Gamma-glutamyl hydrolase - WikipediaGamma-glutamyl hydrolase - Wikipedia

Gamma-glutamyl hydrolase is also known as conjugase, folate conjugase, lysosomal gamma-glutamyl carboxypeptidase, gamma-Glu-X ... Gamma-glutamyl hydrolase is an enzyme that catalyses the following chemical reaction: Hydrolysis of a gamma-glutamyl bond This ... polyglutamate hydrolase, poly(glutamic acid) hydrolase II, pteroylpoly-gamma-glutamyl hydrolase. Click on genes, proteins and ... In humans, gamma-glutamyl hydrolase is encoded by the GGH gene. This gene catalyzes the hydrolysis of folylpoly-gamma- ...
more infohttps://en.wikipedia.org/wiki/Gamma-glutamyl_hydrolase

GGH (gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)GGH (gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)

... folylpolygammaglutamyl hydrolase), Authors: Qing Cheng, William E Evans. Published in: Atlas Genet Cytogenet Oncol Haematol. ... GGH (gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase). Written. 2008-12. Qing Cheng, William E Evans. ... GGH (gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase). Atlas Genet Cytogenet Oncol Haematol. 2009;13(11): ... Low expression of gamma-glutamyl hydrolase (GGH) is strongly associated with CpG island methylator phenotype (CIMP+) in ...
more infohttp://atlasgeneticsoncology.org/Genes/GGHID44358ch8q12.html

Gamma-glutamyl-gamma-aminobutyrate hydrolase - WikipediaGamma-glutamyl-gamma-aminobutyrate hydrolase - Wikipedia

... a gamma-glutamyl-gamma-aminobutyrate hydrolase (EC 3.5.1.94) is an enzyme that catalyzes the chemical reaction 4-(gamma- ... Other names in common use include gamma-glutamyl-GABA hydrolase, PuuD, and YcjL. This enzyme participates in urea cycle and ... This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically ... The systematic name of this enzyme class is 4-(gamma-glutamylamino)butanoate amidohydrolase. ...
more infohttps://en.wikipedia.org/wiki/Gamma-glutamyl-gamma-aminobutyrate_hydrolase

TPMT | Cancer Genetics WebTPMT | Cancer Genetics Web

gamma-Glutamyl Hydrolase. *Methylation. *Alleles. *Asian Continental Ancestry Group. *Tissue Distribution. *Pyrophosphatases ...
more infohttp://www.cancerindex.org/geneweb/TPMT.htm

GO Gene ListGO Gene List

Gamma-glutamyl hydrolase. NM_010281. Gene Info. Gh. Growth hormone. NM_008117. Gene Info. ... Bone gamma carboxyglutamate protein. NM_007541. NM_001037939. Gene Info. Bglap2. Bone gamma-carboxyglutamate protein 2. NM_ ... Peroxisome proliferator activated receptor gamma. NM_001127330. NM_011146. Gene Info. Prkci. Protein kinase C, iota. NM_008857 ...
more infohttps://cgap.nci.nih.gov/Genes/GoGeneQuery?PAGE=1&ORG=Mm&GOID=1901652

GGH (human)GGH (human)

Gamma-glutamyl hydrolase Show on y-axis - References (HTP + LTP). References (LTP). References (HTP). ...
more infohttps://www.phosphosite.org/proteinAction.action?id=9977&showAllSites=true

Human Metabolome Database: HMDB0001846 (Tetrahydrofolic acid) Protein AssociationsHuman Metabolome Database: HMDB0001846 (Tetrahydrofolic acid) Protein Associations

Gamma-glutamyl hydrolase. Q92820 GGH. 8q12.3. Enzyme. Not Available. HMDBP07268. Mitochondrial 10-formyltetrahydrofolate ...
more infohttps://hmdb.ca/metabolites/HMDB0001846/metabolite_protein_links?c=protein_type&d=down

Human Metabolome Database: HMDB0001846 (Tetrahydrofolic acid) Protein AssociationsHuman Metabolome Database: HMDB0001846 (Tetrahydrofolic acid) Protein Associations

Gamma-glutamyl hydrolase. Q92820 GGH. 8q12.3. Enzyme. Not Available. HMDBP07268. Mitochondrial 10-formyltetrahydrofolate ...
more infohttp://www.hmdb.ca/metabolites/HMDB0001846/metabolite_protein_links?c=locus&d=down

Properties of food folates determined by stability and susceptibility to intestinal pteroylpolyglutamate hydrolase action.Properties of food folates determined by stability and susceptibility to intestinal pteroylpolyglutamate hydrolase action.

0/Sulfhydryl Compounds; 50-81-7/Ascorbic Acid; 59-30-3/Folic Acid; EC 3.4.19.9/gamma-Glutamyl Hydrolase ... On the other hand, the presence of polyglutamyl folate necessitates the action of intestinal hydrolases, which could be ...
more infohttp://www.biomedsearch.com/nih/Properties-food-folates-determined-by/9808649.html

The Alveolate Perkinsus marinus: Biological Insights from EST Gene Discovery | BMC Genomics | Full TextThe Alveolate Perkinsus marinus: Biological Insights from EST Gene Discovery | BMC Genomics | Full Text

Gamma-glutamyl hydrolase. PF07722. Pm03998, Pm00516, Pm01387. Peptidase_C48. UIp1 protease family, C-terminal catalytic domain ...
more infohttps://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-11-228

MODULE 212MODULE 212

gamma-glutamyl hydrolase (conjugase, foly.... 8876. 8876. VNN1. vanin 1. 8942. 8942. KYNU. kynureninase. ...
more infohttp://software.broadinstitute.org/gsea/msigdb/cards/MODULE_212.html

