Deletion of the GATA domain of TRPS1 causes an absence of facial hair" by T H. Malik, Stechow D. Von et al.
... and activate transcription. TRPS1, the only other vertebrate protein with the GATA motif, is a large, multitype zinc finger ... GATA transcription factors mediate cell differentiation in diverse tissues, and their dysfunction is associated with certain ... protein that harbors a single DNA-binding GATA domain and represses transcription. Monoallelic TRPS1 mutations cause two ... GATA transcription factors mediate cell differentiation in diverse tissues, and their dysfunction is associated with certain ...https://mouseion.jax.org/stfb2000_2009/408/
CREB-Binding Protein Acetylates Hematopoietic Transcription Factor GATA-1 at Functionally Important Sites | Molecular and...
GATA-1, full-length GATA-1; GATA-1Δf, GATA-1 lacking the zinc finger region and the lysine-rich motifs (aa 198 to 316 deleted ... The transcription factor GATA-1 is a key regulator of erythroid-cell differentiation and survival. We have previously shown ... 1995) Self-association of the erythroid transcription factor GATA-1 mediated by its zinc finger domains. Mol. Cell. Biol. 15: ... 1995) Transcription factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosis. Proc. Natl. ...https://mcb.asm.org/content/19/5/3496?ijkey=9517af90c6376297f6f96a7c5af034e60ae85cf1&keytype2=tf_ipsecsha
Erythroid-cell-specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a gene-targeted cell line. |...
Erythroid-cell-specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a gene-targeted cell line.. ... The zinc finger transcription factor GATA-1 is essential for erythropoiesis. In its absence, committed erythroid precursors ... Erythroid-cell-specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a gene-targeted cell line. ... Erythroid-cell-specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a gene-targeted cell line. ...https://mcb.asm.org/content/17/3/1642.long
Global regulation of erythroid gene expression by transcription factor GATA-1 - CSHL Scientific Digital Repository
Transcription factor GATA-1 is required for erythropoiesis, yet its full actions are unknown. We performed transcriptome ... DNA-Binding Proteins Enhancer Elements genetics Erythroblasts Erythroid-Specific DNA-Binding Factors GATA1 Transcription Factor ... Global regulation of erythroid gene expression by transcription factor GATA-1. Blood, 104 (10). pp. 3136-3147. ISSN 00064971 ( ... Third, up-regulation of some known GATA-1 targets was delayed, suggesting that auxiliary factors are required. For example, ...http://repository.cshl.edu/25396/
Erythroid transcription factor (P15976) | InterPro | EMBL-EBI
Erythroid transcription factor (P15976) Accession. P15976 (GATA1_HUMAN) Species. Homo sapiens (Human) ... GO:0003700 DNA binding transcription factor activity GO:0008270 zinc ion binding GO:0043565 sequence-specific DNA binding ... GO:0006355 regulation of transcription, DNA-templated GO:0030218 erythrocyte differentiation GO:0030219 megakaryocyte ...http://www.ebi.ac.uk/interpro/protein/P15976
Frontiers | The transcription factor nurr1 exerts concentration-dependent effects on target genes mediating distinct biological...
The transcription factor nurr1 plays a pivotal role in the development and maintenance of neurotransmitter phenotype in ... The transcription factor nurr1 plays a pivotal role in the development and maintenance of neurotransmitter phenotype in ... a similar phenomenon has been reported for the hematopoietic transcription factors GATA-1 and Pu.1, where the responsiveness of ... Differential coregulator requirements for function of the hematopoietic transcription factor GATA-1 at endogenous loci. Nucleic ...https://www.frontiersin.org/articles/10.3389/fnins.2011.00135/full
GATA1 gene - Genetics Home Reference - NIH
On the basis of this action, the GATA1 protein is known as a transcription factor. The GATA1 protein is involved in the ... Ferreira R, Ohneda K, Yamamoto M, Philipsen S. GATA1 function, a paradigm for transcription factors in hematopoiesis. Mol Cell ... Two versions of the GATA1 protein are produced from the GATA1 gene: a regular length protein and a shorter version called ... Most of these mutations change a single protein building block (amino acid) in the GATA1 protein. GATA1 gene mutations disrupt ...https://ghr.nlm.nih.gov/gene/GATA1
Molecular Control of Megakaryopoiesis and Thrombopoiesis | SpringerLink
Transcription factor GATA-1 in megakaryocyte development.Stem Cells.1998;16(suppl 2):79-83.PubMedGoogle Scholar ... Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cells.Genes Dev. ... FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic ... A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet ...https://link.springer.com/article/10.1007/BF02982109
GATA1 - Wikipedia
