ...

Other components include γ-terpinene, safranal, p-cymene, and β-pinene. In a reference amount of 100 grams (3.5 oz), cumin ... Therefore, methods used for breeding are in vitro regenerations, DNA technologies, and gene transfers. The in vitro cultivation ... The variabilities of yield and yield components are high. Varieties are developed by sib mating in enclosed chambers or by ... Cuminaldehyde, cymene, and terpenoids are the major volatile components of cumin oil which is used for a variety of flavors, ...

Eugene Syriani and Hans Vangheluwe. A modular timed graph transformation language for simulation-based design. Software and ... Integrating Base Object Model components into DEVS-based simulation. Journal of Defense Modeling and Simulation, April 2010. ...

The Arntl gene is an essential component within the mammalian clock gene regulatory network. It is a point of sensitivity ... including all of the clock genes and genes encoding for proteins that regulate metabolism. The BMAL1 gene was originally ... In addition, BMAL1 gene expression, along with that of other core clock genes, were discovered to be lower in patients with ... However, the genes importance in circadian rhythms was not fully realized until the knockout of the gene in mice showed ...

Exocyst complex component 6 is a protein that in humans is encoded by the EXOC6 gene. The protein encoded by this gene is ... "Entrez Gene: Exocyst complex component 6". Zhang XM, Ellis S, Sriratana A, Mitchell CA, Rowe T (October 2004). "Sec15 is an ... It is one of the components of a multiprotein complex required for exocytosis. The 5 portion of this gene and two neighboring ... A paralogous gene encoding a similar protein is present on chromosome 2. GRCh38: Ensembl release 89: ENSG00000138190 - Ensembl ...

... have had in conclusively identifying genes that cause bipolar disorder has led them to search for an epigenetic component to ... such as the BDNF gene and serotonergic genes. The brain-derived neurotrophic factor (BDNF) gene plays a role in the growth, ... The two genes above are the most researched ones; however, there are still some other genes that are found to have different ... An example of this is in the KCNQ3 gene. This gene encodes a potassium channel which function to prevent hyperexcitability of a ...

"RAD21 cohesin complex component [Homo sapiens]". NCBI gene. National Center for Biotechnology Information (NCBI), U.S. National ... Dorsett D, Merkenschlager M (June 2013). "Cohesin at active genes: a unifying theme for cohesin and gene expression from model ... 1994-01-01). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes ( ... Gene. 537 (2): 279-84. doi:10.1016/j.gene.2013.12.045. PMID 24378232. Boyle MI, Jespersgaard C, Nazaryan L, Bisgaard AM, Tümer ...

"Entrez Gene: SEC61G Sec61 gamma subunit". Wiertz EJ, Tortorella D, Bogyo M, Yu J, Mothes W, Jones TR, Rapoport TA, Ploegh HL ( ... Hartmann E, Sommer T, Prehn S, Görlich D, Jentsch S, Rapoport TA (February 1994). "Evolutionary conservation of components of ... Protein transport protein Sec61 subunit gamma is a protein that in humans is encoded by the SEC61G gene. The Sec61 complex is ... This gene encodes the gamma-subunit protein. Alternatively spliced transcript variants encoding the same protein have been ...

It changes in toto from one allelic form into another; there are no smaller components within it that can change. 3. The gene ... He demonstrated that a gene can be defined as a unit of function. A gene can be subdivided into a linear array of sites that ... Crossing over take place between genes ( the beads in this model ) but never within them. 2. The gene is viewed as the ... The bead theory is a disproved hypothesis that genes are arranged on the chromosome like beads on a necklace. This theory was ...

"Entrez Gene: EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1". Doria M, Salcini AE, Colombo E, Parslow TG ... an adaptor-like protein that interacts with components of the endocytic machinery". J. Cell Biol. 153 (5): 1111-20. doi:10.1083 ... Epidermal growth factor receptor substrate 15-like 1 is a protein that in humans is encoded by the EPS15L1 gene. EPS15L1 has ... Ueki N, Oda T, Kondo M, Yano K, Noguchi T, Muramatsu M (1998). "Selection system for genes encoding nuclear-targeted proteins ...