ArchivesArchives

GGH (gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase). Cheng Q, Evans WE. http://atlasgeneticsoncology. ... PPARG (peroxisome proliferator-activated receptor gamma). Astarci E, Banerjee S. http://atlasgeneticsoncology.org/Genes/ ...
more infohttp://atlasgeneticsoncology.org/DatabaseArchives/2008.html

Reactome | GGH [azurophil granule lumen]Reactome | GGH [azurophil granule lumen]

Gamma-glutamyl hydrolase ecNumber3.4.19.9/ecNumber, GGH_HUMAN Locations in the PathwayBrowser Expand all ...
more infohttps://reactome.org/content/detail/R-HSA-6800950

Genetic Variation in Renal Expression of Folate Receptor 1 (Folr1) Gene Predisposes Spontaneously Hypertensive Rats to...Genetic Variation in Renal Expression of Folate Receptor 1 (Folr1) Gene Predisposes Spontaneously Hypertensive Rats to...

Gamma-glutamyl hydrolase, not glutamate carboxypeptidase II, hydrolyzes dietary folate in rat small intestine. J Nutr. 2007;137 ... Although the role of folate hydrolase 1 in folate transport in the rat intestine is controversial,23 the results of recent ... Specifically, it should be noted that the Folh1 gene encoding folate hydrolase 1, which could affect cellular transport of ... and peroxisome proliferator-activated receptor gamma (Pparg), which is known to encode a transcription factor that regulates ...
more infohttp://hyper.ahajournals.org/content/67/2/335

DHFR | Cancer Genetics WebDHFR | Cancer Genetics Web

... and gamma-glutamyl hydrolase (GGH); irinotecan-related topoisomerase I (TOP1); oxaliplatin-related excision repair cross- ... plasma/RBC folate and folate hydrolase 1 (FOLH1), paraoxonase 1 (PON1), transcobalamin II (TCN2), DNMT1, and DNMT3B; 2) plasma ...
more infohttp://www.cancerindex.org/geneweb/DHFR.htm

Staff PublicationsStaff Publications

gamma-glutamyl hydrolase - lactobacillus-casei - folic-acid - in-vitro - disease - identification - bacteria - cloning - foods ... and almost complete release of folate from the bacterium was achieved by expressing the gene for gamma-glutamyl hydrolase from ... S. thermophilus excreted more folate than L. lactis, presumably as a result of differences in the number of glutamyl residues ... These strains produce folates with different poly glutamyl tail lengths. The growth response of the rats and the concentration ...
more infohttps://library.wur.nl/WebQuery/wurpubs?q=Starrenburg

Frontiers | Microbial Metabolic Capacity for Intestinal Folate Production and Modulation of Host Folate Receptors | MicrobiologyFrontiers | Microbial Metabolic Capacity for Intestinal Folate Production and Modulation of Host Folate Receptors | Microbiology

Identification of single nucleotide polymorphisms in the human gamma-glutamyl hydrolase gene and characterization of promoter ... Human gamma-glutamylhydrolase, GGH, and gamma-glutamyltransferase, GGT, remove glutamate moieties making monoglutamylated ... Of particular interest, the colonoids express high levels of folate hydrolase (FOLH) and γ-glutamyl hydrolase (GGH), enzymes ... Additionally, only the colon expressed folate hydrolase 2 (FOLH1B), another hydrolase known to convert FPGs to ...
more infohttps://www.frontiersin.org/articles/10.3389/fmicb.2019.02305/full

folatefolate

gamma-Glutamyl hydrolase, not glutamate carboxypeptidase II, hydrolyzes dietary folate in rat small intestine. J Nutr. 2007 May ... By contrast, GABA (gamma-aminobutyric acid) is widely regarded as a primary inhibitory neurotransmitter that can decrease nerve ...
more infohttp://www.whfoods.com/genpage.php/genpage.php?tname=nutrient&dbid=63

mRNA/microRNA gene expression profile in microsatellite unstable colorectal cancer | Molecular Cancer | Full TextmRNA/microRNA gene expression profile in microsatellite unstable colorectal cancer | Molecular Cancer | Full Text

gamma-glutamyl hydrolase. 2.10. 0.61. 7.97E-05. 15.87. -0.2232. 0.1553. AK025215 ... end labeled using the polynucleotide kinase in the presence of P32-gamma-ATP. Hybridization was performed at 37°C in 7% SDS/0.2 ...
more infohttps://molecular-cancer.biomedcentral.com/articles/10.1186/1476-4598-6-54

Code System ConceptCode System Concept

Gamma-glutamyl hydrolase (substance). Code System Preferred Concept Name. Gamma-glutamyl hydrolase (substance). ... Pteroyl-poly-alpha-glutamate hydrolase Current Synonym true false 1232804011 Gamma-Glu-X carboxypeptidase Current Synonym true ... Gamma-glutamyl hydrolase Current Synonym true false 3737326016 Gamma-glu-X carboxypeptidase Current Synonym true false ... gamma-Glutamyl hydrolase Current Synonym true false 110540012 Conjugase Current Synonym true false ...
more infohttps://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=66533003

JCI -
Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate...JCI - Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate...

A substrate specific functional polymorphism of human gamma-glutamyl hydrolase alters catalytic activity and methotrexate ... Glutamyl hydrolase. Pharmacological role and enzymatic characterization. Pharmacol. Ther. 2000. 85:207-215. View this article ... γ-glutamyl hydrolase; HDMTX, high-dose MTX; MRP, multidrug resistance-associated protein; MTHFD, methylenetetrahydrofolate ... lysosomal degradation of MTXPGs to MTX via γ-glutamyl hydrolase (GGH) (Supplemental Figure 1; supplemental material available ...
more infohttps://www.jci.org/articles/view/22477