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*  The bHLH transcription factor hand2 is essential for noradrenergic differentiation of sympathetic neurons | Development
Dai, Y. S., Cserjesi, P., Markham, B. E. and Molkentin, J. D. (2002). The transcription factors GATA4 and dHAND physically ... The bHLH transcription factor Hand2 belongs to the network of regulatory factors implicated in the specification and ... The expression of the noradrenergic marker genes th and dbh is strongly reduced, as well as the transcription factors gata2 and ... The basic helix-loop-helix transcription factor Hand2, together with Ascl1, Phox2a, Phox2b and Gata2/Gata3, is induced by bone ...
http://dev.biologists.org/content/133/20/4015
*  Cardiac transcription factors in HL-1 cells: genome binding profiling | Stem Cell Commons
... and TRE promoter driving transcription factor Gata4 or Mef2a or Nkx2-5 or Srf or Tbx5 as indicated for 48 hrs before cells ... We performed bio-ChIP-seq using streptavidin beads immunoprecipitation of biotinylated 5 cardiac transcription factors (fbio) ... 2003) Efficient biotinylation and single-step purification of tagged transcription factors in mammalian cells and transgenic ... Genome occupancy profiling: Identify cardiac active enhancers by identified 5 cardiac transcription factors and P300 peaks. ...
http://stemcellcommons.org/node/16436
*  A population of hematopoietic stem cells derives from GATA4-expressing progenitors located in the placenta and lateral mesoderm...
GATA transcription factors are expressed in the mesoderm and endoderm during development. GATA1-3, but not GATA4, are ... Ver más] GATA transcription factors are expressed in the mesoderm and endoderm during development. GATA1-3, but not GATA4, are ... We have studied the developmental fate of the G2-Gata4 cell lineage using a G2-Gata4Cre;R26REYFP mouse line. We found a ... We have studied the developmental fate of the G2-Gata4 cell lineage using a G2-Gata4Cre;R26REYFP mouse line. We found a ...
https://idus.us.es/xmlui/handle/11441/63935
*  Genetic risk expressed in early regulator of gene expression | Genes 2 Brains 2 Mind 2 Me
The recent paper by Ho et al., 'Basic helix-loop-helix transcription factor NEUROG1 and schizophrenia: Effects on illness… ... Image via Wikipedia The basic helix-loop-helix transcription factor, neurogenin-1 is known to regulate neural development and ... The basic helix-loop-helix transcription factor, neurogenin-1 is known to regulate neural development and neurite outgrowth. As ... Thus, the role of variation in a transcription factor - a gene that regulates the expression of other genes - in the risk of ...
https://genes2brains2mind2me.com/2009/06/29/genetic-risk-expressed-in-early-regulator-of-gene-expression/
*  Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. - PubMed - NCBI
Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis.. Molkentin JD1, Lin Q, Duncan ... The zinc finger transcription factor GATA4 has been implicated in heart development based on its early expression in ... To determine the role of GATA4 in embryogenesis, we generated mice homozygous for a GATA4 null allele. Homozygous GATA4 null ... GATA4 is most highly expressed within the precardiogenic splanchnic mesoderm at the posterior lip of the anterior intestinal ...
https://www.ncbi.nlm.nih.gov/pubmed/9136933
*  Transcription factor GATA-4 | definition of transcription factor GATA-4 by Medical dictionary
What is transcription factor GATA-4? Meaning of transcription factor GATA-4 medical term. What does transcription factor GATA-4 ... Looking for online definition of transcription factor GATA-4 in the Medical Dictionary? transcription factor GATA-4 explanation ... GATA4. (redirected from transcription factor GATA-4) GATA4. A gene on chromosome 8p23.1-p22 that encodes a member of the GATA ... Transcription factor GATA-4 , definition of transcription factor GATA-4 by Medical dictionary https://medical-dictionary. ...
https://medical-dictionary.thefreedictionary.com/transcription+factor+GATA-4
*  The transcription factor GATA4 promotes myocardial regeneration in neonatal mice | EMBO Molecular Medicine
GATA4 belongs to the GATA family of transcription factors, of which six GATA factors exist in vertebrates, all sharing a ... The transcription factor GATA4 promotes myocardial regeneration in neonatal mice. Mona Malek Mohammadi, Badder Kattih, Andrea ... We found in this study that the cardiomyocyte transcription factor GATA4, which is crucial to promote prenatal cardiac ... Li J, Chen X, Yang H, Wang S, Guo B, Yu L, Wang Z, Fu J (2006) The zinc finger transcription factor 191 is required for early ...
