Geminin - Wikipedia
Geminin is absent during G1 phase and accumulates through S, G2 phase and M phases of the cell cycle. Geminin levels drop at ... During S phase, geminin is a negative regulator of DNA replication. In many cancer cell lines, inhibition of geminin by RNA ... Coincidentally, geminin was also shown to expand the neural plate in the developing Xenopus embryo. Geminin is a nuclear ... Ultimately, geminin allows cells uncommitted to any particular lineage to acquire neural characteristics. Geminin has also been ...
GMNN antibody Mouse Anti Human | Geminin antibody | ProSpec
Anti-human Geminin mAb is derived from hybridization of mouse SP2/0 myeloma cells with spleen cells from BALB/c mice immunized ... Geminin can also promote DNA replication. Geminin has 2 roles in 2 different stages of the cell cycle: Geminin is a negative ... Anti-human Geminin mAb is derived from hybridization of mouse SP2/0 myeloma cells with spleen cells from BALB/c mice immunized ... Geminin is a 25 kDa nuclear protein, which inhibits DNA replication and is degraded during the mitotic phase of the cell cycle ...
"Regulation of geminin by neuropeptide Y in vascular smooth muscle cell" by Shi-Yu Liang, You-Li Zhou et al.
In vitro experiments have shown that stimulation of NPY on VSMCs via regulation of geminin is a double-edged sword. Given that ... we focus on the role of geminin interference in determining the fate of VSMCs. Furthermore, we discuss the therapeutic ... Geminin, a key regulator of DNA replication licensing in the cell cycle, plays an essential role in determining the fate of ... Geminin, a key regulator of DNA replication licensing in the cell cycle, plays an essential role in determining the fate of ...
Investigating the Mechanism of Geminin Inactivation - Discovery - the University of Dundee Research Portal
A key regulator of MCM loading is a coiled-coil protein called geminin. Geminin potently inhibits licensing by binding and ... However, in embryonic cell cycles geminin remains stable throughout the cell cycle. This is essential as geminin is a duel ... Investigating the Mechanism of Geminin Inactivation. Creavin, K. (Author). 2015. Student thesis: Doctoral Thesis › Doctor of ... The aim of this project was to identify the molecular mechanism of geminin inactivation in Xenopus egg extracts. Experiments ...
Belirli deniz koşullarında seyreden bir geminin rota kontrolü
Ardışık koordinatların takibi simülasyonu için sekiz farklı koordinat belirlenmiş ve geminin bu koordinatları takip ederek ... Oluşturulan bu simülatör vasıtasıyla geminin seyir bölgesine ve amacına göre, seyir esnasında olabilecek dış kuvvetlerin ... İkinci aşamada ise bu matematiksel modeller kullanılarak geminin başlangıç durumundaki koordinatlarından hareketle başka bir ... Bu belirlenen senaryolar için geminin hedeflenen nokta veya noktalara ulaşması için kontrol sistemi oluşturulmuştur. ...
Genelleştirilmiş Ters Yapay Açıklık Radarı (ısar) İle Hareketli Bir Geminin Görüntülenmesi
Çalışmamızda geminin rotasyon açısı zamana bağlı olduğu için Doppler frekansı zamana bağlı olur ve MATLAB yazılım sonucunda ... SAR (Sentetik Açıklık Radarı) taşıyan bir uçakla denizdeki bir geminin tespitine yönelik simülasyon çalışması yapılmıştır. Hem ... çalışmalardan yararlanılarak denizde hareket eden bir geminin görüntülenmesi amaçlanmaktadır. ... Çalışmamızda denizde düz hareket eden bir geminin görüntülenmesine ait çalışmalar ve kendi merkezi etrafında dönme hareketi ...
Human cytomegalovirus miR-US5-1 inhibits viral replication by targeting Geminin mRNA
Geminin is required for mitotic proliferation of spermatogonia. Dev Biol, 371: 35-46.. doi: 10.1016/j.ydbio.2012.07.031 ... Geminin inhibits a late step in the formation of human pre-replicative complexes. J Biol Chem, 289: 30810-30821.. doi: 10.1074/ ... Expression of geminin as a marker of cell proliferation in normal tissues and malignancies. Am J Pathol, 161: 267-273.. doi: ... Cdt1 and geminin: role during cell cycle progression and DNA damage in higher eukaryotes. Front Biosci, 12: 1629-1641.. doi: ...
GCN - Circulars - 4639: GRB 060202: Gemini-N J, H, K s observations
The Coordination between DNA Replication Initiation and Other Cell Cycle Events | IntechOpen
Geminin and Cdc6 also play important roles in coordinating DNA replication and mitosis. Depletion of geminin results in ... Geminin is a DNA replication licensing inhibitor. Through targeting Cdt1 and interfering with Cdt1-MCM interaction, geminin ... Geminin-depleted cells show over-duplication of centrosomes without the passage through mitosis, suggesting that geminin might ... Geminin is targeted for destruction by APC in M phase (McGarry and Kirschner 1998) and accumulates in late G1 phase, S phase ...
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Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks | Nature Communications
Subcellular - PKN2 - The Human Protein Atlas
U-2 OS FUCCI cells express two fluorescently tagged cell cycle markers, CDT1 during G1 phase (red) and Geminin during S and G2 ...
Genetic and epigenetic alterations in myelodysplastic syndrome | Cytogenetic and Genome Research | Karger Publishers
Luo L, Kessel M: Geminin coordinates cell cycle and developmental control. Cell Cycle 3:711-714 (2004). ...
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HDAC3 | Cancer Genetics Web
Geminin facilitates FoxO3 deacetylation to promote breast cancer cell metastasis.. J Clin Invest. 2017; 127(6):2159-2175 [ ... Geminin expression is essential for embryonic development and the maintenance of chromosomal integrity. In spite of this ... We determined that geminin-associated HDAC3 deacetylates FoxO3 to block its transcriptional activity, leading to downregulation ... Here, we have demonstrated that geminin selectively couples the transcription factor forkhead box O3 (FoxO3) to HDAC3, thereby ...
İngilizce - Türkçe Sözlük | İngilizce - Türkçe Çeviri
Gemini Review
Replication licensing | HSTalks
Spindly is required for rapid migration of human cells | Biology Open | The Company of Biologists
The stabilization of geminin (Fig. 3D) confirmed that the HU treatment was blocking cell cycle progression (McGarry and ... Geminin protein levels confirmed that the HU treatment worked. Tubulin used as loading control. (E-G) Kymographs generated from ... Geminin protein levels confirmed that the HU treatment worked. Tubulin used as loading control. (E-G) Kymographs generated from ... Spindly, tubulin, geminin, GAPDH and PCNA were detected using specific antibodies: rabbit anti-Spindly (Griffis et al., 2007), ...
MyeloCult™ - Long-Term Culture-Initiating Cell (LTC-IC) Assays
DDX5 Regulates DNA Replication and Is Required for Cell Proliferation in a Subset of Breast Cancer Cells | Cancer Discovery |...
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