Transcription Factor 3 Summary Report | CureHunter
It forms a heterodimer with TWIST TRANSCRIPTION FACTOR and ACHAETE-SCUTE GENE COMPLEX-related TRANSCRIPTION FACTORS. ... A basic helix-loop-helix transcription factor that plays a role in determining cell fate during embryogenesis. ... octamer-binding transcription factor 3/4 (OCT3/4), spalt-like transcription factor 4 (SALL4), GATA binding protein 3 (GATA-3), ... Transcription Factor 3. Subscribe to New Research on Transcription Factor 3 A basic helix-loop-helix transcription factor that ...http://www.curehunter.com/public/keywordSummaryD058127-Transcription-Factor-3.do
NCBI Description of GATA3. This gene encodes a protein which belongs to the GATA family of transcription factors. The protein ... Community Annotation of GATA3 Add / Edit GATA3: Annotations. No community annotations yet for GATA3. ... GATA3 Back GATA binding protein 3. External References: Wikipedia GeneCards HUGO COSMIC Google Scholar ...http://tumorportal.org/view?geneSymbol=GATA3
Transcription factor GATA-3 (IPR029521) | InterPro | EMBL-EBI
Transcription factor GATA (IPR039355) *Transcription factor, GATA-2/3 (IPR016374) *Transcription factor GATA-3 (IPR029521) ... GATA-3 belongs to the GATA transcription factor family, which consists of a group of vertebrate GATA factors that have two ... GATA-3 is a trans-acting T-cell-specific transcription factor required for several developmental steps in T-cells [PMID: ... GATA-3 regulates the self-renewal of long-term hematopoietic stem cells.. Nat. Immunol. 14 1037-44 2013 ...http://www.ebi.ac.uk/interpro/entry/IPR029521
JCI - Lineage-affiliated transcription factors bind the Gata3 Tce1 enhancer to mediate lineage-specific programs
Previous studies showed that Gata3 is regulated by transcription factors HEB (37, 38), T cell factor 1 (TCF-1) (39), and RBP-J/ ... The transcription factor GATA3 is essential for the genesis and maturation of the T cell lineage, and GATA3 dysregulation has ... TCF-1, HEB, and RBP-J regulate Gata3 transcription by binding within Tce1. Several transcription factors have been proposed as ... Prediction of putative transcription factor-binding sites. A search for putative transcription factor-binding sites in Tce1 was ...https://www.jci.org/articles/view/83894
RCSB PDB - Protein Feature View - Trans-acting T-cell-specific transcription factor GATA-3 - P23771 (GATA3 HUMAN)
Trans-acting T-cell-specific transcription factor GATA-3 - P23771 (GATA3_HUMAN) ...http://www.rcsb.org/pdb/protein/P23771
The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells. - PubMed - NCBI
The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells.. Mjösberg J1, Bernink J, ... Hence, we identify GATA3, potently regulated by TSLP, as an essential transcription factor for the function of human ILC2s. ... Consistent with this, we report that the transcription factor GATA3 was highly expressed by human ILC2s. CRTH2(+) ILC2s were ... Ectopic expression of GATA3 in Lin(-)CD127(+)CRTH2(-) cells resulted in induction of CRTH2 and the capacity to produce high ...https://www.ncbi.nlm.nih.gov/pubmed/23063330?dopt=Abstract
Adenosine A2A receptor signaling affects IL-21/IL-22 cytokines and GATA3/T-bet transcription factor expression in CD4+ T cells...
Adenosine A2A receptor signaling affects IL-21/IL-22 cytokines and GATA3/T-bet transcription factor expression in CD4+ T cells ... T-box transcription factor (T-bet), GATA3 (GATA Binding Protein 3), and CD152 (CTLA-4) expression in BTBR mice. Our results ... An imbalance in the production of pro- and anti-inflammatory cytokines and transcription factors plays a role in ... The augmented levels of IL-21/IL-22 and GATA3/T-bet could be due to altered A2AR signaling. Our results indicate that A2AR ...https://www.sigmaaldrich.com/catalog/papers/28807491
The Expression Levels of Transcription Factors T-bet, GATA-3, RORγt and FOXP3 in Peripheral Blood Lymphocyte (PBL) of Patients...
