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*  Didox, a unique ribonucleotide reductase inhibitor and free radical scavenger, can protect against doxorubicin caused...
These results further support our premise that a free radical scavenger can be used in conjunction with DOX and not impede its ... Didox, a unique ribonucleotide reductase inhibitor and free radical scavenger, can protect against doxorubicin caused ... Didox, a unique ribonucleotide reductase inhibitor and free radical scavenger, can protect against doxorubicin caused ... Didox, a unique ribonucleotide reductase inhibitor and free radical scavenger, can protect against doxorubicin caused ...
http://cancerres.aacrjournals.org/content/66/8_Supplement/502.1
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To see whether the citreoviridin induced UPR was ROS dependent, free radical scavenger NAC was used. Treating with ... The ROS scavenger NAC was administered to cells at 5 and 10 mmol/L for 30 minutes. After washing, cells were detached, and the ... All the cells were free of mycoplasma as determined by a PCR-based mycoplasma detection method (MBI Fermentas). ...
http://cancerres.aacrjournals.org/content/72/18/4696
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... have indicated that silymarin has strong antioxidative properties and acts as a free radical scavenger reducing free radicals, ... such as silydianin that can act as a free radical scavenger. On treatment with silydianin, decreased superoxide radical release ... The most effective scavengers of these free radicals were silymarin and silychristin, whereas silybinin was ineffective ( 34). ... Feher J, Lang I, Nekam K, Gergely P, Muzes G. In vivo effect of free radical scavenger hepatoprotective agents on superoxide ...
http://cancerres.aacrjournals.org/content/68/6/2033
*  Peroxyl Radical- and Cytochrome P-450-dependent Metabolic Activation of (+)-7,8-Dihydroxy-7,8-dihydrobenzo(a)pyrene in Mouse...
The addition of butylated hydroxyanisole (BHA, a free radical scavenger) decreased the formation of both anti- and syn-BPDE- ... Peroxyl Radical- and Cytochrome P-450-dependent Metabolic Activation of (+)-7,8-Dihydroxy-7,8-dihydrobenzo(a)pyrene in Mouse ... Peroxyl Radical- and Cytochrome P-450-dependent Metabolic Activation of (+)-7,8-Dihydroxy-7,8-dihydrobenzo(a)pyrene in Mouse ... Peroxyl Radical- and Cytochrome P-450-dependent Metabolic Activation of (+)-7,8-Dihydroxy-7,8-dihydrobenzo(a)pyrene in Mouse ...
http://cancerres.aacrjournals.org/content/49/7/1732
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Attenuation of radiation-induced genomic instability by free radical scavengers and cellular proliferation. Free Radic. Biol. ...
http://cancerres.aacrjournals.org/content/63/5/936
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2A). The addition of the free-radical scavenger N-acetyl cysteine (NAC) prevented the elevation of ROS levels and cell death ... and was rescued by the free-radical scavenger N-acetyl-cysteine (NAC) in TSC2-deficient cells. Our studies greatly expand this ... S3). Further studies revealed that Nec-1 and NSA potentiated BSO/auranofin-induced free-radical formation up to 4.3-5.1-fold in ... 37). Thus, the fact that elevated levels of free radicals block the ability of TSC2-deficient cells to accommodate additional ...
http://cancerres.aacrjournals.org/content/76/24/7130
*  An NQO1 Substrate with Potent Antitumor Activity That Selectively Kills by PARP1-Induced Programmed Necrosis | Cancer Research
... a global free radical scavenger (13), partially blocked lethality. Here, we show that deoxynyboquinone undergoes an NQO1- ... Pretreatment of cells with BAPTA-AM (a cytosolic Ca2+ chelator) or catalase (enzymatic H2O2 scavenger) was sufficient to rescue ... Cells were cultured at 37°C in a 5% CO2 95% air humidified atmosphere and were Mycoplasma free. ...
http://cancerres.aacrjournals.org/content/72/12/3038.full
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Curcumin and related compounds inhibit free radical generation and act as free radical scavengers (6, 7, 8) and antioxidants (9 ... Because of its ability to act as a free radical scavenger (6, 7, 8) and to inhibit AP-1 (16) and JNK activation (17) , we ... 33 ), one might suspect that curcumin, as an antioxidant and free radical scavenger, would inhibit the ability of ... Because curcumin acts as a free radical scavenger, it was of interest to evaluate its impact on generation of ROS using ...
http://cancerres.aacrjournals.org/content/62/13/3868
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... system could not be efficiently inhibited by hydroxyl radical scavengers, but could be protected by singlet oxygen scavengers, ... but not free hydroxyl radical probably plays a role in the DNA damage. The above results would suggest that macromolecule- ... Using reactive oxygen scavengers, it was observed that the DNA strand breaks induced by the 1,4-HQ/Cu(II) ... has been shown to be capable of mediating the activation of several xenobiotics producing reactive oxygen and other radicals. ...
http://cancerres.aacrjournals.org/content/54/7_Supplement/1895s
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Measurements of free radical generation. XO has been hypothesized to be an important source of free radical generation in cells ... other studies and indicated that allopurinol did not act as a nonspecific scavenger of either superoxide or hydroxyl radicals ... This xanthine-dependent production of free radicals was completely blocked with allopurinol, confirming that the free radical ... XO was present in these cells and was the primary source of free radicals. We also showed higher XO activity in cells exposed ...
