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*  In vivo epidermal migration requires focal adhesion targeting of ACF7 (Journal Article) | DOE PAGES
... promotes focal adhesion dynamics by targeting of microtubule plus ends towards focal adhesions. However, it remains unclear how ... Turnover of focal adhesions allows cell retraction, which is essential for cell migration. The mammalian spectraplakin protein ... Accepted Manuscript: In vivo epidermal migration requires focal adhesion targeting of ACF7 ... focal adhesion kinase) complex is essential for F-actin binding of ACF7. Using skin epidermis as a model system, we further ...
https://www.osti.gov/pages/biblio/1261624-vivo-epidermal-migration-requires-focal-adhesion-targeting-acf7
*  IJMS | Free Full-Text | Pilot Study: Alteration of Deleted in Liver Cancer1 and Phosphorylated Focal Adhesion Kinase Y397...
... and phosphorylated focal adhesion kinase (p-FAK) have recently been reported as metastasis-related genes. However, the roles ... Fan D-M, Shi H-R. Pilot Study: Alteration of Deleted in Liver Cancer1 and Phosphorylated Focal Adhesion Kinase Y397 Cytoplasmic ... Fan, D.-M.; Shi, H.-R. Pilot Study: Alteration of Deleted in Liver Cancer1 and Phosphorylated Focal Adhesion Kinase Y397 ... Background: Deletion in liver cancer gene (DLC1) and phosphorylated focal adhesion kinase (p-FAK) have recently been reported ...
http://www.mdpi.com/1422-0067/12/12/8489/xml
*  "PIPKIγ Regulates Focal Adhesion Dynamics and Colon Cancer Cell Invasio" by Zhaofei Wu, Xiang Li et al.
... binds talin and is required for focal adhesion formation in EGF-stimulated cells, but its role in regulating focal adhesion ... and inhibited vinculin localizing to focal adhesions. Taken together, PIPKIγ positively regulates focal adhesion dynamics and ... Furthermore, overexpression of PIPKIγ, but not PIPKIγK188,200R, resulted in an increase in both focal adhesion assembly and ... We show here that overexpression of PIPKIγ promoted focal adhesion formation, whereas cells expressing either PIPKIγK188,200R ...
https://uknowledge.uky.edu/markey_facpub/2/
*  Background Focal adhesion Kinase (FAK) is a nonreceptor proteins tyrosine kinase - NF-κB signaling in inflammation and cancer
Background Focal adhesion Kinase (FAK) is a nonreceptor proteins tyrosine kinase that is overexpressed in tumors and plays a ... Background Focal adhesion Kinase (FAK) is a nonreceptor proteins tyrosine kinase. May 18, 2017 ...
http://healthcarecoremeasures.com/2017/05/18/background-focal-adhesion-kinase-fak-is-a-nonreceptor-proteins-tyrosine-kinase/
*  Background The focal adhesion protein p130Cas (Cas) activates multiple intracellular signaling - Drug Resistance to EGFR...
Focal adhesion proteins g130Cas (Cas) is normally a multi-domain docking proteins, with an N-terminal SH3 domains, a central " ... Background The focal adhesion protein p130Cas (Cas) activates multiple intracellular signaling On December 14, 2017 by Freddie ... Background The focal adhesion protein p130Cas (Cas) activates multiple intracellular signaling pathways upon integrin or growth ... adding to the prior results by others back linking focal adhesion elements to 85022-66-8 manufacture the procedure of autophagy ...
http://elevateblogconference.com/background-the-focal-adhesion-protein-p130cas-cas-activates-multiple-intracellular-signaling/
*  Actin flow and talin dynamics govern rigidity sensing in actin-integrin linkage through talin extension | Journal of The Royal...
2013 Vinculin-actin interaction couples actin retrograde flow to focal adhesions, but is dispensable for focal adhesion growth ... 2001 Nascent focal adhesions are responsible for the generation of strong propulsive forces in migrating fibroblasts. J. Cell ... 2005 Cell locomotion and focal adhesions are regulated by substrate flexibility. Proc. Natl Acad. Sci. USA 94, 13 661-13 665. ( ... 1996 Rho-stimulated contractility drives the formation of stress fibers and focal adhesions. J. Cell Biol. 133, 1403-1415. (doi ...
http://rsif.royalsocietypublishing.org/content/11/99/20140734
*  Actin Dynamics Associated with Focal Adhesions
"Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion ... Figure 1: Actin networks in cell migration and organization of nascent adhesions and focal adhesions. Left, scheme of a ... the regulation of actin assembly in focal adhesions.. 2. Initiation of Actin Assembly in Nascent Adhesions. During the ... actin-binding proteins in focal complexes and focal adhesions. PM, plasma membrane; ECM, extracellular matrix. ...
https://www.hindawi.com/journals/ijcb/2012/941292/
*  Turnover of Focal Adhesions and Cancer Cell Migration
... Makoto Nagano,1 Daisuke Hoshino,2 Naohiko Koshikawa,2 Toshifumi Akizawa, ... Makoto Nagano, Daisuke Hoshino, Naohiko Koshikawa, Toshifumi Akizawa, and Motoharu Seiki, "Turnover of Focal Adhesions and ...
https://www.hindawi.com/journals/ijcb/2012/310616/cta/
*  'focal adhesions' Protocols and Video...