http://embomolmed.embopress.org/content/9/2/265
*  Loss of transcription factor GATA-4/-5 by hypermethylation correlated with progression of gastric carcinomas | Cancer Research
Loss of transcription factor GATA-4/-5 by hypermethylation correlated with progression of gastric carcinomas Xianzi Wen, ... Loss of transcription factor GATA-4/-5 by hypermethylation correlated with progression of gastric carcinomas ... Loss of transcription factor GATA-4/-5 by hypermethylation correlated with progression of gastric carcinomas ... Loss of transcription factor GATA-4/-5 by hypermethylation correlated with progression of gastric carcinomas ...
http://cancerres.aacrjournals.org/content/67/9_Supplement/2873
*  Transcription factors GATA-4 and GATA-6 in normal and neoplastic human gastrointestinal mucosa
... Haveri, Hanna; Westerholm-Ormio ... GATA transcription factors direct cell proliferation and differentiation in many organs, and are implicated in tumorigenesis. ... GATA-4 was abundant in the differentiated epithelial cells of the proximal parts of the gastrointestinal tract but was absent ... Both factors were also present in Barrett's esophagus and metaplasia of the stomach. GATA-6 expression was reduced in colon ...
http://tampub.uta.fi/handle/10024/65816
*  Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart. ...
Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart. ... Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart. ... We conclude that GATA-4 is a tissue-specific, retinoic acid-inducible, and developmentally regulated transcription factor. On ... Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart. ...
https://mcb.asm.org/content/13/4/2235?ijkey=43fcc0085470aa98f7334790fabdff986bc86dd4&keytype2=tf_ipsecsha
*  Translational Physiology Block 3 Flashcards by Art Berezovsky | Brainscape
pathway: MAPK (zinc finger transcription factor GATA4; SRF; Sp1; TEF-1 family); catecholamines and angiotensin II activate MAPK ... elevated intracellular calcium activates GATA4); alternate or additional branch: MLP and AP-1 ...
https://www.brainscape.com/flashcards/translational-physiology-block-3-2907375/packs/4590251
*  Deepak Srivastava, MD | Biomedical Sciences Graduate Program
Disease Model of GATA4 Mutation Reveals Transcription Factor Cooperativity in Human Cardiogenesis.. Cell ...
https://bms.ucsf.edu/faculty/deepak-srivastava-md
*  A whole-genome massively parallel sequencing analysis of BRCA1 mutant oestrogen receptor-negative and -positive breast cancers.
0/GATA4 Transcription Factor; 0/GATA4 protein, human; 0/Receptors, Estrogen; 0/TP53 protein, human; 0/Tumor Suppressor Protein ... GATA4 Transcription Factor / genetics. Genomics. Germ-Line Mutation*. Humans. Loss of Heterozygosity. Middle Aged. Receptors, ... and GATA4 are potential additional drivers of breast cancers. This study demonstrates that BRCA1 pathogenic germline mutations ...
http://www.biomedsearch.com/nih/whole-genome-massively-parallel-sequencing/22362584.html
*  Publikationen - KNHI
Mutations in the cardiac transcription factor GATA4 in patients with lone atrial fibrillation. Eur J med Genet, 2010 ... Mitochondrial transcription factors TFA, TFB1 and TFB2: a search for DNA variants/haplotypes and the risk of cardiac ... of association between PFO complicated by cryptogenic stroke and a common variant of the cardiac transcription factor GATA4. ... Activation of STAT1 transcription factor precedes up-regulation of coxsackievirus - adenovirus receptor during viral ...
http://knhi.de/research/publications/
*  REST regulates the cell cycle for cardiac development and regeneration | Nature Communications
The authors show that the transcription factor REST regulates cardiomyocyte proliferation by binding and repressing the cell ... Several transcription factors, such as GATA412, TBX2013, BRG114, YAP15,16, ERBB217, PITX218, and MEIS119 have been shown to be ... REST thus joins a network of transcription factors or cofactors, including MEIS119, YAP15,16, GATA412,33,34, and TBX2013, as a ... The transcription factor GATA4 promotes myocardial regeneration in neonatal mice. EMBO Mol. Med. 9, 265-279 (2017). ...
https://www.nature.com/articles/s41467-017-02210-y?elqTrackId=4adba0bb9f3943159af112b7a90d7293&error=cookies_not_supported&code=bd4d6d07-6491-4882-a764-b14329e1e1be
*  GATA4 (mouse)
Home > Protein > GATA4 mouse. human. rat. water buffalo. New Protein Search:. Transcription factor GATA-4 ...
https://www.phosphosite.org/proteinAction?id=3380&showAllSites=true
*  JCI - Curcumin prevents and reverses murine cardiac hypertrophy
P300 Functions as a coactivator of transcription factor GATA-4. J. Biol. Chem. 276:37178-37185. View this article via: CrossRef ... The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a ... p300 protein serves as an adaptor for hypertrophy-responsive transcription factors including GATA4, which is required for the ... p300 is a critical HAT in muscle that modifies chromatin and associated transcription factors and promotes gene activation (6, ...
