... Immunity. 2014 ... Thus, GATA3 plays parallel roles in regulating the development and functions of CD4(+) T cells and IL-7Rα(+) ILCs. ... Here, we report that GATA3 was indispensable for the development of all IL-7Rα(+) ILC subsets and T cells but was not required ... Conditionally Gata3-deficient mice had no lymph nodes and were susceptible to Citrobactor rodentium infection. After the ILCs ...
GATA3 is a transcription factor that in humans is encoded by the GATA3 gene. Studies in animal models and humans indicate that ... GATA3 belongs to the GATA family of transcription factors. Gene-deletion studies in mice indicate that Gata3 (mouse gene ... "Entrez Gene: GATA3 GATA binding protein 3". Zheng, Wei-ping; Flavell, Richard A (May 1997). "The Transcription Factor GATA-3 Is ... that modulate GATA3s gene-stimulating actions. The GATA3 transcription factor regulates the expression of genes involved in ...
... and defective GATA-2 and GATA-3 expression is associated with obesity. Thus, GATA-2 and GATA-3 regulate adipocyte ... Function of GATA transcription factors in preadipocyte-adipocyte transition Science. 2000 Oct 6;290(5489):134-8. doi: 10.1126/ ... Here, we show that murine GATA-2 and GATA-3 are specifically expressed in white adipocyte precursors and that their down- ... GATA-3-deficient embryonic stem cells exhibit an enhanced capacity to differentiate into adipocytes, ...
T-bet and STAT-4, two Th1 promoting transcription factors, and STAT-6 and GATA-3, transcription factors which govern T helper ... The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell1997;89:587-96 ... transcription factors such GATA-3 and STAT-6 have a major influence on Th2 differentiation and are necessary for expression of ... Szabo SJ, Kim ST, Costa GL, et al. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell2000;100:655-69. ...
The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells. Immunity 37, 649-659 (2012 ... The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells. Immunity 37, 634-648 (2012 ... Transcription factor RORα is critical for nuocyte development. Nat. Immunol. 13, 229-236 (2012). ... Transforming growth factor-beta reprograms the differentiation of T helper 2 cells and promotes an interleukin 9-producing ...
This autosomal dominant syndrome is caused by mutations in the GATA3 transcription factor. Patients present with ... Renal coloboma syndrome (RCS): The RCS is an autosomal dominant condition caused by mutations in the transcription factor PAX2 ... monogenic form of diabetes with an autosomal dominant mode of inheritance caused by mutations in the hepatocyte nuclear factor ...
The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell (1997) 89(4): ... GATA3. STAT6 binds the promoter and activates transcription of GATA3; GATA3 can subsequently induce its own expression and ... The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6. J Clin Invest ( ... Thus, GATA3 is a lineage-defining factor for Th2 cells. GATA3 was expressed at higher levels in colonic tissue from UC patients ...
T-bet and GATA-3 are important transcription factors that affect the differentiation of Th1 and Th2 cells [34]. Th1 cells can ... Effects of Maca polysaccharides on the mRNA expression of spleen T-bet and GATA-3 (. ); vs. control group; ##. and ###. vs. ... T-bet and GATA-3 are key factors that specifically regulate the differentiation of Th0 cells into Th1 and Th2 cells. T-bet is a ... GATA-3 is the opposite of T-bet. We evaluated the Th1/Th2 balance by detecting the mRNA expression of T-bet and GATA-3 in the ...
The transcription factor Gata-3 is a defining marker of the luminal subtypes of breast cancer. To gain insight into the role ... Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation ...
... syndrome is an autosomal dominant disorder caused by mutations in the dual zinc-finger transcription factor GATA-3. Gata3 ... Mechanisms of DNA binding by the transcription factor GATA3 revealed by mutations causing the hypoparathyroidism-deafness-renal ... Mutations leading to haploinsufficiency of the dual zinc finger transcription factor GATA3 result in the hypoparathyroidism- ... In aging women with established osteoporosis, GH and insulin like growth factor -1 (IGF-1) concentrations are low and ...
