Galectin-4 is a protein that in humans is encoded by the LGALS4 gene. The galectins are a family of beta-galactoside-binding ... Circulating levels of galectin-1/-3/-4 in CRC patients were importantly higher compared to those in controls. Gal-1 and gal-4 ... Recommended name:Galectin-4, Short name: Gal-4 Alternative name(s): Antigen NY-CO-27 L-36 lactose-binding protein, Short name: ... 2005). "Galectin-4 and sulfatides in apical membrane trafficking in enterocyte-like cells". J. Cell Biol. 169 (3): 491-501. doi ...

Detection of Proteome Changes in Human Colon Cancer Induced by Cell Surface Binding of Growth-Inhibitory Human Galectin-4 Using ... we applied SILAC-based proteomics on human colon carcinoma cells treated with galectin-4 (Gal-4). The five tested lines-LS 180 ... the capacity of a galectin to affect the proteome of human colon cancer cells at multiple sites is revealed. ... Vaco 432, Colo 205, CX 1, and HCT 116 responded with differentiation and reduced proliferation to Gal-4 binding. In proteomic ...

Galectin-3 (Gal-3) is a biomarker associated with fibrosis and inflammation in patients with HF. The Gal-3 inhibitor modified ... Galectin-3 (Gal-3) is a biomarker associated with fibrosis and inflammation in patients with HF. The Gal-3 inhibitor modified ... Keywords: Galectin-3; Heart failure; Inflammation; Modified citrus pectin; Myocardial fibrosis; TLR4. ... Modified citrus pectin ameliorates myocardial fibrosis and inflammation via suppressing galectin-3 and TLR4/MyD88/NF-κB ...

... Aug 01, 2021. The galectin-lattice: a decoder of bio-equivalent ... The Galectin lattice regulates receptor dynamics at the cell surface. *Galectins and binding partners in an evolutionary dance ... Galectin are synthesized in the cytosol and also localized to the nucleus and cell surface. A primordial function of galectins ... The galectin lattice is a multi-valent interaction of galectins with glycoproteins at the cell surface that displays rapid ...

View Goat Polyclonal anti-Galectin-3BP/MAC-2BP/LGALS3BP Antibody [Unconjugated] (AF2226). Validated Applications: WB, Simple ... Home » Galectin-3BP/MAC-2BP/LGALS3BP » Galectin-3BP/MAC-2BP/LGALS3BP Antibodies » Galectin-3BP/MAC-2BP/LGALS3BP Antibody [ ... Galectin-3BP binds Galectin-3 (formerly MAC-2) with high affinity, but also binds Galectins -1 and -7, several collagen types, ... Blogs on Galectin-3BP/MAC-2BP/LGALS3BP. There are no specific blogs for Galectin-3BP/MAC-2BP/LGALS3BP, but you can read our ...

Galectin 3 (LGALS3) mouse monoclonal antibody,clone UMAB157. * * 100 ul. 100 ul ... Galectin 3 (LGALS3) mouse monoclonal antibody,clone UMAB157. * * 30 ul. 30 ul ... This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an ... Carrier-free (BSA/glycerol-free) Galectin 3 (LGALS3) mouse monoclonal antibody,clone UMAB157 ...

[May 01, 2022 ] 4 for Galectin Therapeutics Inc. (GALT)

GALECTIN THERAPEUTICS INC [GALT] 5. Relationship of Reporting Person(s) to Issuer. (Check all applicable). __X__ Director. ... C/O GALECTIN THERAPEUTICS INC.. 4960 PEACHTREE INDUSTRIAL BLVD., STE 240. NORCROSS, GA 30071. X ... C/O GALECTIN THERAPEUTICS INC., 4960 PEACHTREE INDUSTRIAL BLVD., STE 240. 3. Date of Earliest Transaction (Month/Day/Year). 03/ ... 4). 11. Nature of Indirect Beneficial Ownership. (Instr. 4). Code. V. (A). (D). Date Exercisable. Expiration Date. Title. ...

As galectin-9 was known as an immunosuppression molecule. We found that PKM2 knockdown inhibited galectin-9 expression in HN4 ... A positive correlation between PKM2 and galectin-9 expression is observed in HNSCC tissues. Finally, the induction of galectin- ... 7B). Moreover, galectin-9 is suppressed in a dose- and time-dependent manner after incubation with TNF-α, a well-known NF-κB ... 7J). Knockdown of HDAC3 reversed the inhibition of galectin-9 mediated by TNF-α (Fig. S2, Fig. 7K) and BetA (Fig. 7L) in HN4 ...

Oct 15, 2023 ] 4/A for Galectin Therapeutics Inc. (GALT) ...