Disruptions of this gene have been associated to melanoma tumor progression. Pannexin 1 is also an important component of ... The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap ... "Entrez Gene: Pannexin 1". Retrieved 2012-04-11. Furlow PW, Zhang S, Soong TD, Halberg N, Goodarzi H, Mangrum C, Wu YG, Elemento ... Truncating mutations in this gene have been shown to promote breast cancer metastasis to the lungs by allowing cancer cells to ...

... is a protein that in humans is encoded by the IFNGR1 gene. The gene IFNGR1 encodes IFN-γR1, which is the ligand-binding chain ( ... "Interaction between the components of the interferon gamma receptor complex". The Journal of Biological Chemistry. 270 (36): ... "Entrez Gene: IFNGR1 interferon gamma receptor 1". Novick D, Orchansky P, Revel M, Rubinstein M (Jun 1987). "The human ... Le Coniat M, Alcaide-Loridan C, Fellous M, Berger R (Dec 1989). "Human interferon gamma receptor 1 (IFNGR1) gene maps to ...

Preproglucagon in humans is encoded by the GCG gene. Proglucagon is a precursor of glucagon, and several other components. It ... Schroeder WT, Lopez LC, Harper ME, Saunders GF (1984). "Localization of the human glucagon gene (GCG) to chromosome segment ... It is also cleaved into the following components in different organs: Signal peptide (1-20) - removed from preproglucagon to ... White JW, Saunders GF (June 1986). "Structure of the human glucagon gene". Nucleic Acids Research. 14 (12): 4719-4730. doi: ...

"Entrez Gene: MAP2K5 mitogen-activated protein kinase kinase 5". Sun W, Kesavan K, Schaefer BC, Garrington TP, Ware M, Johnson ... Zhou G, Bao ZQ, Dixon JE (May 1995). "Components of a new human protein kinase signal transduction pathway". The Journal of ... The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase ... Kato Y, Kravchenko VV, Tapping RI, Han J, Ulevitch RJ, Lee JD (Dec 1997). "BMK1/ERK5 regulates serum-induced early gene ...

"Entrez Gene: MAPK7 mitogen-activated protein kinase 7". Hayashi M, Lee JD (December 2004). "Role of the BMK1/ERK5 signaling ... Zhou G, Bao ZQ, Dixon JE (May 1995). "Components of a new human protein kinase signal transduction pathway". The Journal of ... Mitogen-activated protein kinase 7 also known as MAP kinase 7 is an enzyme that in humans is encoded by the MAPK7 gene. MAPK7 ... Kato Y, Kravchenko VV, Tapping RI, Han J, Ulevitch RJ, Lee JD (December 1997). "BMK1/ERK5 regulates serum-induced early gene ...

2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human ... Identification of protein components in the 28 S small subunit". J Biol Chem. 276 (35): 33181-95. doi:10.1074/jbc.M103236200. ... This gene encodes a 28S subunit protein that contains a high level of sequence similarity with ribosomal protein S11P family ... 2004). "ZNF143 activates gene expression in response to DNA damage and binds to cisplatin-modified DNA". Int. J. Cancer. 111 (6 ...

According to the Gene Ontology, the extracellular space is a cellular component defined as: "That part of a multicellular ... Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore ... Extracellular Space by Gene Ontology database (EMBL-EBI) Didangelos, A.; Yin, X.; Mandal, K.; Baumert, M.; Jahangiri, M.; Mayr ... M. (2010). "Proteomics Characterization of Extracellular Space Components in the Human Aorta". Molecular & Cellular Proteomics ...

Eugene V. & Woyke, Tanja (6 April 2017). "Giant viruses with an expanded complement of translation system components". Science ... Koonin, Eugene V.; Krupovic, Mart & Yutin, Natalya (April 2015). "Evolution of double-stranded DNA viruses of eukaryotes: from ...