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*  Comparison of Immunoblotting and ELISA for Detection of Anti-Ganglioside Antibodies in Children with Guillain-Barre Syndrome
Results: Anti-ganglioside antibodies (IgG) were detected in 16 (32%) GBS patients and in 1 (3.3%) control using ELISA assay. ... Objective: This study aimed to determine serum levels of anti-ganglioside antibodies in children with Guillain-Barre syndrome ... The levels of anti-ganglioside antibodies in serum were measured by ELISA and immunoblotting methods using commercial kits. ... However, by employing immunoblotting technique, antibodies against seven gangliosides were found positive in 28 (56%) GBS ...
http://iji.sums.ac.ir/article_17047.html
*  VM -- Diagnosis and Treatment of Guillain-Barre Syndrome, Aug 07 ... Virtual Mentor
Yu RK, Usuki S, Ariga T. Ganglioside molecular mimicry and its pathological roles in Guillain-Barre syndrome and related ... Molecular mimicry, involving similar sequences of bacterial lipo-oligosaccharides and human gangliosides, are believed to ... jejuni infection is thought to induce an anti-ganglioside antibody. ... underlie autoimmune attack on axonal membranes in AMAN [6]. Several gangliosides (GM1, GM1b, GD1a, and GalNAc-GD1a) on the ...
http://virtualmentor.ama-assn.org/2007/08/cprl1-0708.html
*  Why can I not walk today?
... mediated by anti-ganglioside IgG antibodies. The symptoms and severity depend on the type of ganglioside targeted since the ... 2008). "Subclass IgG to motor gangliosides related to infection and clinical course in Guillain-Barré syndrome". J Neuroimmunol ... In GBS, however, anti-ganglioside IgG antibodies trigger similar immune attacks involving complement activation and phagocytic ... possibly targeting a ganglioside antigen, mediate destruction of myelin via the classical complement cascade and formation of ...
https://www.immunopaedia.org.za/clinical-cases/autoimmune-conditions/why-can-i-not-walk-today/
*  The Gangliosides | SpringerLink
Gangliosides are glycosphingolipids that contain sialic acid ( N-acetyl- or N-glycolylneuraminic acid). They have elicited much ... Maccioni, H. J. F., Arce, A., and Caputto, R., 1971a, The biosynthesis of gangliosides, labelling of rat brain gangliosides in ... Watanabe, K., and Hakomori, S.-I., 1979, Ganglioside of human erythrocytes. A novel ganglio-side with a unique N- ... Wiegandt, H., and Schulze, B., 1969, Spleen gangliosides: the structure of ganglioside Glntet1, Z. Naturforsch. Teil B 24: 945- ...
https://link.springer.com/chapter/10.1007/978-1-4684-7541-8_3
*  Advances in Ganglioside Chemistry | SpringerLink
Gangliosides, sialic acid containing glycosphingolipids, are normal components of the plasma membrane of vertebrate cells and ... Novak A, Lowden JA, Gravel YL, Wolfe LS (1979) Preparation of radiolabeled GM2 and GA2 gangliosides. J Lipid Res 678-681.Google ... Elucidation of the structure of ganglioside GM3 lactone. J Biochem 98, 1367-1373.PubMedGoogle Scholar ... Gangliosides, sialic acid containing glycosphingolipids, are normal components of the plasma membrane of vertebrate cells and ...
https://link.springer.com/chapter/10.1007/978-1-4757-5309-7_2
*  Ganglioside (GM1) Antibodies, IgG and IgM
If you would like to schedule an appointment with one of our nationally ranked specialists or Primary Care physicians please click or call 800-881-7385.. ...
https://www.nationwidechildrens.org/specialties/laboratory-services/lab-test-directory/gm1-antibody-panel
*  Gangliosides Potentially Inhibit Extracellular Nucleotide Metabolism | BenthamScience
Keywords:extracellular nucleotide metabolism, CD38, NAD+, sialic acid, glycolipids, Gangliosides. Abstract: Gangliosides are ... Gangliosides are glycolipids that contain sialic acid and they are mainly located on the outer leaflet of the cellular plasma ... Gangliosides Potentially Inhibit Extracellular Nucleotide Metabolism. Author(s): Miki Hara-Yokoyama. Department of Hard Tissue ... Although they are abundant in the central nervous system (CNS), the complete loss of gangliosides in mice does not result in ...
http://www.eurekaselect.com/node/57664/article
*  Gangliosides block Aggregatibacter Actinomycetemcomitans leukotoxin (LtxA)-mediated hemolysis. | Sigma-Aldrich
Furthermore, LtxA did not show a preference for any individual ganglioside. LtxA also bound to ganglioside-rich C6 rat glioma ... Interaction between LtxA and C6 cells could be blocked by gangliosides with no apparent specificity. Gangliosides were only ... Gangliosides block Aggregatibacter Actinomycetemcomitans leukotoxin (LtxA)-mediated hemolysis.. [Michael S Forman, Jason B ... However, gangliosides were able to completely block LtxA-mediated hemolysis. ...