Galectin-4 is expressed as a 38-kD protein in the human colon adenocarcinoma T84 cell line. Galectin-4 is an S-type lectin that ... Description: Galectin-4 is a protein that in humans is encoded by the LGALS4 gene. This gene is mapped to chromosome 19q13.2 ... Galectins are a family of animal lectins defined by an affinity for beta-galactoside-containing saccharides and by shared ... The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions ...

Enhancing clinical and immunological effects of anti-PD-1 with belapectin, a galectin-3 inhibitor. Overview of attention for ... Enhancing clinical and immunological effects of anti-PD-1 with belapectin, a galectin-3 inhibitor ...

Galectin-3 mediates with the alpha-3, beta-1 integrin the stimulation by cspg4 of endothelial cells migration. Galectin-3 plays ... CBP35, GAL3, GALBP, GALIG, LGALS2, MAC2, Galectin-3, Lectin, galactose binding, soluble 3, Lectin, galactose binding, soluble 3 ... Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term ...

In this study we demonstrated that the deletion of galectin-3 in the host affected drastically the in vivo growth rate of 4T1 ... Taken together, our results demonstrate for the first time that the absence of galectin-3 in the host microenvironment favors ... Because of its unique structure, galectin-3 can oligomerize forming lattice upon binding to multivalent oligossacharides and ... Galectin-3 is a multifunctional β-galactoside-binding lectin that once synthesized, is expressed in the nucleus, cytoplasm, ...

ELISA Kit for Galectin 1 (GAL1), LGALS1; GBP; HLBP14; Galaptin; Lectin,Galactoside-Binding Soluble 1; 14 kDa laminin-binding ... Polyclonal Antibody to Galectin 1 (GAL1). WB; IHC; ICC; IP.. PAA321Ra02. Polyclonal Antibody to Galectin 1 (GAL1). WB; IHC; ICC ... Monoclonal Antibody to Galectin 1 (GAL1). WB; IHC; ICC; IP.. MAA321Ra25. Monoclonal Antibody to Galectin 1 (GAL1). WB; IHC; ICC ... Monoclonal Antibody to Galectin 1 (GAL1). WB; IHC; ICC; IP.. MAA321Ra23. Monoclonal Antibody to Galectin 1 (GAL1). WB; IHC; ICC ...

PURPOSE: Galectin-3, a β-galactoside-binding lectin, plays a key role in several cellular pathways involved in chronic ... PURPOSE: Galectin-3, a β-galactoside-binding lectin, plays a key role in several cellular pathways involved in chronic ... Humans, Administration, Oral, Area Under Curve, Dose-Response Relationship, Drug, Double-Blind Method, Galectin 3/antagonists ... Safety and pharmacokinetics of GB1211, an oral galectin-3 inhibitor : a single- and multiple-dose first-in-human study in ...

Human Epidermal Growth Factor Receptor 2 Negative Breast Cancer (HER2- Breast Cancer) (1 ...

Background Galectin-9 (gal-9) acts as a pivotal immuno-suppressor that disables immune mediated activity through modulation of ... 482 Phase1/2 study of an anti-galectin-9 antibody, LYT-200, in patients with metastatic solid tumors ... 482 Phase1/2 study of an anti-galectin-9 antibody, LYT-200, in patients with metastatic solid tumors ... and blocks galectin-9 interactions with its binding partners in biochemical and human cell-based assays. In murine models of ...

Galectin-9 Mac-2 MRP-14 Myelin Basic Protein Neuroligin-1 NrCAM p120 Catenin P-Selectin PYK2 SEMA4A Sialyl Lewis X Siglec-11 ... ELISA Capture (4) ELISA Detection (1) ELISPOT Detection (1) EM (1) FA (35) FC (4102) ICC (176) ICFC (85) ICPG (1) IHC (75) IHC- ... SKII.4 SMI 99 TC15-12F12.2 TRA-2-10 TS1/18 TS2/16 TX31 TX56 URA-1 WM59 ... Mouse IgG1 (4) Mouse IgG1, κ (2048) Mouse IgG1, λ (5) Mouse IgG2a (1) Mouse IgG2a, κ (434) Mouse IgG2a, λ (3) Mouse IgG2b (1) ...

The immunoregulatory glycan-binding protein galectin-1 triggers human platelet activation. Pacienza N, Pozner RG, Bianco GA, ... Among authors: d atri lp. FASEB J. 2008 Apr;22(4):1113-23. doi: 10.1096/fj.07-9524com. Epub 2007 Nov 5. FASEB J. 2008. PMID: ... Activation of toll-like receptors 2 and 4 on CD34+ cells increases human megakaryo/thrombopoiesis induced by thrombopoietin. ... 2009;16(4):417-29. doi: 10.2174/092986709787315513. Curr Med Chem. 2009. PMID: 19199914 Review. ...