The Expression Levels of Transcription Factors T-bet, GATA-3, RORγt and FOXP3 in Peripheral Blood Lymphocyte (PBL) of Patients ... The Expression Levels of Transcription Factors T-bet, GATA-3, RORγt and FOXP3 in Peripheral Blood Lymphocyte (PBL) of Patients ... Objectives: To investigate the expression of transcriptional factors (TFs) T-bet, GATA-3, RORγt and FOXP in peripheral blood ... Conclusion: T-bet mRNA level was reduced whereas GATA-3 mRNA level was increased and T-bet/GATA-3 ratio was significantly ...http://www.medsci.org/v12p0007
Transcription factor GATA-3 | definition of transcription factor GATA-3 by Medical dictionary
What is transcription factor GATA-3? Meaning of transcription factor GATA-3 medical term. What does transcription factor GATA-3 ... Looking for online definition of transcription factor GATA-3 in the Medical Dictionary? transcription factor GATA-3 explanation ... GATA3. (redirected from transcription factor GATA-3) GATA3. A gene on chromosome 10p15 that encodes a zinc finger protein ... Transcription factor GATA-3 , definition of transcription factor GATA-3 by Medical dictionary https://medical-dictionary. ...https://medical-dictionary.thefreedictionary.com/transcription+factor+GATA-3
The transcription factor GATA3 is required for homologous recombination repair by regulating CtIP expression
GATA3, a critical transcription factor involved in the development of the mammary gland, also plays important roles in mammary ... The transcription factor GATA3 is required for homologous recombination repair by regulating CtIP expression. ... Using vectors encoding GATA3 with mutations frequently occurring in mammary tumors, we found that several mutations on GATA3 ... and promotes the transcription of CtIP. Overexpression of CtIP in GATA3 depleted cells rescues the decline of HR, and cell ...https://insights.ovid.com/oncog/201736360/00006374-201736360-00008
The Diagnostic Value of Transcription Factors T-bet-GATA3 Ratio in Predicting Antibody-Mediated Rejection - pdf descargar
The Diagnostic Value of Transcription Factors T-bet-GATA3 Ratio in Predicting Antibody-Mediated Rejection. . Biblioteca virtual ... The Diagnostic Value of Transcription Factors T-bet-GATA3 Ratio in Predicting Antibody-Mediated Rejection - Descarga este ... The Diagnostic Value of Transcription Factors T-bet-GATA3 Ratio in Predicting Antibody-Mediated Rejection. ... We compared the intraglomerular T-bet-GATA3 ratio in ABMR and TCMR. The intragraft expression of T-bet and GATA3 was studied ...http://libros.duhnnae.com/2017/jun9/149862664350-The-Diagnostic-Value-of-Transcription-Factors-T-bet-GATA3-Ratio-in-Predicting-Antibody-Mediated-Rejection.php
Clinical significance of T-bet, GATA-3, and Bcl-6 transcription factor expression in bladder carcinoma | Journal of...
However, GATA-3 and Bcl-6 expression could be considered as predictive factors for good patient survival. ... The aim of this study was to investigate the clinical significance of three immune cell-related transcription factors, T-bet, ... Expression of these transcription factors was evaluated by RT-qPCR. a Statistical analyses of GATA-3 expression for poor and ... We further compared the expression of the three transcription factors, T-bet, GATA-3 and Bcl-6 to treatment with BCG, in good ...https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-016-0891-z
The transcription factor XBP-1 is essential for the development and survival of dendritic cells | JEM
Transcription factor GATA-3 is required for development of the T-cell lineage. Nature. 384:474-478. ... several intracellular signaling molecules and transcription factors-including Gfi1, Id2, Ikaros, IFN regulatory factor 2 (IRF-2 ... The transcription factor XBP-1 is essential for the development and survival of dendritic cells. Neal N. Iwakoshi, Marc Pypaert ... Transcription factor PU.1 is necessary for development of thymic and myeloid progenitor-derived dendritic cells. J. Immunol. ...http://jem.rupress.org/content/204/10/2267
JCI - Volume 126, Issue 3
The transcription factor GATA3 is essential for the genesis and maturation of the T cell lineage, and GATA3 dysregulation has ... Gata3. transcription in vivo. Here, we determined that the canonical Gata3. promoter is insufficient for Gata3. transcriptional ... Gata3. expression in T cells. Instead, we demonstrated that multiple lineage-affiliated transcription factors bind to Tce1. and ... Lineage-affiliated transcription factors bind the Gata3 Tce1 enhancer to mediate lineage-specific programs. ...https://jci.org/126/3
Safety, Tolerability, and Pharmacokinetics After a Single Dose of Orally Inhaled DNAzyme Solution for Nebulisation in Male...
The transcription factor GATA-3 plays a key role in mediating the asthmatic immune response and has been shown to be necessary ... By cleaving GATA-3 mRNA, hgd40 reduces specific cytokine production and thereby reduces key features of allergic airway ... a Human GATA-3-specific DNAzyme Solution for Nebulisation - A Randomised, Double-blind, Placebo-controlled, Parallel-group (Per ...https://clinicaltrials.gov/ct2/show/NCT01577953
Transcription Factor ets-2 Plays an Important Role in the Pathogenesis of Pulmonary Fibrosis
The roles of transcription factors, such as Smad3 (4), Nrf2 (5), CEBPβ (6), GATA-3 (7), PPARs (8, 9), Fra-2 (10), and p53 (11 ... Overexpression of the transcription factor GATA-3 enhances the development of pulmonary fibrosis. Am J Pathol 2006;169:96-104 [ ... Transcription Factor ets-2 Plays an Important Role in the Pathogenesis of Pulmonary Fibrosis. Christopher P. Baran,1 Sara N. ... The transcription factor NRF2 protects against pulmonary fibrosis. FASEB J 2004;18:1258-1260 [PubMed] ...http://pubmedcentralcanada.ca/pmcc/articles/PMC3262682/
The BTB-ZF Family of Transcription Factors: Key Regulators of Lineage Commitment and Effector Function Development in the...