https://www.sigmaaldrich.com/catalog/papers/22069577
*  Enhanced insulin sensitivity in mice lacking ganglioside GM3 | PNAS
Brain gangliosides of GM3S−/− mice. Gangliosides were isolated from brains of GM3S+/+ and GM3S−/− mice. The samples were either ... 2). Brain gangliosides from GM3S+/+ and GM3S−/− mice were treated with V. cholera sialidase. On complex brain gangliosides, the ... 1A). The GM3S−/− mice expressed major ganglioside species that comigrated with GM1b and GD1α gangliosides of the 0-series (Figs ... Ganglioside Analysis.. Gangliosides were isolated as described (9). For sialidase treatment, the reaction mixture contained the ...
https://www.pnas.org/content/100/6/3445?ijkey=9f8691f1ebebe037b75cf82fc7e1d04abe9000a3&keytype2=tf_ipsecsha
*  Targeting O-Acetyl-GD2 Ganglioside for Cancer Immunotherapy
Repeated injection of gangliosides alone in human or in mouse is not enough for inducing the synthesis of anti-ganglioside ... Figure 2: Schematic representation of the main pathway of O-acetyl-GD2 ganglioside biosynthesis. GD2 ganglioside is synthesized ... 3. Metabolism of O-Acetyl-GD2 Ganglioside. The modification of ganglioside expression in oncogenesis is mainly associated with ... a specific ganglioside profile, which is modified during embryogenesis, and ontogenesis [13]. Some ganglioside species further ...
https://www.hindawi.com/journals/jir/2017/5604891/
*  gangliosides - Humpath.com - Human pathology
Lipids , sphingolipids , glycosphingolipids , gangliosides Definition: Gangliosides are glycosylated sphingolipids enriched in ... Lipids > sphingolipids > glycosphingolipids > gangliosides. Definition: Gangliosides are glycosylated sphingolipids enriched in ... Cerebrosides have a single glucose or galactose at the 1-hydroxy position, while gangliosides have at least three sugars, one ... Further studies pointed out that in AD brain tissue the total ganglioside pattern is significantly altered, which emphasizes ...
http://www.humpath.com/spip.php?article13081
*  Toxins | Free Full-Text | Gangliosides Block Aggregatibacter Actinomycetemcomitans Leukotoxin (LtxA)-Mediated Hemolysis
Furthermore, LtxA did not show a preference for any individual ganglioside. LtxA also bound to ganglioside-rich C6 rat glioma ... Interaction between LtxA and C6 cells could be blocked by gangliosides with no apparent specificity. Gangliosides were only ... However, gangliosides were able to completely block LtxA-mediated hemolysis. ... and the effect was only observed when a high ratio of ganglioside:LtxA was used over a short incubation period. Based on the ...
https://www.mdpi.com/2072-6651/2/12/2824/xml
*  Frontiers | Molecular Recognition of Gangliosides and Their Potential for Cancer Immunotherapies | Immunology
In this review, we describe how proteins recognize gangliosides, focusing on the molecular recognition of gangliosides ... In this review, we describe how proteins recognize gangliosides, focusing on the molecular recognition of gangliosides ... Gangliosides perform important functions through carbohydrate-specific interactions with proteins, for example as receptors in ... Gangliosides perform important functions through carbohydrate-specific interactions with proteins, for example as receptors in ...
https://www.frontiersin.org/articles/10.3389/fimmu.2014.00325/full
*  Anti-Ganglioside GD3 antibody [4F6] (ab6217) References | Abcam
References for Abcam's Anti-Ganglioside GD3 antibody [4F6] (ab6217). Please let us know if you have used this product in your ...
http://www.abcam.com/ganglioside-gd3-antibody-4f6-ab6217-references.html
*  Ganglioside - Wikipedia
Gangliosides at the US National Library of Medicine Medical Subject Headings (MeSH) Overview of gangliosides at lipidlibrary.co ... Natural and semisynthetic gangliosides are considered possible therapeutics for neurodegenerative disorders. Gangliosides are ... More than 60 gangliosides are known, which differ from each other mainly in the position and number of NANA residues. It is a ... A ganglioside is a molecule composed of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acids (e.g. ...
https://en.wikipedia.org/wiki/Ganglioside
*  A Proton Water T1-NMRD Study of Ganglioside Micelles
Ganglioside GM1 (GM1) micelles have been studied by means of water proton T1 NMRD experiment. The field dependent spin-lattice ... A Proton Water T1-NMRD Study of Ganglioside Micelles. Westlund, Per-Olof Umeå University, Faculty of Science and Technology, ... Proton T1.NMRD Profiels, Proton Spin-lattice Relaxation, Ganglioside Micelles National Category Chemical Sciences Identifiers. ...
http://www.diva-portal.org/smash/record.jsf?pid=diva2:956454
*  ganglioside catabolic process QuickView - Correlation Engine
The chemical reactions and pathways resulting in the breakdown of ganglioside, a ceramide oligosaccharide carrying, in addition ... Biosynthesis of gangliosides containing C18:1 and C20:1 [3-14C]sphingosine after administrating [1-1… ...