The jury "Researcher of the Month" elected Judith Leitner for her publication "TIM -3 does not act as a receptor for galectin - ... TIM-3 DOES NOT ACT AS A RECEPTOR FOR GALECTIN-9. Judith Leitner1, Katharina Grabmeier-Pfistershammer2, Armin Rieger2, Winfried ... Workshop 4 CHRISTIAN MACHACEK for the poster. DECIPHERING THE FUNCTION OF FOLATE RECEPTOR BETA. Christian Machacek, Verena ... 4, Markus Jaritz5, Philip Zimmermann6, Robert Zeillinger2, Diana Mechtcheriakova ...

... express galectin-1, -3, -8, and -9; however, expression of galectin-1 and -3 is more prominent than that of other galectins. ... Galectin-1 knockout reduces the immunosuppressive effect of T-MSCs on CD4+ T cells [58]. After galectin-1 knockout, CD4+ and ... However, the effect of MSCs on NK cells was unaffected by the downregulation of galectin-1. MSC-derived galectin-1 ... Human multipotent mesenchymal stromal cells use galectin-1 to inhibit immune effector cells. Blood. 2010;116:3770-9. ...

Chemokines and galectins form heterodimers to modulate inflammation. EMBO Rep. 2020, 21, e47852. [Google Scholar] [CrossRef] [ ... Figure 4. Network analysis of central HERV-PLS CREs genes. The final network includes 90 input genes (indicated with gray ... Figure 4. Network analysis of central HERV-PLS CREs genes. The final network includes 90 input genes (indicated with gray ... 4. Discussion. In this paper a framework on the regulatory roles of Human Endogenous Retroviruses was developed. My approach ...

This galectin, as well as galectin-1 and galectin-4, are prominent inducers of phosphatidylserine exposure, a common eat me ... Galectin-1, galectin-3 and galectin-8 enhance phosphatidylserine exposure on activated neutrophils and myeloid HL-60 cells, ... intracellular galectin-3 and galectin-7 form heterodimers with Bcl-2, which modulate cellular apoptosis. Galectin-7-Bcl-2 ... Galectin-3 and galectin-1 bind distinct cell surface glycoprotein receptors to induce T cell death. J Immunol 2006; 176: 778- ...

Extracellular galectin 4 drives immune evasion and promotes T-cell apoptosis in pancreatic cancer ...

Extracellular galectin 4 drives immune evasion and promotes T-cell apoptosis in pancreatic cancer. Cancer Immunol Res. (2023) ... In a separate investigation, galectin-4 (Gal4), a protein secreted by tumor cells that accumulates in the ECM, was identified ... 4. Humphris, JL , Chang, DK , Johns, AL , Scarlett, CJ , Pajic, M , Jones, MD, et al. The prognostic and predictive value of ... 4) Library construction: fragmentation and adapter tagging of cDNA, followed by amplification, culminate in the formation of a ...

Rotshenker S. Galectin-3 (MAC-2) controls phagocytosis and macropinocytosis through intracellular and extracellular mechanisms ... 2d). Further downregulated genes include macrophage receptor with collagenous structure (MARCO) and LGALS3 (galectin-3), which ... 4 COVID-19, mild m 58 Acute COVID-19 with respiratory symptoms COPD, hypertension (initial presentation to the ER due to ... 4 COVID-19, mild m 58 Acute COVID-19 with respiratory symptoms COPD, hypertension (initial presentation to the ER due to ...

Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance. Cell. 2016 Nov 3;167(4):973-984.e12. doi: ... Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance. In: Cell. 2016 ; Vol. 167, No. 4. pp. 973-984 ... Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance. Pingping Li, Shuainan Liu, Min Lu, Gautum ... Galectin-3 (Gal3), a lectin mainly secreted by macrophages, is elevated in both obese subjects and mice. Administration of Gal3 ...

Recombinant Human Galectin-8 (LGALS8) (Active) , CSB-EP012894HU , CusabioProtein Description: Full LengthAlternative Name (s ... Recombinant Human Ribonuclease 4 (RNASE4) , CSB-YP019796HU , CusabioAlternative Name(s): RNS4Gene Names: RNASE4Research Areas: ... Recombinant Human Lysozyme C (LYZ) , CSB-EP013283HU , CusabioAlternative Name(s): 1,4-beta-N-acetylmuramidase CGene Names: ...

PLoS One (2012) 7(4) : e35384. Oger P and Franzetti B. Des microbes qui repoussent les limites de la vie.. Biofutur (2012) 336 ... Biopolymers (2013) 99(4) : 233-238. Zaccai G. The ecology of protein dynamics.. Current Physical Chemistry, Special Issue on ... Journal of Synchrotron Radiation (2005) 12(Pt 4) : 402-409. de Bono S, Riechmann L, Girard E, Williams RL and Winter G. A ... Journal of Molecular Biology (2003) 325(4) : 651-660.. Girard E, Anelli PL, Vicat J and Kahn R. High-phasing-power lanthanide ...