... focal adhesions' include 'Preparation of Complaint Matrices for Quantifying Cellular Contraction', 'Micromanipulation ... Analyzing Cell Surface Adhesion Remodeling in Response to Mechanical Tension Using Magnetic Beads', 'Induction of Adhesion- ... Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced ... Nanotopology of Cell Adhesion upon Variable-Angle Total Internal Reflection Fluorescence Microscopy (VA-TIRFM)', 'Simple ...
https://www.jove.com/keyword/focal+adhesions
*  Mechanosensing of substrate stiffness regulates focal adhesions dynamics in cell | SpringerLink
Focal adhesions are part of the cell mechanosensing machinery and, operating at the very dynamic... ... Geiger B, Spatz JP, Bershadsky AD (2009) Environmental sensing through focal adhesions. Nat Rev Mol Cell Biol 10:21-33CrossRef ... Focal adhesions are part of the cell mechanosensing machinery and, operating at the very dynamic interface between cell and ... Giannone G (2015) Super-resolution links vinculin localization to function in focal adhesions. Nat Cell Biol 17:845-847CrossRef ...
https://link.springer.com/article/10.1007/s11012-017-0676-3
*  KEGG PATHWAY: Focal adhesion - Homo sapiens (human)
Focal adhesion - Homo sapiens (human) [ Pathway menu , Organism menu , Pathway entry , Download KGML , Show description , User ... Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin ... At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of ... Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell ...
https://www.genome.jp/kegg-bin/show_pathway?133806541429257/hsa04510.args
*  Focal Adhesion (Homo sapiens) - WikiPathways
Pathway:Human:Focal adhesion KEGG]] moved to [[Pathway:Homo sapiens:Focal adhesion KEGG]]: Renaming species. 7651. view. 16:07 ... Focal adhesions: structure and dynamics.''; Biol Cell, 2000 PubMed*Mitra SK, Hanson DA, Schlaepfer DD; ''Focal adhesion kinase ... gpml file for [[Human:Focal_adhesion_KEGG]]. External references DataNodes. View all...", "View last 5...")' style='cursor: ... Focal Adhesion (Homo sapiens). From WikiPathways. Revision as of 01:02, 17 November 2017 by Ariutta (Talk , contribs) ...
https://www.wikipathways.org/instance/WP306_r95135
*  Focal adhesion kinase and p53 signal transduction pathways in cancer. - PubMed - NCBI
Focal Adhesion Kinase (FAK) structure. FAK has the N-terminal, Kinase domain and the C-terminal domains. The N-terminal domain ... Focal adhesion kinase and p53 signal transduction pathways in cancer.. Golubovskaya VM1, Cance W. ... Focal Adhesion Kinase is overexpressed in tumor samples. Immunohistochemical staining is shown for colon cancer sample. Left ... One of the critical tyrosine kinases that is linked to these processes of tumor invasion and survival is the Focal Adhesion ...
https://www.ncbi.nlm.nih.gov/pubmed/20515733?dopt=Abstract
*  Evidence That Focal Adhesion Complexes Power Bacterial Gliding Motility | Science
Evidence That Focal Adhesion Complexes Power Bacterial Gliding Motility Message Subject. (Your Name) has forwarded a page to ... Evidence That Focal Adhesion Complexes Power Bacterial Gliding Motility. By Tâm Mignot, Joshua W. Shaevitz, Patricia L. ... Evidence That Focal Adhesion Complexes Power Bacterial Gliding Motility. By Tâm Mignot, Joshua W. Shaevitz, Patricia L. ... Unexpectedly, bacteria can move as eukaryotes do, by adhering to the surface via transient adhesion sites that continually ...
http://science.sciencemag.org/content/315/5813/853
*  Actin retrograde flow actively aligns and orients ligand-engaged integrins in focal adhesions | PNAS
2012) Archipelago architecture of the focal adhesion: Membrane molecules freely enter and exit from the focal adhesion zone. ... Integrin coalignment in focal adhesions. Vinay Swaminathan, Joseph Mathew Kalappurakkal, Shalin B. Mehta, Pontus Nordenfelt, ... Integrin coalignment in focal adhesions. Vinay Swaminathan, Joseph Mathew Kalappurakkal, Shalin B. Mehta, Pontus Nordenfelt, ... 1994) Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature 372:786-791. ...
https://www.pnas.org/content/114/40/10648
*  RCSB PDB - Protein Feature View - Focal adhesion kinase 1 - Q05397 (FAK1 HUMAN)
The carboxy-terminal region is the site of focal adhesion targeting (FAT) sequence which mediates the localization of FAK1 to ... formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. ... Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, ...
http://www.rcsb.org/pdb/protein/Q05397
*  Focal adhesion kinase modulates cell adhesion strengthening via integrin activation.
