The transcription factor GATA3 is critical for the development of all IL-7Rα-expressing innate lymphoid cells
... Immunity. 2014 ... Thus, GATA3 plays parallel roles in regulating the development and functions of CD4(+) T cells and IL-7Rα(+) ILCs. ... Here, we report that GATA3 was indispensable for the development of all IL-7Rα(+) ILC subsets and T cells but was not required ... Conditionally Gata3-deficient mice had no lymph nodes and were susceptible to Citrobactor rodentium infection. After the ILCs ...
GATA3 - Wikipedia
GATA3 is a transcription factor that in humans is encoded by the GATA3 gene. Studies in animal models and humans indicate that ... GATA3 belongs to the GATA family of transcription factors. Gene-deletion studies in mice indicate that Gata3 (mouse gene ... "Entrez Gene: GATA3 GATA binding protein 3". Zheng, Wei-ping; Flavell, Richard A (May 1997). "The Transcription Factor GATA-3 Is ... that modulate GATA3s gene-stimulating actions. The GATA3 transcription factor regulates the expression of genes involved in ...
Function of GATA transcription factors in preadipocyte-adipocyte transition
... and defective GATA-2 and GATA-3 expression is associated with obesity. Thus, GATA-2 and GATA-3 regulate adipocyte ... Function of GATA transcription factors in preadipocyte-adipocyte transition Science. 2000 Oct 6;290(5489):134-8. doi: 10.1126/ ... Here, we show that murine GATA-2 and GATA-3 are specifically expressed in white adipocyte precursors and that their down- ... GATA-3-deficient embryonic stem cells exhibit an enhanced capacity to differentiate into adipocytes, ...
Regulation of the T helper cell type 1 transcription factor T-bet in coeliac disease mucosa | Gut
T-bet and STAT-4, two Th1 promoting transcription factors, and STAT-6 and GATA-3, transcription factors which govern T helper ... The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell1997;89:587-96 ... transcription factors such GATA-3 and STAT-6 have a major influence on Th2 differentiation and are necessary for expression of ... Szabo SJ, Kim ST, Costa GL, et al. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell2000;100:655-69. ...
TH2, allergy and group 2 innate lymphoid cells | Nature Immunology
The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells. Immunity 37, 649-659 (2012 ... The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells. Immunity 37, 634-648 (2012 ... Transcription factor RORα is critical for nuocyte development. Nat. Immunol. 13, 229-236 (2012). ... Transforming growth factor-beta reprograms the differentiation of T helper 2 cells and promotes an interleukin 9-producing ...
Multicystic Renal Dysplasia: Practice Essentials, Background, Pathophysiology
This autosomal dominant syndrome is caused by mutations in the GATA3 transcription factor. Patients present with ... Renal coloboma syndrome (RCS): The RCS is an autosomal dominant condition caused by mutations in the transcription factor PAX2 ... monogenic form of diabetes with an autosomal dominant mode of inheritance caused by mutations in the hepatocyte nuclear factor ...
Frontiers | Effector T Helper Cell Subsets in Inflammatory Bowel Diseases
The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell (1997) 89(4): ... GATA3. STAT6 binds the promoter and activates transcription of GATA3; GATA3 can subsequently induce its own expression and ... The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6. J Clin Invest ( ... Thus, GATA3 is a lineage-defining factor for Th2 cells. GATA3 was expressed at higher levels in colonic tissue from UC patients ...
Immunomodulatory Effects of Lepidium meyenii Walp. Polysaccharides on an Immunosuppression Model Induced by Cyclophosphamide
T-bet and GATA-3 are important transcription factors that affect the differentiation of Th1 and Th2 cells [34]. Th1 cells can ... Effects of Maca polysaccharides on the mRNA expression of spleen T-bet and GATA-3 (. ); vs. control group; ##. and ###. vs. ... T-bet and GATA-3 are key factors that specifically regulate the differentiation of Th0 cells into Th1 and Th2 cells. T-bet is a ... GATA-3 is the opposite of T-bet. We evaluated the Th1/Th2 balance by detecting the mRNA expression of T-bet and GATA-3 in the ...