... and is controlled by distinct transcription factors (e.g. GATA-3, IRF4, PU.1, STAT6). Th9 polarized cells are present in low ... Intracellular markers include transcription factors that control CD4+ T cell differentiation as well as signature cytokines as ...
GATA binding protein 3 (GATA3) is a zinc-finger pioneer transcription factor involved in diverse processes. GATA3 regulates ... Mutations in GATA3 are linked to breast and bladder cancer. GATA3 expression is a feature of the luminal subtype of bladder ... This paper reviews the structure and function of GATA3, its role in cancer and its use and pitfalls as an immunohistochemical ... During development, GATA3 plays a key role in cell differentiation. ...
This interval harbors binding sites for lung-expressed transcription factors, including GATA3, ESR1, and YY1, and is flanked by ... transcription factor gene cluster, and review of the literature. Eur J Med ... 7. Shaw-Smith C. Genetic factors in esophageal atresia, tracheo-esophageal. fistula and the VACTERL association: roles for ... lethal lung developmental disorder in neonates due to heterozygous loss-of-function of the mesenchymal transcription factor ...
They also discussed the diagnostic value of transcription factors T-bet/GATA3 ratio in predicting AMR, which may be of value in ... Many factors contribute to late graft dysfunction, and among them immunological factors are the leading cause of late grafts ...
Prevention was associated with the downregulation of signal transducer and activator of transcription 3 (STAT3)-activating and ... To compare transcription factor expression level in human Th cell subtypes, naïve CD4+ T cells were isolated from the PBMC ... Surprisingly, the expression levels of T-bet, RORγt, and GATA3 were not reduced in the colon of Rag2−/−Cd44v7−/− transfer ... For expression analysis of transcription factors, murine CD25−CD4+CD62Lhigh naïve T cells were isolated from erythrocytes ...
TBX21 (Th1), GATA3 (Th2), RORγt (Th17) and FOXP3 (Treg) are the primary subset-specific transcription factors of these CD4+T ... T-box transcription factor 21; TGF-β: transforming growth factor-β; TGFBI: transforming growth factor-beta-inducible gene h3; ... The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell. 1997; 89:587 ... To investigate whether the methylation level of master transcription factors (TBX21, GATA3, RORγt and FOXP3) and inflammatory ...
64 Additional transcription factor genes, including ETV6, RUNX1, and GATA3, are altered by deletion or sequence mutation but ... encode C2H2-type zinc-finger transcription factors and are rearranged with genes encoding N-terminal transcription factors (e.g ... Alterations of B-lineage transcription factor genes, particularly IKZF1, are a hallmark of BCR-ABL1 ALL18 and are a key ... Other transcription factor-driven subtypes of B-cell acute lymphoblastic leukemia. Two B-ALL subtypes have distinct alterations ...
Zheng W and Flavell RA: The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T ... Kim H, Lee E, Lim T, Jung J and Lyu Y: Inhibitory effect of Asparagus cochinchinensis on tumor necrosis factor-alpha secretion ... Qu ZH, Yang ZC, Chen L, Lv ZD, Yi MJ and Ran N: Inhibition airway remodeling and transforming growth factor-β1/Smadsignaling ... Zha W, Su M, Huang M, Cai J and Du Q: Administration of pigment epithelium-derived factor inhibits airway inflammationand ...
... are characterized by the transcription factor GATA-3 and the IL-33 specific receptor ST-2. They respond to IL-25, IL-33 and ... Cytokines and transcription factors were stained using the FoxP3 staining buffer set (eBioscience) according to the ... in which the RORα transcription factor that is critical for ILC2 development is deleted in IL7Rα-expressing ILC2s (Oliphant et ... 4B). These included canonical ILC2-signature genes such as Gata3 and Il1rl1 (coding for the IL-33 receptor ST-2), as well as ...