PLZP was shown to interact directly with the Th2-promoting transcription factor GATA-3 and could antagonize GATA-3 binding to ... In a temporal and developmental sense, ThPOK functions downstream of GATA-3, an early CD4+ lineage transcription factor, and ... Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells. Nat. ... A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/ ...http://www.jimmunol.org/content/187/6/2841
Cytokines and Transcription Factors That Regulate T Helper Cell Differentiation: New Players and New Insights | SpringerLink
The transcription factors Stat6, GATA-3, c-Maf, NFATs, and the cytokine IL-4 promote TH2 differentiation. These key regulators ... Zhang DH, Cohn L, Ray P, Bottomly K, Ray A: Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells ... Zhang DH, Yang L, Ray A: Differential responsiveness of the IL-5 and IL-4 genes to transcription factor GATA-3. J Immunol 161(8 ... Ko LJ, Yamamoto M, Leonard MW, George KM, Ting P, Engel JD: Murine and human T-lymphocyte GATA-3 factors mediate transcription ...https://link.springer.com/article/10.1023%2FA%3A1023381027062
Related Articles by Review for PubMed (Select 10935639) - PubMed - NCBI
Transcription factor GATA3 and the human HDR syndrome.. Van Esch H, Devriendt K. ... GATA3 haplo-insufficiency causes human HDR syndrome.. Van Esch H, Groenen P, Nesbit MA, Schuffenhauer S, Lichtner P, ... Role of the vascular endothelial growth factor isoforms in retinal angiogenesis and DiGeorge syndrome. ...https://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed_reviews&from_uid=10935639
NF-κB Family of Transcription Factors: Central Regulators of Innate and Adaptive Immune Functions | Clinical Microbiology...
The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89:587-596. ... B lymphocytes differentially use the Rel and nuclear factor κB1 (NF-κB1) transcription factors to regulate cell cycle ... Neisseria gonorrhoeae epithelial cell interaction leads to the activation of the transcription factors nuclear factor κB and ... there is reduced expression of the transcription factor GATA3 (39), which has an important role in differentiation of Th2 cells ...https://cmr.asm.org/content/15/3/414?ijkey=34c2f6ff70e5f7187dc02d10dd1e45b75ed76fa7&keytype2=tf_ipsecsha
A reverse-engineering approach to dissect post-translational modulators of transcription factor's activity from transcriptional...
An on-line web-tool enabling the user to use DMI to identify post-transcriptional modulators of a transcription factor of ... to infer post-translational modulators of a transcription factor from a compendium of gene expression profiles (GEPs). DMI is ... showing its predictive ability in correctly identifying kinases regulating the activity of 14 different transcription factors. ... Transcription factors (TFs) act downstream of the major signalling pathways functioning as master regulators of cell fate. ...https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-015-0700-3
T helper cell - Wikipedia
The key Th2 transcription factors are STAT6 and GATA3. IL-4 is the positive feedback cytokine for Th2 cells differentiation ... The key THαβ transcription factors are STAT1 and STAT3 as well as IRFs. IL-10 from CD4 T cells activate NK cells' ADCC to ... The key Th1 transcription factors are STAT4 and T-bet. IFN-γ secreted by CD4 T cells can activate macrophages to phagocytose ... "Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation ...https://en.wikipedia.org/wiki/Helper_T_cells
GATA3 - GATA-binding factor 3 - Gallus gallus (Chicken) - GATA3 gene & protein
Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites ... RNA polymerase II transcription factor binding Source: GO_Central. *transcriptional activator activity, RNA polymerase II ... sp,P23825,GATA3_CHICK GATA-binding factor 3 OS=Gallus gallus GN=GATA3 PE=2 SV=1 ... R-GGA-8939236. RUNX1 regulates transcription of genes involved in differentiation of HSCs. R-GGA-983231. Factors involved in ...http://www.uniprot.org/uniprot/P23825
Critical roles for transcription factor GATA-3 in thymocyte development. Immunity 2003;19:863-75. ... GATA-binding protein 3 (GATA3) is a transcription factor and a putative tumor suppressor that is highly expressed in normal ... GATA-binding protein 3 (GATA3) is a transcription factor that is highly expressed in normal breast luminal epithelium and the ... have shown by targeted disruption of GATA3 in mice that GATA3 is required for proper hair follicle stem cell function (28). In ...http://cebp.aacrjournals.org/content/16/11/2269
Two Receptors, Two Kinases, and T Cell Lineage Determination | Science Signaling
Critical roles for transcription factor GATA-3 in thymocyte development. Immunity 19, 863-875 (2003).. ... There are a number of transcription factors that are important for lineage determination; elimination of ThPOK, TOX, or GATA-3 ... The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment. Nature 433, 826-833 (2005).. ... which induces expression of the lineage-specific transcription factor Runx3 (19). The authors wish to suggest that CD8 lineage ...https://stke.sciencemag.org/content/3/114/pe11?ijkey=a8720f58790b8fcdadc7586f4406d3f7616e340d&keytype2=tf_ipsecsha