Focal adhesion kinase (FAK) is an essential nonreceptor tyrosine kinase regulating cell migration, adhesive signaling, and ... Cell Adhesion / drug effects. Fibroblasts / cytology*, drug effects, enzymology*. Fibronectins / metabolism. Focal Adhesion ... Focal adhesion kinase (FAK) is an essential nonreceptor tyrosine kinase regulating cell migration, adhesive signaling, and ... EC 2.7.10.2/Focal Adhesion Protein-Tyrosine Kinases; F8VB5M810T/Tetracycline ...
http://www.biomedsearch.com/nih/Focal-adhesion-kinase-modulates-cell/19297531.html
*  FAK+ - pp125-focal adhesion kinase | AcronymAttic
FAK+ stands for pp125-focal adhesion kinase. FAK+ is defined as pp125-focal adhesion kinase rarely. ... The pp125 focal adhesion kinase (FAK) is involved in integrin-mediated cell signalling and overexpressed in a variety of solid ... Focal adhesion kinase expression has been correlated to invasion and metastasis, but the data on breast cancer are inconclusive ... A mouse monoclonal antibody to pp125 focal adhesion kinase (clone 2A7) was purchased from Upstate Biotechnology, Inc. (Lake ...
https://www.acronymattic.com/pp125_focal-adhesion-kinase-
*  Other Focal Adhesion Molecules Research Areas: R&D Systems
Find Other Focal Adhesion Molecules research area related information and Other Focal Adhesion Molecules research products from ...
https://www.rndsystems.com/research-area/other-focal-adhesion-molecules
*  VASCULAR INJURY CHANGE TYROSINE PHOSPHORYLATION OF FOCAL ADHESION PROTEINS | Heart
... and then analysed by Western blot with antibodies against focal adhesion kinase (FAK), paxillin, and phosphotyrosine. ...
http://heart.bmj.com/content/98/Suppl_2/E55.2
*  Evrogen Tools for labeling of focal adhesion kinase
Subcellular localization vectors: labeling of focal adhesion kinase (FAK). CAT.#. PRODUCT. REPORTER. COLOR OF FLUORESCENCE. ... TagRFP fusion with focal adhesion kinase. red (orange). 20 μg. € 400 / 200*. ... Transiently transfected HeLa cells expressing TagRFP fusion with focal adhesion kinase. Image was kindly provided by Michael W ...
http://evrogen.com/products/Organelle-labeling-FAK.shtml
*  Restructuring of Focal Adhesion Plaques by Pi 3-Kinase | JCB
To determine if PDGF modulates the structure of focal adhesions, REFs were examined using IRM. Since focal adhesions are the ... In contrast, the integrin receptor and the focal adhesion proteins talin and paxillin remained localized to the focal adhesion ... Activation of PI 3-kinase by PDGF Induces Focal Adhesion Disassembly. Focal adhesions are plaquelike accumulations of proteins ... formation of focal adhesions and stress fibers (Couchman and Woods 1996; Greenwood and Murphy-Ullrich 1998). Focal adhesions ...
http://jcb.rupress.org/content/150/3/627.full
*  Targeting and transport: How microtubules control focal adhesion dynamics | JCB
Focal adhesion kinase modulates tension signaling to control actin and focal adhesion dynamics. J. Cell Biol. 176:667-680. doi: ... Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase. Nat. Cell Biol. 7:581-590. doi ... Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion ... Asymmetric focal adhesion disassembly in motile cells. Curr. Opin. Cell Biol. 20:85-90. doi:10.1016/j.ceb.2007.10.009. ...
http://jcb.rupress.org/content/198/4/481?ijkey=ec8ff4fda9e6691ab573704d38b1bc694c451b1f&keytype2=tf_ipsecsha
*  Stretch activates human myometrium via ERK, caldesmon and focal adhesion signaling. | Sigma-Aldrich
Stretch activates human myometrium via ERK, caldesmon and focal adhesion signaling.. [Yunping Li, Maya Reznichenko, Rachel M ... These results suggest that focal adhesion proteins may present new targets for drug discovery programs aimed at regulation of ... stretch-dependent focal adhesion signaling, facilitated by the ERK activator SmAV, can contribute to myometrial activation. ... we identify 3 stretch-activated focal adhesion proteins, FAK, p130Cas, and alpha actinin. FAK-Y397, which signals integrin ...
https://www.sigmaaldrich.com/catalog/papers/19834610
*  Focal Adhesion Kinase
Aurora Kinases as Druggable Targets in Cancer Therapy » Focal Adhesion Kinase Menu Not Found. Skip to content *Home ... These A431-III cells secrete a higher level of MMP-9 and show higher adhesion, distributing, migration, and invasive ability ... Omental extra fat improved the appearance of transcription elements, mRNA of extracellular matrix protein, and adhesion ... pirfenidone modulates a variety of cytokines and it has been demonstrated that it decreases levels of intercellular adhesion ...
http://www.exposed-skin-care.net/category/focal-adhesion-kinase/