... allowing transcription factors and RNA polymerase II to bind and increase gene transcription (15, 16). This process is mediated ... Differentiation into Th2 cells occurs via a pathway that involves STAT-6, GATA-3, nuclear factor of activated T cells-c (NFATc ... including GATA-3, nuclear factor of activated T cells-c (NFATc), and c-maf (2, 4). Interestingly, Th1/Th2 counter-regulation ... and the T-bet transcription factor (1, 3). In the presence of CD8α- DCs and/or IL-4 (which can come from IgE-activated mast ...
Such down-regulation is linked to an increase in the transcription factor KLF4, as well as CD44 and CK5, with the subsequent de ... Chou J, Lin JH, Brenot A, Kim JW, Provot S, Werb Z. GATA3 suppresses metastasis and modulates the tumor microenvironment by ... as well as other factors, including metalloproteases (MMPs), insulin growth factor (IGF), platelet growth factor (PDGF) ... miR-141 increases the CD44+ and CK5+ cell population, while reducing PR and Stat-5 levels, two important transcription factors ...
The Expression Levels of Transcription Factors T-bet, GATA-3, RORγt and FOXP3 in Peripheral Blood Lymphocyte (PBL) of Patients ... Nerve Growth Factor Protects the Ischemic Heart via Attenuation of the Endoplasmic Reticulum Stress Induced Apoptosis by ...
Here, we provide a global view of the transcription factors, and their upstream signaling pathways, involved in the programming ... The transcription factor BACH2 promotes tumor immunosuppression. J. Clin. Investig. 2016, 126, 599-604. [Google Scholar] [ ... Indeed, T-Box Expressed in T cells (T-bet), GATA Binding Protein 3 (GATA3), Retinoic Acid Receptor (RAR)-related Orphan ... Transcription Factor IRF4 Promotes CD8(+) T Cell Exhaustion and Limits the Development of Memory-like T Cells during Chronic ...
The Runx1 transcription factor decreases GATA3 and IL-4 expression and Th2 skewing and promotes Th1/Th17/Tregulatory (Treg) ... Germ-line heterozygous mutations in the hematopoietic transcription factor AML1 (RUNX1) have been identified in patients with ...
Haploinsufficiency for the trans-acting T-cell-specific transcription factor GATA-3 (encoded by the GATA3 gene, and mapped to ...
GATA3), transcription termination factor 1 (TTF1), paired box 2 (PAX2), and cluster of differentiation (CD10). All except one ... GATA3), paired box 2 (PAX2), transcription termination factor 1 (TTF1), and cluster of differentiation 10 (CD10); negative or ... Hormone receptor-negative, thyroid transcription factor 1-positive uterine and ovarian adenocarcinomas: report of a series of ... GATA3 staining intensity was strong even in patchy areas. Solid areas displayed reduced GATA3 expression compared to tubular ...
GATA3 transcription factor abrogates Smad4 transcription factor-mediated fascin overexpression, invadopodium formation, and ...
... which serves as a transcription factor and mediates the transactivation of Th2 target genes, in CD4+cess. Therefore, our study ... Activation of Th2-type responses is featured by the activation of Il-4Ra/STAT6 and the up-regulation of GATA-3, ...
We further identify Gata-3, a zinc-finger transcription factor in the dysfunctional module, as a regulator of dysfunction, and ...
Essential dose-dependent role for the transcription factor Gata3 in the development of IL-5+ and IL-13+ type 2 innate lymphoid ... ILC2 secrete TH2-like cytokines under the control of the transcription factors GATA-3 and RORa. ILC3 includes several ... Staying innate: transcription factor maintenance of innate lymphoid cell identity. Immunol Rev. 2014 ... GATA-3 function in innate and adaptive immunity. Immunity. 2014. 6: Spits H, Artis D, Colonna M, Diefenbach A, Di Santo JP, ...