... transcription factor regulating cell cycle progression), TAL1 (a transcription factor), FOG2 (a transcription factor ... GATA-binding factor 1 or GATA-1 (also termed Erythroid transcription factor) is the founding member of the GATA family of ... Reduced levels of GATA1 due to reductions in the translation of GATA1 mRNA into its transcription factor product are associated ... "Entrez Gene: GATA1 GATA binding protein 1 (globin transcription factor 1)".. *^ a b c Da Costa L, O'Donohue MF, van Dooijeweert ...https://en.wikipedia.org/wiki/GATA1
Anti-GATA1 antibody (ab11852) | Abcam
Rabbit polyclonal GATA1 antibody. Validated in WB, CHIPseq and tested in Mouse, Human. Cited in 8 publication(s). Independently ... GATA binding factor 1 antibody. *GATA binding protein 1 (globin transcription factor 1) antibody ... Staining of the GATA1 band is inhibited by the GATA1 peptide (amino acid residues 394-413). ... Epigenetics and Nuclear Signaling Transcription Domain Families Zinc Finger Share by email ...https://www.abcam.com/gata1-antibody-ab11852.html?productWallTab=Abreviews
ISBT: Red Cell Immunogenetics and Blood Group Terminology
Transcription Factor GATA1 Transcription Factor KLF1. Geoff Daniels. Blood Group Allele Terminology ... Currently, guidelines and tables for 27 of the 30 blood groups are listed, as well mutations in GATA1 and KLF1 responsible for ...http://isbtweb.org/working-parties/red-cell-immunogenetics-and-blood-group-terminology/
KAKEN - Research Projects | c-kitがん原遺伝子の発現と機能 (KAKENHI-PROJECT-06281111)
Publications] Yomogida,K.et al.: 'Developmental stage-and spermatogenic cycle-specific expresseion of transcription factor GATA ... Publications] Morii E.et al.: 'Loss of DNA binding ability of the transcription factor encoded by the mutantmi locus.' Biochem ... auto-stimulated KIT receptor as a tumor promoting factor in papillomavirus-induced tumorigenesis.' Oncogene. 10. 341-347 (1995) ...https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06281111/
Down Syndrome: Practice Essentials, Background, Pathophysiology
Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1. Nat Genet. 2005 Jun. 37(6 ... GATA1. Leukemia in children with Down syndrome requires at least 3 cooperating events: trisomy 21, a GATA1 mutation, and a ... Annerén G, Gustavson KH, Sara VR, Tuvemo T. Growth retardation in Down syndrome in relation to insulin-like growth factors and ... Down's syndrome is a risk factor for severe lower respiratory tract infection due to respiratory syncytial virus. Acta Paediatr ...https://emedicine.medscape.com/article/943216-overview
Down Syndrome Clinical Presentation: History, Physical Examination, Complications
Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1. Nat Genet. 2005 Jun. 37(6 ... Mutations in this transcription factor lead to a truncated mutant protein, GATA1short or GATA1s. [41, 42] This preleukemia is ... A French study, by Alimi et al, indicated that Down syndrome is a risk factor for pulmonary hemosiderosis and that the ... Annerén G, Gustavson KH, Sara VR, Tuvemo T. Growth retardation in Down syndrome in relation to insulin-like growth factors and ...https://emedicine.medscape.com/article/943216-clinical
Diamond-Blackfan anemia: erythropoiesis lost in translation | Blood Journal
Another transcription factor, GATA1, is similarly translated into 2 isoforms.71 The full-length GATA1 isoform is required for ... initiation sites are found in mRNAs of several transcription factors and enable translation of different transcription factor ... Alternative translation initiation site usage results in two functionally distinct forms of the GATA-1 transcription factor. ... The transcription factor C/EBPα is translated into a short product in cells with high levels of eIF4E and eIF2α and a longer ...http://www.bloodjournal.org/content/109/8/3152?ijkey=7aafd28102ed2d9e1ace402db0e280ff30a29408&keytype2=tf_ipsecsha&sso-checked=true
Genetic and epigenetic regulation of gene expression in fetal and adult human livers | BMC Genomics | Full Text
... these genes were enriched for transcription factor binding sites of HNF1A and HNF4A. We also identified 1,000 genes specific to ... fetal liver, which were enriched for GATA1, STAT5A, STAT5B and YY1 binding sites. We saw strong liver-specific effects of ... Our analyses generated a comprehensive resource of factors involved in the regulation of hepatic gene expression, and allowed ... less is known about the epigenetic factors. By analyzing the methylomes and transcriptomes of 14 fetal and 181 adult livers, we ...https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-15-860
Table of Contents | Blood Journal
Global regulation of erythroid gene expression by transcription factor GATA-1 John J. Welch, Jason A. Watts, Christopher R. ... Potential role of APRIL as autocrine growth factor for megakaryocytopoiesis Désirée Bonci, Michael Hahne, Nadia Felli, Cesare ... Distinct roles of ADP receptors in von Willebrand factor-mediated platelet signaling and activation under high flow Mario ... Differences in the chromatin structure and cis-element organization of the human and mouse GATA1 loci: implications for cis- ...http://www.bloodjournal.org/content/104/10?sso-checked=true