Mammary gland | Semantic Scholar
Bone | 0013 | SFEBES2007 | Society for Endocrinology BES | Endocrine Abstracts
... syndrome is an autosomal dominant disorder caused by mutations in the dual zinc-finger transcription factor GATA-3. Gata3 ... Mechanisms of DNA binding by the transcription factor GATA3 revealed by mutations causing the hypoparathyroidism-deafness-renal ... Mutations leading to haploinsufficiency of the dual zinc finger transcription factor GATA3 result in the hypoparathyroidism- ... In aging women with established osteoporosis, GH and insulin like growth factor -1 (IGF-1) concentrations are low and ...
Protocol for the Characterization of Human Th9 Cells: R&D Systems
... and is controlled by distinct transcription factors (e.g. GATA-3, IRF4, PU.1, STAT6). Th9 polarized cells are present in low ... Intracellular markers include transcription factors that control CD4+ T cell differentiation as well as signature cytokines as ...
Gene of the month: GATA3 | Journal of Clinical Pathology
GATA binding protein 3 (GATA3) is a zinc-finger pioneer transcription factor involved in diverse processes. GATA3 regulates ... Mutations in GATA3 are linked to breast and bladder cancer. GATA3 expression is a feature of the luminal subtype of bladder ... This paper reviews the structure and function of GATA3, its role in cancer and its use and pitfalls as an immunohistochemical ... During development, GATA3 plays a key role in cell differentiation. ...
PDF) Genotype-phenotype correlation in two Polish neonates with alveolar capillary dysplasia
This interval harbors binding sites for lung-expressed transcription factors, including GATA3, ESR1, and YY1, and is flanked by ... transcription factor gene cluster, and review of the literature. Eur J Med ... 7. Shaw-Smith C. Genetic factors in esophageal atresia, tracheo-esophageal. fistula and the VACTERL association: roles for ... lethal lung developmental disorder in neonates due to heterozygous loss-of-function of the mesenchymal transcription factor ...
Immunological Aspect on Late Allograft Dysfunction
Absence of specific alternatively spliced exon of CD44 in macrophages prevents colitis | Mucosal Immunology
Prevention was associated with the downregulation of signal transducer and activator of transcription 3 (STAT3)-activating and ... To compare transcription factor expression level in human Th cell subtypes, naïve CD4+ T cells were isolated from the PBMC ... Surprisingly, the expression levels of T-bet, RORγt, and GATA3 were not reduced in the colon of Rag2−/−Cd44v7−/− transfer ... For expression analysis of transcription factors, murine CD25−CD4+CD62Lhigh naïve T cells were isolated from erythrocytes ...
Aberrant DNA methylation of GATA binding protein 3 (GATA3), interleukin-4 (IL-4), and transforming growth factor-β (TGF-β)...
TBX21 (Th1), GATA3 (Th2), RORγt (Th17) and FOXP3 (Treg) are the primary subset-specific transcription factors of these CD4+T ... T-box transcription factor 21; TGF-β: transforming growth factor-β; TGFBI: transforming growth factor-beta-inducible gene h3; ... The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell. 1997; 89:587 ... To investigate whether the methylation level of master transcription factors (TBX21, GATA3, RORγt and FOXP3) and inflammatory ...
Pediatric acute lymphoblastic leukemia | Haematologica
64 Additional transcription factor genes, including ETV6, RUNX1, and GATA3, are altered by deletion or sequence mutation but ... encode C2H2-type zinc-finger transcription factors and are rearranged with genes encoding N-terminal transcription factors (e.g ... Alterations of B-lineage transcription factor genes, particularly IKZF1, are a hallmark of BCR-ABL1 ALL18 and are a key ... Other transcription factor-driven subtypes of B-cell acute lymphoblastic leukemia. Two B-ALL subtypes have distinct alterations ...
Saponin-enriched extract of Asparagus cochinchinensis alleviates airway inflammation and remodeling in ovalbumin-induced asthma...
Zheng W and Flavell RA: The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T ... Kim H, Lee E, Lim T, Jung J and Lyu Y: Inhibitory effect of Asparagus cochinchinensis on tumor necrosis factor-alpha secretion ... Qu ZH, Yang ZC, Chen L, Lv ZD, Yi MJ and Ran N: Inhibition airway remodeling and transforming growth factor-β1/Smadsignaling ... Zha W, Su M, Huang M, Cai J and Du Q: Administration of pigment epithelium-derived factor inhibits airway inflammationand ...