http://cancerres.aacrjournals.org/content/66/4/2257
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Free iron participates in the Fenton reaction generating hydroxyl radicals and hydroxide anions from hydrogen peroxide ( 19). ... The glutathione peroxidase mimetic ebselen or the hydroxyl radical scavenger butylated hydroxyl-anisole equally blocked ROS ... Hydroxyl radicals can react with the backbone of proteins and amino acid side chains resulting in the formation of further ... We found that free intracellular iron and reactive oxygen species (ROS) are the main mediators of this cell death. Antioxidants ...
http://cancerres.aacrjournals.org/content/69/6/2365
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Another free radical, nitric oxide (NO•) can enhance the generation of O2• and subsequent generation of H2O2 by inhibiting the ... a H2O2 scavenger (14) . ... Halliwell B, Gutteridge JMC . Free Radicals in Biology and ... hydroxyl radical, superoxide, and hypochlorous acid. Free Radic Biol Med, 6: 593-7, 1989. ... Cells were then infected with either adeno-CAT or Adeno-βGal in 3 ml of tetracycline-free medium and incubated for 1 h. Cells ...
http://cancerres.aacrjournals.org/content/64/7/2350
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Free radical production was assessed by EPR by measuring the intensities of the DMPO-OH spin adduct, which corresponds to the ... In another approach to test our hypothesis, we used Tempol as an O2•− scavenger. Tempol is a stable nitroxide radical that has ... S. Kaewpila was partially supported by Ministry of Science under Royal Thai Government and Free Radical and Radiation Biology ... to form a more stable free radical product (spin adduct), which can be studied by EPR. The intensity of the spin adduct signal ...
http://cancerres.aacrjournals.org/content/68/8/2781
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Murine T cells were stimulated in l-Arg-free RPMI 1640. Simultaneously, TAMC or non-TAMC populations were cultured for 24 h in ... a hydrogen peroxide scavenger (Fig. 8, C and D) ⇓ , demonstrating that the depletion of l-Arg by tumor-associated myeloid cells ... and hydroxyl radical. Dihydroethidium (Molecular Probes) was used to test the production of superoxide anion. Cells were ... and hydroxyl radicals. Freshly isolated enriched tumor-associated myeloid cells did not have detectable levels of reactive ...
http://cancerres.aacrjournals.org/content/64/16/5839
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... vaccine was administered to 20 breast cancer patients who had undergone radical treatment and were classified as disease-free. ... S1 and S2). This is in agreement with recent studies showing that cancer mucins without sialic acids are removed by scavenger ... stage III/IV after treatment and disease-free) enrolled in a phase I study. Sera from breast cancer (n = 28), ovarian cancer (n ... are removed by scavenger receptors and hence inherently represent insensitive biomarkers. This selective clearance provides a ...
http://cancerres.aacrjournals.org/content/70/4/1306
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It is a powerful scavenger of reactive oxygen species (ROS), such as hydroxyl, peroxyl radicals, singlet oxygen, and nitric ... and reduce side effects via its free radical scavenging/antioxidant properties ( 7). In most of the combination trials where ... melatonin has been reported to be a powerful scavenger of ROS as well as an inducer of many antioxidant enzymes. Both of these ... 0.7 months and the time free from brain progression was 5.9 ± 0.8 versus 2.7 ± 0.6 months in patients receiving melatonin ( 23 ...
http://cancerres.aacrjournals.org/content/66/20/9789
*  Resistance to Paclitaxel Is Proportional to Cellular Total Antioxidant Capacity | Cancer Research
Direct effect of Taxol on free radical formation and mitochondrial permeability transition. Free Radic Biol Med 2001; 31: 548- ... Antioxidants pyruvate and selenium, the NO synthase inhibitor Nω-nitro-l-arginine methyl ester, and the NO scavenger manganese ... 27) speculated that many chemotherapeutic agents exert their toxic effects on cancer cells by producing free radicals, leading ... H2O2 is known to produce the •OH radical in the presence of Fenton metals. O2− can also react rapidly with NO• to form ...
http://cancerres.aacrjournals.org/content/65/18/8455?ijkey=7846fdcef81302dfadeb2b51f1be84207bab1fed&keytype2=tf_ipsecsha
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In addition, 18 nontumor tissues and two RNA pools from cancer-free prostates were used for genetic comparisons. In an initial ... Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk. ... a comparative study based on radical prostatectomy specimens. J Urol 1998; 160: 437-42. ...
http://cancerres.aacrjournals.org/content/68/3/927
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Gao Z, Huang K, Yang X, Xu H. Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of ... Then, a hydrogen peroxide scavenger, catalase, efficiently blocked the apoptosis caused by TRAIL and baicalein in PC3 cells, ... Interestingly, baicalein induced reactive oxygen species (ROS) and a ROS scavenger prevented DR5 expression and TRAIL ... serum-free medium with 0.2% bovine serum albumin (BSA; Sigma). Normal human hepatocytes (Cell System-Hc cells) were obtained ...
http://cancerres.aacrjournals.org/content/68/21/8918