https://www.jci.org/articles/view/32865
*  Anti-GATA4 antibody (ab124265) | Abcam
Rabbit polyclonal GATA4 antibody validated for WB, IP, IHC, ICC/IF and tested in Human. With 1 independent review. Immunogen ... Transcription factor GATA 4 antibody. *Transcription factor GATA-4 antibody. *Transcription factor GATA4 antibody ... All lanes : Anti-GATA4 antibody (ab124265) at 0.1 µg/ml. Lane 1 : 293T whole cell lysate at 50 µg/ml. Lane 2 : 293T whole cell ... ab124265 at 1 µg/ml detecting GATA4 in 293T whole cell lysate by WB following IP. Lane 1: IP with an antibody which recognizes ...
http://www.abcam.com/gata4-antibody-ab124265.html
*  The deployment of cell lineages that form the mammalian heart | Nature Reviews Cardiology
Disease model of GATA4 mutation reveals transcription factor cooperativity in human cardiogenesis. Cell 167, 1734-1749.e22 ( ... Durocher, D., Charron, F., Warren, R., Schwartz, R. J. & Nemer, M. The cardiac transcription factors Nkx2-5 and GATA-4 are ... The bHLH transcription factor Tcf21 is required for lineage-specific EMT of cardiac fibroblast progenitors. Development 139, ... Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum. Nature 392, 182-186 (1998). ...
https://www.nature.com/articles/s41569-018-0086-9?error=cookies_not_supported&code=d45c1ddb-4892-4b1a-8a70-9da8b20e4e8c
*  Regeneration in humans - Wikipedia
This was done using three transcription factors: GATA4, Mef2c, and Tbx5. Cardiac fibroblasts make up more than half of all ... Blackburn, CC (April 2014). "Regeneration of the aged thymus by a single transcription factor". Development. 141: 1627-1637. ... 2010). "Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors". Cell. 142: 375-386. doi:10.1016 ...
https://en.wikipedia.org/wiki/Regeneration_in_humans
*  Disruption of a GATA4/Ankrd1 signaling axis in cardiomyocytes leads to sarcomere disarray: implications for anthracycline...
Doxorubicin also induced depletion of the cardiac transcription factor GATA4 in cardiomyocytes. CARP expression is regulated in ... Adenoviral overexpression of GATA4 (AdV-GATA4) in cardiomyocytes prior to doxorubicin exposure maintained GATA4 levels, ... We postulate that GATA4 regulates CARP expression and both act to induce sarcomere gene transcription. CARP expression is ... GATA4-siRNA knockdown in cardiomyocytes inhibited CARP expression and myofilament gene transcription, and induced extensive ...
https://www.ncbi.nlm.nih.gov/pubmed/22532871
*  Linda Boxer, MD, PhD | Stanford Medicine Profiles
Transcription factor gata4 regulates cardiac BCL2 gene expression in vitro and in vivo. FASEB journal Kobayashi, S., Lackey, T ... Transcription factor GATA4 regulates cardiac BCL2 gene expression in vitro and in vivo FASEB JOURNAL Kobayashi, S., Lackey, T ... The transcription factor GATA-4 protects cardiomyocytes against doxorubicin-induced cardiotoxicity. Here, we report the ... Bcl-2 transcription from the proximal P2 promoter is activated in neuronal cells by the Brn-3a POU family transcription factor ...
https://med.stanford.edu/profiles/linda-boxer?tab=teaching
*  Development and Structure of the Cardiac Conduction System | SpringerLink
... including the known molecular and cellular factors that regulate development of the conduction system are outlined. Part II ... GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. Genes Dev. 1997;11:1048-60.PubMed ... The zinc finger-containing transcription factors GATA-4, -5, and -6. Ubiquitously expressed regulators of tissue-specific gene ... Transcription factor Sp3 knockout mice display serious cardiac malformations. Mol Cell Biol. 2007;27:8571-82.PubMedCentral ...
https://link.springer.com/chapter/10.1007/978-1-4939-2739-5_1
*  Anti-STAT6 antibody (ab44718) | Abcam
The transcription factor GATA4 promotes myocardial regeneration in neonatal mice.. EMBO Mol Med 9:265-279 (2017). Read more ( ... Signal Transducer And Activator Of Transcription 6 Nirs Variant 1 antibody. *Signal transducer and activator of transcription 6 ... Signal transducer and activator of transcription 6 antibody. *Signal Transducer And Activator Of Transcription 6 Interleukin 4 ... Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling. ...
https://www.abcam.com/stat6-antibody-ab44718.html