Maternal group 2 innate lymphoid cells contribute to fetal growth and protection from endotoxin-induced abortion in mice
... are characterized by the transcription factor GATA-3 and the IL-33 specific receptor ST-2. They respond to IL-25, IL-33 and ... Cytokines and transcription factors were stained using the FoxP3 staining buffer set (eBioscience) according to the ... in which the RORα transcription factor that is critical for ILC2 development is deleted in IL7Rα-expressing ILC2s (Oliphant et ... 4B). These included canonical ILC2-signature genes such as Gata3 and Il1rl1 (coding for the IL-33 receptor ST-2), as well as ...
JCI - New insights into the pathogenesis of asthma
... allowing transcription factors and RNA polymerase II to bind and increase gene transcription (15, 16). This process is mediated ... Differentiation into Th2 cells occurs via a pathway that involves STAT-6, GATA-3, nuclear factor of activated T cells-c (NFATc ... including GATA-3, nuclear factor of activated T cells-c (NFATc), and c-maf (2, 4). Interestingly, Th1/Th2 counter-regulation ... and the T-bet transcription factor (1, 3). In the presence of CD8α- DCs and/or IL-4 (which can come from IgE-activated mast ...
Breast cancer stem cells: The role of sex steroid receptors
Such down-regulation is linked to an increase in the transcription factor KLF4, as well as CD44 and CK5, with the subsequent de ... Chou J, Lin JH, Brenot A, Kim JW, Provot S, Werb Z. GATA3 suppresses metastasis and modulates the tumor microenvironment by ... as well as other factors, including metalloproteases (MMPs), insulin growth factor (IGF), platelet growth factor (PDGF) ... miR-141 increases the CD44+ and CK5+ cell population, while reducing PR and Stat-5 levels, two important transcription factors ...
Volume 12, Issue 1 - ijms
The Expression Levels of Transcription Factors T-bet, GATA-3, RORγt and FOXP3 in Peripheral Blood Lymphocyte (PBL) of Patients ... Nerve Growth Factor Protects the Ischemic Heart via Attenuation of the Endoplasmic Reticulum Stress Induced Apoptosis by ...
Cancers | Free Full-Text | Transcriptional Control of Regulatory T Cells in Cancer: Toward Therapeutic Targeting?
Here, we provide a global view of the transcription factors, and their upstream signaling pathways, involved in the programming ... The transcription factor BACH2 promotes tumor immunosuppression. J. Clin. Investig. 2016, 126, 599-604. [Google Scholar] [ ... Indeed, T-Box Expressed in T cells (T-bet), GATA Binding Protein 3 (GATA3), Retinoic Acid Receptor (RAR)-related Orphan ... Transcription Factor IRF4 Promotes CD8(+) T Cell Exhaustion and Limits the Development of Memory-like T Cells during Chronic ...
3905-RUNX1 - risk management | eviQ
Orphanet: Distal deletion 10p
Mesonephric-like Adenocarcinoma of the Uterine Corpus: Comprehensive Analyses of Clinicopathological, Molecular, and Prognostic...
GATA3), transcription termination factor 1 (TTF1), paired box 2 (PAX2), and cluster of differentiation (CD10). All except one ... GATA3), paired box 2 (PAX2), transcription termination factor 1 (TTF1), and cluster of differentiation 10 (CD10); negative or ... Hormone receptor-negative, thyroid transcription factor 1-positive uterine and ovarian adenocarcinomas: report of a series of ... GATA3 staining intensity was strong even in patchy areas. Solid areas displayed reduced GATA3 expression compared to tubular ...
Enkel-keten antilichamen tegen actinebindende eiwitten als tool voor het bestuderen van de immuunrespons in dendritische cellen...
NIOSHTIC-2 Search Results - Full View
... which serves as a transcription factor and mediates the transactivation of Th2 target genes, in CD4+cess. Therefore, our study ... Activation of Th2-type responses is featured by the activation of Il-4Ra/STAT6 and the up-regulation of GATA-3, ...
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EN (en)
Essential dose-dependent role for the transcription factor Gata3 in the development of IL-5+ and IL-13+ type 2 innate lymphoid ... ILC2 secrete TH2-like cytokines under the control of the transcription factors GATA-3 and RORa. ILC3 includes several ... Staying innate: transcription factor maintenance of innate lymphoid cell identity. Immunol Rev. 2014 ... GATA-3 function in innate and adaptive immunity. Immunity. 2014. 6: Spits H, Artis D, Colonna M, Diefenbach A, Di Santo JP, ...