ERG Is a Megakaryocytic Oncogene | Cancer Research
Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1. Nat Genet 2005; 37: 613-9. ... Somatic mutations acquired during fetal hematopoiesis in the GATA1 transcription factor are detected in megakaryoblasts from ... Ets-related gene (ERG) is a member of the ETS transcription factor gene family located on Hsa21. ERG is known to have a crucial ... Ets-related gene (ERG) is a member of the ETS transcription factor gene family and is closely related to another ETS family ...http://cancerres.aacrjournals.org/content/69/11/4665.full
Embryonic stem cells and transgenic mice in the study of hematopoiesis. - Semantic Scholar
One of the first, and best, characterized hematopoietic transcription factors is GATA-1. Herein studies of GATA-1 are reviewed ... transcriptional regulators have been identified by characterizing factors mediating cell-specific gene transcription and by ... These processes are controlled in large part by cell-restricted transcription factors which cooperate with more widely ... expressed factors to direct lineage-specific gene expression. Candidate hematopoietic ...https://www.semanticscholar.org/paper/Embryonic-stem-cells-and-transgenic-mice-in-the-of-Orkin/ef17a9aebc86929aa356db3afc6165c99050f556
GATA3-dependent cellular reprogramming requires activation-domain dependent recruitment of a chromatin remodeler | Genome...
This process typically requires pioneer transcription factors (TFs) to induce de novo formation of enhancers at previously ... Successful reprogramming requires stable binding to a nucleosomal site; activation domain-dependent recruitment of co-factors ... Transcription factor-dependent cellular reprogramming is integral to normal development and is central to production of induced ... Tissue-specific mitotic bookmarking by hematopoietic transcription factor GATA1. Cell. 2012;150:725-37.PubMed CentralView ...https://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-0897-0
Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models...
Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1. Nat. Genet. 37:613-619. ... GLIS2 (GLI-similar 2) is a member of the Krüppel-like zinc finger transcription factors that are closely related to the GLI ... GLIS2 is a Krüppel-like zinc finger DNA-binding transcription factor related to GLI involved in the response to the Hedgehog ... patients and presents with acquired GATA1 mutations leading to the expression of a GATA1-short (GATA1s) isoform lacking the ...http://jem.rupress.org/content/209/11/2017
WikiGenes - GATA1 - GATA binding protein 1 (globin...
Neurokinin-B transcription in erythroid cells: direct activation by the hematopoietic transcription factor GATA-1. Pal, S., ... Neurokinin-B transcription in erythroid cells: direct activation by the hematopoietic transcription factor GATA-1 . ... High impact information on GATA1. *Acquired somatic mutations in exon 2 of the hematopoietic transcription factor GATA-1 have ... Anatomical context of GATA1. *Defects in the X-linked DNA-binding megakaryocyte transcription factor GATA1 cause ...https://www.wikigenes.org/e/gene/e/2623.html
ZFIN Publication: Blake et al., 2000
... expression of scl and gata-1 in the same hematopoietic mutants to ascertain the relative order of these transcription factors ... Mammalian CBFB encodes a transcription factor (CBFbeta) that in combination with CBFalpha2 binds to specific DNA sequences and ... Zebrafish homolog of the leukemia gene CBFB: its expression during embryogenesis and its relationship to scl and gata-1 in ... its expression during embryogenesis and its relationship to scl and gata-1 in hematopoiesis. Blood. 96(13):4178-4184. ...http://zfin.org/ZDB-PUB-001221-16
Prediction of tissue-specific cis-regulatory modules using Bayesian networks and regression trees | BMC Bioinformatics | Full...
At its core is a regression tree modeling the effect of combinations of transcription factors bound to a module. A new ... the network predicts a number of important transcription factor combinations whose concerted binding is associated to specific ... transcription factor expression data, and target gene expression data. ... The network integrates predicted transcription factor binding site information, ...https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-8-S10-S2
Browsing Department of Molecular Biology by Subject "Differentiation"
One of the complexes formed by the hematopoietic transcription factor Gata1 is a complex with the Ldb1 (LIM domain-binding ...http://bora.uib.no/handle/1956/921/browse?value=Differentiation&type=subject