http://www.nextbio.com/b/search/ov/ganglioside%20catabolic%20process?id=34775&type=biogroup
*  GM2 (ganglioside) - Wikipedia
GM2 is a type of ganglioside. G refers to ganglioside, the M is for monosialic (as in it has one sialic acid), and 2 refers to ... Ganglioside GM2 activator protein Sphingolipidoses Structures of GM1, GM2, GM3 gangliosides Guetta E, Peleg L (2008). "Rapid ... Ganglioside GM2 at the US National Library of Medicine Medical Subject Headings (MeSH). ... the fact that it was the second monosialic ganglioside discovered. It is associated with GM2 gangliosidoses such as Tay-Sachs ...
https://en.wikipedia.org/wiki/GM2_(ganglioside)
*  JCI - Ganglioside GD2 identifies breast cancer stem cells and promotes tumorigenesis
Here, we report that ganglioside GD2 (a glycosphingolipid) identifies a small fraction of cells in human breast cancer cell ...
https://www.jci.org/articles/view/59735/pdf
*  Ganglioside antibodies-GD1a, GD1b and GT1b
... Clinical Indications (specialist request only). Neuropathies ... Detection of IgG and IgM antibodies against gangliosides GD1a, GD1b and GT1b. ...
http://www.southend.nhs.uk/pathology-handbook/test-directory/test-directory-g-index/ganglioside-antibodies-gd1a,-gd1b-and-gt1b/
*  Anti-Ganglioside GM₁ Rabbit pAb | 345757
... recognizes ganglioside GM₁. Cross-reacts slightly with asialo-GM₁. ELISA and TLC immunoblotting. - Find MSDS or SDS, a COA, ... Anti-Ganglioside GM₁ Rabbit pAb Anti-Ganglioside GM₁, rabbit polyclonal, ... Anti-Ganglioside GM₁, rabbit polyclonal, recognizes ganglioside GM₁. Cross-reacts slightly with asialo-GM₁. ELISA and TLC ... More,, Anti-Ganglioside GM₁, rabbit polyclonal, recognizes ganglioside GM₁. Cross-reacts slightly with asialo-GM₁. ELISA and ...
http://www.emdmillipore.com/PR/en/product/Anti-Ganglioside-GM1-Rabbit-pAb,EMD_BIO-345757
*  G(M2) Ganglioside - Ganglioside GM2 Summary Report | CureHunter
Ganglioside: A glycosphingolipid that accumulates due to a deficiency of hexosaminidase A or B (BETA-N-ACETYLHEXOSAMINIDASES), ... Ganglioside GM2; GM2, Ganglioside; Ganglioside, Tay-Sachs Disease; Tay Sachs Disease Ganglioside; Tay-Sachs Disease Ganglioside ... G(M2) Ganglioside (Ganglioside GM2). Subscribe to New Research on G(M2) Ganglioside ... 08/27/1999 - "Effect of a chimeric anti-ganglioside GM2 antibody on ganglioside GM2-expressing human solid tumors in vivo.". 04 ...
http://www.curehunter.com/public/keywordSummaryD005678-G-M2--Ganglioside-Ganglioside-GM2.do
*  GM1 Ganglioside Effects on Parkinson's Disease - Full Text View - ClinicalTrials.gov
Subjects were randomized to receive GM1 ganglioside for 24 weeks.. Drug: GM1 ganglioside 100 mg twice per day by subcutaneous ... GM1 ganglioside is a chemical that is normally found in the brain and is a normal part of the outer covering or membrane of ... The study is designed to further examine the extent to which GM1 ganglioside can improve symptoms, delay disease progression, ...
https://clinicaltrials.gov/ct2/show/NCT00037830
*  Ganglioside GD3 - AM10173SU-N | acris-antibodies.com
Ganglioside GD3, 1 ml. Almost all melanomas, astrocytomas, a proportion of sarcomas, a small number of carcinomas, some nevi, ... Product Description for Ganglioside GD3. Mouse anti Ganglioside GD3 4F6.. Presentation: Supernatant. Product is tested for ... Cross reacts with 9-O-AcGD3 ganglioside (9OAcNeuAc alpha 2-8NeuAc alpha 2-3Gal beta 1-4Glc beta 1-1Cer) and GT1a ganglioside ( ... Recommended Secondary Antibodies for Ganglioside GD3 (11 products). Catalog No.. Host. Clone/Iso.. Pres.. React.. Applications ...
https://www.acris-antibodies.com/antibodies/primary-antibodies/ganglioside-gd3-am10173su-n.htm
*  Modulation of epidermal growth factor receptor phosphorylation by endogenously expressed gangliosides | Biochemical Journal
Modulation of epidermal growth factor receptor phosphorylation by endogenously expressed gangliosides. Adolfo R. ZURITA, Hugo J ... Modulation of epidermal growth factor receptor phosphorylation by endogenously expressed gangliosides. Adolfo R. ZURITA, Hugo J ... The effect of changing the ganglioside composition of Chinese hamster ovary K1 cells on the function of the epidermal growth ... Results suggest that changes in the ganglioside composition of cell membranes might be important in the regulation of the EGF ...
http://www.biochemj.org/content/355/2/465